Professional Documents
Culture Documents
STEMI
DR RAJESH K F
Applying Classification of Recommendations and
Level of Evidence
Class I Class IIa Class IIb Class III
Benefit >>> Risk Benefit >> Risk Benefit ≥ Risk Risk ≥ Benefit
Additional studies with Additional studies with No additional studies
focused objectives broad objectives needed
needed needed; Additional
registry data would be Procedure/Treatment
Procedure/ IT IS REASONABLE to helpful should NOT be
Treatment SHOULD perform performed/administered
be performed/ procedure/administer Procedure/Treatment SINCE IT IS NOT
administered treatment MAY BE CONSIDERED HELPFUL AND MAY
BE HARMFUL
Level A: Multiple populations evaluated; Data derived from multiple randomized clinical trials or meta-analyses
Level B: Limited populations evaluated. Data derived from a single randomized trial or non-randomized studies
Level C: Very limited populations evaluated. Only consensus opinion of experts, case studies, or standard-of-care.
Applying Classification of Recommendations
and Level of Evidence
Class I Class IIa Class IIb Class III
Benefit >>> Risk Benefit >> Risk Benefit ≥ Risk Risk ≥ Benefit
Additional studies with Additional studies with No additional studies
focused objectives broad objectives needed
needed needed; Additional
registry data would be Procedure/Treatment
Procedure/ Treatment IT IS REASONABLE helpful should NOT be
SHOULD be to perform performed/administered
performed/ procedure/administer Procedure/Treatment SINCE IT IS NOT
administered treatment MAY BE CONSIDERED HELPFUL AND MAY BE
HARMFUL
3
Evolution of Guidelines for STEMI
Golden Hour = first 60 min. Total ischemic time: within 120 min.
13
Management in Emergency
Department
Initial patient evaluvation
• Targeted history
II IIa
IIa IIb
IIb III
III
• Physical examination including focused
and limited neurological examination to
look for prior stroke or cognitive defects
prior to thrombolysis
ECG
100
Multiples of the URL
50
Cardiac troponin-no reperfusion
20 Cardiac troponin-reperfusion
10 CKMB-no reperfusion
CKMB-reperfusion
5
2
Upper reference limit
1
0 1 2 3 4 5 6 7
URL = 99th %tile of
8 Days After Onset of STEMI Reference Control Group
• 325
• Continue indefinitely
• (COMMIT/CCS 2)
Reperfusion
II IIa
IIa IIb
IIb III
III
• It is probably indicated in aspirin
hypersensitivity or GI intolerance
If PCI is planned, one of the following
• Nifedipine is contraindicated in
treatment of STEMI
Blood sugar control
• It is reasonable to use an insulin
based regimen to achieve and
maintain glucose levels less than 180
mg/dl while avoiding hypoglycemia
for patients with STEMI with either
a complicated or uncomplicated
course
• NICE SUGAR
Emergency Management of Complicated STEMI
Clinical signs: Shock, hypoperfusion, congestive heart failure, acute pulmonary edema
Most likely major underlying disturbance?
Systolic BP
Greater than 100 mm Hg 70 to 100 mm Hg 70 to 100 mm Hg less than 70 mm Hg
NO signs/symptoms Signs/symptoms Signs/symptoms of shock
Systolic BP
of shock of shock
Greater than 100 mm Hg
and not less than 30 mm Hg
below baseline Nitroglycerin Dobutamine Dopamine Norepinephrine
10 to 20 mcg/min IV 2 to 20 5 to 15 0.5 to 30 mcg/min IV
mcg/kg per mcg/kg per
ACE Inhibitors minute IV minute IV
Short-acting agent such as
captopril (1 to 6.25 mg)
Third line of action
76
RV infarction
• Refractory polymorphic VT
Yes No
Spontaneous VT or VF
48 hours post-STEMI
Recommendations for Treatment of
Atrioventricular and Intraventricular Conduction
Disturbances During STEMI
Atrioventricular Conduction
INTRAVENTRICULAR First degree AV block Mobitz I second degree AV block Mobitz II second degree AV block
CONDUCTION Normal ANTERIOR MI NON-ANTERIOR ANTERIOR MI NON-ANTERIOR ANTERIOR MI NON-ANTERIOR
Normal ACTION CLASS ACTION CLASS ACTION CLASS ACTION CLASS ACTION CLASS ACTION CLASS ACTION CLASS
Observe I Observe I Observe I Observe IIb Observe IIa Observe III Observe III
A III A III A III A* III A III A III A III
TC III TC IIb TC IIb TC I TC I TC I TC I
TV III TV III TV III TV III TV III TV IIa TV IIa
Old or New Observe I Observe IIb Observe IIb Observe IIb Observe IIb Observe III Observe III
Fascicular block A III A III A III A* III A III A III A III
(LAFB or LPFB) TC IIb TC I TC IIa TC I TC I TC I TC I
TV III TV III TV III TV III TV III TV IIa TV IIb
Old bundle Observe I Observe III Observe III Observe III Observe III Observe III Observe III
branch block A III A III A III A* III A III A III A III
TC IIb TC I TC I TC I TC I TC I TC I
TV III TV IIb TV IIb TV IIb TV IIb TV IIa TV IIa
New bundle Observe III Observe III Observe III Observe III Observe III Observe III Observe III
branch block A III A III A III A* III A III A III A III
TC I TC I TC I TC I TC I TC IIb TC IIb
TV IIb TV IIa TV IIa TV IIa TV IIa TV I TV I
Fascicular Observe III Observe III Observe III Observe III Observe III Observe III Observe III
block + RBBB A III A III A III A* III A III A III A III
TC I TC I TC I TC I TC I TC IIb TC IIb
TV IIb TV IIa TV IIa TV IIa TV IIa TV I TV I
Alternating Observe III Observe III Observe III Observe III Observe III Observe III Observe III
left and right A III A III A III A* III A III A III A III
bundle branch TC IIb TC IIb TC IIb TC IIb TC IIb TC IIb TC IIb
block TV I TV I TV I TV I TV I TV I TV I
81
Permanent pacemaker
• Persistent second degree AV block in
His purkinje system with bil BBB
• Third degree AV block with in or
below His purkinje system
• Transient or advanced 2nd or 3rd
degree infranodal AV block and BBB
• Persistent and symptomatic 2nd or 3rd
degree AV block
• Persistent second degree AV block in
His purkinje system with bil BBB
Pericarditis
II IIa
IIa IIb
IIb III
III
• Corticosteroids
• NSAIDS
• ibuprofen
Long term management
• Smoking -Complete cessation
• Blood pressure-< 140/90 mm Hg or <130/80 mm Hg if
chronic kidney disease or diabetes
• Physical activity-Minimum goal is 30 minutes 3 to 4 days
per week, optimally daily
• Weight management- Goal BMI 18.5 to 24.9 kg/m2, Waist
circumference-Women: < 35 in,Men: < 40 in.
• Diabetes management-Appropriate hypoglycemic therapy
to achieve near-normal HbA1c.
Lipid management
• Start dietary therapy in all patients (< 7% of
total calories as saturated fat and < 200 mg/d
cholesterol, trans fatty acids)
• Adding plant stanol/sterol(2gm/day)and /or
viscous fiber (>10gm/d).
• Promote physical activity and weight
management.
• Encourage increased consumption of omega-
3 fatty acids in form of fish or capsules
1gm/d.
• Assess fasting lipid profile in all patients,
preferably within 24 hours of STEMI.
• Add drug therapy according to the
following guide
• LDL-C should be < 100 mg/Dl
• Further reduction to <70mg/dl is
reasonable
• LDL-C ≥ 100 mg/dL
• LDL-C–lowering therapy
• If TGs are ≥ 150 mg/dL or HDL-C is < 40
mg/dL
Emphasize weight management and
physical activity. Advise smoking cessation.
• If TG is 200 to 499 mg/dL
After LDL-C–lowering therapy, consider
adding fibrate or niacin.
• If TG is ≥ 500 mg/dL
Consider fibrate or niacin before LDL-C–
lowering therapy
warfarin
• Managing warfarin to INR 2 to 3 in
patients when clinically indicated(AF
or LV thrombus)
• when used in conjunction with
antiplatelets should be monitored
closely
• INR of 2 to 2.5 is recommended in
such patients
• HRT with estrogen plus progestin
should not be given
• Antioxidant vitamins should not be
prescribed for sec preveventoin