DR.

MADIHA BATOOL ZAHEER

Senior Medical Officer
Darul Sehat Hospital
 WHAT IS JOURNAL CLUB???
• A journal club is a form of meeting regularly held among health practitioners to discuss recently
published related literature.
 OBJECTIVES

 Understand the article

ü Keeping up-to-date with the literature
ü Teaching critical appraisal skills
ü Promoting evidence based medicine (EBM)
ü Providing continuing education
ü Promoting social interaction
 HISTORY OF JOURNAL CLUB

• Sir William Osler of Montreal, Canada, is credited with starting the first formal
journal club in 1875
• However Sir James Paget wrote of a similar group of students at St.
Bartholomew's Hospital in London who read journals together from 1835 to
1854. 
• Osler founded the first journal club in the United States at the Johns Hopkins
Hospital around ten years later (in 1889).
 SECTIONS OF ARTICLE
• Introduction (Title, Author, Aim)
• Abstract
• Evidence-Based
• Study Design
• Methodology
• Results
• Discussion
• Limitation
• Applicability
• Conclusion
• Source: International Journal Of Contemporary Pediatrics
• Author: Savitha M.R. , Raj prakash
• Study Place: Cheluvamba hospital
       Mysore Medical College & Research Institute, Mysore,India
• Study Period: From November 2011 to February 2012 (15 months)
 OBJECTIVE OF THE STUDY:

• To determine the role of intravenous magnesium sulphate therapy in

promoting early recovery & favourable neurological outcome for
asphyxiated  term neonates.
 INTRODUCTION

• One of the main causes of early neonatal death is Perinatal Asphyxia. It refers
to the disruption of the exchange of breathing gases during and delivery and
the subsequent negative impact on the fetus.
 Perinatal
Asphyxia

Fetal Maternal

Uterine Placental
 WHY NEED OF STUDY

• In view of conflicting results about the role OF INTRAVENOUS

MAGNESIUM in perinatal asphyxia & paucity of studies,
• The goal of the current study was to establish that intravenous magnesium
sulphate therapy help in asphyxiated newborns by accelerating their recovery
and have better neurological outcomes after being discharged.
 STUDY DESIGN

• Study Type:
Comparative Randomised Control Trial

• Study Population:
• 120 term neonates (60 study group & 60 controlled group)
INCLUSION CRITERIA EXCLUSION CRITERIA

• Term Neonates • History of maternal magnesium administration

• Perinatal Asphyxia prior to delivery

(APGAR < 7 at 1 minute of age)

• History of mother receiving
Pethidine,Phenobarbitone which are likely depress
the baby

• Obvious external congenital malformations

 RISK FACTORS
Age of mother
PIH
Antenatal Anemia
Bleeding
Infection
History
M.O.D
PROM
Meconium
Intrapartum
stained liquor
Malpresentation
Cord prolapse
 METHODOLOGY

• Neonates were assigned with computer generated random numbers

in Study Group or Comparison Group
• Both group Were treated according to NICU Protocol for Birth Asphyxia
• Study group received Magnesium Sulphate intravenous infusion at 250mg/kg/dose
(1ml/kg/dose in 20ml of 5% dextrose solution) over 1 hour within 6 hours of birth
• 2 additional doses repeated after 24 hours & 48 hours.