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THREATENING CONDITIONS/ACUTELY
ILL/MULTI-ORGAN PROBLEMS/HIGH ACUITY
AND EMERGENCY SITUATIONS, ACUTE AND
CHRONIC -RLE
A. Aerosol Delivery Devices and
Therapy
• Nebulizers
• MDIs
AEROSOL DELIVERY
DEVICES
BENEFITS OF DELIVERING
MEDICATION VIA INHALED
ROUTE
1. Rapid onset of action
2. High local concentration by delivery directly to the
airways
3. Needle-free systemic delivery of drugs with poor
oral bioavailability.
A. NEBULIZER
Nebulization
• is the process of medication administration via inhalation. It utilizes a
nebulizer which transports medications to the lungs by means of mist
inhalation.
Nebulization therapy
• is used to deliver medications along the respiratory tract and is
indicated to various respiratory problems and diseases such as:
Bronchospasms, Chest tightness, Excessive and thick mucus
secretions, Respiratory congestions, Pneumonia, Atelectasis, and
Asthma.
TYPES OF NEBULIZER
Jet Nebulizers
• A jet nebulizer delivers compressed gas through a jet (see image below).This causes a region of negative
pressure, in which a solution or suspension is entrained into the gas stream and is sheared into a liquid film. This
film is unstable and breaks into droplets due to surface tension forces. A baffle in the aerosol stream produces
smaller particles, and it is further conditioned by factors such as the relative humidity of the carrier gas.
Mesh Nebulizers
• Mesh nebulizers use a mesh or plate with multiple apertures
to produce an aerosol (See image below). Mesh nebulizers
have very low residual volume, fast treatment time, and the
ability to nebulize a variety of solutions and suspensions.
These devices are powered by batteries or electricity, and an
external gas flow is not required.
Ultrasonic Nebulizers
Ultrasonic nebulizers convert electrical energy to high-frequency ultrasonic
waves. The ultrasonic waves are transferred to the surface of a liquid, thus
producing an aerosol (Shown in the image below). Small-volume ultrasonic
nebulizers are commercially available for delivery of inhaled bronchodilators.
Their cost is greater than that of jet nebulizer/compressor systems but
comparable to that of mesh nebulizers. A drug/device combination that uses an
ultrasonic nebulizer is the treprostinil/Tyvaso system.
ADMINISTERING INHALED
MEDICATIONS BY NEBULIZERS
Purpose:
1. Right Drug.
2. Right Patient.
3. Right Dose.
4. Right Route.
5. Right Time and Frequency.
6. Right Documentation.
7. Right History and Assessment.
8. Drug approach and Right to Refuse.
9. Right Drug-Drug Interaction and Evaluation.
10. Right Education and Information
5. Assemble nebulizer as per manufacturer’s
instructions.
6. Add medication as prescribed by pouring
medication into the nebulizer cup.
7. Use a mask if patient is unable to tolerate a
mouthpiece, and an adaptor specific to
tracheostomies if the patient has a
tracheostomy.
8. Perform hand hygiene
9. Position patient sitting up in a chair or in bed
at greater than 45 degrees.
10. Turn on air to nebulizer and ensure that a sufficient mist is
visible exiting nebulizer chamber. A flow rate of 6 to 10 L
should provide sufficient misting.
Ensure that nebulizer chamber containing medication is
securely fastened. Ensure that chamber is connected to face
mask or mouthpiece, and that nebulizer tubing is connected
to compressed air or oxygen flow meter