• Step 0 : Cultivate a spirit of inquiry • Step 1 : Formulate the clinical PICOT/PICO question • Step 2 : Search for the best evidence • Step 3 : Critical appraisal of Evidence • Step 4 : Integrate the evidence with clinical expertise and patients prefrence to make the best clinical decision • Step 5 : Evaluate the out comes based on Evidence • Step 6 : Disseminate the outcome Appraising an evidence Purpose: NOT to find RIGHT or WRONG but to find out the truth and the practical of the knowledge The knowledge is valid, reliable, practical in clinical setting Randomized Control Trial: RCT Randomized control trial is the STRONGEST study design to answer questios of efficacy & effectiveness of intervention Approaches to conducting RCT • Efficacy study how well intervention actually work? everything is controlled tightly, homogeneus participants
• Effectiveness study pragmatic value of an
intervention in clinical practice Rapid critical appraisal questions for RCT
Validity
Result
Applicability Bagaimana Melakukan Critical Appraisal? Are the result of the study valid?
• Apakah menggunakan metode penelitian yang tepat?
• Subject randomly assigned ? • Subject & providers kept blind to study group? • Bagaimana prosedur pemberian intervensinya? • Apakah hasil penelitian nya ? • Apakah Intervensi layak untuk diterapkan di klinik What are the results?
• Apakah intervensi berhasil?
• Seberapa besar efek diperoleh? • Apakah tenaga kesehatan diperkirakan akan mendapatkan hasil yang sama jika mereka menerapkan intervensi dilapangan? • How precise is the intervention or treatment? Will the results help me in caring for my patients? (Applicability)
• Apakah subyek dalam penelitian mirip dengan pasien yang
ditangani • Memiliki manfaatnya lebih besar dan resiko minimal (Risk & benefit of the treatment) • Intervensi layak untuk diterapkan di klinik (Feasibility) • Pasien setuju dan menginginkan intervensi tersebut (Patient’s/family’s values & expectations) Analysis using JBI and CASP SINTESIS HASIL ANALISA JURNAL
Apakah intervensi memiliki manfaat yang tinggi
Apakah intervensi memiliki procedure yang jelas
Apakah alat-alat yang di gunakan mudah di dapatkan
Apakah SDM (sumber daya manusia) ada / apakah memerlukan keahlian
khusus Apakah harga nya terjangkau
Apakah sesuai kebutuhan pasien
References Bhandari, M & Giannoudis, P.V.(2006). evidence-based medicine: what it is and what it is not. Journal Injury. DOI:10.1016/j.injury.2006.01.034 Sutherland, S.E.(2001). evidence-based dentistry: part iv. research design and level of evidence. JBI.(2014). Supporting document for the joanna briggs institute kevel of evidence and grades of recommendation. The university of Adelaide JBI.(2014). Level of evidence. The university of Adelaide CEMB.(2013). Level of evidence. Oxford University . www.cebm.net
Clinically Inapparent Gallbladder Cancer Presenting With Paraneoplastic Cranial Neuropathies Aunali S Khaku, MD Lisa Aenlle MD, Irene A Malaty, MD University of Florida Department of Neurology