Hyperactivity

of
Posterior Pituitary
 Anti diuretic hormone (Vasopressin)

 ADH is secreted by supraoptic nucleus of hypothalamus

 It is released from posterior pituitary

 It is a polypeptide containing 9 amino acids.

 Actions of ADH

 Retention of water by acting upon kidneys

ADH ADH

Less More
reabsorption reabsorption

Diluted Concentrated
urine urine

 ADH(Vasopressin) constricts the arteries raises blood pressure

SIADH (syndrome of inappropriate
hypersecretion of Antidiuretic hormone)

It is characterized by

 ADH
 Loss of sodium
through urine (concentrated urine)
Causes of SIADH

SIADH occurs due to

• Cerebral tumors

• Lung cancer

• Lung tumors
ADH under normal conditions
ADH acts on kidney

Reabsorbs water

Concentrated urine with sodium

formed

Sodium osmolality of plasma

Hypotonic plasma inhibit ADH

Restore plasma osmolarity

SIADH (hypersecretion of ADH)
ADH secreted by tumor cells

Hypotonic plasma

Does not inhibit ADH

Sodium osmolality of plasma

Persistent plasma hypotonicity

 Symptoms of SIADH

 Weight loss
 Loss of appetite
 Headache
 Nausea
 Vomiting
 Fatigue
 Muscle spasm