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“Resurrect dying organs”

In a world medical first, scientists at Yale University (United States) managed


to preserve the function of multiple organs in pigs, such as the brain, heart,
liver and kidneys, one hour after the animals had died. This research could
help prolong the viability of vital human organs destined for transplants,
thousands of which are discarded each year because they are not immediately
preserved.
Organs usually need to be removed right after the heart stops pumping blood to
make them viable. But a sapphire-blue solution called OrganEx, developed by
neuroscientist Nenad Sestan and his team, allowed them to restore basic organ
functions long after the tissues had last received fresh blood. The researchers
induced cardiac arrest in pigs and left the carcasses at room temperature for an
hour before infusing their blood with OrganEx, which contains amino acids,
vitamins, metabolites, and 13 other compounds. Using a machine, they circulated
the mixture for six hours and observed signs of resuscitation in the dying organs:
heart cells began to beat, liver cells absorbed glucose from the blood, and DNA
repair resumed.
Still, Sestan urges caution. "We can say that the heart beats, but to what
extent does it beat like a healthy heart: that will require further study."
Next steps will include transplanting OrganEx-treated organs into live pigs
to see how they work.
BIBLIOGRAPHIC SOURCE
Staff, N. G. (2022). Los 22 descubrimientos científicos más impactantes
de 2022. Nacional Geographi.

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