- Pick a Site - Time Daily June 02, 2000

'Brain Retraining'
Gives Hope to Stroke Patients

An experimental rehabilitation technique has scientists in a cautiously optimistic

mood.

Scientists debate endlessly whether we will ever really understand the workings
of the mind — and every once in a while they're given reason to hope. The latest
source of optimism is a study published in Friday's issue of Stroke: Journal of
the American Heart Association, which shows for the first time that a new type
of rehabilitation may help stroke victims regain nearly full use of their paralyzed
limbs. The experimental therapy, employed by researchers at the University of
Alabama and the Friedrich Schiller University in Germany, involves immobilizing
the good arm of a stroke victim and forcing the patient to use their "bad" arm to
perform daily tasks. Patients performed the exercises six hours a day for two
weeks. When the course of therapy was complete, a brain scan indicated
renewed muscle activity in the paralyzed limb — a finding that seems to
vindicate scientists' previous theory that the brain can, in fact, be actively
rewired. "For years there's been hope that you can retrain the brain," says TIME
medical correspondent Christine Gorman. As our understanding of the brain
becomes more sophisticated, Gorman explains, we get further from the
erroneous idea that the brain is static, or fixed. "Now we know that tasks like
learning a language or playing a new instrument change the brain," Gorman
says. And although the stroke therapy remains experimental, it offers renewed
hope for even more dramatic and practical discoveries down the road.

The new medicine has fundamentally changed how we think about disease.
Instead of devising ways to treat illnesses, scientists conduct genetic
manipulations that could eliminate problems entirely. What's a reality, is where
the science is going, offers wonderful possibilities.
http://www.nytimes.com/library/national/science/health/060200hth-brain-
stroke.html

Date: Posted 6/2/2000

Science Authors Report
Adult Stem Cells Can Produce A Wealth Of Cell Types

Washington D.C. -- Reprogrammed adult neural stem cells can potentially

generate a cornucopia of cell types-giving rise to cells in heart, liver, muscle,
intestine and other tissues, a 2 June Science study suggests. When adult neural
stem cells from mice are grown with embryonic cells or within an embryo, the
adult stem cells can revert to an unspecialized state and give rise to different cell
lineages, according to the Science study. The research, completed by a team of
Swedish scientists, adds to a growing body of data indicating that adult stem
cells, like embryonic stem cells, may be more versatile than previously assumed.

Embryonic stem cells are the "blank slates" of an organism, capable of

developing into all types of tissue in the body. Scientists have long been
interested in the therapeutic potential of embryonic stem cells, which may be
used someday to create new tissues for organ transplants and replacements for
cells destroyed by diseases like diabetes or trauma like spinal cord injuries.

As ethical and legal controversy threatens to cloud the future of embryonic stem
cell research, however, some scientists have turned to adult stem cells to
discover whether they also have the same open-ended potential. Until recently,
researchers thought that the more specialized adult stem cells, found in areas of
the body like the skin, nervous system, and blood and lymph systems, could
only give rise to their own kind. Now, scientists are accumulating evidence--
including last year's mouse study showing how brain stem cells transplanted into
bone marrow could produce blood cells (see Science, 22 January 1999)--that
adult stem cells may be capable of reprogramming themselves.

The Science study confirms that adult stem cells are in fact more chameleon-like
than previously suspected, taking cues from their cellular environment to
produce offspring of the same type as the cells that surround them. To test the
influence of environment on adult stem cell destiny, the Swedish team exposed
genetically tagged mouse neural stem cells to a variety of tissue types by
growing them together with embryo cell cultures in the lab and injecting them
into early-stage chick and mouse embryos.

In the lab cultures, the offspring of the stem cells switched their identities to
become muscle cells. Depending on which early cell layer they managed to
infiltrate in the developing chick and mouse, the stem cell progeny incorporated
into these embryos contributed to heart, lung, intestine, kidney, liver, nervous
system, and other tissues.

As the researchers discovered, even lone neural adult stem cells displayed this
ability to differentiate themselves into various cell types. In all these cases, the
cells looked and acted just like the host cells around them. The "most striking
indications" of this complete cellular makeover, say the authors, were the
apparently normal and beating embryonic mouse hearts containing very large
amounts of these derived stem cells.

Although the scientists are certain that environment plays a major role in
determining an adult stem cell's fate, they aren't entirely sure what critical factor
environment supplies.

"The short answer is that we have no clue," says co-author Jonas Frisén of the
Karolinska Institute in Stockholm. "We can speculate that the crucial elements
are extracellular signals, or secretions from the embryonic cells. There is
probably a cocktail of various factors involved, but we have no solid data yet
about what these molecules are."

If scientists can determine the molecular composition of these extracellular

signals, Frisén says, researchers could take the next step and coax these adult
stem cells toward several different cellular lineages, without exposing them to
embryonic cells at all.

Frisén and colleagues want to test other types of adult stem cells, not just neural
cells, to see if they have similarly plastic potential.

"This could be very valuable in a clinical setting, since neural stem cells are
really the least accessible," says Frisén.

The research team is also planning future experiments to see how long the
transformed stem cells survive within these tissues, and whether they retain
their new commitments indefinitely.

Note: This story has been adapted from a news release issued by American Association For
The Advancement Of Science for journalists and other members of the public. If you wish to
quote from any part of this story, please credit American Association For The Advancement Of
Science as the original source. You may also wish to include the following link in any citation:
http://www.sciencedaily.com/releases/2000/06/000602072837.htm

Science News / HowComYouCom.com

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