Cell communication

Week 12
Learning objectives
• 3.5.1 Explain, using visuals, how cell signaling evolved (Illustrative examples: Communication between
mating yeast cells, Quorum sensing in bacteria) CH9
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• 3.5.2 Describe how cells communicate with one another through direct contact (Illustrative examples:
Immune cells interact by cell-cell contact, antigen-presenting cells (APCs), helper T-cells and killer T- cells,
and plasmodesmata between plant cells)
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• 3.5.3 Compare and contrast short and long distance signaling

• 3.5.4 Provide examples of local regulators, short distance signaling, and long distance signaling
(Illustrative examples: Neurotransmitters, plant immune response, morphogens in embryonic development,
insulin, human growth hormone, thyroid hormones, testosterone, estrogen)
• 3.5.5  Describe, using representations, the three stages of cell signaling including reception, transduction,
and response
Learning objectives
• 3.5.6  Compare and contrast three main types of membrane receptors
• 3.5.7  Describe, using examples, intracellular receptors
• 3.5.8 Explain, using visuals, how receptors recognize different chemical messengers (peptides, small
chemicals, or proteins), in a specific one-to-one relationship
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• 3.5.9 Identify how the signal transduction pathway links between signal reception and cellular response
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• 3.5.10 Explain, using visuals and models, the signal transduction pathways including protein
modification and phosphorylation cascades
Learning objectives
• 3.5.11 Explain, using visuals and models, the role of second messengers in signal transduction cascades
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• 3.5.12 Explain how signaling cascades relay signals from receptors to cell targets, amplifying the
incoming signals, resulting in appropriate responses
•  3.5.13 Compare and contrast nuclear and cytoplasmic responses
• 3.5.14 Explain how signal transmission within and between cells mediates cell function (Illustrative
example: Mating pheromones in yeast trigger mating genes expression and sexual reproduction
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• 3.5.15 Explain how signaling pathways ultimately regulate protein synthesis
Learning objectives
• 3.5.16 Describe, using visuals and models, how a signal transduction pathway leads to the regulation of
cellular activities
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• 3.5.17 Recognize, using visuals and models, how signaling pathways with multiple steps provide signal
amplification, which allow fine- tuning of the cell’s response, and contribute to the specificity of the
response
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• 3.5.18 Describe, using visuals and models, the role of apoptosis in termination of the signal
transduction pathway (Illustrative example: apoptosis in the soil worm Caenorhabditis elegans)
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• 3.5.19  Explain how the changes in signal transduction pathways can alter cellular response
• 3.5.20  Recognize that chemicals that interfere with any component of the signaling pathway may
activate or inhibit the pathway
Recall: Membrane Protein Diversity
Cell communiaction and cell cycle
Action of a Steroid Hormone