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BIOPHYSICS
MA Letsoalo
0829358999
molamo.letsoalo@ul.ac.za
Maila MT 202016280 0715855552
Ramaila E 202054001 071 389 7680
My Expectations
• Come to class
• Be punctual and manage your time well
• Do your work
• Do not fall behind
• Collaborate
• Do not cheat
• If you have questions get them answered
• If you have a problem tell me about it
Important Information
• Module outline: on Bb in Course Materials
• Classes: 07:30 Tuesday and 07:30 Wednesday
• Practical: Weekly (TBA)
• Assignments: Weekly
• Tests : Monthly
• Exam : around June/July
PHYSICS
What is Physics
• the branch of science concerned with the
nature and properties of matter and energy.
Matter: Solids, liquids and gases
Energy: ability to make things change
• Moreover, it's the basis of many other
sciences and can be applied to biological,
health, agricultural and medical science.
Biophysics
• Biophysics is an interdisciplinary science that
uses the methods of physics to study
biological systems, with the ultimate goal of
understanding at a fundamental level the
structure, dynamics, interactions, and
ultimately the function of biological systems
What is involved
• Charges
• Matter
• Waves
• and how they interact with living tissues
Charges
• Electricity
– Electrostatics
– Electrodynamics
– Electronics
Waves
• Mechanical waves:
– Water waves
– Sound
• Electromagnetic waves:
– Light
– Heat
– Radio waves
– X-rays
– γ-rays
– Ultra Violet rays
– microwaves
Wave
• A wave can be described as a
disturbance/vibration that travels through a
medium, transporting energy from one
location (its source) to another location
without transporting matter.
• Each individual particle of the medium is
temporarily displaced and then returns to its
original equilibrium positioned.
• A medium is a substance or material that
carries the wave. The wave medium is not the
wave and it doesn't make the wave; it merely
carries or transports the wave from its source
to other locations
• A wave transport energy without transporting
matter
Mathematical representation of a wave
Frequency (f)
measured in Herts (Hz)
Amplitude (A)
measured in meters (m)
Relationships
• y=
• f∞
• f∞
• Speed (c) =
Categories of waves
• A transverse wave is a wave in which particles
of the medium move in a direction
perpendicular to the direction that the wave
moves
• A longitudinal wave is a wave in which
particles of the medium move in a direction
parallel to the direction that the wave moves
OPTICS
Optics is a branch of physics that describes the behavior and properties of light and
the interaction of light with matter. Optics explains optical phenomena.
SUNLIGHT LIGHTNING
BEAM
Nature of Light
• Transverse wave
• Electromagnetic wave
Electromagnetic waves
Colour is related to the frequency and/ or
wavelength of light wave
•
Brightness is related to Amplitude of light wave
Dim light
Bright light
• Frequency/wavelength is related to colour
• Amplitude is related to brightness
Speed of light
• The speed of light is about
• 300 000 km per second
• 300 000 000 m/s
• 3 x108m/s
Sources of light
Common sources of light
• Incandescence
• Fluorescence
• Light Emitting Diode
• Laser
Incandescence
Electron absorbs some thermal (heat)
energy which causes it to “jump” to a
higher energy level. This is called
excitation. E2
Energy
E1
Nucleus
de-excitation
The electron, preferring to be in the
lower energy, immediately drops back
down to the lower energy level.
E2 Energy
E1
In order to conserve energy, a photon
(discrete bundle of energy) is emitted.
E2 Photon Energy
E1 Photon Energy = E2 – E1
High-speed
electron
e- Hg
atom
UV Phosphor
Photon Coating
Fluorescence
Fluorescence
• Health issues:
• If a fluorescent lamp is broken, mercury can
contaminate the surrounding environment.
• Fluorescent lamps can trigger problems among
individuals with pathological sensitivity to ultraviolet
light.
• In addition to causing headache and fatigue, and
problems with light sensitivity they are listed as
problematic for individuals with epilepsy lupus,[12]
chronic fatigue syndrome, and vertigo.
Light Emitting Diode (LED)
A light-emitting diode (LED) is a
semiconductor diode that emits light when an
electric current is applied in the forward direction
of the device
LED
• Excitation of atom due to p-n junction
• Efficient, long lasting, bright, small size, robust
• Space lighting, automotive lighting, indicator, tv
• Operate only on dc or ac dc inverter
•
Advantages of LED
Light
Amplification
by Stimulated
Emission
of Radiation
Laser Light
45
Optical media/material
• Transparent material
• Opaque materials
Transparent material
• Specular reflection
• Surface looks shiny
• Smooth optical surface is also called
Mirror
Sight
We see objects when they reflect light rays into
our eyes
Recap
• Physics: Interaction of matter and energy
• Biophysics: Application of Physics to Biological
systems
• Scope: Optics(light wave), Acoustics(sound wave),
Thermodynamics(heart wave), Body
mechanics(solids), Fluid mechanics(liquids and gases),
Electricity, Modern Physics(radiations and therapies)
• Waves: Quantities: wavelength, frequency, amplitude
• Optics: Nature of light, sources of light, speed of light,
optical media(transparent & opaque),
reflections( defused and specular)
model
Laws of reflection
1. Angle of incident θi =angle of reflection θr
2. Incident ray, reflected ray and the normal lie
in the same plane
vision
•
Mirrors(smooth surfaces)
1. Spherical mirrors
Mirrors
1. Spherical mirrors
Convex
mirror
Concave mirror
• Converges light rays
• Has a positive radius
• Has a positive focal point
Nature of an image
• Real image
– Can be cast on a screen
• Virtual image
– Can not be cast on a screen
Image size
• Enlarged or magnified image
– The image is bigger than the object
• Inverted image
– The image’s orientation is opposite that of
the object.
Mirror Equations
C.
Sign conversion
• If a measured quantity is on the same side of
the mirror as the INCIDENT ray then the
quantity is positive
• If a measured quantity is not on the same side
of the mirror as the INCIDENT ray then the
quantity is negative
Image characteristics
• Nature
– real image s’ is positive
– Virtual image s’ is negative
• Orientation
– Upright/erect m is positive
– Inverted m is negative
• Magnification/size
– Enlarged image |m|>1
– Diminished |m|<1
– Same size as the object |m|=1
Example
• A 4cm tall pencil placed at 5cm from a
concave mirror with a focal length of 10cm.
• +=
=--==
s’=-10cm
m=-=-=2
Example
The wave length becomes shorter and the wave speed decreases.
The Frequency Remains the same
if it strikes the interface with an
angle of incidence of 0 degrees,
then no bending will occur.
When a beam of light moves from low index of refraction (air) into a high index of refraction
(glass), its path is bent toward the normal. The angle of refraction is smaller than the angle of
incidence
When a beam of light moves from high index of refraction (glass) into a low index of
refraction (air), its path is bent away from the normal. The angle of refraction is larger than
the angle of incidence
• Apparent Depth
• Real Dr and Apparent depth Da
•
Law of refraction
Snell’s Law
1. The incident ray, the refracted ray and the normal lie on the same plane.
2. The angle of refraction Θ2 is related to the angle of incident Θ1 by
n1 sin 1 n 2 sin 2
• Example
The angle of refraction depends on the angle of incident and on the indices of
Refraction, n2 and n1, of the media.
Critical angle
The angle of incident for which the angle of
refraction is 90° OR
The angle of incident for which the refracted ray
emerges tangent to the surface.
Critical angle
• n1sinθ=n2sin90 o
• ncsinθ=n2sin90 o
Total internal reflection
When the angle of incidence exceeds the critical angle, there is no refracted light. All the
•
incident light is reflected back into the medium from which it came, a phenomenon called
Total Internal Reflection.
How Optical Fiber Works
The advantages of using fibre optics
• Because of the Low loss, high bandwidth properties of fiber cable they can be used over
greater distances than copper cables
• Their light weight and small size also make them ideal for applications where running
copper cables would be impractical
• Its immunity to Electro Magnetic Interference (EMI), and the fact that glass is not an
electrical conductor
• Security aspect, it is very, very difficult to tap into a fibre cable to read the data signals
Angle of deviation
The speed of light through a material varies slightly with the wavelength or frequency
of the light. Thus, each wavelength is refracted at a slightly different angle when
passing through a material at an angle. This spreading out of the beam of light
is called dispersion or chromatic dispersion.
A substance in which the speed of a wave varies with wavelength is said to exhibit
DISPERSION
White light separates into different colours
(wavelengths) on entering the raindrop
because red light is refracted by a lesser
angle than blue light. On leaving the raindrop,
the red rays have turned through a smaller
Some rainbows appear to be exceptionally close.
This one is formed by a waterfall
1 1 1 1 1
n 1 Lens maker’s Equation
s s' f R1 R2
s'
m
s
y'
m
y s s’
Image characteristics
• Nature
– real image s’ is positive
– Virtual image s’ is negative
• Orientation
– Upright/erect m is positive
– Inverted m is negative
• Magnification/size
– Enlarged image |m|>1
– Diminished |m|<1
– Same size as the object |m|=1
Examples
• Convex lens s=30cm f=10cm s’=?
1 1 1 1 1 1
s s' f s' f s
1 1 1 3 1 2 1
s’=15cm
s ' 10cm 30cm 30cm 30cm 15cm
s ' 15cm 1
m 0.5
s 30cm 2
s' (10cm) 10
m 2
s 5cm 5
s' (3.3cm)
m 0.66
s 5cm
• Accommodation
• Near point
• Far point
• Lens power
IRIS( colored ring)- adjusts size and regulate the amount of light entering the eye through
the pupil- Adaptation
Ciliary Muscles – Control the shape and focal length of the lens
Relaxed – light from the distance is focused on the retina
Contract – lens assume round shape and reduces its focal length bringing light
from nearby object into focus
Accommodation – The ability of the lens to adjust its focal length.
Near Point:- Is the nearest the eye at which an object can be placed
and still produced a sharp Image on the retina. Normal near point is
25cm. Varies with age and race
Far Point :- Is the location of the farthest object on which the fully
relaxed eye can focus
Normal far point is infinity ∞
Accommodation
•
Optical Defects of the eye
Myopia: nearsightedness Hyperopia: farsightedness
EYE DEFECTS
NEARSIGHTED [MYOPIC] (Can only see nearby objects clearly) :
Then lens is too strong and bends light too much.
The far point is nearer than infinity
Light from a distant object focuses before reaching the retina.
Myopia
Example: Myopic eye
• The far point of a certain myopic eye is 50cm in front of the
eye. What lens should be used to see clearly distant objects.
1 1 1
s s' f
1 1 1
1 1 1
f 50cm'
f s s'
f=-50cm = -0.5m
Concave lens
Lens power =1/f=1/-0.5m=-2 diopter
FARSIGHTED [HYPEROPIC] (Can only see distant objects clearly):
Then lens is too weak And bends light too little. Light from a nearby object
doesn’t reach a focus by the time it strikes the retina and focus beyond the
retina.
Hyperopia
Example: Hyperopic eye
• The near point of a certain hyperopic eye is 100cm in front of
the eye. What lens should be used to see clearly an objects
25cm in front of the eye.
Most astigmatic corneas have two curves – a steeper curve and a flatter curve.
This causes light to focus on more than one point in the eye, resulting in blurred
vision at distance or near.
PRESBYOPIA
Reduction in accommodation that occurs with age, is the result of gradual weakening of
the Ciliary muscles and diminishing flexibility of the lens
EYE DISEASES
Cataracts
EYE DISEASES
Cataracts
• Vacuum?
Categories of sound
• Infrasonic (low frequency sound)
• Audible sound
• Ultrasonic (very high frequency sound)
Categories of sound
• f<20Hz Infrasonic
• Can not be heard but can be felt: courses
anxiety, extreme sorrow Examples: heartbeat,
digestion, earthquake, tsunami
• Carries huge amounts of energy( can course
acoustic trauma)
How infrasonic Interaction with matter
• Q=mcΔT
Thermal Equilibrium
• Q=mL
Thermal Expansion