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1:estrogen,
The third stage of labor describes the period between the birth
of the baby and the delivery of the placenta, which normally
lasts less than 30 minutes.The delivery of the placenta causes an
abrupt drop off of placental hormones.This drop, specifically in
progesterone, allows prolactin to work effectively at its receptors
in the breast, leading to an array of changes over the next
several days that allow the milk to "come in"; these changes are
known collectively as Lactogenesis II.
Many other physiologic changes occur under the control of
progesterone and estrogen. These changes include, but are not
limited to, dilation of blood vessels, increased blood flow to the
uterus, increased availability of glucose (which subsequently is
passed through the placenta to the fetus), and increased skin
pigmentation, which results in darkening of the nipples and
areola, formation of the linea nigra, and onset of melasma
of pregnancy.
4: Oxytocin
dual activity
Oxytocin, which signals the smooth muscle of the uterus to
contract during pregnancy, labor, birth and following delivery, is
also involved in the process of breastfeeding.Oxytocin also
contracts the smooth muscle layer of band-like cells surrounding
the milk ducts and alveoli to s the newly produced milk through
the duct system and out through the nipple.This process is
known as the milk ejection reflex, or let-down. Because of
oxytocin's dual activity at the breast and the uterus,
breastfeeding mothers may also experience uterine cramping at
the time of breastfeeding, for the first several days to weeks.
Lactogenesis III