Physiology

Topic: Erythropoiesis

Presented By: Amna Malik

Scheme
Definition
Types Of Stem Cells
Sites Of Erythropoiesis
Stages Of Erythropoiesis
Erythropoietin
Changes During Erythropoiesis
Factors Affecting Erythropoiesis
Abnormalities Regarding Erythrocytes
 Erythropoiesi
s of the formation of
Erythropoiesis is the process
new red blood cells(erythrocytes)

Erythropoiesis occurs in the red bone marrow

Stem cells become mature to form rbc's

 Types Of Stem Cells

1 2
Myeloid stem Lymphoid stem
cells cells
become rbc's and become lymphocytes
some wbc's
 Sites Of Erythropoiesis

1st week of gestation it takes place in In mid trimester it takes place in the
1 2 liver spleen and lymph nodes
the yolk sac

Last month of gestation through adulthood in

3
the bone marrow
Stages Of Erythropoiesis
Basic Components Building Red Blood Cells
Require

01 02 03
3.Vitamin
Amino
Iron B12, B6 and
acids
Folic Acid
 Erythropoietin(EPO)
It is a glycoprotein hormone It’s molecular weight 34000. Also
called Erythropoiesis stimulating hormone, a hormone secreted
by the kidneys that increases the rate of production of red blood
cells in response to falling levels of oxygen in the tissues
Diagram
Factors Affecting Erythropoiesis
Factors Affecting Erythropoiesis
Factors Affecting Erythropoiesis
Factors Affecting Erythropoiesis
Factors Affecting Erythropoiesis
Factors Affecting Erythropoiesis
Sites Of Erythropoiesis By Age
 Abnormalities Regarding Erythrocytes
Anemia is a condition that develops when your blood produces a lower-
than-normal amount of healthy red blood cells.

1.Microcytic 2 Megaloblastic 3. Sickle Cell

Hypochromic Anemia Anemia
Anemia

1 2 3
It's a type of anemia in which It's a type of anemia in which In this type of anemia the shape
the size of RBC become smaller there is a larger and irregular of RBC become spherical
and the concentration of shape of RBC due to the rather than biconcave so the
haemoglobin is low deficiency of Vitamin D12 RBC easily destroy.