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AMINOGLYCOSIDE
S
 • Aminoglycosides are antibiotics produced from soil
INTRODUCTION actinomycetes.

• They are generally administered as sulphate salts.

• Streptomycin is the prototype of this class.

• Gentamicin and netlimicin are derived from the species of

actinomycetes.

• The sugars are linked to aminocyclitol ring by glycosidic

bond.

• Gentamicin is the first line aminoglycoside antibiotic.

INTRO…

• MICINS are derived from the micromonospora.

• MYCINS are derived from the streptomyces.

• They are generally used to treat gram negative bacteria.

• They are acting as poly actions and have some polarity.

• Aminoglycoside are bacteriocidal in nature.

 • These drugs interfere with initiation of protein synthesis,
MECHANISM OF leading to accumulation of abnormal initiation complexes
ACTION ;these drugs can also cause misreading of mRNA.

• These mostly acted by binding to 30s ribosomes.

• These drugs have little activity against aerobic microorganisms

and gram positive activity is limited.

• Penicillins + aminoglycosides achieves synergistic bacteriocidal

action.
 • GENTAMICIN:

• Gentamicin is obtained from the

Micromonospora purpurea.

SOME IMPORTANT • It is surprised streptomycin because of high

potency.
AMINOGLYCOSIDE • This drug is ineffective against TB.

S
TOBRAMYCIN
• Pharmacological profile as same as
Gentamicin.

• It is obtained from the S.

Tenebrarius.

• Given through IV and IM.

• Do not combined with penecillins .

NETLIMICIN
• This drug has broad spectrum activity.

• It is used to treat serious infections due to susceptible

Enterobacteriae.

• Used to treat urinary tract infections.

• LESS TOXIC THAN ALL OTHER AMINOGLYCOSIDES.

STREPTOMYCIN
• Generally used in combination with all other
antibacterial agents.

• It has narrow spectrum of activity.

• Less potent than other aminoglycosides.

• Active against aerobic gram negative

bacteria.

• It is obtained from the streptomyces griseus.

COMMON ADRs
• Ototoxicity and nephrotoxicity

• Neuromuscular blockade

• Little allergic potential

 • UTI

USES
• Pneumonia

• Meningitis

• Peritonitis

• Bacterial endocarditis

• Sepsis

• Tularemia

• Cystic fibrosis

• Topical applications.