PRACTICAL LESSON NR.

6
CUTANEOUS LUPUS ERYTHEMATOSUS.
MORPHEA. VITILIGO.ALOPECIA AREATA

Emet Iulia
asistent universitar
LUPUS ERITEMATOS CUTANAT:PATOGENIA
LUPUS ERITEMATOS SISTEMIC:PATOGENIA
 LUPUS ERITEMATOS:CLASIFICAREA
Düsseldorf classification of cutaneous lupus erythematosus 2003 (3)
• Acute cutaneous lupus erythematosus (ACLE)
• Subacute cutaneous lupus erythematosus (SCLE)
• Chronic cutaneous lupus erythematosus (CCLE)
 Discoid lupus erythematosus (DLE)
 Hypertrophic/verrucosus variant
 Teleangiectoid variant
• Lupus erythematosus profundus (LEP)
• Chilblain lupus erythematosus (CHLE)
• Intermittent cutaneous lupus erythematosus (ICLE)
• Lupus erythematosus tumidus (LET)
• Bullous lesions in lupus erythematosus (BLE)
LE – specific bullous skin lesions
LE – nonspecific bullous skin lesions
• Primarily bullous skin disorders associated with LE

Acta Dermatovenerol Croat Hypertrophic lupus erythematosus 2009;17(2):134-138

CLE subtype Manifestations Photosensitivity [6] Systemic Disease Association

ACLE •Malar rash or maculopapular +++ Frequent

eruption on sun exposed areas
•spares joints when located on
hands

SCLE •Papulosquamous (psoriasiform) +++ Reported at 48.7% [7, 8]

or annular lesions typically on
sun exposed areas
•Does not scar or atrophy but can
leave pigmentation changes

CCLE

DLE •Annular ++ Reported at 40% [7, 8]

erythematousviolaceous plaques
•Follicular plugging
•Frequently scars and atrophies

LEP •Painful subcutaneous nodules −/? Unknown

due to deep dermal inflammation
•Results in lipoatrophy

CHLE •Single or multiple macules, − unknown

papules, plaques or nodules on
feet>hands
•Erythematous or violaceous in
color
•Arise after cold exposure

LET •Juicy, smooth erythematous ++++ Understudied, possibly 10% [9]

papules and plaques Non-
scarring
LUPUS ERITEMATOS CUTANAT DISCOIDAL
SEMNUL BESNIER-MESHERSKII
 LUPUS ERITEMATOS CUTANAT
AFECTAREA SCALPULUI SI MUCOASELOR
LUPUS ERITEMATOS CUTANAT
AFECTAREA MUCOASELOR
LUPUS ERITEMATOS CUTANAT DISCOIDAL
EXAMENUL HISTOPATOLOGIC
LUPUS ERITEMATOS CUTANAT
FORMA HIPERTROFICĂ
FORMA HIPERTROFICĂ:HISTOPATOLOGIE
LUPUS ERITEMATOS CUTANAT PROFUND
(LUPUS PANICULITA)
LUPUS PANICULITA:HISTOPATOLOGIE
CHILBLAIN LUPUS HUTCHINSON
LUPUS ERITEMATOS CUTANAT
FORMA TUMIDUS
FORMA TUMIDUS:HISTOPATOLOGIE
LUPUS ERITEMATOS CUTANAT
FORMA BULOASA
FORMA BULOASA:HISTOPATOLOGIE
LUPUS ERITEMATOS SUBACUT DISEMINAT
 EXAMENUL PARACLINIC
IMUNOFLUORESCENTA DIRECTA

https://link.springer.com/chapter/10.1007%2F3-540-26581-3_22
 MORPHEA
CIRCUMCSRIBED SCLERODERMA
MORFEA:PATOGENIE
EVOLUTIA CLINICO-PATOLOGICA A ERUPȚIEI
MORFEA:CLASIFICAREA
MORFEA FORMA IN PLACI
MORFEA FORMA IN PICATURI
MORFEA LINIARA
HEMIATROFIE FACIALA PARRY-ROMBERG
MORFEA FORMA GENERALIZATA
CREST SYNDROME
EXAMENUL HISTOPATOLOGIC
MORFEA:DIAGNOSTIC
http://www.rheumatology.org/I-Am-A/Patient-
Caregiver/Diseases-Conditions/Scleroderma
VITILIGO
PATOGENEZA
HISTOPATOLOGIE
 Therapeutic management of vitiligo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume: 16, Issue: 11, Pages: 1309-1313, First published: 18 October 2018, DOI: (10.1111/ddg.13680)
 Therapeutic management of vitiligo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume: 16, Issue: 11, Pages: 1309-1313, First published: 18 October 2018, DOI: (10.1111/ddg.13680)
ALOPECIA AREATA
https://www.nejm.org/doi/full/10.1056/nejmra1103442