Topic: Cold Diuresis

Submitted To: Dr. Zia ur Rehman

Submitted By: Mubashra Batool
 Cold Diuresis
 Cold diuresis is the body’s way of preserving heat when it feels that

you may be in danger of hypothermia.

 Cold Diuresis is technically a warning sign of your body sensing

hypothermia, so you should pay attention and make sure you enjoy

the cold weather safely.

 You should also remember to drink extra water when you come in

from the cold, because even though you probably didn’t sweat, you

may still have lost too much fluid from the effects of cold diuresis.
Cause of cold diuresis
 Our body wants to avoid losing too much heat

 If we become cold very quickly, the body protects our internal

organs in a number of ways. One is “cold-induced diuresis”, or
an increase in urine excretion in response to the cold. Initially,
blood is diverted away from the skin to avoid losing its heat to
the outside air.
Cold diuresis refers to an increase in urine production that occurs

when a person is exposed to cold temperatures.

Cold Diuresis Mechanisms
Several mechanisms contribute to cold diuresis:
1.Peripheral vasoconstriction:
When the body is exposed to cold, peripheral blood vessels

constrict to reduce heat loss and maintain core body

temperature.
This vasoconstriction causes an increase in blood pressure

and shifts blood from the periphery to the core organs,

leading to increased blood volume in the central circulation.
2.Increased secretion of antidiuretic hormone (ADH):

Cold exposure triggers the release of ADH, also known

as vasopressin, from the pituitary gland.
ADH acts on the kidneys, specifically on the collecting
ducts, increasing their permeability to water.
This increased reabsorption of water from the kidneys
into the bloodstream leads to a reduction in urine
output.
3.Activation of the sympathetic nervous system:

Cold exposure stimulates the sympathetic nervous system, leading

to the release of catecholamines such as norepinephrine and

epinephrine.

These hormones cause renal vasoconstriction, reducing blood flow

to the kidneys.

Reduced renal blood flow activates the renin-angiotensin-

aldosterone system (RAAS), which increases sodium and water

retention, contributing to decreased urine output.

4.Increased metabolic rate:

 Cold temperatures can stimulate an increase in metabolic rate to

generate heat, which may lead to an increased production of waste

products that need to be excreted through urine.

5.Shift in fluid distribution:

 Cold exposure can cause shifts in fluid distribution within the body,

with some fluid moving from the intracellular space to the

extracellular space.

 This shift can affect renal blood flow and filtration, contributing to

increased urine production.

Overall, cold diuresis is a complex physiological response

involving hormonal, neural, and circulatory mechanisms aimed

at conserving heat and maintaining internal temperature, often
resulting in increased urine production.
Thank You