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Lab tests in
Rheumatology
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Common Laboratory Tests in Rheumatology

 Acute phase reactants

 Anti-nuclear antibodies
 Rheumatoid factor
 Anti-cyclic citrullinated peptide antibodies (CCP)
 Anti-neutrophil cytoplasmic antibodies (ANCA)
 Antiphospholipid antibodies
 Complement
 Cryoglobulins
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Acute Phase Reactants
Positive reactants Negative reactants

 C-reactive protein  Albumin

 Ceruloplasmin  Transferrin
 Alpha-1 antitrypsin  Transthyretin
 Complement
 Ferritin
 Fibrinogen
 Haptoglobin
 Serum amyloid A
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Acute Phase Reactants
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Non-inflammatory Causes of Mild CRP Elevation

 Periodontitis  Obesity
 Smoking  Diabetes mellitus
 Uremia  Hypertension
 Aging  Sedentary lifestyle
 Oral hormone replacement  Chronic fatigue
therapy  Depression
 Alcohol consumption
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Antinuclear Antibodies
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ANA patterns
Nuclear/Homogeneous
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ANA patterns
Homogeneous Nucleolar
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ANA patterns
Speckled
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ANA patterns
Centromere
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ANA patterns
Nuclear Fine Speckled
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ANA patterns
Nuclear large speckled
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ANA patterns
Multiple nuclear dots
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Positive ANA in Diseases Other than Systemic
Autoimmune Disease

 Hepatitis C  Crohn’s disease

 HIV infection
 Tuberculosis
 Graves disease
 Hashimotos’ thyroiditis
 Primary biliary cirrhosis
 Primary autoimmune
cholangitis
 Lymphoproliferative disorders
 Infectious mononucleosis
 Subacute bacterial
endocarditis
 Idiopathic pulmonary
hypertension
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Diseases with Positive dsDNA Antibody
 SLE
 Rheumatoid arthritis
 Sjogren’s syndrome
 Scleroderma
 Drug-induced lupus
 Raynaud’s phenomenon
 Mixed connective tissue
disease
 Discoid lupus
 Myositis
 Chronic active hepatitis
 Uveitis
 Graves disease
 Women with silicone breast
implants
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 Anti-Smith and anti-U1RNP antibodies

 Anti-SSA/anti-SSB antibodies
 Anti-histone antibodies
 Antiribosomal P protein antibodies
 Anti-Scl 70, anti-centromere, and anti-U3RNP antibodies.
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Antibodies in inflammatory myopathies
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Rheumatoid Factor (RF)
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ACPA/ANTI CCP

 RA

 Tuberculosis

 Alpha-1 antitrypsin deficiency

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Antiphospholipid antibodies

 LA

 aCL

 antiß2GP1
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ANCA
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ANCA Positivity in Non-vasculitic Conditions