BIOLOGICAL OXIDATION

Theories of oxidative phosphorylation and shuttle systems

Lecture 3
Department of Biochemistry
NKP Salve Institute of Medical Sciences, Nagpur
 At the end of the lecture the student should be able to

no Learning objectives Domain Competency

level
1. Mechanism of oxidative Cognitive Must know
phophorylation

2. Shuttle systems across the Cognitive Must know

mitochondrial membrane
 F1

FO

Intermembrane space

FOF1 ATPase (ATP Synthase)

Shuttle systems across the mitochondrial
membrane
 Summary
• Mechanism of oxidative phophorylation
• Shuttle systems
 Applied aspects

Mitochondrial defects –
Alzheimers disease
Parkinsons disease
Leber hereditary neuropathy – complex I

Mitochondrial Encephalopathy lactic

acidosis and stroke – complex I and IV
 Bibliography
1.Harper’s Illustrated Biochemistry, 8th Edi.
Murray & Bender
2. Text Book of Biochemistry,6th edi.
Vasudevan & Sreekumari S
 Commonly asked questions in university
exams

• Discuss mechanism of oxidative phosphorylation. (8m)

• Discuss the shuttle systems. (4m)
Thank you