MEDICAL PHYSIOLOGY

Guyton & Hall text book of Medical Physiology 13th edition

NESAR A. ZAHIER, MD, PGD

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‫بسم هللا الرحمن الرحیم‬

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 7- EXCITATION
OF SKELETAL MUSCLE
Transmission of impulses from nerve
endings to skeletal muscle fibers
 Anatomy of neuromuscular junction 
Motor end palate
Secretion Of Acetylcholine .1
By The Nerve Terminals
 Mechanism of secretion
 Acetylcholine esterase
 End plate potential & excitation of
the skeletal muscle fiber
 Fatigue of junction
 continues stimulations
 acetylcholine decreased
Clinical correlations

 Drugs that stimulate muscle fibers  Drugs that block transmission at

by acetylcholine like action the neuromuscular junction
 Methacholine, Carbachol, Nicotine  curariform
 drugs  can't destroyed by
choline esterase  long action 
 Myasthenia Gravis
muscle spasm
  Antibodies  destroy ACh
Drugs that stimulate muscle fibers
receptors  muscle weakness
by inactivating acetylcholine
esterase
 Neostigmine, physostigmine…
MUSCLE ACTION POTENTIAL

 Action potential:
1. Resting potential  -80 -90
2. Duration  1-5 millisec
3. Velocity of conduction  3-5m/sec

 Action potential spread to the Interior of

the muscle fiber by way of Transverse
Tubules
EXCITATION-CONTRACTION COUPLING
 Transverse tubule–sarcoplasmic
reticulum system
 Release of calcium ions by the
sarcoplasmic reticulum
 Calcium Pump Removes Calcium
Ions from the Myofibrillar Fluid
After Contraction Occurs
THANKS