This document summarizes the pathophysiological mechanisms underlying Takayasu disease, which is an inflammatory condition of large arteries that can lead to stenosis. It involves cellular retention of sodium leading to water retention and increased blood volume. This disrupts the sodium-potassium pump, increasing intracellular sodium and calcium levels, prolonging vasoconstriction and stimulating smooth muscle growth and narrowing of arteries. Inflammation causes the release of substances that increase vascular permeability and the accumulation of materials that promote vessel thickening and elevated blood pressure.
This document summarizes the pathophysiological mechanisms underlying Takayasu disease, which is an inflammatory condition of large arteries that can lead to stenosis. It involves cellular retention of sodium leading to water retention and increased blood volume. This disrupts the sodium-potassium pump, increasing intracellular sodium and calcium levels, prolonging vasoconstriction and stimulating smooth muscle growth and narrowing of arteries. Inflammation causes the release of substances that increase vascular permeability and the accumulation of materials that promote vessel thickening and elevated blood pressure.
This document summarizes the pathophysiological mechanisms underlying Takayasu disease, which is an inflammatory condition of large arteries that can lead to stenosis. It involves cellular retention of sodium leading to water retention and increased blood volume. This disrupts the sodium-potassium pump, increasing intracellular sodium and calcium levels, prolonging vasoconstriction and stimulating smooth muscle growth and narrowing of arteries. Inflammation causes the release of substances that increase vascular permeability and the accumulation of materials that promote vessel thickening and elevated blood pressure.