Hypertension Increased Intravascular Pressure

Renal arterial walls thickens to

withstand pressure

Narrowing of the vascular lumen

Decreased of blood and oxygen

that enters the kidney

Increased production of Renin

Activation of RAAS

Increased HR and BP

Ischemic injury & loss of

nephrons

Immune cells (macrophages, foam cells)

enter the damaged glomerulus &
secrete growth factors TGF-B1

Mesangial cells regress to

Mesangioblast
 Excess production of extracellular matrix

Excessive fluid accumulates

inGlomerulosclerosis
the tissues Glomerulosclerosis Decreased urea
excreted

Fluid retention
Decreased ability to filter Azotemia
blood
Decreased potassium
Edema excreted

Chronic Renal
Hyperkalemia
Failure