lnsulin Receptor Pathway

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Glucose
INSULIN

G L UT 4 PIP3 PIP2
t
Lipid Raf
P P SHC
PI3K GRB2
P SOS
Flotilli P IRS1
n
P Insulin
Nck Crk Ras
c-CbI CAP ReceptorP GTP
GLUT4
Fyn
Translocation
P
4
Ra b
GRB10
PIP2 P Raf
GLUT4 P
IRS1/2 SHC
Vesicle
PIP3 P P P
PPtase1 APS

c-CbI
PDK P
PKC P
P
Rac P
n P
Akt t or atio P
MEKs
p
e ce aliz
PKB R er n Insulin
Int
mTOR
Insulin EAI
ERKs
EAI
Glycogen
Synthase BAD on
GSK3
dati +
p70S6K ra H+
D eg ptor ion
n e at
s uli Rec oryl
In & sph
eIF4EBP o
e ph
H+ D
FKHRL1 EEF2K
P
se
lya

BAD
tra P
Ci AT

JNK
te

eIF2B 14-3-3 S6
EEF2
eIF4
Elk

Translation EBS
Anti-apoptosis Translation c-Jun
os
Fatty Acid c-F
Gene
Synthesis Gene Expression E
TR Expression