Insulin pathway

Glucose SNARE Insulin

complex
Lipid rafts
Insulin
receptor

Flotillin
Cav SHIP
CAP PIP3
GAB1
Cbl PTEN PI3K
p85 SOCS3
GLUT-4
Synip APS
Shc
CrKII JAK
GLUT-4 translocation
C3G PDK1/2 IRS-1
TC10
P
SHP2 NIK
CIP4/2 PKCα Akt SOS
ASIP Akt GRB2
GLUT-4
Vesicle PP2A Crk
P P p70 IRS-1
Bad Fyn Ras
Tsc2 P
-P
Glycogen PKC JNK
Apoptosis synthase P Tsc1 PDE3B
PP1 Raptor c-Raf
GSK3
Glycogen GRB10
SGK Stress
synthesis ATP citrate 4E-BP1 cAMP P
lyase mTOR
P
ATP Sodium MEK1/2
Fatty acid eIF4B ENaC
eIF2B PKA transport P
synthesis Protein p70 S6K Amino
Key ERK
synthesis acids
Lipolysis
Apoptosis Growth
Kinase

Akt SGK
P P P

Phosphatase FKHR AFX FKHR1 ERK

Transcription
factor

Ligand

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