Ass.Prof.

Marwa Monier Refaie

Assistant professor of pharmacology
Minia University

1-It is useful in malignant hypertension

a. α-Methydopa
b. Cocaine
c. Clonidine
d. Salbutamol
2-It is used as nasal decongestant
a. Phenylephrine
b. Cocaine
c. Clonidine
d. Salbutamol
3-Selective alpha 2 agonist as
a. Phenylephrine
b. Cocaine
c. α-Methydopa
d. Salbutamol
4-It acts as direct and indirect sympathomimetic drug
a. Phenylephrine
b. Ephedrine
c. Clonidine
d. Salbutamol
5-Clonidine is complicated by……..on sudden stopage
a. Hypertension
b. Bradycardia
c. Heart block
d. Rebound hypertension

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

6-Alpha methyl dopa side effects include

a. Hypertension
b. Tachycardia
c. Nephrotoxic
d. hyperprolactinemia
7-Precaution of clonidine administration includes
a. It should be given at bed time
b. It should be given with diuretics
c. not used in hypertensive patient
d. It should be given slowly and never sudden stoppage
8-Dobutamine acts on
a.β1 b. β2 c. β1, β2 d. α1
9-Somatic nervous system is mediated by
a. Adrenaline
b. Norepinephrine
c. Actylcholine
d. Dopamine
10-It is complicated by parkinsonian symptoms and used in
gestational hypertension

a. α-Methydopa
b. Cocaine
c. Clonidine
d. Salbutamol

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

11-It decreases catecholamines reuptake

a. Phenylephrine
b. Cocaine
c. Clonidine
d. Salbutamol
12-One of the following is used in acute asthmatic attack
a. α-Methydopa
b. Cocaine
c. Clonidine
d. Salbutamol
13-The mechanism of previous drug is
a. Decrease bronchial secretion
b. Bronchodiltation
c. Respiratory Centre stimulant
d. Anti-histaminic
14-One of the following is an effect of sympathetic nervous system
activity
a-Bradycardia
b-Hypotension
c-Miosis
d-Anxiety
15- Actylcholine is destroyed by
a- Actylcholineestrase
b- Actylcholine hydroxylase
c-Peroxidase
d- Acetyl-coA

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

16-It is responsible for fight and flight response

a-Sympathetic nervous system
b- Parasympathetic nervous system
c- Enteric nervous system
d- Somatic nervous system
17-Somatic nervous system
a-Control skeletal muscle
b- Control GIT
c- Control eye
d- Control heart muscle
18-Major blood vessels are under effect of
a-β1 b- β2 c- α1 d- α2
19-The neurotransmitter in sympathetic nervous system is
a-Tyrosine
b- Dopamine
c- Choline
d- Dopa
20-Degradation of adrenaline by
a-Dopamine hydroxylase
b- Tyrosine hydroxylase
c- Actylcholine esterase
d- MAO

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

21-Beta 2 receptor controls function of

a-Minor blood vessels
b- Bronchi
c- Ovary
d-Heart and CNS
22-Nicotinic m receptors are found in
a-Cardiac muscle
b- Neuromuscular junction
c- Smooth muscle
d- Fatty tissue
23- Tachycardia and tolerance are considered as the side effects of
a-Propranolol
b- Atropine
c- Formoterol
d- Ephedrine
24-Nn receptor is found in
a-Cardiac muscle
b- Skeletal muscle
c- Autonomic ganglion
d- Fatty tissue
25-Beta1 receptor is widely distributed in
a-Cardiac muscle
b- Skeletal muscle
c- Smooth muscle
d- Fatty tissue

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

26-Phenylephrine is useful in
a-Attention deficit hyperactivity disorder
b-Nasal congestant
c-Atropine poisoning
d-Bradycardia
27-Epinephrine acts on
a-M1
b- β1, β2
c-M2
d- β2
28-Dopamine action on
a-D1
b- α2
c-M2
d- β2
29-Beta one agonist control
a-Hear function
b- Respiratory tract function
c-Eye muscle contraction
d- Urinary bladder contraction
30-It is used as an adjuvant with local anesthetic
a. α-Methydopa
b. Cocaine
c. Noradrenaline
d. Salbutamol

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

31-It acts as both direct and indirect sympathomimetic

a. Phenylephrine
b. Ephedrine
c. Clonidine
d. Salbutamol
32-Selective alpha 2 agonist as
a. Phenylephrine
b. Cocaine
c. Alpha methyldopa
d. Salbutamol
33-It is the major precursor of endogenous catecholamines
a. Phenylephrine
b. Cocaine
c. Dopamine
d. Formoterol
34-It acts as indirect sympathomimetic drug
a. Phenylephrine
b. Cocaine
c. Clonidine
d. Salbutamol
35-One of cocaine side effects is
a. Hypotension
b. Bradycardia
c. Heart block
d. Addiction

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

36-Isoprenaline is complicated by
a. Hypertension
b. Tachycardia
c. Heart block
d. Hypotension
37-Clonidine side effects include
a. Hypertension
b. Endocrine disorders
c. Nephrotoxic
d. Rebound hypertension
38-This should be followed during administration of clonidine
a. It should be given at bed time
b. It should be given with diuretics
c. not used in hypertensive patient
d. It should be given slowly and never sudden stoppage
39-Short acting beta 2 agonist is
a. Salbutamol
b. Cocaine
c. Clonidine
d. Salmeterol
40-It is used in nocturnal bronchial asthma
a. Formoterol
b. Cocaine
c. Clonidine
d. Salbutamol

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

41-Complications of beta 2 agonist include

a. Tremors
b. Parkinsonism
c. Nephrotoxic
d. Rebound hypertension
42-It is used in acute bronchial asthma
a. Formoterol
b. Cocaine
c. Clonidine
d. Terbutaline
43-Adrenaline acts on
a.β1 b. β2 c. β, α d. α2
44-Salmeterol acts as
a. Anti-hypertensive agent
b. Nasal decongestant
c. Local anesthetic
d. Bronchodilator
45-It is used in cardiogenic shock
a. Dobutamine
b. Atropine
c. Actylcholine
d. Ephedrine

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

46-It has dose dependent action

a. Dopamine
b. Atropine
c. Actylcholine
d. Ephedrine
47-It acts on all sympathetic receptors
a. Dopamine
b. Adrenaline
c. Actylcholine
d. Ephedrine
48-Its derivatives is used in treatment of glaucoma
a. Adrenaline
b. Atropine
c. Actylcholine
d. Ephedrine
49-It is used in hypotensive shock
a. Noradrenaline
b. Atropine
c. Actylcholine
d. Ephedrine
50-Actylcholine synthesis limiting step is
a-Uptake of choline
b-Release by exocytosis
c-Destruction by actylcholine esterase
d-Combination with acetyl-coA

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

51- Major source of parasympathetic nervous system

a-Vagus
b- Oculomotor
c- Facial
d-Sacral
52-It receives only sympathetic innervation
a- Sweet gland
b- Stomach
c- Eye
d-Bronchi
53-It controls skeletal muscle
a- Parasympathetic nervous system
b- Sympathetic nervous system
c- Somatic nervous system
d-Sensory
54- The site OUT of actylcholine actions
a- Neuromuscular junction
b- Sympathetic nervous system nerve terminals
c- Ganglion
d-Adrenal gland
55-One of non-natural catecholamine
a- Adrenaline
b- Actylcholine
c- Dopamine
d-Dobutamine

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Ass.Prof.Marwa Monier Refaie
Assistant professor of pharmacology
Minia University

56-It triggers release of actylcholine from storage vesicles

a- Uptake of choline
b- Actylcholine estrase
c- Release of calcium
d-Rupture of storage vesicle
57-The major precursor of catecholamines is
a-Tyrosine
b- Dopamine
c- Choline
d- Adrenaline
58-Degradation of catecholamines by
a-Dopamine hydroxylase
b- Tyrosine hydroxylase
c- Actylcholine estrase
d- COMT, MAO
59-Initial precursor of catecholamine is
a-Tyrosine
b- Dopamine
c- Choline
d- Adrenaline
60-The rate limiting step in norepinephrine synthesis is conversion of
a- Dopamine to epinephrine
b- Dopamine to norepinephrine
c- Tyrosine to dopa
d- Dopa to dopamine

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