Mariano Marcos State University

College of Health Sciences

Department of Pharmacy

PHARMACOLOGY 2 (PHBS 107)

MULTIPLE CHOICE: Each of the questions, statements, or incomplete statements can be correctly
answered or completed by one of the suggested answers or phrases. Choose the best answer.
1. Which of the following drug is used for the treatment of sickle cell anemia?
a. Hydroxyurea
b. Cisplatin
c. Paclitaxel
d. Carboplatin
2. Sterility is caused by:
a. Vinca alkaloids
b. Alkylating agents
c. Antimetabolites
d. Actinomycin D
3. Which of the following is widely used in the management of carcinoma breast?
a. Actinomycin-D
b. Bleomycin
c. Doxorubicin
d. Dacarbazine
4. People with high risk for development of breast cancer should be treated by prophylactic
administration of:
a. Tamoxifen
b. Aminoglutethimide
c. Diethylstibesterol
d. Flutamide
5. Proliferation independent agents include all the following except:
a. Vincristine
b. Carmustine
c. Melphalan
d. Cyclophosphamide
6. Methotrexate is used for the management of all of these conditions except:
a. Rheumatoid arthritis
b. Psoriasis
c. Sickle cell anemia
d. Organ transplantation
7. All are alkylating agents, except:
a. 5-Fluorouracil
b. Melphalan
c. Cyclophosphamide
d. Chlorambucil

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

8. All of the following are true regarding ifosfamide, except:

a. Metabolised by cytochrome p450 enzymes
b. Less neurotoxic than cyclophosphamide
c. Chloracetaldehyde is the metabolite of ifosfamide
d. It is a nitrogen mustard
9. Pulmonary fibrosis is seen with:
a. Bleomycin
b. Cisplatin
c. Methotrexate
d. Actinomycin D
10. Hemorrhagic cystitis is caused by:
a. Cyclophosphamide
b. 6 Mercaptopurine
c. 5 Fluorouracil
d. Busulfan
11. Which of the following anti-cancer drugs is cell cycle specific?
a. Ifosfamide
b. Melphalan
c. Vinblastine
d. Cyclophosphamide
12. Which of the following causes peripheral neuritis?
a. Methotrexete
b. Vincristine
c. Busulfan
d. Cyclophosphamide
13. Leucovorin rescue is related to:
a. Methotrexate toxicity
b. Cyclophosphamide toxicity
c. Oncovin toxicity
d. Cisplatin toxicity
14. Cyclophosphamide can cause:
a. Hemorrhagic cystitis
b. Cardiomyopathy
c. Neuropathy
d. Convulsions
15. Which of the following anticancer drug is excreted by lungs?
a. 5-Fluorouracil
b. Cyclophosphamide
c. Doxorubicin
d. Cisplatin

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

16. Mechanism of action of paclitaxel is:

a. Topoisomerase inhibition
b. Increases the polymerization of tubulin
c. Inhibits protein synthesis
d. Alkylation of DNA
17. Which of the following drugs is topoisomerase 1 inhibitor?
a. Doxorubicin
b. Irinotecan
c. Etoposide
d. Vincristine
18. All of the following anticancer agents cause bone marrow suppression, except:
a. Chlorambucil
b. Daunorubicin
c. Doxorubicin
d. Flutamide
19. The mechanism of anticancer action of fluorouracil is:
a. Cross linking of double stranded DNA and the resulting inhibition of DNA
replication and transcription
b. Cytotoxicity resulting from a metabolite that interferes with the production of
dTMP
c. Irreversible inhibition of dihydrofolic acid reductase
d. Selective action on DNA polymerase
20. A cell cycle specific anticancer drug that acts mainly in the M phase of the cycle is:
a. Cisplatin
b. Etoposide
c. Methotrexate
d. Paclitaxel
21. Toxicity of nitrogen mustards can be decreased by:
a. Amifostine
b. Folinic acid
c. GM-CSF
d. MESNA
22. Folinic acid counteracts the toxicity of:
a. Doxorubicin
b. Methotrexate
c. Cyclophosphamide
d. Fluorouracil

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

23. Which of the following is an antimetabolite drugs that inhibits DNA polymerase and is one
of the most active drugs in the treatment of leukemia?
a. Bleomycin
b. Cytarabine
c. Mercaptopurine
d. Methotrexate
24. Which of the following anticancer drugs can cross blood brain barrier?
a. Cisplatin
b. Nitrosourea
c. Vincristine
d. Vinblastine
25. Most common side effect of 5-fluorouracil is:
a. G.I. toxicity
b. Bone marrow depression
c. Cardiotoxicity
d. Neurotoxicity
26. All of following statements about are true about 6-mercaptopurine, except:
a. It is metabolized by xanthine oxidase
b. It does not cause hyperuricemia
c. Its dose should be reduced when allopurinol is given concurrently
d. It is an active metabolite of azathioprine
27. All of the following statements about vincristine are true except:
a. It acts by inhibiting mitosis
b. Its prominent adverse effect is peripheral neuropathy
c. It does not suppress bone marrow
d. It is a drug of choice for solid tumors
28. All of the following statements about methotrexate are true except:
a. It is cell cycle specific and kills cells in the S phase
b. Its toxicity primarily affects bone marrow and epithelial structures
c. Folic acid reverses its toxic effects
d. It is the drug of choice for choriocarcinoma
29. Sterile hemorrhagic cystitis is caused by:
a. Busulfan
b. Ketoprofen
c. Methicillin
d. Cyclophosphamide

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

30. Which of the following chemotherapeutic agents is associated with secondary leukemia?
a. Vinblastine
b. Paclitaxel
c. Cisplatin
d. Bleomycin
31. Which of the following drugs is associated with untoward side effect of renal tubular
damage?
a. Cisplatin
b. Streptozocin
c. Methysergide
d. Cyclophosphamide
32. Cerebellar toxicity is seen with:
a. Cisplatin
b. Cytarabine
c. Bleomycin
d. Actinomycin D
33. ‘Hand and Foot’ syndrome can be caused by:
a. Cisplatin
b. Vincristine
c. Capecitabine
d. Mitomycin-C
34. Which of the following is used to treat hormone-responsive breast cancer?
a. Adriamycin
b. Clomiphene citrate
c. Diethylstibestrol
d. Tamoxifen
35. Which of the following is a highly emetogenic chemotherapy drug:
a. 5-Fluorouracil
b. Paclitaxel
c. Vincristine
d. Cisplatin
36. The chemotherapeutic agent of choice for concurrent chemoradiation in carcinoma
cervix is:
a. Paclitaxel
b. Hydroxyurea
c. 5 FU (fluorouracil)
d. Cisplatin

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

37. Methotrexate resistance is due to:

a. Increased concentrations of intracellular DHFR through gene amplification
b. Failure of efflux pumps
c. Bacterial modification
d. Increased synthesis of poly glutamates
38. Which antineoplastic drug has a very high cardiac toxicity?
a. Bleomycin
b. Actinomycin-D
c. Doxorubicin
d. Mitomycin-C
39. The top four most commonly diagnosed cancers include all of the following except
a. lung.
b. prostate.
c. colon and rectum
d. thyroid.
e. Breast
40. All of the following chemotherapy agents can be administered intrathecally except
a. methotrexate.
b. cytarabine.
c. hydrocortisone.
d. thiotepa.
e. Vincristine

For numbers 41-45. Each agent in this section is most closely associated with one of the
following adverse effects. Each effect is used only once. Choose the best answer.

41. Vincristine
a. cardiotoxicity
b. hypersensitivity
c. diarrhea
d. gastrointestinal hemorrhage
e. peripheral neuroparthy
42. Irinotecan
a. cardiotoxicity
b. hypersensitivity
c. diarrhea
d. gastrointestinal hemorrhage
e. constipation

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 Mariano Marcos State University
College of Health Sciences
Department of Pharmacy

43. Doxorubicin
a. cardiotoxicity
b. hypersensitivity
c. diarrhea
d. gastrointestinal hemorrhage
e. constipation
44. Paclitaxel
a. cardiotoxicity
b. hypersensitivity
c. diarrhea
d. gastrointestinal hemorrhage
e. constipation
45. Bleomycin
a. cardiotoxicity
b. hypersensitivity
c. diarrhea
d. pulmonary fibrosis
e. constipation
46. The following is true of cancer chemotherapy:
a. Anticancer drugs increase the risk of developing leukaemias and lymphomas
several years later
b. All anticancer drugs are highly emetogenic
c. Growth fraction of cancers is higher than any nomral tissue of the body
d. All of the above are correct
47. Alkylating agents exert cytotoxic action by inducing:
a. Breakage of DNA strand
b. Cross linking of DNA strands
c. Abnormal pairing of purine and pyrimidine bases
d. All of the above
48. Which of the following statements is FALSE regarding vincristine?
a. It is an alkaloid
b. Its use is associated with neurotoxicity
c. It does not cause alopecia
d. It is a useful drug for induction of remission in acute lymphoblastic leukemia

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