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Inhibition of Apoptosis

Survival Factors:
TNF- Growth Factors,
Cytokines, etc.

TNFR1
TRADD

CYLD PTEN
FADD
cIAP
Cytopla
TRAF2

A20 sm
RIP

Ras
HSP27 PI3K HSP90
Raf
NIK TAK1 FLIP
TAB HSP90
Casp-8/10 JNK PIP3 PDK1

IKK cdc37 IKK IKK

HSP70 Bax
IKK HSP90 IKK
Bid
GSK-3 Akt p70S6K Erk1/2 PKC Jak Src
HSP90
FoxO1
Smac/ Bim
IB Diablo Bax Bcl-2

NF-B tBid Bcl-xL Bad p90RSK

XIAP
Bim
IB
Casp-3,-6,-7 Bax
Mcl-1 PKA FoxO1 CREB Stat1 Stat3
HSP27
NF-B Apoptosis
Casp-9
[cAMP]
Apaf-1 Cyto c Mule HSP70 Bim
Akt

HSP90 HSP70 HSP27

m
plas
Cyto

leus
Nuc
CREB
FLIP FAS Bcl-2 Stat1
XIAP Bim Bcl-xL
NF-B A20 FoxO1 Stat3

2002 2010 Cell Signaling Technology, Inc. Inhibition of Apoptosis created January 2002 revised November 2010
 www.cellsignal.com

Signaling Pathways Key

Direct Stimulatory Modification

Kinase
Direct Inhibitory Modification
Phosphatase
Multistep Stimulatory Modification
Transcription Factor
Multistep Inhibitory Modification
Caspase
Tentative Stimulatory Modification

Receptor Tentative Inhibitory Modification

Enzyme Transcriptional Stimulation

Transcriptional Inhibition
Cyclin, pro-apoptotic
Translocation
pro-survival
Separation of Subunits or Cleavage Products
GAP / GEF
Joining of Subunits
GTPase

G-protein, ribosomal subunit

Acetylase

Deacetylase

2003 - 2010 Cell Signaling Technology, Inc.