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  • MAPK Family Pathway Signaling Cascade

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    The MAPK family pathway is activated by growth factors, inflammatory cytokines, and other signals. These signals activate receptor tyrosine kinases or cytokine receptors which initiate a phosphorylation cascade involving MAP kinase kinases (MAP2Ks) and MAP kinases (MAPKs). This leads to activation of transcription factors that regulate gene expression related to cell growth, differentiation, and stress responses.

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    MAPK_Family_Pathway

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    The MAPK family pathway is activated by growth factors, inflammatory cytokines, and other signals. These signals activate receptor tyrosine kinases or cytokine receptors which initiate a phosphorylation cascade involving MAP kinase kinases (MAP2Ks) and MAP kinases (MAPKs). This leads to activation of transcription factors that regulate gene expression related to cell growth, differentiation, and stress responses.

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    14 views1 page

    MAPK Family Pathway Signaling Cascade

    Uploaded by

    capra1
    The MAPK family pathway is activated by growth factors, inflammatory cytokines, and other signals. These signals activate receptor tyrosine kinases or cytokine receptors which initiate a phosphorylation cascade involving MAP kinase kinases (MAP2Ks) and MAP kinases (MAPKs). This leads to activation of transcription factors that regulate gene expression related to cell growth, differentiation, and stress responses.

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    MAPK Family Pathway

    EGF Inflammatory
    N TGF Cytokines ILs
    TNFs
    EGFR
    Growth
    Growth T TNFR
    T
    Factors
    Factors G
    G G
    F
    Growth Factor P F
    Receptors C  
    R IL-Rs
    R R
    SOS C GRB2
    Ras
    G-Proteins TRADD Daxx
    SHC
    TRAF2 RIP
    GRB2 SOS HPK1
    PAK1

    PI3K PAK2 Crk


    CGK
    CrkL
    CGKR
    GLK
    Raf GEFs HGK
    ZPK NI
    MAP4Ks K
    TPL2 CDC42

    MEKK2 MAP3K6 TAK1 MEKK1


    MEKK4
    MLK1
    MEKK3 MAP3Ks ASK1
    MLK2
    LZK
    MLK3 MAP3Ks
    MAP3Ks
    MAP3Ks IKKs

    SEK1 MKK7
    MKK3 MKK6
    MEK1 MEK2 MEK5
    MAP2Ks MAP2Ks
    ERK3
    MAP2Ks Related
    JNK1 JNK2 p38- p38-2
    ERK3 ERK3
    JNK3 p38- p38-
    ERK1 ERK2
    MAPKs
    MAPKs MAPKs
    MAPKs
    MAPKAPK2 NF-B
    IBs
    Elk1
    ATF2
    MSK1/2 PRAK P
    RSK1 RSK2 MNK1/2 MAPKAPK3

    RSK3 c-Jun

    eIF4E
    NF-B
    CREB
    HSP25/27
    Histone-H3 IBs
    Degradation
    Cytoskeleton
    Chromatin Translation Gene C 2007-2009
    Expression
    Remodeling SABiosciences.com

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