PATHOPHYSIOLOGY OF DENGUE

Bite of a virus carrying Aedes mosquito

Mosquito injects fluid into victim’s skin

Virus enters blood stream

Infects cells and generate cellular response

Initiates immune response

(Stimulates release of cytokines)

Cytokines destroys cell membrane and cell wall

(Viral Antigens found in monocytes)
Fluid Shift

When treated early with doctor prescribed medications and When illness becomes severe
managed to prevent the appearance of other symptoms

IVF and electrolyte replacements and precautions Damage cells due to cytokines and virus

Patient recovers Fluid shift from ICF- ECF

Manifest evanescent rashes rashes in several areas in the body

Bloody vomittus, urine and stool

Circulatory collapse

Shock

DEATH