PATHOPHYSIOLOGY OF SARS

Predisposing Precipitating
Factor: Factor:

Age: 71 y/o Immunocompro

mised (DM)
Gender: Male

Exposure: to
infected person

TRANSMISSION:
DROPLET (containing SARS-
CoV)

Affecting
SARS-CoV attaches
Respiratory Tract
to Epithelial Cells Lungs

Sensory Receptors
VIREMIA
detect foreign
substances
Passes the…
Bloodstream HYPOTHALAMUS

Triggers Action
Affecting
Potentials
Disrupts Normal
Circulatory System Thermal Regulation
Along the…

Resulting to… Vagus nerve

Thrombosis of the Increase heat Towards

Pulmonary Arteries production and
due to advanced age. conservation
Medulla Oblongata
Resulting to…
Triggers….
Inadequate bloodflow Increased
through the Temperature Cough Reflex
pulmonary capillaries. (INEFFECTIVE
AIRWAY
CLEARANCE)
FEVER
Reduces the total
amount of
hemoglobin. Increase pressure in
Y
the alveoli

X
XX
 PATHOPHYSIOLOGY OF SARS

X XX

Leading to…

Reduces the capacity Rupture and destruction

of blood to transport of alveolar walls.
of oxygen
Decreased surface
Leading to… area
Loss of elastic
Anemia fibers
Decreased gas
Resulting to… exchange
Reduced ability of the
lungs to recoil and
 Decrease RBC expel air
 Decrease Hgb

Y
Emphysema

Phagocytosis Enlargement of Shortness of

(Autoimmunity) thoracic cavity Breath
the immune
response of the If untreated…
body turned
against its own Difficulty of Breathing
cells and tissues (Exacerbation)

SEVERE ACUTE RESPIRATORY

SYNDROME

L E G E N D :

PRECIPITATING AND Manifesting signs textbox

PREDISOSING FACTORS

TRANSMISSION Resulting action Viremia

SYSTEM/ORGAN
Affects Laboratory
AFFECTED
Results