Ogan Gurel, MD

Biology 301
Lecture #4
Roosevelt University

Biology 301
Cellular and Molecular Biology
Fall 2002

Lecture # 4: Proteins
 Ogan Gurel, MD
Biology 301
Lecture #4
Roosevelt University

Overall outline
 Protein Function
 Protein Chemistry
 Protein Structure
 Ogan Gurel, MD
Biology 301
Lecture #4
Roosevelt University

Protein Function
 Protein Functions
 Ogan Gurel, MD
Biology 301
Lecture #4

Protein Functions
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4
Roosevelt University

Protein Chemistry
 Synthesis of polymers
 Breakdown of polymers
 Amino acid structure
 Amino acid titration curve
 Amino acid classification
 Hydrophobic amino acids
 Charged amino acids
 Polar amino acids
 Amino acid isoelectric point
 The peptide bond
 Peptide bond synthesis
 Ogan Gurel, MD
Biology 301
Lecture #4
Roosevelt University

Synthesis of Polymers
 Ogan Gurel, MD
Biology 301
Lecture #4

Breakdown of Polymers
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Amino acid structure

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Amino acid titration curve

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Amino acid classification

Roosevelt University

• Twenty amino acids

• Hydrophilic vs. hydrophobic
• Charged vs. Polar
 Ogan Gurel, MD
Biology 301
Lecture #4

Hydrophobic amino acids

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Polar amino acids

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Charged amino acids

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Amino acid isoelectric point

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

The peptide bond

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Peptide bond synthesis

Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4
Roosevelt University

Protein Structure
 Functional Conformation
 Principles of protein structure
 Primary structure
 Secondary structure
 Tertiary structure
 Bonds contributing to tertiary structure
 Hydrophobic effect
 Quarternary structure
 Review: Four levels of protein structure
 Protein folding
 Back to function
 Ogan Gurel, MD
Biology 301
Lecture #4

Functional Conformation
Roosevelt University
Principles of protein Ogan Gurel, MD
Biology 301
Lecture #4

structure
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Primary structure
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Secondary structure
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Tertiary structure
Roosevelt University
 Ogan Gurel, MD

Bonds contributing to tertiary Biology 301

Lecture #4
Roosevelt University

structure
 Ogan Gurel, MD
Biology 301
Lecture #4

Hydrophobic effect
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Quarternary structure
Roosevelt University
 Ogan Gurel, MD

Review: Four levels of protein Biology 301

Lecture #4
Roosevelt University

structure
 Ogan Gurel, MD
Biology 301
Lecture #4

Protein folding
Roosevelt University
 Ogan Gurel, MD
Biology 301
Lecture #4

Back to function
Roosevelt University