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    The document summarizes several common genetic mutations found in different types of hematological neoplasms and their significance. It lists several cancers such as Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, chronic myelogenous leukemia, acute lymphocytic leukemia, and others. It provides the specific chromosome translocations associated with each cancer, the percentage of cases with these mutations, and the proto-oncogenes or genes affected in each translocation. For many cancers, it also notes their association with specific treatment outcomes or disease subtypes.

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    Genetics of Hematologic Neoplasia

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    The document summarizes several common genetic mutations found in different types of hematological neoplasms and their significance. It lists several cancers such as Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, chronic myelogenous leukemia, acute lymphocytic leukemia, and others. It provides the specific chromosome translocations associated with each cancer, the percentage of cases with these mutations, and the proto-oncogenes or genes affected in each translocation. For many cancers, it also notes their association with specific treatment outcomes or disease subtypes.

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    Download as PDF, TXT or read online from Scribd
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    13 views1 page

    Genetic Mutations

    Uploaded by

    BigBoosting
    The document summarizes several common genetic mutations found in different types of hematological neoplasms and their significance. It lists several cancers such as Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, chronic myelogenous leukemia, acute lymphocytic leukemia, and others. It provides the specific chromosome translocations associated with each cancer, the percentage of cases with these mutations, and the proto-oncogenes or genes affected in each translocation. For many cancers, it also notes their association with specific treatment outcomes or disease subtypes.

    Copyright:

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    Summary on genetic mutations in hematological neoplasm , and significance

    Modified, Table 16-2 of T&T Genetics, 7th, p466


    Neoplasm Burkitt lymphoma

    Chromosome Translocation
    t(8;14)(q24;q32)

    Percentage of Cases
    80%

    Proto-oncogene Affected Translocation of c-MYC into close to IgH gene (V region) BCL2-IgH

    Follicular lymphoma

    t(14;18)(q32;q21)

    100%

    Mantle cell lymphoma

    t(11;14)(q13;q32)

    70%

    Cyclin D1-IgH

    Chronic myelogenous leukemia (CML) Acute lymphocytic leukemia (ALL) Acute Myeloid leukemia AML-(M2) AML-M4

    t(9;22)(q34;q11) Philadelphia t(12;21) Hyperploidy

    90%-95%

    BCR-ABL

    --Gleevec sensitive

    25.4%

    CBFa and ETV6

    t (8;21) inv (16) 95%

    CBF

    --good prognosis --good prognosis

    Acute promyelocytic leukemia t(15;17)(q22;q11) (AML-M3) Chronic lymphocytic leukemia Trisomy 12 (CLL) del(17) Chronic Myeloid Disorders JAK2 V617F mutations

    RARA-PML --good prognosis

    Unknown P53 PV-95-100% ET-50%, 50% in MF

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