Scribd Logo
Upload

Welcome to Scribd!

  • Leukemia Tables

    Uploaded by

    Devin Burrup
    24 views2 pages
    This document provides information about several types of leukemia and related conditions: 1. It describes characteristics of acute lymphoblastic leukemia (ALL) in individuals aged 15-39, including increased lymphoblasts that can spread to the central nervous system and testes, and a better prognosis associated with a 12;21 translocation. 2. It summarizes subtypes of acute myeloid leukemia (AML) in individuals aged 15-60, noting that M2 is the most common subtype and involves Auer rods, and that acute promyelocytic leukemia (M3 subtype) involves a 15;17 translocation and disseminated intravascular coagulation. 3. It provides brief descriptions of

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    XLSX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document provides information about several types of leukemia and related conditions: 1. It describes characteristics of acute lymphoblastic leukemia (ALL) in individuals aged 15-39, including increased lymphoblasts that can spread to the central nervous system and testes, and a better prognosis associated with a 12;21 translocation. 2. It summarizes subtypes of acute myeloid leukemia (AML) in individuals aged 15-60, noting that M2 is the most common subtype and involves Auer rods, and that acute promyelocytic leukemia (M3 subtype) involves a 15;17 translocation and disseminated intravascular coagulation. 3. It provides brief descriptions of

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    24 views2 pages

    Leukemia Tables

    Uploaded by

    Devin Burrup
    This document provides information about several types of leukemia and related conditions: 1. It describes characteristics of acute lymphoblastic leukemia (ALL) in individuals aged 15-39, including increased lymphoblasts that can spread to the central nervous system and testes, and a better prognosis associated with a 12;21 translocation. 2. It summarizes subtypes of acute myeloid leukemia (AML) in individuals aged 15-60, noting that M2 is the most common subtype and involves Auer rods, and that acute promyelocytic leukemia (M3 subtype) involves a 15;17 translocation and disseminated intravascular coagulation. 3. It provides brief descriptions of

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    ALL - 15-39 yoa

    Increased Lymphoblasts
    TdT, CALLA, CD10
    Spreads to CNS and Testes
    12;21 translocation = better prognosis

    AML - 15-60 (15-39 = MC; 40-59 = 60%)


    M0-M7; M2 is MC
    Auer Rods in M2 & M3 (Red, Splinter-to-Rod inclusions)
    Treat M3 w/ Retinoic Acid (Vit A)
    M3 (Acute Promyelocytic) is d/t 15;17 translocation
    M3 involves DIC (always present)
    Thrombocytopenia, Gen Lymph, Hepatosplenomegaly
    Increased Myeloblasts

    Myelofibrosis and Myeloid Metaplasia (MMM)


    Mutation in JAK2 gene of Chromosome 9
    Ineffective erythropoiesis, Immature granulocytes, Reactive myelofibrosis
    Extramedullary hematopoiesis in spleen, liver, other
    Hepatosplenomegally

    Hairy Cell Leukemia (middle-aged men)


    Uncommon, Chronic B-Cell Leukemia
    Rarely has Lymphadenopathy
    Cytoplasmic projections - Stain TRAP +
    CLL - > 60 yoa
    MCC of Generalized Nontender Lymphadenopathy
    MC overall leukemia
    Smudge cells in peripheral smear
    Warm antibody AHA (IgG)

    CML - 40-60 (40%)


    Philadelphia Chromosome (9;22) + bcr-abl fusion
    Increased Neutrophils and Basophils
    Blast Crisis (CML to AML or ALL) --> Death in 3-6 mths
    LOW Leukocyte Alkaline Phosphatase
    No Auer Rods
    Thrombocytosis OR Thrombocytopenia

    JAK2 Mutations = MMM, Polycythemia vera

    Presence of Basophilia = PV, Ess thrombocytosis, MMM, CML

    You might also like