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Coronary Artery Disease Pathophysiology
Coronary Artery Disease Pathophysiology
Non Modifiable Factors Age Gender Family History Modifiable factors Smoking Lack of exercise Stress Diet high in fat Hypertension Elevated Serum cholesterol levels Alcohol consumption Diabetes Mellitus
Lipids are engulfted by the cells (foam cells) and Smooth Muscle Cells Develop
Thrombus Formation
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Coronary
Myocardial Ischemia
Anaerobic metabolism
Inflammatory response
Conduction System Disorder will reset the Hypothalamic thermostat to high temperature Decreased myocardial contractility Fever/Hyperthermia Decreased Cardiac Output
Prostaglandins
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the major
Sympathetic receptors are stimulated Inadequate Pallor Increase in heart rate/ pumping action as a compensatory mechanism Weakness Tachycardia Deterioration of hearts ability to pump cerebral perfusion oxygenated blood to other organs Decreased perfusion of
Stimulation of Baroreceptors
Peripheral Vasoconstriction
Left ventricle is unable to fully eject the returning blood to systemic circulation
Dyspnea
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