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GM Crops: Risks & Benefits With Special Reference to Bt Cotton Cultivation in Sudan زراعة المحاصيل المحورة وراثيا: المنافع و المخاطر وتجربة القطن المحور بالسودان
GM Crops: Risks & Benefits With Special Reference to Bt Cotton Cultivation in Sudan زراعة المحاصيل المحورة وراثيا: المنافع و المخاطر وتجربة القطن المحور بالسودان
2012
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Abdelbagi M. Lei Zhang, Hengyong Xu ,Nasrein M. Kamal, Osama M. Elhassan, Ahmed M.
Mustafa, Yasir S. A. Mohammed , Elnayer H. Suliman, Ahmed H. Assar, Salah Elturabi,
Carman, J. 2012. Expert Scientific Opinion on CSIRO GM Wheat Varieties. A paper presented
to Safe Food Institute. Fitzroy, Australia. Available at:
http://safefoodfoundation.org/wordpress/wp-content/uploads/2012/09/Carman-ExpertScientific-Opinion.pdf
39
Christou, P., and R. Twyman. 2004. The potential of genetically enhanced plants to address
food insecurity. Nutr. Res. Rev. 17:23-42.
Cohen, S.; Chang, A.; Boyer, H.; Helling, R. 1973. Construction of biologically functional
bacterial plasmids in vitro. Proceedings of the National Academy of Sciences of the United
States of America 70: 32403244.
Committee on Agriculture, 2012. Cultivation of Genetically Modified Food Crops Prospects
and Effects. Thirty seventh report. Lok Sabha Secretariat. New Delhi.
Conner, A.J., T.R. Glare, and J.P. Nap. 2003. The release of genetically modified crops into
the environment. Part II. Overview of ecological risk assessment. Plant J. 33:19-46.
CSA, 2007. Preliminary Assessment Report from a Field Visit: Mortality in Sheep Flocks after
grazing on Bt Cotton Fields. Centre for Sustainable Agriculture. Hyderabad. Available at:
http://www.munlochygmvigil.org.uk/Mortality_in_Sheep.pdf
Darvas, B., Lauber, E., Polgar, L. A., Peregovits, L., Ronkay, L., Juracsek, J., et al. 2004.
Non-target effects of DK-440-BTY (Yieldgard) Bt-corn. First
De Grassi, A. 2003. Genetically modified crops and sustainable poverty alleviation in SubSaharan Africa: An assessment of current evidence. Available at http://www.twn.org. Third
World Network Africa.
Douville, M., Gagne, F, Blaise, C. & Andr, C. 2007. Occurrence and persistence of Bacillus
thuringiensis (Bt) and transgenic Bt corn cry1Ab gene from an aquatic environment.
Ecotoxicology and Environmental Safety 66: 195203. Cambers, CP., Whiles, M.R.,
Douville, M., Gagne, F., Andr, C. & Blaise, C. 2009. Occurrence of the transgenic corn
cry1Ab gene in freshwater mussels (Elliptio complanata) near cornfields: evidence of exposure
by bacterial ingestion. Ecotoxicology and Environmental Safety 72: 1725.
Felke, M., Lorenz, N. & Langenbruch, G-A. 2002. Laboratory studies on the effects of pollen
from Bt-maize on larvae of some butterfly species. Journal of Applied Entomology 126: 320
325.
40
/. . -
Felke, V.M. & Langenbruch, G.A. 2003. Wirkung von Bt-Mais-Pollen auf Raupen des
Tagpfauenauges im Laborversuch (Effect of Btmaize-pollen on caterpillars of Inachis io in a
laboratory assay). Gesunde Pflanzen, 55: 1-7.
Flores, S., Saxena, D & Stotzky, G. 2005. Transgenic Bt plants decompose less in soil than
non-Bt plants. Soil Biology and Biochemistry 37: 1073-1082.
FOE. 2005. Tackling GMO Contamination: making segregation and identity preservation a
reality. Available at: http://www.foei.org/ publications/index.html. FOE, Montreal.
FOE. 2006. Who benefits from GM crops? Available at http://www.foei.org/publications/
index.html. FOE, Nigeria.
Friesen, L.F., A.G. Nelson, and R.C. van Acker. 2003. Evidence of contamination of
pedigreed canola (Brassica napus) seedlots in western Canada with genetically engineered
herbicide resistance traits. Agron. J. 95:1342- 1347.
Gallagher, L., M. 2010. BT Brinjal Event EE1 The Scope and Adequacy of the GEAC
Toxicological Risk Assessment (Review of oral toxicity studies in rats). Available at:
http://www.testbiotech.de/sites/default/files/Report%20Gallagher_2011.pdf
Hammond, B., Dudek, R., Lemen, J. and Nemeth M. 2004. Results of a 13 week safety
assurance study with rats fed grain from glyphosate tolerant corn. Food and Chemical
Toxicology. 42:10031014
Harwood, J.D., Wallin, W.G. & Obrycki, J.J. 2005. Uptake of Bt endotoxins by non-target
herbivores and higher order arthropod predators: molecular evidence from a transgenic corn
agroecosystem. Molecular Ecology 14: 2815-2823.
Haygood, R., A.R. Ives, and D.A. Andow. 2003. Consequences of recurrent gene flow from
crops to wild relatives. Proc. R. Soc. London B (Biol. Sci.) 270(1527):1879-1886
Heinemann, J. A. (2009). Hope not Hype. The future of agriculture guided by the
International Assessment of Agricultural Knowledge, Science and Technology for
Development (Penang, Third World Network).
41
Icoz, I. & Stotzky, G. 2008. Fate and effects of insect-resistant Bt crops in soil ecosystems.
Soil Biology & Biochemistry 40: 559586.
International assessment of agricultural knowledge, science and technology for development
(IAASTD) 2009. Global report / edited by McIntyre, B. D., Herren, H. R., Wakhungu, J. and
Robert, T.W. Washington, DC
Ismael, Y. 2001. Smallholder adoption and economic impacts of Bt cotton in the Makhathini
Flats, Republic of South Africa. Rep. DFID Nat. Resour. Policy Res. Prog., Project R7946.
DFID, London.
Lang, A. & Vojtech, E. 2006. The effects of pollen consumption of transgenic Bt maize on the
common swallowtail, Papilio machaon L.(Lepidoptera, Papilionidae). Basic and Applied Ecology
7: 296306.
LDLRAP1: evidence of crosskingdom regulation by microRNA. Cell Res 22, 107126.
Lvei, G.L. & Arpaia, S. 2005.The impact of transgenic plants on natural enemies: a critical
review of laboratory studies. Entomologia Experimentalis et Applicata 114: 114, 2005.
Mellon, M., and J. Rissler. 2004. Gone to seed: Transgenic contaminants in the traditional
seed supply. Available at http://www.ucsusa.
org/food_and_environment/biotechnology/page.cfm?pageID=13-15. Union Concerned
Scientists, Cambridge MA
42
/. . -
Navdanya. 2009. The Devastating Effects of GMOs on the Future of Soil. Available at
http://www.wellnessuncovered.com/joomla/index.php?view=article&catid=34%3Aarticles-ongmo-safety&id=113%3Athe-devastating-effects-of-gmos-on-the-future-ofsoil&format=pdf&option=com_content&Itemid=15
Obrist, L.B., Dutton, A., Romeis, J. & Bigler, F. 2006. Biological activity of Cry1Ab toxin
expressed by Bt maize following ingestion by herbivorous arthropods and exposure of the
predator Chrysoperla carnea. BioControl 51: 31-48.
Pemsl, D., H. Waibel, and A.O. Gutierrez. 2005. Why do some Bt-cotton farmers in China
continue to use high levels of pesticides? Int.J. Sustain. 3:44-56
Pengue, W.A. 2005. Transgenic crops in Argentina: The ecological and social debt. Bull. Sci.
Tech. Soc. 25:314-322
Ramirez-Romero, R., Desneux, N., Decourtye, A. Chaffiol, A., Pham-Delgue, M.H. 2008.
Does Cry1Ab protein affect learning performances of the honey bee. Apis mellifera L.
(Hymenoptera, Apidae)? Ecotoxicology and Environmental Safety 70: 327333.
Ramdas, Sagari R. 2009. Bt Cotton and Livestock: Health Impacts, Bio-safety concerns and
the Legitimacy of Public Scientific Research Institutions. Paper presented at National workshop
on genetically modified crops/foods & Health Impacts. Centre for Sustainable Agriculture,
Doctors for Food & Bio-Safety, Greenpeace India and Sustainet on July 8-9 at India
International Centre, New Delhi
Rosi-Marshall, E.J., Tank, J.L., Royer, T.V., Whiles, M.R., Evans-White, M., Chambers, C.,
Griffiths, N.A., Pokelsek, J. & Stephen, M.L. 2007. Toxins in transgenic crop byproducts may
affect headwater stream ecosystems. Proceedings National Academy Sciences 41: 16204
16208.
Rosi-Marshall, E.J., Tank, J.L., Royer, T.V., Griffiths, N.A., Evans-White, M.A. & Stojak,
A.R.. 2010. Responses of stream macroinvertebrates to Bt maize leaf detritus. Ecological
Applications 20:19491960.
43
Saxena, D., Flores, S. & Stotzky, G. 2002. Bt toxin is released in root exudates from 12
transgenic corn hybrids representing three transformation events. Soil Biology and Biochemistry
34: 133-137.
Seralini, et.al. 2007. New Analysis of a Rat Feeding Study with Genetically Modified Maize
Reveals Signs of Hepatorenal toxicity. Arch.Environ.Contam.Toxicol.52, 596-602.
Sralini, G. E., Emilie, Clair, E., Mesnage, R., Gress, S., Defarge, N., Malatesta, M.,
Hennequin, D., and de Vendmois, J. S. 2012. Long term toxicity of a Roundup herbicide and
a Roundup-tolerant genetically modified maize. Food and Chemical Toxicology, 50 : 4221
4231
Stotzky, G. 2004. Persistence and biological activity in soil of the insecticidal proteins from
Bacillus thuringiensis, especially from transgenic plants. Plant and Soil 266: 77-89.
within transgenic Bacillus thuringiensis corn tissue in the field. Molecular Ecology 12: 765-775.
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