Brand name: Plavix

Generic name: Clopidogrel

Drug Classification: Anticoagulant, antithrombotics & fibrinolytics
Indication: for the reduction of atherosclerotic events (MI, stroke & vascular death) in
patients w/ atherosclerosis documented by recent stroke, MI or established
peripheral arterial disease. For the treatment of patients suffering from non- ST
segment elevation acute coronary syndrome (unstable angina or non-Q wave MI) in
combination w/ ASA.
Mechanism of Action: low dosage aspirin appear to inhibit clot formation by blocking the
synthesis of prostaglandin, which in turn prevents formation of the platelet-
aggregating substance thromboxane A2. Clopidogrel
Dosage: 75 mg daily
Contraindication: Severe liver impairment. Peptic ulcer and intracranial hemorrhage.
Lactation.
Special Precaution: Patients who may be at risk of increased bleeding from trauma, surgery
or other pathological conditions. Patients w/ moderate hepatic disease who may
have bleeding diatheses. Pregnancy.
Adverse Reaction:
CNS: depression, dizziness, fatigue, headache
 EENT: epistaxis
RESP: cough, dyspnea
CV: Chest pain, edema, hypertension
GI: GI bleeding, abdominal pain, diarrhea, dyspepsia, gastritis
DERM: pruritus, purpura, rash
HEMAT: bleeding, neutropenia, thrombotic thrombocytopenic purpura
METAB: hypercholesterolemia
MS: arthralgia, back pain
MISC: fever, hypersensitivity reactions
Form: Film- coated tablet- 75mg
Pregnancy Risk Category: B
Nursing Responsibilities:
 Assess patient for symptoms of stroke, peripheral vascular disease, or MI
periodically during therapy.
 Monitor patient for signs of thrombotic thrombocytic purpura
(thrombocytopenia, microangiopathic hemolytic anemia, neurologic findings,
renal dysfunction, fever).
 Monitor bleeding time during therapy.
 Monitor CBC with differential and platelet count periodically during therapy.