GnRH antagonist anti prostate cancer

degarelix

chloroquine mefloquine blood

plasmodiaHb Heme+fe2+ X?1) Insoluble sequestration 2) liver, blood, or both? plasmodia Folate X1)? DNA 2)liver, blood or both?
plasmodia mt O2 ETC X1)? ATP+Ubiquinone 2) Liver, blood, or both?

proguanil both

atovoquone both

CaSR agonist antihyperparathyroid

Cinacalcet

GI Phosphate binder

sevelamer

GI Phosphate binder

lanthanum

mycophenolate mofetil

IMP X? guanineDNAB/T cell

azathioprine

? 6 mercaptopurineX purinesB/T cell

GI Na+/K+ exchange resin antihyperkalemia

kayexcelate

cyclosporine/tacrolimus rapamycin/sirolimus

T cell ReceptorCalcineurinX1 .......................... MAPKNFATn+NFATc .................... +fos/jun......IL2 early/genes ...........2)X T IL2RmTORCDKproliferation

ADH receptor antagonist anti hyponatremia

tolvaptan

direct renin inhibitor

aliskerin

aspirin

Atrial fibrillation. CHADS=0-1 CHF=1 point HT=1 Age=75=1 Diabetes=1 Stroke/TIA=2 points

anagrelide

drugX phosphodiesterase X megakaryoctye differentiation lowers platelet count

alemtuzumab

mature B/T cell membrane X? CD52=GPI anchor

ADA resistant purine analog

fludarabine

Nitrogen Mustard Alkylating agent

chlorambucil

ADA resistant purine analog

cladribine

ADA inhibitor

pentostatin

azacytidine

drug X Cytosine Methyltransferase global demethylationapoptosis

GPiib/iiia inhibitor

tirofiban

gpiib/iiia inhibitor

eptifibitide

gpiib/iiia inhibitor

abciximab

cilostazol dipyridamole

cAMP X? ATPReceptorPlatelet Aggregation

clopidogrel prasugrel thienopyridine ticlopidine

ATP X? receptorplatelet aggregation

RANKL inhibitor antiosteoclast

denosumab

amylin co-insulin analog

pramlintide

sitagliptin

GI incretin+insulin (dipeptidyl peptidase)X? degradation

GI Incretin+insulin What are the incretin analogs?

exenatide liraglutide

GH antagonist anti acromegaly

pegvisomant

aldosterone analog

fludrocortisone

brush border alpha glucosidase inhibitor hypoglycemic

miglitol

alcohol dehydrogenase inhibitor

fomepizole

ssri

fluvoxamine

CNS cholinesterase inhibitor antiAlzheimer

donepezil

CNS cholinesterase inhibitor antiAlzheimer

galantamine

CNS cholinesterase inhibitor antiAlzheimer

Rivastigmine

capsaicin cream

sensory nerve X substance P +pain

topiramate

anti seizure medicationglaucoma

oxcarbazepine

anti seizure medicationvertigo+ataxia

carbamazepine

DrugX trigeminal neuralgia

SNRI

milnacipran

SNRI

duloxetine

SNRI

venlafaxine

SNRI

drugXfibromyalgia

riluzole

Na+ channel X? depolarization glutamate release=ALS progression

thrombopoietin analog

eltrombopag

thrombopoietin analog

romiplostin

ribavirin

virus dna/-rna GTP synthesis X? mRNA

warfarin

Rat poison contains an active ingredient that is a derivative of what human pharma agent?

ipecac syrup

druggastric mucosa irritation+CTZ Vomit induction

metoclopromide/domperidone erythromycin

vagus......FoodEC cell5HT XDiabetes.................... AChExcitatory neuron1GI neuron ....XD2 X1?.................... proximal..................Inhibitory Neuron contraction............... .............................NO motilin2?............. ..............distal relaxation

Ursodeoxycholic acid

Drug Increases bile hydrophilicity Improves bile flow Primary BIliary cirrhosis relief

Muscarinic antagonist Anti GI spasm

hyoscyamine

Muscarinic antagonist Anti GI spasm

dicyclomine

Cl- channel stimulant anti IBS constipation

Lubiprostone

direct thrombin inhibitor

lepirudin

direct thrombin inhibitor

argatroban

C5 inhibitor anti PNH

eculizumab

IL12/23 inhibitor anti psoriasis

efalizumab

VItamin A analog

tazarotene

Vitamin D analog

calcipotriene

TNF alpha inhibitor

adalimumab

TNF alpha inhibitor

golimumab

IL1 inhibitor anti RA

anakinra

abatacept

drug=Fc gamma fused to CTLA-4 (T helper). Binds B7 (APC). Blocks T costimulation.

leflunomide

DMARD drugblocks de novo pyrimidine synthesis

hydroxychloroquine

DMARD drugincreases lysosome pH decreases antigen processingdecrease APCdecreases T activation

XO inhibitor

febuxostat

nicotinic partial agonist anti Smoking

varenicline

DAT NET

bupropion target

kallikrein inhibitor anti hereditary angioedema

ecallantide

muscarinic antagonist anti incontinence

darifenacin

muscarinic antagonist anti incontinence

oxybutynin

histamine

scombroid fish poisoningbacteriarelease?vomit. Fastest onset food poisoning

metronidazole

drugmicrobe FeS proteinsradicalsXDNA

imiquimod

drugCD8+ stimulationkeratinocyte apoptosis

anaerobes gram+

Coverage of clindamycin lincosamide? binds 50s. blocks translocation similar to macrolide.

Protein C analog anti Sepsis

drotrecogin

MDR g- bacillus pneumonia Topical infections

Indications for polymyxin/colistin Disrupts plasma membrane.

linezolid

binds 23subunit/50Sblocks INITIATION complex.

daptomycin

drugmembrane depolarizationbacteriocide

MRSA VRE

Indications for daptomycin and linezolid (oral med)

anaerobe ETC inhibitor anti cryptosporidium

nitazoxanide

rifaximin traveler diarrhea

Nonabsorbed version of rifampin? treats?

clindamycin macrolide

binds 23subunit/50SBlocks ELONGATION

Phosphodiesterase inhibitor positive inotrope

milrinone

anaerobes gram+ gram-

pipercillin/tazobactam spectrum

aminoglycoside

macrolide or aminoglycoside? streptomycin

nonsedating 1st generation H1 blocker anti motion sickness

dimenhydrinate

alpha agonist decongestant

metazoline

intestinal lipase inhibitor anti obesity

orlistat

ACE inhibitor

maternal drug X fetal renal development

drug X OAT at multiple locations blocks renal secretion+absorption

probenecid

helix loop helix leucine zipper Zn2+ finger

DNA binding motifs

leucine zipper dna binding motif

leucine at every 7th position

cytosol

CO2+Glutamine+2ATP Carbamoyl PhosphatePYRIMIDINE

Where does THIS 1st reaction occur? CO2+NH4+2ATP Carbamoyl PhosphateUREA CYCLE Where does THIS 1st reaction occur? Where do the rest of the UREA CYCLE rxns occur?

liver mitochondria liver cytosol

wall

what is more external, the fungal cell wall or the fungal cell membrane?

Ca2+

hyper ion? X AQP2 membrane expression A cause of nephrogenic diabetes insipidus

integrin

what kind of protein is glycoprotein iibiiia, the platelet fibrinogen receptor?

clopidogrel

prodrug liver p450 active drug X platelet aggregation

daptomycin

antibiotic->myopathy+CPK elevation

daptomycin

pulmonary surfactant->X antibiotic

linezolid

antibiotic>thrombocytopenia

linezolid

antibiotic->X 50s optic neuritis

linezolid

antibiotic->serotonin syndrome