PGE1

 gemeprost (termination of pregnancy)

 misoprostol (prevention of NSAIDs-induced gastric ulcer)
Prostaglandin  alprostadil (erectile dysfunction)
PGE2→dinoprostone (facilitation of labor)
PGF2→latanoprost (glaucoma by ↑ drainage)
PEI2→epoprostenol (pulmonary hypertension)
Corticosteroids (PLA2)
NSAIDs (COX)
non-selective (COX-1 and 2): aspirin, indomethacin, diclofenac, ibuprofen
Eicosanoid
selective (COX-2): Celecoxcib
antagonists
Paracetmol (COX-3)
Zileuton (5-LOX inhibitor)
Montelukast (LTs receptor)
Morphine
Drugs ↑ Histamine Tubocurarine
Succinylcholine
First generation: diphenhydramine – dimenhydrinate - promethazine- meclizine -
chlorpheniramine
Second generation: cetrizine, loratidine terfenadine & its metabolite fexofenadine
H1 Blocker -allergic conditions
-Motion sickness: dimenhydrinate, promethazine& hyoscine (antimuscarinic)
-Vertigo: meclizine & dimenhydrinate
-Morning sickness of pregnancy: meclizine + B6
Cimetidine
H2 Blocker Ranitidine
Famotidine
H3 Blocker Pitolisant (tiprolisant):approved for Narcolepsy.
5-HT1A →Buspirone → anxiolytic
5-HT1B/1D→Sumatriptan (short acting), Zolmitriptan (long acting) in Migraine
5-HT2C →Lorcaserin→In obesity
5-HT agonists 5-HT4 →Tegaserod (Zelmac)→ chronic constipation (IBS) in women under 65
5-HT4 →Mosapride →in gastro-esophageal reflux *increase prestalisis*
5-HT and a-adrenergic receptors→Ergotamine→in Migraine *V.C. of peripheral &
cranial*
5-HT2A
 Appetite stimulant →Cyproheptadine
 Relieve allergic reactions →Cyproheptadine
5-HT antagonists
 V.D (antihypertensives) → Ketanserin,Ritanserin
 Atypical antipsychotics
5-HT3→Ondansetron→anti-emetic
Angiotensin II Captopril - Lisinopril- Enalapril (ACE inhibitors)
antagonist losartan (AT1receptor blocker)
Organic nitrates (glyceryl trinitrate)
NO doner
(Nitroprusside) a direct NO donor
NO potentiators PDE5 Inhibitor (Sildenafil)