dnaloP ,kotsylaiB fo ytisrevinU lacinhceT ,scitamrofnI fo etutitsnI 3

dnaloP ,kotsylaiB fo ymedacA lacideM ,ycnangerP fo ygoloisyhpotaP fo tnemtrapeD 2

dnaloP ,kotsylaiB fo ymedacA lacideM ,ygolotanireP fo tnemtrapeD 1

.)secneics
-oiB mahsremA ,metsyS ASILE kartoiB namuH ,2-PMIT ;sec
-neicsoiB mahsremA ,metsyS yassA ytivitcA kartoiB 2-PMM
;secneicsoiB mahsremA ,metsyS AS I L E kartoiB ,namuH
, 2-PMM( syassa tnebrosonummi deknil-emyzne tnereffid
3 fo esu eht htiw se l p m a s eniru ni derusaem erew 2-PMIT
dna )latot dna evitca( 2-PMM fo slevel ehT .]6[ airetirc GOCA
ot gnidrocca edam saw ruobal mreterp fo sisongaid ehT
.dedulcxe osla erew
noitcefni rehto yna ro level PRC desaercni ,00081 > fo tnuoc
llec doolb etihw ,egrahcsid lanigav gnillems-luof ,ssenrednet
eniretu ,aidracyhcat latef ro lanretam :sngis gniwoll o f eht fo
owt tsael ta htiw denibmoc ,C E 83 > erutarepmet ydob fo tned
-icni eno tsael ta .e.i ]5 ,4[ denifed ylsuoiverp sa ,sitinoinmaoir
-ohc lacinilc htiw stneitaP .lm/gn 0.2 > eninitaerc mures enil
-esab sa denifed esaesid laner dna setebaid ,snoitidnoc desim
-orpmoc-onummi ,aiverp atnecalp ,gnideelb lanigav ,egalcrec
lacivrec ,noitatseg elpitlum ,skeew 3 tsap eht nihtiw ypareht
citoibitna erew yduts eht rof airetirc noisulcxE .nacs dnuos
-artlu retsemirt tsrif yb demrifnoc dna doirep laurtsnem tsal
f o etad eht ot gnidrocca detaluclac saw ega lanoita t s e G
.)8 = n ,VI puorg( mret ta robal
htiw nemow dna )9 = n ,III puorg( yreviled mret ot dedeecorp
ohw robal ni ton skeew 63-62 t a nemow ,)noitanimaxe laun
-am ni xivrec eht fo gninediw ro gninetrohs a dna noitanimaxe
yhpargocotoidrac yb setunim 01 gnirud snoitcartnoc 2 t sael
t a ( y r e vil e d m r et o t d e d e e c o r p o h w ) 9 = n , I I p u o r g ( r u o b a l
m r e t e r p d e n e t a e r h t h t i w n e m o w ,) 4 1 = n ,I puorg( yreviled
mreterp ni erew ohw skeew 63-42 ta n e m o w :spuorg ruof
otni dedivid erew stcejbuS .tnesnoc nettirw rieht evag dna
noitagitsevni eht fo erudecorp dna esoprup eht tuoba gnitirw
ni dna yllabrev demro f n i llew erew seelorne laitnetoP
.eettimmoC lacihtE lacol eht morf deniatbo
saw tcejorp eht rof lavorppA .kotsyaiB fo ytisrevinU lacideM

eht fo ycnangerP fo ygoloisyhpohtaP fo tnemtrapeD dna ygol

-otanireP fo tnemtrapeD eht ta detcudnoc saw yduts ehT

sdohtem dna slairetaM

.robal erutamerp denet

-aerht gnicneirepxe retfa mret hcaer ot ylekilnu era stneitap
hcihw gniniatrecsa rof hcaorppa evisavninon ,elpmis a reffo
thgim eveileb ruo ni hcihw y c n a n g e rp gnirud eniru ni slevel
2-PMIT sa llew sa 2-PMM fo smrof latot dna evitca erusaem
ot saw yduts eht fo mia eh T . e n i r u niatbo ot tluciffid yllac
-inhcet ssel a no sucof ot dediced ew ,erudecorp evisavni yllait
-netop si hcihw ,mures ni sPMIT dna sPMM fo noitanimreted
denrecnoc seiduts demrofrep otrehtih eht fo tsom ecniS
.]2[ yreviled
mreterp fo r e k r am lacimehcoib elbissop a detseggus osla
saw 2-PMM .2-PMIT o s l a ,sPMIT tnereffid yb detaidem eb
thgim hcihw ,ruobal fo tesno dna ycnangerp gnirud elor tnat
-ropmi na syalp sisyloetorp detaidem-esanietorpollateM
.]3[ diulf citoinma
ni esanitaleg evitutitsnoc a sa dedr a g e r si ti dna ]2[ senarb
-mem ruobaltsop dna ruobalerp htob ni tneserp si 2-PMM
.2-PMIT dna 2-PMM gnidulcni ,sPMIT dna sPMM tnereffid fo
noisserpxe ecudni ,noitcefni ro ruobal evitca sa hcus ,noitam
-malfni ni gnitapicitr a p srotcaf elpitlum yb detaluger snoitid
-noc cificepS .ycnangerp gnirud xivrec eht ni dna ,senarbmem
latef ,suretu eht ni gnilledomer eu s s it llarevo ot etubirtnoc
sPMIT dna sPMM taht tnedive erom dna erom gnimoceb si
tI .noitavitca ro/dna ytivitca rieht gnitibihni ,sesanietorpollat
- e m e v i t c a - n o n r o e v i t c a h ti w s e x e l p m o c m r o f t a h t s e d i t p e p
-ylop fo ylimaf a era )sPMIT( sesanietorpollatem fo srotibih
-ni eussiT .stnenopmoc xirtam ralullecartxe fo noitadarged rof
elbisnopser ylniam era hcihw ,]1[ se s a e t o rpollatem fo ssalc
eht ot gnoleb taht semy z ne tnedneped-cniz fo ylimaf gnitser
- e t n i n a t n e s e r p e r ) s P M M ( s e s a ni e t o r p o l l a t e m x i r t a M

noitcudortnI

ASILE ,ruobal mreterp ,2-PMIT ,2-PMM :sdrowyeK

.eniru ni
noitartnecnoc 2-PMIT desaerced dna 2-PMM desaercni htiw detcennoc si ruobal mreterp taht sisehtopyh eht tcejer ot yrassecen era noitalupop
regral a ni seiduts noinipo ruo nI .noisulcnoC .stneitap fo spuorg ruof neewteb 2-PMIT dna 2-PMM latot ,2-PMM evitca fo snoitartnecnoc eht ni
secnereffid tnacifingis on dnuof eW .stluseR .)8 = n ,VI puorg( mret ta robal htiw nemow dna )9 = n ,III puorg( yreviled mret ot dedeecorp ohw
robal ni ton skeew 6362 ta nemow ,yreviled mret ot dedeecorp ohw )9 = n ,II puorg( ruobal mreterp denetaerht htiw nemow ,)41 = n ,I puorg(
yreviled mreterp ni skeew 63-42 ta nemow :spuorg ruof otni dedivid erew stcejbuS .syassa tnebrosonummi deknil-emyzne tnereffid 3 fo esu eht
htiw selpmas eniru ni derusaem erew 2-PMIT dna )latot dna evitca( 2-PMM fo slevel ehT .sdohteM .ruobal mret dna ruobal mreterp deneta
-erht ,ruobal mreterp gnirud nemow fo eniru ni 2-PMIT dna 2-PMM fo snoitartnecnoc eht erolpxe ot saw yduts ruo fo mia ehT .dnuorgkcaB
tcartsbA
NABRU NAJ ,3AKSWOTRK ATAZROGAM ,2IKSYZREIP RTOIP
,2UK EWAP ,2IKSADUAL RTOIP ,1ZCIWECNAMEL MADA

Matrix metalloproteinase-2 and tissue inhibitor

of metalloproteinase-2 urine levels in preterm labouring patients
REPAP LANIGIRO

7002 ,25-05 ,)2(31 enicideM latanireP fo sevihcrA

stneitap fo spuorg ruof neewteb 2-PMIT dna

2-PMM latot ,2-PMM evitca fo seulav naem fo nosirapmoC .1 .giF

.]21 ,3[ snoit

-artnecnoc diulf citoinma 2 -PMIT fo esaerced dna 41-PMM
fo noitavele yb detavitca si tI .]2[ senarbmem ruobaltsop
dna robalerp htob ni tneserp dnuof osla saw ti dna ,]11[ diulf
citoinma fo esanitaleg evitutitsnoc a dedrager si 2-PMM
.]01 ,9[ sPMIT
fo noitavitcaed )ro( dna s P M M fo noitavitca ecudni yam
stnega eseht ,yllanoitiddA .]8 ,7[ senarbmem latef ni syawhtap
citotpopa fo noitaitini ot sa llew sa ,noitcudorp nidnalgatsorp
desaercni ot dael dna senikotyc yrotammalfni fo e s a e l
- e r d n a noitcudorp ecudni yam taht stnega cixot ro evitcefni
sevlovni M O RP dna ruobal mreterp fo sisenegohtaP
.soinmardyhylop ro
noitatseg elpitlum ,srotcaf cimonoce-oicos ,noitcefni sa hcus
,srotcaf lacigoloite nommoc gnirahs snoitidnoc htob , MORP
htiw detaicossa era ruobal mreterp fo sesac fo %05 yletam
-ixorppA .emoctuo latanoen dna latanirep esrevda ot dael yam
taht noitacilpmoc ycnangerp nommoc a si ruobal mreterP
noissucsiD

.)1 erugiF( stneitap fo spuorg

ruof neewteb 2-PMIT dna 2-PMM latot ,2-PMM evitca fo snoit
-artnecnoc eht ni secnereffid tnacifingis on erew erehT
.2 elbaT ni detneserp era puorg yduts hcae ni snoit
-artnecnoc 2-PMM dna 2-PMIT fo )DS( seulav naem ehT
.1 elbaT ni nwohs era stneitap fo scitsiretcarahc lacinilC
stluseR

.deilppa saw level ecnacifingis 50.0 ehT .)SU ,etutitsnI SAS(

TATS SAS dna )SU ,daP hparG( MSIRP gnisu d e m r o frep
saw sisylana lacitsitats ehT .deilppa erew stse t s 'tteltraB
dna vonrimS-vorogomloK ,snoitpmussa tset eht k c e hc
oT .)AVONA( ecnairav fo sisylana fo esu eht yb d e m r ofrep
saw stneitap fo spuorg ruof neewte b 2 - P M IT dna 2-PMM
latot ,2-PMM evitca fo seulav naem fo nosirapmoC
sisylana lacitsitatS

29
5
13
p

33 9.751
7.0 1.5
1.41 3.63
DS naem
VI puorG

8.23 2.561
8.0 8.4
1.41 9.32
DS naem
III puorG

2.44 2.661
2.1 94
7.41 3.62
DS naem
II puorG

3.33 4.751
4.1 5.5
8.51 7.13
DS naem
I puorG

2-PMM evitcA
2-PMM latoT
2-PMIT

puorg yduts hcae ni snoitartnecnoc 2-PMM dna 2-PMIT fo )DS ( seulav naem ehT .2 elbaT
mret ta yreviled VI puorG
yreviled mret ot dedeecorp ohw ega lanoitatseg rof dehctam namow III puorG
;yreviled mret ot dedeecorp ohw ruobal mreterp denetaerht namow II puorG ;yreviled mreterp I puorG

9=n
III puorG

8=n
VI puorG

2.6 5.82

4.4 1.62

4.2 6.23

2.1 52.93

)87( 7

)05( 4

)33( 3

)46( 9

0.3 4.13
8.4 3.03
9=n
II puorG

9.3 9.03
0.4 8.72
41 = n
I puorG

)%( )n( suorapilluN

)DS naem(
ega lanoitatseG
)DS naem(
ega lanretaM

yduts eht fo stneitap fo spuorg ruof fo scitsiretcarahc lacinilC .1 elbaT

nemow gniruobal mreterp fo eniru ni 2-PMIT dna 2-PMM lamroN

15

lp.airetni@cnamel :liam-e
dnaloP ,kotsyaiB 672-51 ,a42 eiruC-akswodolkS
latipsoH ytisrevinU ,ygolotanireP fo tnemtrapeD
zciwecnameL madA

.58-97 :)02 .lpus(011

.loceanyG .tetsbO .J .tanretnI :GOJB .ruobal mreterp fo tnemeg
-anam eht ni segnellahc dna smelborP )3002( .M .H aramaNcM ]51[
.671-071 :)3(41 .deM .latan
-oeN lateF .nretaM .J .hcaorppa lacinilc a :robal mreterp denet
-aerht dna mret gnirud nemow fo eniru dna mures/amsalp ni
1-esanietorpollatem fo rotibihni eussit dna 9-esanietorpollatem
xirtaM )3002( .la te .E inuoksuoK ,.O uoirogirG ,.E sikarkaM ]41[
.9S :)2 tP 1( 081 .locenyG .tet
-sbO .J .mA .noitirutrap namuh ni rotibihni sti dna esanitaleg adk
27 eht rof elor A )9991( .la te .S nassaH ,.R zemoG ,.E nomyaM ]31[
.863-263 :)5(72
.deM latanireP .J .erutpur enarbmem ot yawhtap suonegodne rof
troppus tceridni nA :MORP gnirud diulf citoinma ni ecnalabmi
PMIT/PMM )9991( .J .S idrabmoL ,.R noneM ,.J .S otanutroF ]21[
.498-788 :)4(381 .locen
-yG .tetsbO .J .remA .noitcefni citoinma-artni dna ,senarbmem
fo erutpur suoenatnops ,noitirutrap ni 2 dna 9 sesanietorpollat
-em xirtam fo smrof evitca eht fo ytilibaliavaoib laitnereffid oviv
ni fo ecnedivE )0002( .la te .P arocaP ,.R oremoR ,.E nomyaM ]11[
.851-351 :)1(181 .locenyG .tetsbO .J .remA .robal fo
noitarud dna noitatalid lacivrec fo egats htiw snoitalerroc :mret
ta noitirutrap gnirud tnemges eniretu rewol eht ni sisyloneg
-alloC )9991( .la te .H ehcsehcsT ,.A relhciprebO ,.M relkniW ]01[
.6041-5041 noissucsid
;5041-9931 :)7(481 .locenyG .tetsbO .J .remA .senarbmem fo erut
-pur erutamerp dna robal mreterp rof syawhtap tnereffid tseg
-gus stneve ralucelom tcnitsiD )1002( .R noneM ,.J .S otanutroF ]9[
.144-734 :)6(62 .deM
latanireP .J .yreviled mreterp fo noitcudni eht ni xirtam ralullec
-artxe fo ecnatropmi ehT )8991( .B pmeK ,.M relkniW ,.W htaR ]8[
.243-182
:)2(22 .lotanireP .nilC .ygoloisyhpohtap dna sisongaid ni senik
-otyc eht fo elor dna stcepsa lacinilC :noitcefni citoinma-artni dna
robal erutamerP )5991( .la te .R oremoR ,.F izzehG ,.R zemoG ]7[
.001 :7991 .de ht4
.stsigolocenyG dna snaicirtetsbO fo egelloC naciremA eht dna
scirtaideP fo ymedacA naciremA .eraC latanireP rof senilediuG ]6[
.765-065 :)2(981 ;0771 :)6(981 ;ceD
.locenyG .tetsbO .J .mA .ycnangerp gnirud noitcefni tcart latin
-eg reppu tneuqesbus timrep senikotyc yrotammalfniorp lacivrec
desaerceD )3002( .la te .A .M nhorK ,.N .S sitiraC ,.N .H nahmiS ]5[
.62-32 :421 .loiB .tcudorpeR .locen
-yG .tetsbO .J .poruE .yreviled dna robal mreterp ni 91 LCC/ateb
3-enikomehc yrotammalfni egahporcam fo level mures desaerc
-eD )6002( .la te .P iksnyzreiP ,.A zciwecnameL ,.P iksaduaL ]4[
.029-419 :)4(381 .locenyG .tetsbO
.J .remA .senarbmem fo erutpur erutamerp mreterp ni )1 es
-anietorpollatem xirtam( esanegalloc laititsretni fo noitapicitrap
eht rof ecnedivE )0002( .la te .P arocaP ,.R oremoR ,.E nomyaM ]3[
.147-137 :)4(771.locenyG .tetsbO .J .remA .enarbmem cinoir
-ohcoinma namuh ni srotibihni rieht dna )sesanitaleg( semyzne
citylonegalloC )7991( .J .S idrabmoL ,.R noneM ,.J .S otanutroF ]2[
.822-381 :842 .lomyznE .hteM .sesadipepolat
-em fo seilimaf yranoitulovE )5991( .J.A tterraB ,.D .N sgnilwaR ]1[
secnerefeR

.eniru nemow ni noitartnecnoc 2-PMIT desaerced

d n a 2 - P M M d e s a e r c n i h ti w d e t c e n n o c s i r o b a l m r e t e r p t a h t
sisehtopyh eht tcejer ro mrifnoc ot yrassecen era noitalupop
detceles-llew ,regral a ni seiduts rehtruf ,noinipo ruo nI
.]51[ ylerutamerp sreviled robal mret
-erp denetaerht ta sesac fo flah ylno sa gnitseretni ylralucitrap
si sihT .senarbmem t c a t n i htiw ruobal mreterp denetaerht
ta ne m o w ni snoitanimreted PMIT/PMM eniru fo eulav
citsongorp lautneve fo noitseuq eht gnirewsna fo evitceps
-rep eht sevig spuorg yduts fo noitisopmo c a h cuS .yreviled
mret ot dedeecor p ohw ruobal mreterp denetaerht ta stneit
-ap 9 dna htrib erutamerp evag ohw ruobal mreterp ni stneit
-ap 41 devresbo ew ,yduts ruo nI .snoitcartnoc enire t u mret
- e r p f o y g o l o h t a p g n i t n e s e r p st n e i t a p e r e w 0 6 f o p u o r g d e i d
-uts fo tuo stne i t a p 0 2 fo puorg a ylno la te sikarkaM fo noit
-a c ilbup eht nI .ruobal mreterp sa hcus semordnys lairotcaf
-itlum ni detacilpmoc yllaicepse si taht ytitne na snoitalupop
deiduts fo yticinegomoh hcaer ot gnimia ,tnemtiurcer fo airet
-irc tcirts fo ecneuqesnoc a ylbaborp si sihT .puorg yduts det
-imil rehtar morf tluser yam yduts ruo ni ecnacifingis citsitats
fo kcaL .ruobal mret dna ycnangerp mreterp ,ruobal mreterp
d e n et a e r h t , r u o b a l m r e t e r p g n i r u d s n o i t a r t n e c n o c 2 - P M I T
dna 2-PMM evi t c a dna latot eniru ni segnahc detartsnomed
ton evah eW .]41[ sutats ruobal-non ot derapmoc snoitcartnoc
mreterp ro mret eniretu htiw sesac ni rewol yltnacifingis erew
1-PMIT tub ,eniru dna mures dna rehgih yltnacifing i s erew
9-PMMorp eniru dna amsalp detroper .la te sikarkaM .noitcel
-loc elpmas fo ssenevisavni-non dna esae eht rof ylniam ,snos
-aer lareves rof etairporppa tsom smees eniru fo eciohc ehT
.ruobal mreterp eurt ro denetaerht dna ruobal mret gnicneir
-epxe nemow tnangerp fo eniru ni snoitartnecnoc 2-PMIT
n i s a l l e w s a 2 - P M M e v it c a d n a l a t o t n i s e g n a h c y f i t n e d i
ot gnimia tsrif eht egdelwonk ruo ot si yduts tneserp ehT
.]31[ robal
mreterp htiw stneitap ni ton tub senarbmem fo erutpur erut
-amerp mreterp ni ytivac citoinma eht fo noisavni laiborcim
htiw stneitap ni desaerced s a w noitartnecnoc 2-PMM puorg
nomyaM yb detcudnoc yduts suoiverp a nI .]21[ senarbmem
fo erutpur erutamerp mrete rp ni desaercni era 2-PMM fo
smrof evitca taht detroper srotagitsevni fo puorg rehtonA
.noitcefni eniretuartni ot esnopser tsoh dna ,senarbmem
fo erutpur , r o bal fo smsinahcem eht ni sesanietorpollatem
fo noitapicitrap eht rof troppus gnorts edivorp snoi tavresbo
esehT .senarbmem fo erutp u r erutamerp mreterp ni ytivac
citoinma eht fo noisavni l a i b o r c im dna ,)mreterp dna mret
htob( senarbmem fo erutpur ,mret ta robal suoenatnops htiw
s t n ei t a p n i r e w o l y l t n a c i f i n g i s e r e w s n o i t a r t n e c n o c 2 - P M M
fo smrof evitca diulf citoinma ni taht detroper .la te nomyaM
.]11[ diulf citoin m a n i esanitaleg evitutitsnoc a sa dedrager
si 2-PMM .]21[ senarbmem fo erutpur erutamerp mreterp
dna ,)mreterp dna mret htob( senarbmem fo erutpur ,mret ta
robal suoenatnops htiw stneitap ni diulf citoinma ni desaerced
yltnacifingis eb ot nwohs neeb evah 2-PMM fo smrof evitcA

nabrU .J ,akswotrK .M ,iksyzreiP .P ,uK .P ,iksaduaL .P ,zciwecnameL .P

25