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  • Γονιδιακές Αλλαγές, Διαυλοπάθειες Και Αιφνίδιος Θάνατος

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    Giannis Papadakis
    185 views60 pages
    - %)&6:<==#2E<==#2- . '<5#2E<==#2-7:=!A )8 + . . % 9,"#'; .#% . 7 5 / $#1# 0*$"**#(!&+# '+#!.' !(' # # #!+) #!!+) #" 5 0 #" &.&4)!0" &)#$%!)#P%/) $"+)/!((3!0#!+#016#0!0 +++ 01 +#( *'5. #1)(3* ## #1+6 01($!*#+&1*(#" 5 *!(' .'$ .')%$"+)/&6##'#'1 6#)(01##(!1#'#*6"1+#.6#)6#% #$&'*6 (#'5) +(#'1##.&-)1$()$1" $*+#*1()$"+),T$*+!6##'U5 !0''#1('#(!$6" #-.#!+-(#'# # !6-*+1()$*+!6#%/+.*'$##"/& *' #-($6&+'6#!#*.*'!&115 0:515 :;3$&'&:9: !.6#*+0*()'!0$$*.. !0*!*+1-(61-(5 %):%@1;%=&9"#'1)&'$*+!6##'#(=7w8"$ VDBb q{7ww8"$ YLFbAhA5 "$ VDBbq{7Vq{8#( 0'!*(3#!0!, * q{ $. ' *2+0 ($* 1 .6#' +&' , *6 (#'5 -(3#)'*11#&'7+01) #++4#)1($8.#!(, 7+01) $.' #!#' . +.2' - )85 "$ YLFbAhA-$&''-'['#!!0+)' $1#(*#-($6/#4('+%*6 %5-#(, +###' #++4#'*1$(*SWInQ!*)$!#(*'$", +*' 5 + #( )' *) 0' #!% .'5 *;.3) 7; 9 0'!6-*+1(')$*+!6#%!, #+#(1!*46#!#*%1%0#-, #*0 0 # 1$0 #!(!#$

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    - %)&6:<==#2E<==#2- . '<5#2E<==#2-7:=!A )8 + . . % 9,"#'; .#% . 7 5 / $#1# 0*$"**#(!&+# '+#!.' !(' # # #!+) #!!+) #" 5 0 #" &.&4)!0" &)#$%!)#P%/) $"+)/!((3!0#!+#016#0!0 +++ 01 +#( *'5. #1)(3* ## #1+6 01($!*#+&1*(#" 5 *!(' .'$ .')%$"+)/&6##'#'1 6#)(01##(!1#'#*6"1+#.6#)6#% #$&'*6 (#'5) +(#'1##.&-)1$()$1" $*+#*1()$"+),T$*+!6##'U5 !0''#1('#(!$6" #-.#!+-(#'# # !6-*+1()$*+!6#%/+.*'$##"/& *' #-($6&+'6#!#*.*'!&115 0:515 :;3$&'&:9: !.6#*+0*()'!0$$*.. !0*!*+1-(61-(5 %):%@1;%=&9"#'1)&'$*+!6##'#(=7w8"$ VDBb q{7ww8"$ YLFbAhA5 "$ VDBbq{7Vq{8#( 0'!*(3#!0!, * q{ $. ' *2+0 ($* 1 .6#' +&' , *6 (#'5 -(3#)'*11#&'7+01) #++4#)1($8.#!(, 7+01) $.' #!#' . +.2' - )85 "$ YLFbAhA-$&''-'['#!!0+)' $1#(*#-($6/#4('+%*6 %5-#(, +###' #++4#'*1$(*SWInQ!*)$!#(*'$", +*' 5 + #( )' *) 0' #!% .'5 *;.3) 7; 9 0'!6-*+1(')$*+!6#%!, #+#(1!*46#!#*%1%0#-, #*0 0 # 1$0 #!(!#$

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    © All Rights Reserved
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    185 views60 pages

    Γονιδιακές Αλλαγές, Διαυλοπάθειες Και Αιφνίδιος Θάνατος

    Uploaded by

    Giannis Papadakis
    - %)&6:<==#2E<==#2- . '<5#2E<==#2-7:=!A )8 + . . % 9,"#'; .#% . 7 5 / $#1# 0*$"**#(!&+# '+#!.' !(' # # #!+) #!!+) #" 5 0 #" &.&4)!0" &)#$%!)#P%/) $"+)/!((3!0#!+#016#0!0 +++ 01 +#( *'5. #1)(3* ## #1+6 01($!*#+&1*(#" 5 *!(' .'$ .')%$"+)/&6##'#'1 6#)(01##(!1#'#*6"1+#.6#)6#% #$&'*6 (#'5) +(#'1##.&-)1$()$1" $*+#*1()$"+),T$*+!6##'U5 !0''#1('#(!$6" #-.#!+-(#'# # !6-*+1()$*+!6#%/+.*'$##"/& *' #-($6&+'6#!#*.*'!&115 0:515 :;3$&'&:9: !.6#*+0*()'!0$$*.. !0*!*+1-(61-(5 %):%@1;%=&9"#'1)&'$*+!6##'#(=7w8"$ VDBb q{7ww8"$ YLFbAhA5 "$ VDBbq{7Vq{8#( 0'!*(3#!0!, * q{ $. ' *2+0 ($* 1 .6#' +&' , *6 (#'5 -(3#)'*11#&'7+01) #++4#)1($8.#!(, 7+01) $.' #!#' . +.2' - )85 "$ YLFbAhA-$&''-'['#!!0+)' $1#(*#-($6/#4('+%*6 %5-#(, +###' #++4#'*1$(*SWInQ!*)$!#(*'$", +*' 5 + #( )' *) 0' #!% .'5 *;.3) 7; 9 0'!6-*+1(')$*+!6#%!, #+#(1!*46#!#*%1%0#-, #*0 0 # 1$0 #!(!#$

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    © All Rights Reserved
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    of 60

    HIPIAHuII1

    ANAP1HMINON
    ANAKOINO1ION
    190
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I01I
    MA1 1h AN1UXh AN1I8IU1IkA MIkUUIANIM0N
    U XUN AUMUN0OI AhOMU 8UUI0N
    Xutn0sopou O.
    1*
    , unuono0ou X.8
    2
    4. Tpizosznc Ooiznznc ldzpiknc Ixonc dvsnioznou lodvvvov,
    2. Yns0uvn Movdc Mikpofiooydc kdi Yyisivnc Tpoov, Lpydoznpio
    Mikpofiooydc, ldzpikn Ixon, dvsnioznio lodvvvov
    Jd dvciiocik xpnoionoiovcdi s kdi dpkscsc skdscsc uc ounnp-
    dcd idcponc ocnv kcnvocpod, dsvc yid cnv npnn cuv oiu-
    v vooncuv ocd d svcdciknc skcponc kdi dscspou yid cnv cdxcs-
    pn dnon cou oudciko pouc couc. N supsd xpnon ducnc cnc npdkci-
    knc onynos ocdidk kdi sod dn couc vouc cnc uoiknc snioync
    ocnv dvncun ocssxv dkcnpuv, nou svidv dvcoxn ocd dvciioci-
    k cd onod xpnoionoiovcdv ocnv kcnvocpod. Ikonc cnc spydodc
    ducnc svdi n kdcdypdn cuv nspiocdcikv dnovuonc dv0skcikv ikpo-
    idkv ocssxv, cd onod sxouv dnoovu0s dn nn0uooc oosiv,
    d kdi dn dv0pnouc Ixopcoyouc kdi kpsdcoyoucl, n nspiypdn
    cuv s0uv nou xpnoionoiovcdi yid cnv kdcdypdn cnc dv0skcikcn-
    cdc kdi cuv cpnuv dvciscnionc duco cou oodpo yid cnv noid
    uysd npondcoc dn cn is0vn sniocnovikn koivcncd. N ni0dvn sc-
    oon noudv0skcikv ikpoidkv ocssxv dn cov uik nn0uo
    ocov dv0pnivo nn0uo, sou cnc kdcdvuonc cpouv uiknc npos-
    suonc dnocss svd oodp npnd noidc uysdc onspd. Mi-
    ocd, s sosvo cnv ndpdcnposvn dnon cnc dv0skcikcncdc cuv
    dkcnpidkv ocssxv nou dnoovvovcdi oosvd kdi ouxvcspd ocic
    dvdncuysvsc xpsc, nou kdc kpio yo yvscdi kdcxpnon cnc xopn-
    ynonc dvciiocikv, co npnd duc xpnsi sonc dvciscnionc.
    *U k. Xdcn0sopou sknvnos cnv spydod ducn ocd ndoid cou kdc'
    snioynv d0ndcoc cnc Mikpoiooydc kdi yisivnc Jpouv, nou i-
    okscdi oco L' snvo onouv cnc |dcpiknc Ixonc cou hdvsniocnou
    |udvvvuv, s uns0uvn d0ndcoc cnv snkoupo kd0nyncpid Mikpoioo-
    ydc k. X. hdndonoou.
    I02I
    IUM1hh
    ununouo Asn
    ldzpikn Ixon dvsnioznou A0nvov, 5o szoc
    kon tn spyucu: N ondod kdi o poc cnc oniposcpnonc ocn iyvuon,
    npooiopio cnc dpcncdc kdi ndpdkoo0non cuv iopuv dvdnvsuocikv
    vooncuv kdi siikcspd cuv xpovuv dnopdkcikv nvsuovond0siv IXAhl.
    hpooiopioc cuv ndpdyvcuv oi onooi doivouv cd dnocssodcd cnc oni-
    poscpnonc kdi kpicnpid dnooxnc idc oniposcpiknc npoon0sidc.
    |k ku| s0oo|: N spydod ocnpx0nks os iioypdiksc nnysc sc dn dvd-
    ncnon os sysc idcpiksc iocoossc cou idikcou kdi kdc scspo yo os
    iopd ouypdcd nvsuovooydc. Jo kpio poc cnc spydodc dopoos
    ocnv ndpdocdcikn ndpouoion cuv dnocssocuv sod dn iopouc nvdksc
    kdi ypdiksc ndpdocosic.
    Anotsscutu: N onipscpnon dnocss cnv ondvcikcspn ndpscpo cou si-
    coupyiko ssyxou cnc dvdnvonc kdi svdi xpnoin ocn sscn cuv ouncucuv
    cou dvdnvsuociko, cov kd0opio cnc dpcncdc cnc idcdpdxnc cou dvdnvsu-
    ociko ouocndcoc, cn sscn cnc nd0ouoiooyiknc idcdpdxnc kdi cnv skcnon
    cou dnocssodcoc cnc 0spdnsuciknc dyuync. Jd dnocssodcd cnc oniposcpn-
    onc ouxv ouoxscovcdi s cnv voonpcncd, cnv sniuon n dkd kdi cnv noi-
    cncd cnc sniuonc os do0svsc s yvuocn nvsuovikn voo. Jd supndc cnc
    xpnoionoiovcdi dn idcpoc idpuv siikocncuv: nd0oyouc kdi nvsuovo-
    youc yid couc ndpdnvu dvdspsvouc youc kdi yid cnv snioyn dcuv s
    npoid0soikoc ndpyovcsc kivvou yid cnv dvncun voou, sninioyouc
    kdi idcpoc spydodc yid cnv skcnon cnc snpdonc cnc pndvonc n cnc sndyys-
    dciknc sk0sonc ocnv nvsuovikn sicoupyd, xsipoupyoc yid cnv nposyxsipncikn
    skcnon do0svv s nvsuovon0sid,k.d.
    unspcutu: Ui kiviko yidcpo 0d npsnsi vd xpnoionoiov cnv oniposcpnon
    dkn nspioocspo ocn kd0nspivn idcpikn npn. hpsnsi uocoo vd scdi iid-
    cspo poc ocn ouocn csxvikn s cnv onod 0d yvsi n okidod ducn kdi cd ouns-
    podcd vd syovcdi sod dn npooskcikn dnooxn cuv kd0opiosvuv kpicn-
    puv.
    I03I
    AIIIUIN1IkUI AAIUN1 1h OIUAUIIA kAI AOUOIUAUIIA
    1U NMUNA
    Atvn N|kuo
    ldzpikn Ixon A0nvov
    kon tn spyucu: N sscn cou pou cuv opovv nou ovoovcdi
    dyysioysvsciko ndpyovcsc ocic iopsc sicoupysc cou dv0pnivou
    opydvioo kdi nio siik ocnv uyin dvncun kdi cic voouc cou dvd-
    nvsuociko ouocndcoc.
    |k ku| s0oo|: Lnioysc dn svd sup od iioypdikv nnyv,
    kupuc nooisosuv os is0vn sniocnovik nspioik, dn spsuvncsc npu-
    conpouc kdi du0svcsc ocov cosd nuc oi U.D. ancopou|os kdi N. Ferrara,
    nou iducouv yid cd nsov oyxpovd sosvd ocov cosd cuv ouoiv
    nou sxouv sniskcikn pon oco svo0nio, ouyypdcd uoiooydc, dy-
    ysiooydc kdi nvsuovooydc kd0c kdi nnysc dn co idkcuo.
    Anotsscutu: U dyysidkc svo0nidkc duncikc ndpyuv kdi oi dy-
    ysionoincvsc svdi oi kpioi ndpyovcsc nou su0vovcdi yid cn idpu-
    on cou dyysidko ikcou ocov opydvio nuc sxouv ssi oi sscsc
    s idyoviidk d. U vLUF su0vscdi yid cn nioupyd cuv ikpv dy-
    ysuv nou ndpouoiouv syn idnspdccncd, sv n dyysionoincvn
    pvcdc nio vupc kdc cd npcd ocid cnc dvncunc cou kukoopiko
    svdi uns0uvn yid cn nioupyd cuv syuv kdi ocd0spv dyysuv. N
    iooppond scd couc svdi npucdpxiknc ondodc yid cn opn cou dy-
    ysidko ikcou. Tsin cou vLUF kdc cnv spukn un npokds ov-
    poo dvdnvsuociknc uoxspsidc cuv vsoyvv. Ico APDS dvsupokovcdi
    dunsvd snnsd vLUF, cd onod iocd oxscovcdi s xsipcspn np-
    yvuon. Ico o0d sxsi ps0s sndvsinsvuc dunsvn skpdon dyysio-
    ysvscikv ndpdyvcuv os iosc cuv syovuv dspdyuyv kci nou
    niocsscdi ci oxscscdi s cn idikdod cuv scdov cuv dspdyuyv
    cdv n vooc scdnncsi ocn xpovicncd. Icov kdpkvo cou nvsovd, n
    skpdon dyysioysvscikv ndpdyvcuv oxscscdi s cn nioupyd ikcou
    0psnc kdi cnv sni0scikcncd cuv ykuv kdi n 0spdnsd s dvcidyysioysvs-
    cikoc ndpyovcsc sxsi dnosi no sniopd nvdcd.
    unspcutu: Ui dkd kdivopioi duco ndpyovcsc npsnsi vd ispsu-
    vn0ov nspdicspu oxscik s co po couc ocnv npyvuon cnc skdonc
    cuv idpuv vouv cou nvsovd do no ocoixsd couc dnoouv
    npoc co ndpv duc co uvdik. Lninsov, coo oi ioi oo kdi oi dvcd-
    yuviocsc couc nopov kiocd vd dnosix0ov dnocssodciksc 0spd-
    nsuciksc ouosc yid co o0d, cnv kdkon0n vsondod cou nvsovd kdi
    uv opyvuv kdi sc voouc.
    I04I
    OA1Ikh kA0NUUIhh kAI M1AMUXI
    |v|u M|xun, kkkun Ispy|o kuccustn uvuy|tn, konot|tn
    uvuy|tn
    kon: hpoon0sid skscsuonc cuv vsuv csxvikv s xpnoiononon cuv
    nouvduv ocssxiduv kuccpuv yid 0spdnsucikoc okonoc.
    |k ku| s0oo|: Avcikdcocdon cou nupnvd udpou dn nupnvd kuccpou cou
    dvcocoixou ioco.
    Lndvdnpoypddcioc nupnvd kuccpou.
    Mscdop nupnvd os upio s okon cn nioupyd dnoyvou s sni0u-
    ncsc knpovonoisc iicncsc.
    Anotsscutu: Aunsvn i d0soi cncd i ocooudcv ooxsucuv.
    Iuon ocn sscn cnc dvncunc cou dv0pnivou spou s ocxo
    cov sndvdnpooiopio cnc "oo" nou 0d dkoou0nosi id od kuc-
    cpuv npoksisvou vd idoponoin0s od.
    uvdccncd xpnoionononc opyvuv dn d nuc oi xopoi.
    Xpnoiononon dv0pnivuv kuccpuv yid 0spdnsucikoc okonoc.
    unspcutu: N sdpoyn cnc s0ou ndpsxsi syn id0soicncd
    ooxsucuv os soyo xpovik iocnd, sv s cn xpnoiononon svn-
    ikuv nouvduv kuccpuv ndpdkncovcdi coo cd n0ik kdi koivuvi-
    k snid oo kdi oi voiko nspiopioo.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    191
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I05I
    MM8ANIkUI UUXI 11U1UNh: ANIXNh,
    UUI IA8I8Ah hMA1U,IAIN01Ikh kAI UIN01Ikh 1U A5IA
    ky|u X., kun M., unukvctuvtn .A., tu0nouo .,
    toupvpu X., kuctuv h.
    Lpydoznpid Lpydoznpidknc Lvokpivooydc, Bioxnsdc kdi d0ooyod-
    vdzodc, dvsnioznio kpnznc, ldzpikn Ixon, Hpksio, 0R-74440, Lc
    Xpnoionoivcdc npoocdcik kdpkivik kccdpd LNCaP, pnkds ci n iu-
    pocsocoocspvn kdi co dvoy cnc csocoocspvn-8SA, duvouv cd-
    xsuc cnv dnssu0spuon cou PSA oco soov cnc kdispysidc. Mspdvi-
    ksc 0sosic sosuonc cnc csocoocspvnc dvsups0nodv os ndpdoksdod
    spdvv, s nsipdcd sosuonc, kuccdposcpd ponc kdi ouvsocidkn
    ikpookond. N sosuon svdi xpvo- kdi oooddpcsvn kdi siikn yid
    cnv csocoocspvn, ndpouoiovcdc kD 10.9nM kdi svdv dpi0 dn 144
    fmo|es/mg npucsivnc I 13000 0sosic/kccdpol. Ui spdviksc 0sosic s-
    vdi dvooooyik idopsciksc dn couc svokuccpiouc unooxsc dv-
    poyvuv. N skkpion cou PSA sc cn isyspon cou spdviko unoo-
    xsd csocoocspvnc dvdocsscdi dn cnv nposndon s kucoxddovn 8,
    n onod dnoiopydvvsi cov kuccdpookssc cnc dkcvnc. Lninpo0scd, n
    spdvikn sosuon cnc csocoocspvnc dsi cnv svokuccpid u-
    vdikn iooppond ovospoc kdi nouspiosvnc dkcvnc kdi dvdid-
    opvsi ondvcik cnv opyvuon cou kuccdpookssco cnc dkcvnc, sou
    cnc uoopuuonc cuv ididocikv npucsvv FAkP|-3kivonCdc42/
    Pac1. N dvdocon cuv ididocikv ducv npucsvv kdcdnysi os cpo-
    nononon cnc opyvuonc cnc dkcvnc kdi cnc skkpionc PSA. hspdicspu dv-
    xvsuon spdvikv unooxsuv csocoocspvnc os sydcd dv0pnivou
    kdpkvou cou npooccn dnssis ci oi spdviksc 0sosic ovsonc cnc
    csocoocspvnc skpovcdi siik ocd kdpkivik kccdpd cou npooccn,
    sv kccdpd dn unspndod cou npooccn kdi n kdkon0n sni0nidk
    kccdpd sviodv xdnn n kd0ou sosuon. Tcoi, oi spdviko
    unooxsc cnc csocoocspvnc nops vd svdi xpnoioi yid cn ypnyopn
    dvxvsuon cou kdpkvou cou npooccn dvdsikvovcdc svd vso idyvu-
    ocik skcn yid cn voo. Jsoc, pnkds ci co dvoyo csocoocspvn-
    8SA suovsi cn pon cnc cdnc ocov kdpkvo cou npooccn, ysyovc
    nou sxvsi ci dyuviocsc ducnc cnc spdviknc 0sonc ovsonc nops
    vd svdi xpnoioi odv vsoi 0spdnsuciko ndpyovcsc.
    I06I
    IhMIUAUIIA 10N MUkA1Ik0N NUXAhMA10N 1U AXNA
    1U NUhA1
    8upkn Xpucv0n, 1|opu kv/vo, kukuskn kup|ko
    uvspyctnkuv: spyun Mupu, 8ukn tu|uv
    ldzpikn Ixon dvsnioznou kpnznc 8 Tnd Noonsuziknc TLl kpnznc
    kon: N duxsvikn opd cnc II dnocss nspioxn ocnv onod sknvs-
    cdi syoc dpi0c ouncucuv, sk cuv onouv dpksc npokdovcdi n
    snnpsovcdi dn cnv spydod. Ikonc cnc spydodc ncdv n dvspson sni-
    niooyikv ocoixsuv oxscikv s uooksscik svoxndcd cnc ns-
    pioxnc cou duxsvd oco voonsucik npoounik kdi n npcdon scpuv
    npnnc yid cnv suon cnc ouxvcncc couc.
    Ms0oo-|k: Jnv nspoo |dvoupioc - Isncspioc 2000 sscnods
    cuxdo syd 127 voonsucv nou spyovcdv oco hdvsniocnidk No-
    ookoso Npdksou. N sscn npdydconoin0nks sou ouvsvcsunc kdi
    ounnpuonc spucndcooyou kdi dnookonoos ocnv dvspson cou
    sninodoo, cuv npoid0scikv kdi cuv dvdspsvuv diciooyikv
    ndpdyvcuv cuv uooksscikv idcdpdxv cou duxsvd. Lnonc syivs dvd-
    oknnonc cnc iioypddc yid cnv csknpuon kdvvuv nponnciknc
    ndpsdonc.
    Anotsscutu-unspcutu: Jo 24,17 cuv spydosvuv dvsps ou-
    ncudcooyd dn co uooksscik ocnv nspioxn cou duxsvd cnv onod
    ouoxscsi s co snyys cou, svoxonoivcdc iopouc ndpyovcsc -
    kupuc cov kdk spyovoik oxsido kdi cnv svcovn oudcikn spydod.
    N on os duc co undpkc npnd npsnsi vd dvdncn0s sod dn cnv
    spyovoikn skndsuon cou voonsuciko npoouniko Ineck schoo|l kdi
    cn nn scpuv - cd onod ouncovcdi - nou dnookonov ocn suon cuv
    sninokv dn cnv unspscpn kdcdnvnon cou duxsvd, sou: dl sccu-
    onc cou pouc nou sxscdi n nspioxn, l suonc cou oxopdxovd
    isoo cou onoou co ouykskpisvo poc snip ocnv nspioxn, yl dn-
    onc cnc vdnc kdi cnc dvcoxnc cuv duxsvopdxiduv uv kdi l scu-
    onc cou vsupouko ouvcovioo.
    I07I
    1A1UINh U UkAAI1AI AU 1hN IAhTIA kAI 1A kIA
    AN1IIAh1IkA OAMAkA IAOI. ANAkUhh 1h 8I8AIUIAOIA
    Auc|0|tkn k., 1ousskn A., kup|un A., unuut0u|kn ., 1c|yo0n .
    dvsnioznio kpnznc, ldzpikn oxon Hpdksou
    N scuon cnc iyvuonc kdi cnc 0spdnsdc cnc snindc snicpsnsi os
    nosc sninnciksc yuvdksc vd ndvcpsovcdi kdi vd ysvvov ndii. Ui
    sninnciksc sykusc dnocsov co 0.57 cou ouvou cuv sykuovouov.
    An ducsc svd ondvcik nooooc 0d sdvosi snisvuon cuv kposuv
    kdc cn ipksid cnc knonc kdi n idkonn cnc 0spdnsdc sxsi snikvuvsc
    snincosic oco spuo kdi ocn ncspd. N snind sxsi svoxonoin0s yid
    cnv svion iddpciv os ndii sninncikv ncspuv dn cd sod cou
    divd. U poc cnc snindc per se kdi cuv sninncikv kposuv ocnv
    cspdcoysvson sv sxsi dnoodnviocs kdi n svsin yid ysvscikn oxson
    scd snindc kdi cspdcoysvsonc sv svdi ioxupn. Avci0scuc, co ALG
    kdpddsnvn doks cnv dnossiysvn cspdcoyvo pon cou id sou
    cuv scdoicv cou kdi npokds cnv svion iddpciv cou vsupiko
    ounvd, ikpoksdd, dvudsc cou kdpidyysidko kdi cou ouponoin-
    ciko. Jo dnpok npokds cspdcoysvson id sou cuv pdocikv s-
    cdoicv cou nou npoosvovcdi ioxup oco DNA kdi id cnc sndysvnc
    dvsnpksidc cou oiko. Lu0vscdi kupuc yid iddpcsc cou vsupiko
    ounvd kd0c kdi yid kpdvionpoouniksc iddpcsc. N divodpicn kdi
    npiivn npokdov cspocoysvson id cnc dvcdyuviociknc ponc nou
    dokov oco oik o kdi id cnc idcdpdxnc cou scdoioo cuv
    pscivosiv. Mikpoksdd, kpdvionpoouniksc dvudsc, iddpcsc cuv
    dkcuv kdi kpuopxd svdi oi kpisc idcdpdxsc nou oxscovcdi s cnv
    svoncpid sk0son cou ndiio os divodpicn n npiivn. N divu-
    vcovn sou cnc ioxupnc nposonc cuv scdoicv cnc ocd vouksk
    osd npokds unspcsopio, iddpcsc cuv dkcuv, kpdvionpoouni-
    ksc dvudsc kdi noikid uv iddpciv nou dvdspovcdi uc spui-
    k udvcovik ovpoo.
    I08I
    U UAMUOIMU UN1 55ML 1h AAU5UNAh hA2I 1hN
    NIU1h1A 1h AF-AP 1hN PDL IIh A1UMA
    M. Opsvtv, O. koupu, A. kukunku*, . 5svovto**, A. 1unkn***, M.
    kup|ou**, M. |c*, A. 1cssnn***
    * Tosdc d0ooydc ldzpiknc Ixonc dvsnioznou lodvvvov, ** lvozizozo
    Nsupooydc kdi Isvsziknc knpou, *** Tnd Xnsdc dvsnioznou lodvvvov
    Liodyuyn: Jd xdn snnsd cnc NDL xonocspnc oco nod dnocsov dvs-
    pcnco ndpyovcd kivvou yid cnv svion kdpidyysidknc voou. hpodcsc
    sscsc ssidv ci skcc dn cnv dvcocpon scdop cnc xonocspnc, n NDL
    doks cnv suspyscikn cnc pon kdi idsoou cnc dnsu0sdc upuonc cuv u-
    ooiniikv uponsposiuv. N dvcpdon ducn kdcdscdi dn cd svud
    nou svdi ouvsssvd s cnv NDL: cnv ndpdoovon I PUN1l kdi cnv PAF- dkscu-
    opoon IPAF- ANl.
    Ikonc cnc sscnc: N snpdon cuv nouopiov cnc ndpdoovonc IPUN1
    55ML kdi PUN1 1920Pl kdi cnc PAF-AN I379 vAl ocic svspycncsc ducv cuv sv-
    uv, kd0c kdi oco inidiik npo cou nn0uoo cnc sscnc.
    ik kdi s0ooi: Icn sscn ouscsxdv 122 uyin cod I60 vpsc kdi 62 yuvd-
    kscl nikdc 38 9 scn, cd onod sv sxdv iocopik unspxonocspodidc n ocs-
    dviddc voou. Icd cod cnc sscnc npooiopocnkdv oi inidiiksc ndps-
    cpoi kdi oi svspycncsc cuv svuv cou opo. Lninpo0scd, syivs yoviidkn dv-
    uon s PCP yid cnv dvspson cuv nouopiov cnc PUN1 kdi cnc PAF-AN.
    Anocssodcd: Ui nouopioo cuv svuv nou sscn0nkdv sv snnpsouv
    co inidiik npo cou nn0uoo cnc sscnc. Jd cod s couc yovcunouc
    PUN1 00 kdi MM sdvouv ondvcik ikpcspn svspycncd ndpdoovonc
    oco nod os oykpion s cd cod nou sdvouv couc yovcunouc PUN1 PP
    kdi LL. U yovcunoc PUN1 LL oxscscdi s no xdn snnsd svspycncdc cnc
    PAF-AN ocnv NDL, sv sv snnpssi cnv svspycncd cou oiko svou oco
    nod. Jsoc, o nouopioc cnc PAF-AN dvscdi ci sv snnpssi cd snns-
    d cuv iniuv n cic svspycncsc cuv svuv ocov op uyiv vopoinidiikv
    dcuv.
    Iunspdod: U nouopioc PUN1 55ML snnpssi cnv svspycncd cnc PUN1
    oco nod kdi cnv svspycncd cnc PAF-AN ocnv NDL os vopoinidiik cod.
    Auc co spnd svdi iidcspd ondvcik yid cnv npnn cnc ocsdviddc voou
    os cod s uoiooyik inidiik npo, cd onod uc sdvouv cn ouyks-
    kpisvn ysvscikn ndpddyn.
    192
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I09I
    AIU1UIk AI 10N 1A1IN0N
    kock|v kv/vo, tu|uvkn Ispy|o, 8ukpn Avuctucu,
    Mnptcou 8uc||kn
    Ui ocdcvsc dnocsov od dpkuv s kpid pon cnv dvdocon cou sv-
    ou NMU-CoA dvdyuyon kdi sccuon cnc ov0sonc cnc xonocspnc. Jd uns-
    pvu cuv npoookiv kivik osn nou ndpdcnpn0nkdv kdc cn xopnynon couc
    kdcssidv cnv ndpn nsiocponikv posuv dvspcncuv dn cn suon cnc
    xonocspnc, nou nspidvouv cn scuon cnc svo0nidknc sicoupydc,
    cn ocd0spononon cuv d0npooknpucikv ndkv, cnv dvciosiucikn kdi dvci-
    syovn pon kdi cnv snpdon oco nnkcik nxdvio.
    N scuon cnc svo0nidknc sicoupydc snicsscdi sou dnonc cnc ndpdyu-
    ync dyysioidocdcikv INU, PU|2l kdi sccuonc dyysioouondocikv ouoiv Isv-
    o0nvn, Ang||l. N ocd0spononon cuv d0npooknpucikv ndkv kdi n sndk-
    ou0n sccuon cnc ni0dvcncdc pnnc couc, ndpyovcdc ondvcikcspoc kdi
    dn co sys0oc cuv ndkv, snicuyxvscdi s cnv sccuon cnc ndpdyuync cuv
    scdonpucsdov kdi cnv dvdocon cou nodndoidoo cuv dkpoyuv.
    Ui dvciosiuciksc posic ouvocdvcdi ocn suon cnc ndpdyuync ss0spuv piv
    ouyvou kdi cnv sndkou0n sccuon cnc dnononc cou NU kdi cnc osu-
    onc cnc LDL. N dvcisyovnc pon couc oxscscdi s cnv sccuon cuv sy-
    ovuv kuccpuv ocnv d0npudcikn nkd kdi cnv ncon cuv sninsuv cnc hs-
    CPP. Ui dvci0pouciksc iicncsc snyovcdi dn cn suon cnc ndpdyuync cnc
    0poovnc A2 kdi cnc skpdonc cou PA|-1, kd0c kdi cnv dnon cnc skpdonc
    cou t-PA ocd svo0nidk kccdpd. hsipddciksc sscsc, nou svsi vd snisdiu-
    0ov kivik, kdcdsikvouv cnv dvdocon cnc sndysvnc dn cnv Ang|| uokdp-
    idknc unspcpodc kdi vuonc.
    Jsoc, nsipddciksc kdi sniniooyiksc sscsc sxouv ssi uvncik
    usisc posic cnc xopnynonc ocdcivv os n kdpidksc kdcdocosic,
    nuc n oocsonpuon, n vooc A|zheimer's kdi o odkxdpnc idncnc.
    I10I
    NA UMNA X1IkA M 1U NUMU U5IA 8AA8h NMUNA -
    U5IA ANAN1Ikh XIA IALI-AkDSI
    uuvn A., nu ., Mn|kn A., Optn .
    Ooiznzsc ldzpiko zndzoc dvsnioznou kpnznc
    Yns0uvoc kd0nynznc :Isopynouoc ., kd0nynznc Lvzdziknc ldzpiknc
    dvsnioznou kpnznc
    kon: hdpouodon vsuv sosvuv nou ouvsddv ocnv nnpsocspn kdcd-
    vnon cnc nd0ouoiooydc cou APDS kdi ocov npoodvdcoio npoc vsouc cp-
    nouc 0spdnsdc
    N Acute Lung |njury IAL|l kdi co Acute Pespiratory Distress Syndrome IAPDSl
    svdi ouvsnsid cou nvsuoviko oindcoc dunsvnc idnspdccncdc kdi
    yu cnc unnc snncuonc couc Is on cou Nationa|e |nstitute of Nea|-
    th IN|Nl n snncuon cou APDS skcicdi ocouc 75/100.000 kdcokoucl dno-
    csov kivik ondvciksc ovccncsc.
    Jo ovpoo ssooscdi npoosucik kdi xdpdkcnpscdi dn idkpic
    ocid. Apxik sxous cnc osd n sipudcikn on, n onod nops vd
    scdnsosi os ivonoi kuscid kdi oco csoc dkoou0scdi dn cn on
    cnc dnokdcocdonc. Indvcikc ndpyovcdc yid co cssucdo svdi n dno-
    pon cou nvsuoviko oindcoc, n onod sdpccdi dn cnv iooppond
    cuv uvsuv Star|ing, dn cn sikn ndpoxscsuon kdi dn cn idsni0n-
    idkn scdop cou vdcpou, nou dkoou0scdi dn cnv nd0ncikn scdk-
    vnon cou N
    2
    U su dn cic kussc.
    N scdop cou vdcpou idsoou cou sni0nou yvscdi svspyncik dn
    cd cnou || nvsuovokccdpd, s cn on0sid cnc dvcdc vdcpou INd + / k
    + AJPasel.
    Aucn n yvon npoossps npoonciksc yid vsd 0spdnsucikn dyuyn, ocnpi-
    svn os
    2
    -dpsvspyikoc dyuviocsc nou duvouv cn pdocnpicncd cnc
    dvcdc kdi snicdxvouv cnv dnopon cou nvsuoviko oindcoc. Icnv
    npcn sscn nou syivs os dv0pnouc xpnoionoin0nks odscspn
    I
    2
    -dpsvspyikc dyuviocncl yid cnv snicxuvon cnc dnoponc cou nvsu-
    oviko oindcoc, nou npokn0nks os opsicsc yu syou us-
    cpou. Iuvd s cd ndpdnvu, n odscspn 0d nopoos vd xpnoio-
    noin0s ocn 0spdnsd cou APDS.
    I11I
    XNU1h1A kAkUhOU AI1IA IAOUA NUAAMA1A
    Auyoy|vvn |pnvn, o0cco Avuctc|o, koutcoun Avuctc|o, O|nnou
    N|knpo, 1pounn Ispy|o
    kon: Nd dvdsp0s n ouxvcncd svionc unsukociknc ouoync os vso-
    nodcd, kdc cn voonsd do0svv os nvsuovooyikn kivikn kdc cn ipksid
    cpiv scv.
    |k - s0oo: Msscn0nkdv 126 do0svsc, nikdc 32-75 scv IM.U. 53,5l,
    nou kdc cnv kivikn sscdon kdi cov dnsikoviocik ssyxo svidv
    unsukocikn ouoyn. Is sc cic nspincosic kdcdypnks n svcnion
    cnc unsukociknc ouoync Isi, dpiocsp ni0upkio n docspnsu-
    pnl.
    Anotsscutu: An couc 126 do0svsc nou sscn0nkdv, idnioc0nks
    ci n ouxvcspn dicd kdkon0ouc nsupiciknc ouoync svdi o kdpkvoc
    cou nvsovoc, s ouxvcncd 53,27 I67 do0svscl. Ui unoinoi do0svsc
    svidv unsokucikn ouoyn s npucond0nc socd: doc, 21 I16,67l,
    uo0nksc 10 I7,97l, ocdxo 6 I4,77l, ncpd 2 I1,77l, nndp 1 I0,87l, puy-
    yd 1 I0,87l, vsp 1 I0,87l, op0 1 I0,87l, npooccn 1 I0,87l, nsoc 1 I0,87l,
    oupoxo kocn 1 I0,87l, 0upsosin dsvd 1 I0,87l, spd 2 I1,67l kdi
    nykpsdc 1 I0,87l. Is 10 do0svsc I7,97l n npucond0nc socd ndpssvs
    yvuocn. Icic 67 nspincosic cou npucond0oc kdpkvou cou nvsovd :
    49 I73,17l ncdv dsvokdpkvud, 12 I18,27l ikpokuccdpik kdpkvud kdi
    6 I9,17l ndksc kdpkvud. Is 61 do0svsc I48,47l idnioc0nks unso-
    kucikn ouoyn si, os 55 I43.67l dpiocsp kdi os 10 I0,87l docsp-
    nsupn ouoyn uypo. hdpdcnpn0nks ci sv unpxsi skskcikn ouo-
    yn cou uypo os knoio ni0upkio, nuc oudvsi os n vsondodcikn
    nd0ooy d.
    unspcutu: hdpdcnpos oinv, ci n unsukocikn ouoyn vso-
    ndodciknc diciooydc osscdi os kdpkivudcn in0non cou uns-
    ukcd os sydcspn ouxvcncd yu poyxoysvn kdpkvo cou nvso-
    vd kdi os ikpcspn ouxvcncd yu ykuv sunvsuoviknc diciooydc,
    nou svdi kupuc docc, uo0nksc kdi ocdxoc.
    I12I
    M8A1Ikh INhh kAI OAIA AON0N M NMUNIA
    kA1A 1h IAkIA MhXANIkU AIMU
    I|vtcou ., Auputnouo N., uvn k., Ntxu X.,Xutnkup|kou .,
    Mno0po ., Mnvnouo I.I.
    A' pondisuzikn Xsipoupyikn kivikn, Movd Lvzdziknc 6spdnsdc, kdi
    vsuovooyikn kivikn, nokpizsou dvsnioznou 6pknc.
    kon: N ouykpicikn dioynon cnc ouonc cou poyxokusiiko
    skndcoc I8ALl kdi cnc idcpdxsidknc dvdpponosuc ocnv sniuon,
    ipksid voonsdc kdi xpnon dvciiocikv os do0svsc s nvsuovd kdc
    cnv ipksid nxdviko dspioo.
    |k -Ms0oo|: hpksicdi yid npooncikn, cuxdionoinsvn sscn 132 do0s-
    vv os nxdvik dspio, isonc nikdc 58 Ispoc22-73,l scv, 60 v-
    psc I45,67l, 72 yuvdksc I54,47l s kiviksc svssic nvsuovdc .Ui do0s-
    vsc cuxdionoin0nkdv os o osc, cnv npcn nou nspisdvs 67
    do0svsc ocouc onoouc n iyvuon kdi 0spdnsd doicdv ocnv noooci-
    kn kdispysid 8AL kdi cnv scspn nou nspisddvs 65 do0svsc ocouc
    onoouc n iyvuon kdi 0spdnsd doicdv ocnv nooocikn kdispysid
    idcpdxsidknc dvdpponosuc. Mscpn0nkdv n 0vnccncd ocic 14 nspsc
    voonsdc, o sooc xpvoc voonsdc kdi co ovoo cuv dvciiocikv ocic
    o osc.
    Anotsscutu: U sooc xpvoc voonsdc ocnv 1n od ncdv 14 nspsc,
    sv ocnv 2n 23 Ix7.47, p<0.005l. N 0vnccncd ocic 14 nspsc voonsdc
    ocnv 1n od ncdv 23 I347l, sv ocnv 2n 39 I607l Ix 8,88, p<0.005l. Jo
    yivsvo xopnyn0svcuv dvciiocikv sn cic nspsc voonsdc onv 1n od
    ncdv 1960 sv ocnv scspn 4278 Ix 11.95 p<0.005l.
    unspucu: Jo 8AA dvscdi ci on0 ondvcik ocn suon cou xp-
    vou voonsdc,cnc 0vnccncdc kdi cou dpi0o cuv dvciiocikv ocn vAP
    os oxson s cnv idcpdxsidkn dvdppnon.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    193
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I13I
    ACIN1U8AC1k 8A0MANII kAI NMUNIA AON0N
    MhXANIkU AIMU
    I|vtcou ., Auputnouo N., upu|ou ., uvounou A.,Xutnkup|-
    kou ., Mnvnouo I.I.,Muv k.I.
    A' pondisuzikn Xsipoupyikn kivikn, Movd Lvzdziknc 6spdnsdc, kdi
    vsuovooyikn kivikn, nokpizsou dvsnioznou 6pknc.
    kon: N dioynon cnc ouscoxnc cou Acinetobacter baumannii ocnv
    nd0oysvsid cnc nvsuovdc do0svv os nxdvik dspio.
    |k-Ms0oo|: N iyvuon nvsuovdc kdc cnv ipksid nxdviko ds-
    pioo scs0n s kdispysid poyxokusiiko skndcoc os 95 do0s-
    vsc, 40 vpsc,55 yuvdksc, isonc nikdc 57,8 Ispoc 22-73 l scv, dn
    couc 397 nou scs0nodv os nxdvik dspio kdc cnv nspoo 2000-2001 .
    Msscn0nkdv oi dvdncuoosvoi ikpoopydvioo I>104/mLl ocic kdisp-
    ysisc cou skndcoc kdi iidcspd co Acinetobacter. baumannii, n oxson
    cou s nponyn0sod nn dvciiocikv kdi n dvncun cou sn npinc n
    inc nvsuovdc I< n > 7 nspsc, dvcocoixdl.
    Anotsscutu: An ovoo 35 snsioouv nvsuovdc s Acinetobacter .
    baumannii kdc cnv ipksid nxdviko dspioo, 46 7 idnioc0nkdv os
    do0svs c s npi n nvsuov d kdi 547 os do0svs c s i n Ix
    4,88,p<0,005l.hponyn0sod nn dvciiocikv kdc cic 15 nspsc npo cnc
    dvdncsuc nvsuovdc idnioc0nks os 4777 cuv do0svv s npin
    kdi os 5377 cuv do0svv s in nvsuovd Ix0,17 ,p>0,005l.
    unspucu: Jd sosvd cnc ndpoodc sscnc snicpsnouv cnv ovs-
    on cou Acinetobacter .baumannii s cnv in nvsuovd d xi s cnv
    nponyn0sod nn dvciiocikv.
    I14I
    IAIN01Ikh UIIIh AONU M 20kU1Ikh AAUIh
    Xutnuxup| N., upucksukou I.
    Iutp|kn xon .k..A.
    Ikonc cnc spydodc ducnc svdi n ndpouodon cnc idyvuocikn npoosyyi-
    onc cou do0svoc s nsupicikn ouoyn os ocid, ocs n iyvuon vd
    cs0s ypnyopd, oo co uvdcv sukocspd kdi s sydcspn oiyoupi.
    N npoosyyion cou do0svoc skiv s cn nn cou iocopiko kdi s cn
    uoikn sscdon, s cd onod nopos vd dvcnoous nosc xpnoisc
    nnpoopsc nou 0d dc kdcsu0vouv ocn npoon0sid yid iyvuon. Jnv
    sikvd cou idcpo yid co nspiocdcik ounnpvsi n dnn dkcivoypdd
    0pdkd kdi csoc kd0opiocikn on0sid vscdi dn cnv dvuon cou nsu-
    piciko uypo. Jo uyp dvscdi s ndpdksvcnon cou 0pdkd kdi ocs-
    vscdi yid cic dndpdcncsc spydocnpidksc sscosic. Icnv nsiond cuv
    nspincosuv n iyvuon c0scdi sc cnv npcn ndpdksvcnon. Av duc
    sv svdi uvdc ccs nopos vd kdcdyous ocn xpnon cnc doviknc
    cooypddc, cnc poyxooknnonc, cnc nsupooknnonc n cnc iodc
    cou unsukcd.
    II6I
    OAIA 1h kAIAkh ANAkIA
    Xutnuxup| N., upucksukou I.
    Iutp|kn xon .k..A.
    Ikonc cnc spydodc ducnc svdi n ouyypdn cuv kdcsu0uvcnpiuv ypdv
    cnc 0spdnsdc cnc kdpidknc dvsnpksidc s dn kdi nspiskcik cpno.
    0c kdpidkn dvsnpksid IkAl opscdi n dvsndpknc sicoupyd cnc kdp-
    ic, ndn n duvdd vd idcnpnosi ndpoxn dvoyd s cic dvyksc
    cuv iocv, cdv sxsi uoiooyikn nnpuon Inisosicl. U opioc ioxsi
    soov n sikn sniocpon svdi uoiooyikn. Icnv kA co kod s0n-
    onc svdi <507. kivik, n kA idkpvscdi dp os dpiocspn, si kdi oikn
    kdi coco yidc n dvsnpksid idc koidc, iuc cnc dpiocspnc, onys os
    kn kdi cnc nc koidc s dnocssod cnv oikn kA. Lknvscdi
    kivik s iopd ouncdcd kdi onsd, sv ouoidociksc nnpoo-
    psc nopos vd dvcnoous dn cnv dnn dkcivoypdd 0pdkoc, dn
    co nskcpokdpioypnd, co unspnxoypnd, cn okidod konosuc,
    cn pdioooconikn koiioypdd kdi cov kd0scnpidoc cuv kdpidkv
    koiocncuv. Jo dodsocspo kpicnpio yid cnv skcnon cnc kdpidknc si-
    coupydc svdi n ikdvcncd npoc oknon kdi ouvd s ducn n kA idkp-
    vscdi os 4 kdcnyopsc n csic kdc NNA INew ork Neart Associassionl.
    N 0spdnsd cnc kA ouvsxc ssccdi, dsi kdi npoodpscdi ocd
    kdivopyid sosvd kdi ounspodcd nou npokncouv. Lnonc, vssc
    oxscik sscsc sxouv dnossi nuc pdkd nou nddicspd dndyo-
    psucdv n xpnon couc os do0svsc s kA, dokov suspyscikn pon kdi
    scoi nid n xopnynon couc 0supscdi snicdkcikn. |svik ocn 0spdnsd cnc kA
    onspd xpnoionoiovcdi n dkcucid, cd ioupncik, oi dvdocosc cou
    scdcpsnciko svou cnc dyysiocsvovnc, oi dvdocosic cnc dyysioicsv-
    ovnc || oi -dvdocosc,n ooucdvn, oi dvdocosc cnc uooisocs-
    ponc, oi sudio0nconoincsc cuv ivcuv Ca+2 oco uokpio kdi d
    pdkd, nuc npsiocik, ouyvo, dvcidppu0ik, dvcinnkcik kd., d
    kdi ndpsdciksc s0ooi, nuc dddn, svdopcikn dvcd, skksvucikn
    ndpdksvcnon 0pdkoc kdi uokdpiondocikn. Jsoc, ooi do0svsc nn-
    pov cic dndpdcncsc svssic nopov vd snisouv cn idikdod cnc
    scdoxsuonc kdpic.
    I15I
    h IN0UAh 1U hAIkI0MNU AONU
    Xutnuxup| N., upucksukou I., nuvkn O.
    Iutp|kn xon .k..A.
    N unspoxn cnc 0pouonc svdvci cnc npucoysvoc snsdciknc 0spd-
    nsdc oco o spdyd cou uokdpou IULMl ouncscdi dkn supcd-
    cd. Msxpi kdi npodcd, unpxouv spydosc nou sxvouv ndpoid dno-
    cssodcd cuv o csxvikv.
    Is sc cic ionxdviksc xpsc n dvdoyd cuv nikiusvuv dcuv du-
    vscdi kdi duc snisi o kdi nspioocspo cnv snuon cou npond-
    coc cnc snioync cnc s0ou sndvdicuonc kdc co o ocio cou ULM.
    hdp cd nskcpokdpioypdik kpicnpid snioync Idvondon cou SJ n
    dnoksio cou dpiocspo oksoucl noo do0svsc ouxv dnokso-
    vcdi dn cd npuckod sndvdicuonc yu uno kivvou 0vnccn-
    cdc. N dndon yid ivuuon os svd nikiusvo do0svn svdi okon,
    ici os svd cnd cuv nikiusvuv do0svv co soc svdi sydcspo
    oov dop cnv sniuon, d kdi os svd o spoc o kvuvoc diop-
    pdydc svdi soou dunsvoc. Iuvoik, n sscn UuSJU-| ssis ci os
    ducv cov nn0uo co kd0dp kivik soc Iidou0sosc usc sov
    cd dyysidk syksdik snsioidl svdi 0scik.
    N spydod ducn ndpd0scsi sosvd nou dopov cnv sniniooyd cou
    ULM ocouc nikiusvouc kdi co soc cnc sndvdicuonc s ivuuon
    n/kdi dyysiondocikn s okon cn isukuvon ocnv dioynon cnc oxs-
    osuc kocouc/kivvou kdi cnv snioyn cnc kdcdncspnc ocpdcnyiknc
    sndvdicuonc os k0s nspncuon.
    194
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I17I
    OIUAUIIA 1U AI1IkU IU kAI AOUINIA
    1h 20kU1Ikh AAUIh
    Xutnuxup| N., Isvvnut ., upucksukou I.
    Ikonc cnc spydodc ducnc svdi n ndpouodon vscspuv sosvuv nvu
    ocnv uoiooyd cou nsupiciko uypo kd0c kdi ocnv nd0oysvsid cnc
    unsukociknc ouoync.
    nsukocikn koicncd kdscdi n koicncd nou nioupyscdi dvsod
    ocd uo nscdd cou unsukcd, co nspcovo kdi co nspionxvio. Guoio-
    oyik n unsukocikn koicncd svdi yscn s co nsupicik uyp. Jo
    nsupicik uyp sxsi yko 0,26 m|/kg pouc odcoc kdi n v0son cou
    svdi sksvn cou nodcoc do sxsi icpdpio0s dn uo spvsc,
    co cpixosiik svo0nio kdi co soo0nio cou unsukcd. N noocncd
    cou nsupiciko uypo ndpdsvsi ocd0spn uc dnocssod cnc iooppond
    ocn scdop cou dn kdi npoc cnv unsukocikn koicncd idsoou cuv
    nscuv cou unsukcd. Icn ixuon cou nsupiciko uypo idsoou
    cuv spdvv snipov oi uvsic cnc upoocdciknc kdi cnc koosio-
    ouciknc nsonc. Lninsov uyp, sukdcd kdi kccdpd ndpoxscsovcdi
    s cd sdyysd kdi csoc, ikpn noocncd uypo dkoou0s cn scdo-
    p cuv nskcpoucv kdi cnv svokuccpuon npucsvv.
    0c unsukocikn ouoyn opscdi n ouoyn k0s uypo ocnv unsukoci-
    kn koicncd. Usscdi os iopd dcid nou sxouv uc dnocssod cn
    scdon cnc upoocdciknc n cnc koosiuouciknc nsonc, dnon cnc
    iddccncdc cuv cpixosiv n uosicoupyd cuv sdyysuv yu dvd-
    coiknc n sicoupyiknc dnpdnc.
    I18I
    AANUUIhh 1U X0MU0MA1U X: IXUN Uk1AI
    Aupvo I|yko
    1
    , Ayysn Ayys|kn
    2
    , 8uxonntpn Ayys|kn
    1
    , Muv-
    kou uvuy|tu
    1
    ,unupy0pn Avvu
    2
    , Ospvoyou Xp|ctvu
    2
    ,
    Xpnctou Mupu-8uc||kn
    1
    4. Msoc L.L.O.l.L.Indppznd A0nvovI,suzsposznc oiznznc.pid ldzpiknc
    Ixonc L.k..A., 2. suzsposznc oiznzpid ldzpiknc Ixonc L.k..A.
    kon tn spyucu: Lv n dpdvononon cou xpuoodcoc X dnocss svd
    ko cnc oyxpovnc opidknc ysvsciknc nou cuyxvsi skcscdsvnc spsuvdc is-
    0vc, ocnv snvikn iioypdd ondvouv oi oxsciksc nooisosic. N spydod
    dc sniiksi vd ousi ocnv nnpuon cou ksvo duco ouvoovcdc cd
    nopodcd cnc oxsciknc spsuvdc, sociovcdc ndpnd ocic nposkcosic sksvsc
    cou divosvou nou ndpouoiouv cn sydcspn npdkcikn dd yid cov sndyys-
    dcd cnc uysdc.
    |k ku| Ms0oo|: N spsuvncikn dc od diononos dpxsidk uik
    kdi npodcsc nooisosic cnc is0voc iioypddc nsp ysvsciknc
    kdi opidknc iooydc Inspioikc sniocnovikc cnoc, scnoisc dvdoko-
    nnosic, ouyypdcdl. Lninsov snsspydocnkds ondvcik dpi0 id-
    ikcudkv nnyv nnpopnonc, sv co nspisxsvo cuv idssuv s-
    v .L.h. cnc |dcpiknc Ixonc L.k.h.A. oc0nks svd ioxup sps0iod yid
    cnv snskcdon cnc sscnc dc npoc vssc kdcsu0vosic.
    Anotsscutu: Jo npov odpvcd kdi nsov scv spsuvdc sxsi onynosi
    ocn idpuon svc ikdvonoinciko ovcsou yid co nxdvio cnc dpd-
    vonononc cou xpuoodcoc X, ndpci duc ouvsxc ounnpvscdi s
    vsd supndcd. 8doik po oco nxdvio cou divosvou kdcsxouv co
    yovio X|SJ kdi oi dnouxsc L|NL-1 sv d yovid IJS|X,Xcel kdi
    npucsviko oundpyovcscICJCFl ououv ocn idikdod. Lkcponsc
    cou divosvou ouvnyopov os ondvcikoc nd0ooyikoc divocnouc
    nuc nvsudcikn kd0uocspnon, oopn dvncun kdi sknuon X-u-
    oovscuv vouv os 0nsd cod.
    unspcutu: N dpdvononon cou xpuoodcoc X dnocss svd sdi-
    pscik ovcso yid cnv kdcdvnon cnc sncnc p0ionc cou yoviidcoc
    d kdi cnv ssikcikn cnc cssucddc, nuc npokncsi dn cn sscn
    snispouc opydviov-ovcsuv. Lninsov ouvioc svd nso syou
    idcpiko svidspovcoc, do spnvssi cnv sknuon ikdvo dpi0o
    voonpv divocnuv.
    I19I
    AMOI8Ah1UIUAOIA U0U1h1A IkUI
    Auyku|vo0 Mupu, uvo0n 8ucs|o
    Yn znv snfsn zou kd0nynzn o0dooyiknc kiviknc ndvsniozn-
    ou dzpov lovvn koinouou.
    Icnv spydod nspidvovcdi: id iocopikn dvdpon cnc voou dn co
    1940 sxpi kdi onspd kdi sniniooyik ocoixsd nuc yid ndpsiyd
    os noisc nspioxsc ndpdcnpovcdi sydcspd nooooc cnc voou, os noisc
    niksc k.d. N spydod svdi cidysvn scoi ocs vd coviocov oi npoid0s-
    oiko ndpyovcsc cnc voou scd cuv onouv kupdpxn 0son vscdi ocn
    pon cou U2 Isvdi suspyscikc n dncikc ndpyovcdc os svd vsoyv?l.
    Indvcikn dvdop yvscdi kdi ocouc ysvscikoc ndpyovcsc nou ni0dv-
    cdcd su0vovcdi yid cnv sknuon PUP. Icnv spydod ducn dc dndoxo-
    ov kdi oi uo snikpdcsocspsc 0supsc oxscik s cn nd0oysvsid cnc
    voou Io dyysioondoc cuv dinocposiikv dpcnpiouv n n pd-
    ocnpicncd cuv dcpdkcosiv sosyxudcikv kuccpuv su0vovcdi yid
    cn PUP?l. N kivikn sikvd, npyvuon kdi ocdiononon kdcsxouv ond-
    vcik spoc cnc spydodc kdi sou ducv npokncouv ondvcik ocoixsd
    .Ixscik s cn ocdiononon ndpd0scous kdi sikvsc nou on0ov ocn
    kdcdvnon cuv snispouc ocduv cnc voou. Jsoc dvdspdocs ocn
    0spdnsd cnc voou nou nspidvsi cnv kpuonnd ,co |aser, udosis-
    kcon kdi cnv nio ouvcnpncikn dvciscnion n onod syksicdi ocn xopnyn-
    on icdivv kdi nsvikidivv. hocs npsnsi vd skivsi n 0spdnsd?
    hoid cd nooooc snicuxdc kdi noisc oi sninoksc? Jssivovcdc ndpd0s-
    cous knoid ounspodcd oxscik s cn voo n onod dnocss onou-
    dd dicd cuonc .
    I20I
    AINUIkh h AOhNAIA, MIA AXAIA AAhNIA IA1U
    |npnouo Iopvn
    N ndpn cnc Ayvoknc dpcupcdi vo dn cov yvo, Adcvo ouyypd-
    sd cou npcou divd .X., o onooc kdi nspiypsi cnv no svidspou-
    od iocopd cnc. N conpn ducn Lnvd cou cscpcou divd n.X. scd-
    isocnks os vpd yid vd onouosi idcpikn, do kci cscoio ncdv dnd-
    yopsusvo oci c yuvd ksc sks vn cnv nsp oo.
    hdp co ysyovc ci n iocopikcncd cnc Ayvoknc dioncscdi, n iocopd
    cnc, nuc nspiypscdi dn cov yvo, dc snicpsnsi vd yous svid-
    spovcd ounspodcd yid cnv iicncd cou idcpo sksvn cnv snoxn kd-
    0c kdi yid cd npondcd nou dvciscnis kdc cnv oknon cou si-
    coupyndcc cou.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    195
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I22I
    MUXMA1A kAI NOMA1A 1h INUAA1Ikh
    kokokn Ispy|o
    1
    , Xupuunkn 8ucn
    1
    , uckukn Mpko
    2
    , Muv|
    Avpsu
    3
    4. Ooiznznc ldzpiknc dvsnioznou kpnznc, 2. Liiksusvoc xsipoupyiknc
    oykooydc AINH, 3. dozikc xsipoupyc , Lnisnznc B' Xsipoupyiknc,
    0ykooyiknc kiviknc AINH
    Ui sdpoysc ooxsucuv kdi sv0scuv ocnv dio0ncikn kdi sndvop0u-
    cikn xsipoupyikn pivc ndpouoiouv iidcspo svidspov cd cssucdd
    xpvid.
    Jd ooxsdcd nops vd svdi oocik kdi dvovcdi dn dyvio ooc,
    kpdvo, uskpdvo kdi nsupsc. Jscoid ooxsdcd npocivcdi os sy-
    d ssdcd okssco pivc sc dn skcosc, os nspincosic sin-
    niosioc pivc kdi os kpdvionpoouniksc dvudsc. Xvpivd ooxsd-
    cd dn pivik ipdyd, nsupikoc xvpouc n co ncspyio cou ucc
    sxouv 0son scs os sndvop0ucikn n os dio0ncikn scuon cnc pivc. Auc
    yvscdi snonc kdi yid cn scuon cnc sicoupydc cnc ndn cnv dnokd-
    cocdon cnc sou piviknc ddc. Aucoooxsdcd snonc nops vd
    n0ov dn xpio n nspicovd. Is nspincosic icpnonc idpydcoc
    kdi sinniosioc pivc nops vd svskvucdi n xpnon spdcikv do-
    ooxsucuv IA||oderml
    Icnv ndocikn dnokdcocdon cnc pivc xpnoionoiovcdi snonc sv0sd-
    cd oiikvnc, Prop|ast, Uore-Jex, nopouc noudi0usvou n kokkuv
    upoudndccn.
    Iunspdodcik, cd ooxsdcd kdi cd vsd npovcd cnc iocsxvooydc
    sxouv sciosi ondvcik cd dnocssodcd cnc pivondociknc kdc cn
    ipksid cuv cssucduv skdsciv.
    I24I
    UAU 10N 1A1IN0N A A'1I AN1IAIIAIMIk 1U IkANU1h1
    unuyspyou N|kuo, Mnsptc| nntp|o
    Indvcikn 0son oco po kdi cn sicoupyd cuv ocdcivv ndsi n dvdoco-
    n cou sdoviko osoc s noikicponsc sniposic. Txsi dvdsp0s,
    ci oi ocdcvsc dvdocsouv cn scdop kdi cov nodndoido cuv
    odv dyysidkv kuccpuv IvSMC'sl, sivouv cnv ivcspsukvn kdc si
    opsc ocd vSMC's, scivouv cnv dyysiokivncikcncd oco svo0nio kdi
    dvdocsouv coo co ndoivoyvo cou svspyo dvdocosd-1 oo kdi co
    ksvcpo ysvsonc cuv scdonpucsivdov ocd svo0nidk kccdpd. In-
    dvcik svdi, ci oi sniposic ducsc cuv ocdcivv svdi dvspcncsc cou
    sninsou cou nodcoc xonocspnc.
    Ui ocdcvsc dnocsov ndpyovcsc suonc cuv iniuv, s no osn
    kdi dvspcncd dn cn suon cnc xonocspnc, sxouv oxson s cnv
    npoocdod kdi cnv scuon cnc sicoupydc cou svo0nou. Auc svdi
    snicuxsc kupuc sou cnc dunsvnc ndpdyuync kdi idcnpnonc cou NU.
    Txsi ps0s ci oi ocdcvsc sxouv dvciosiuciksc ikdvcncsc kdi dionoiov
    iopd dvsvspy ocoixsd ouyvou.
    Iunspdodcik, ouvsiospouv ocn suon cnc nsonc cou ddcoc os
    unspcdoikoc do0svsc, sxovcdc dvci0pouciksc kdi dvcidpcnpiooknpu-
    vciksc ikdvcncsc, ndpsxouv npoocdod dn spdyd, sdvovcdi vd
    scivouv cnv dnppin ooxsucuv os scdooxsosic kdi csoc s-
    civouv yvuociksc sicoupysc os do0svsc s void.
    hdp'd duc nspdicspu spsuvsc svdi dndpdcncsc npoksisvou vd sd-
    x0s ounspdod yid cic coo ondvciksc kdi noikicponsc sniposic
    cuv ocdcivv.
    I21I
    h XIUIIkh AN1IM10Ih 10N kAAUhO0N UIk0N
    1U 0kAAk1AU
    nntp|n X., kuvso I., 2uxupkn ., ktc|o I., kuvso .,
    Mnstcn .
    dvsn.kn Xsipoupyikn kivikn A..6.
    kon tn spyucu svdi vd ndpouoiosi cnv snsipd dc dn cnv dvci-
    scnion kdon0v ykuv cou uskddkcou.
    |k-Ms0oo|: kdc cnv xpovikn nspoo 1989-2001 dvciscunods ou-
    voik 6 do0svsc s kdon0sic ykouc cou uskddkcou. cdv 4 v-
    psc kdi 2 yuvdksc dn 45 suc 76 scv I.o nikdc 64,4 scnl. An ducoc
    couc do0svsc, oi 5 dvciscunocnkdv yid sioud I83,37l kdi 1 yid ds-
    vud cou uskddkcou I16,77l.
    Anotsscutu: N dvdid ncdv n npcn kivikn sknuon os 4 do0svsc
    I66,67l, sv n dioppdyd dn co dvcspo nsncik os 2 do0svsc I33,47l.
    Ad ouncdcd ncdv oi sdivsc ksvosic Iv2l kdi n sniydocpikn sudi-
    o0nod Iv3l. N svooknnon cou dvucspou nsnciko kdcssis cnv nd-
    pouod cou ykou. Doi oi ykoi sxdv iscpo > 2 sk. kdi n svookonikn
    ddpson sv ncdv sikcn. Doi oi do0svsc dvciscunocnkdv xsipoupyi-
    k s uskddkcuocon kdi conikn skcon cou ykou. N scsyxsipnci-
    kn 0vnccncd kdi voonpcncd ncdv nsvikn. sv ndpdcnpn0nks unocpo-
    nn cou ykou os kdvsvd do0svn.
    unspcutu: Ui kdon0sic ykoi cou uskddkcou svdi onvioi. N
    nio ouxvn sknuon couc svdi n idsnouod n dikn dioppdyd dn co
    dvcspo nsncik. N iyvuon c0scdi s uskddkcuooknnon kdi n
    svssiysvn 0spdnsd svdi n xsipoupyikn sdpson cdv n iscpc cou
    ykou unspdvsi cd 2 sk.
    I23I
    1UINh UAhTh IIA 1h MI0h 1h 1OANIAIA NUU
    AONI M AkXA0h IA8h1h
    unuyspyou N|kuo, Mnsptc| nntp|o
    |syovc svdi, nuc o idncnc duvsi cnv ni0dvcncd svionc kdpidy-
    ysidknc voou. 0ocoo n sucspoysvnc npnn ouxv ndpdsnscdi
    ocouc idncikoc do0svsc.
    Icxoi cnc sucspoysvoc npnnc dnocsov: dl n ocd0spononon cuv
    nn unpxououv dv, l n npnn nioupydc vsuv, yl n scuon
    cnc sicoupydc cou svo0nou.
    N scuon cou ssyxou cou idncn, scs sou dpkuv oouovuou-
    pdc, scs sou unopidc xopnynonc ivoouvnc, onys os scuon cnc
    oiknc xonocspnc, cnc LDL xonocspnc kdi cuv sninsuv oikv cpi-
    yukspiuv.
    6spdnssc, oi onosc nspiopouv cnv npucsvoupd , svdi snonc ni0dvv
    vd sdccvouv cnv svion cnc kdpidyysidknc voou, sv xpnon cou
    dvdocosd ACL, sdccvsi co pu0 ssinc cnc idnciknc vspon-
    0sidc kdi cnv ni0dvcncd svionc cnc kdpidyysidknc voou.
    Lninpoo0scuc, cponononon cnc dvcocdonc cnc ivoouvnc, sdccvsi cd
    snnsd yuknc oco dd, cnv LDL xonocspn kdi cd cpiyukspid.
    hdpnd, cd snnsd cnc ivoouvnc, n pon PA|1 kdi co ivuoyvo, cd
    onod sxouv oxson s cnv svion cnc kdpidyysidknc voou, sivo-
    vcdi. Akn, ondvcikn 0spdnsd npoospouv oi 8-dvdocosc, d kdi n
    xpnon cnc donipvnc.
    Indvcik 0d npsnsi vd 0supovcdi, n dyuyn dpkuv kdc cnc ndxu-
    odpkdc kdi n idkonn cou kdnvodcoc, sv ssxouod 0son ocn 0spdnsd
    kdcsxouv oi NMU-CoA dvdocosc.
    Icic spsc dc, oosvd kdi nspioocspsc spsuvsc isyovcdi yid cnv sni-
    kpcnon cnc sucspoysvoc npnnc ocouc idncikoc do0svsc, ocs
    n onoudicncd cnc vd dvdyvupiocs kdi vd xpnoionoin0s kdcnd.
    196
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I25I
    NUOhAIAkh AI1UIIA-AI1UIIA kAI OA1Ikh
    AN1IM10Ih
    unuyspyou N|kuo, Mnsptc| nntp|o
    kon: hdpouodon doikv svo0nidkv sicoupyiv kdi dioynonc 0spd-
    nsucikv sdpoyv os uosicoupyd cou svo0nou.
    Anotsscutu: Jo dyysidk svo0nio dnocss svd uvdik pydvo kdi poks-
    cdi ocnv snivsid uv cuv diopuv dyysuv cou dv0punvou odcoc, snics-
    vcdc ssxouodc ondodc sicoupysc, nuc: p0ion dyysidko uiko cvou,
    sniknon sukokuccpuv kdi syovn, kd0c kdi idcnpnon cnc iooppondc
    scd nnnc kdi ivuuonc. Icic sicoupysc ducsc ondvcik po idpddc-
    ouv skkpivsvsc dn duc ouosc, nuc co ovosio cou dcou INUl, npoocd-
    kukvn, pdukivvn, svo0nvn, P.D.U.F, v.L.U.F, J.U.F k.. N uosicoupyd cou
    svo0nou dvdyvupscdi dn cn idcdpdysvn svo0nio-sdpcsvn dyysio-
    idocon, npokdvcdc cnv ssin cuv ocsdviduv d0npooknpucikv d-
    v kdi 0poucik ouvcd, nuc co o spdyd cou uokdpou kdi n docd-
    0nc ocn0yxn. N npoosyyion cou uosicoupyiko svo0nou nspidvsi no-
    sc csxviksc, nuc idocsdvidd syxuon dkscuoxovnc, PLJ scanning, nn0u-
    oioypdd, k.. 6spdnsucik nopov vd sdpoocov n-dpdksuciksc kdi dp-
    dksuciksc s0ooi. An cic n-dpdksuciksc, dnocssodciksc, ouvd s s-
    scsc, kp0nkdv n xopnynon icdvnc C os do0svsc s ocsdvidd voo, kdpidkn
    dvsnpksid kdi unspcdon, n nn uiko osoc dn do0svsc s dunsvd sn-
    nsd ookuocsvnc, n xopnynon L-dpyivvnc, kd0c kdi n oknon kdi n sccuon
    cou kdnvodcoc. Gdpdksuciksc ouosc nou xpnoionoiovcdi ocn ip0uon cnc
    svo0nidknc uosicoupydc svdi oi Avdocosc cou Mscdcpsnciko Lvou
    Ayysiocsvovnc IA.M.L.A.l, odocdcvn, npddocdcvn, oudocdcvn, dvdocosc
    NMU-CoA reductase kdi onipovodkcvn.
    unspcutu: Tvdc syoc dpi0c dpdkooyikv kdi n-dpdkooyikv
    0spdnsiv sdpscdi yid cn scuon cnc sicoupydc cou svo0nou. hdp'd
    duc, cd dnocssodcd ndpdsvouv dsdid. |id co yo duc, xpnoionoiovcdi
    kivik dnossiysvsc 0spdnssc, yid cnv dvciscnion cuv opydvikv dv
    cnc svo0nidknc uosicoupydc.
    I26I
    NUINIkU OhMA10h AkUIN..A.I 8 OhMA10h
    AkUI.A.I 1h AIIkh hAIkIA
    Mnsptc| nntp|o, unuyspyou N|kuo
    kon: hAPUI|AIN kA|N|k0N86LPAhLJ|k0N LUMLN0N
    Anotsscutu: U L.A. dnocss id onvid kdcocdon os ndii. Iuykskpisvd o
    N.L.A. sdvscdi s ouxvcncd 1/20000 ysvvnosic vcuv kdi o L.A. cnc ndiiknc
    nikdc dvsi xpd os 0.6/100000 ndii scnouc. npxsi ioxupn ouoxscion s
    co o cou do0svoc, nou poksi cd kopcoid vd npooovcdi ouxvcspd dn
    cd dypid. kdi oi uo cnoi osovcdi, dsvc sv ocn pon kukoopovcuv
    ncpikv ducodvcioucuv, nuc cd anti-Po ISS-Al kdi anti-La ISS-8l oco N.L.A.
    kd0c kdi co dvcinupnviko dvcoud IANAl, anti-dsDNA, anti-Sm, anti-PNP, anti-
    PoISS-Al, anti-La ISS-8l ocov L.A. cnc ndiiknc nikdc, dscspou s os ouc nd-
    pyovcsc, nuc n ysvscikn npoi0son, n ioysvnc uvon, k.. yvuocd dcid.U
    N.L.A. sknvscdi ouvn0uc npokdvcdc ocs spdciksc sc Icndyysis-
    kcdosc, sdyxposic, iokosisc sv0nd, k.l kdi ocs kdpidksc sc,
    nndcoonnvosydd, nvsuovd, 0pookuconsvd. Iuvn0uc, oi sc ducsc
    svdi duconspiopisvsc, s sdpson cov kdpidk dnoksio Ib|ockl, nou oxs-
    cscdi kdi s syn 0vnccncd dkd kdi sc cnv scsuon ndcocn. U L.A.
    cnc ndiiknc nikdc npoosi nspioocspo co spd n nops vd sdvscdi s
    cn opn I.L.A. npooovcdc k0s opydvik oocnd,s ouxvcspd couc vs-
    poc,cic dp0posic kdi co dd. U N.L.A. sv dndics ouykskpisvn 0spdnsd. And-
    pdcncn kd0ocdcdi n scsuon ndcocn,cdv ouvunpxsi kdpidkc dno-
    ksioc. Icov L.A. cnc ndiiknc nikdc nopov vd xopnyn0ov kopcikoocsposi-
    n, conik kopcikoocsposin kdi dvoookdcdocdciko ndpyovcsc.
    unspcutu: hdp cn ondvicncd cuv vouv dndicovcdi kdcnoi xsipi-
    oo, ocs vd npon0ov n vd dvciscuniocov oi sknosic couc. hpoysvvn-
    cikc ssyxoc Iskcicdi ci 257 cuv snsvuv ysvvnosuv dn ncspd ndiio s
    N.L.A. 0d svdi npoosnsvscl, opooyiksc kdi kdpiooyiksc sscosic svs-
    kvuvcdi.
    I28I
    h M1AUh 1U IU PIv-1 AU 1h Mh1A 1U M8U
    ks|cupxkn A.
    N ndpood spydod svdi id dvdoknnon ocd oyxpovd sosvd kdi
    couc ndpyovcsc kivvou nou dopov cnv nspiysvvncikn scoon cou
    io N|v-1,n kdcdvnon cuv onouv svdi dvdykdd yid co oxsido vsuv
    nponncikv kdi 0spdnsucikv ndpsosuv yid co ndpdnvu ondvcik
    npond noidc uysdc, nou dnocss syn koivuvikn npocspdicn-
    cd.
    |k ku| s0oo|: Jpsxouod iioypdd ,dp0poypdd kdi idikcudkn
    idcpikn.
    Anotsscutu: N nspiysvvncikn scoon cou io kudvscdi dn 137-
    347 ocic dvsncuysvsc xpsc sv unooyscdi ypu oco 437 ocic dvd-
    ncuoosvsc xpsc. Iuvd s kiviksc, opooyiksc kdi iooyiksc spsu-
    vsc n scoon cou io dvsi xpd cooo kdc cov coksc, oo kdi kdc
    cnv svoncpid un kdi co 0ndo, s ouxvcspn cn scoon cou io
    kdc cov coksc I40-807l. hdpyovcsc nou oxscovcdi s dunsvo kvu-
    vo scoonc cou io dopov cn ncspd, co spuo, cov coksc, co 0n-
    do dd kdi cnv iidcspn dvooooyikn dnvcnon cou vsoyvo ocov i
    nou nops vd onynosi sxpi kdi os "dnoon" cnc ounc dn co
    vsoyv. Apksco dn couc ndpdnvu ndpyovcsc nopouv vd cpononoin-
    0ov ndpsnoovcdc cn scoon cnc voou oco spuo.
    unspcutu: N ouxvcspn scoon cou io kdc cov coksc os ouv-
    udo s couc cpononoinoiouc ndpyovcsc kivvou svdi sv0dppuvci-
    ksc yid cnv dvncun nponncikv kdi 0spdnsucikv ndpsosuv nou
    sociouv ocn suon cou ncpiko iikou opcou s xnsionpoudn,
    ocnv svoxuon cnc ncpiknc kdi vsoyviknc dvooooyiknc dnvcnonc kdi
    ocn suon cnc nspi- kdi cnc scd-ysvvnciknc sk0sonc ocov i.
    I27I
    OUIIkU 5UOOAAMU-NUkINIkh UOOAAMUAOIA
    A|ncn A0uvc|o
    kon tn spyucu: kdcdvnon cnc uoiooydc cuv 0upsosiikv op-
    ovv, cou nxdvioo nioupydc cou 0upsosiiko so0ou, skcs-
    cdsvn sscn cnc nd0ooydc kdi nd0ouoiooydc cnc svokpiviknc
    o0don0sidc, snsnynon cuv oyxpovuv s0uv cdivnonc cou
    so0ou kdi ndpouodon vsuv cpnuv ouvcnpnciknc kdi snsdciknc
    dvciscnionc.
    |k ku| s0oo|: Iyxpovsc sscsc nou sxouv npodcd nooisucs
    oco idkcuo kdi dopov ocnv dvoknnon kdi ounnpuon cuv sxpi
    ociync yvosuv nvu ocnv nd0ouoiooyd cnc svokpiviknc o0do-
    n0sidc Urave's, nn0uoidksc sscsc nou isnx0nodv oco sucspik
    kdi nooio ucoypdik uik dn snsosic kpdvioxsipoupyiknc yid
    cn ip0uon cnc o0diknc npncuonc.
    Anotsscutu: ikpion cnc nd0ooydc kdi cnc dvciscnionc cuv ouvn-
    0socspuv opv so0ou s dvcindpdon ocoixsuv yid idyvuoci-
    kn kdi 0spdnsucikn npoonsdon.
    unspcutu: U s0doc sdvscdi odv ysvikcspo oncud idc
    dvooioysvoc odc vooncuv, k0s id sk cuv onouv xpnsi ido-
    psciknc dvciscnionc, s npospxouod dpcncd kdi ouxvcncd n svo-
    kpivikn o0don0sid.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    197
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I29I
    h I10h 10N AUIM050N XIUIIkh Oh 4 XIUIIk
    kAINIk 1h kh1h
    Auc|0|tkn kctu, 1ousskn Apy0pn, 1c|yo0n tu|uv, kup|un
    Aouk, Ikku Ax|su*
    *Aoio(ioyoc Ln. kd0. ldzpiko zndzoc, dvsnioznou kpnznc
    ldzpikn Ixon Hpdksou, dvsnioznio kpnznc.
    kon: U unooyioc ocd0iosvuv sikcv snncuonc cuv Aoisuv
    Xsipoupyiknc 0sonc IAX6l sc dn kdiodpikn con, dp0pondocikn ioxou
    kdi yvdcoc kdi 3 siv snsosuv ysviknc xsipoupyiknc kdi n dioyn-
    on cuv ndpdyvcuv kivvou yid dvncun AX6, os voookosd cnc kpn-
    cnc.
    Ms0oooyu: hpooncikn svspyncikn sniniooyikn snicnpnon cuv do0s-
    vv nou unon0nkdv ocic ndpdnvu snsosic s onsvo spucnd-
    coyi o.
    Anotsscutu: kdcdypnkdv sosvd dn 225 xsipoupyiksc sns-
    osic I125 kdiodpiksc cosc, 21 dp0pondociksc ioxou, 14 dp0pondociksc
    yvdcoc, 34 xookuocskcosc, 28 ndociksc dnokdcdocosic ouuvokn-
    nc kdi 13 okunkosiskcoscl. N snncuon cnc AX6 ncdv 6,677 nou cdi-
    von0nks dvducikcspd os sninonc AX6 1,337, sv cu 0si AX6 4,07 kdi
    oun opyvuv xpuv 1,337. Lsyx0nkdv ouvoik 14 ndpyovcsc kiv-
    vou kdi ps0nks ocdciocik ondvcikn ouoxscion s cnv ndpcdon cnc
    nposyxsipnciknc ipksidc voonsdc.
    unspucu: Icic kiviksc nou sscn0nkdv n ipksid cnc voonsdc
    npiv dn cnv xsipoupyikn snsdon svdi douvn0iocd syn duvovcdc
    scoi cov kvuvo yid AX6.
    I30I
    M8UAIA
    kuno0poyou Ispy|o, 2o|n A0uvc|o
    kon tn spyucu: Msscn doikv dvooooyikv dpxv cou soid-
    oo, ouyksvcpuon kdi kdcnyopiononon uv cuv undpxvcuv souv,
    sscn ouv pokovcdi os nsipddcik ocio kdi cuv spsuvncikv npo-
    ond0siv yid cnv ndpdoksun vsuv souv. 6snods vd dnocss n
    spydod dc svdv ony yid co oicncn kdi co yidcp, dn cov onoo 0d
    nops vd dvcnosi nnpoopsc yid cd sid.
    |k ku| s0oo|: 8iioypdikn dvdncnon os sniocnoviksc iio0n-
    ksc, internet, npodcd nooisusvd p0pd os idcpik nspioik kdi
    snoksn os dpdksuciksc scdipsc ndpdoksunc souv.
    Anotsscutu: Ao kvous id ovcon dvdoknnon cnc iocopdc cuv
    souv, dvdspdocs ocic dvooooyiksc dpxsc cou soidoo ILvsp-
    yncikn kdi nd0ncikn dvood, dvooooyikn dnvcnon ocov soidol.
    Akoou0s dvdop cuv dvsni0ncuv svspysiv cou soidoo kdi
    cuv kupicspuv dvciyvuv nou xpnoionoiovcdi uc sid. Icn ouvs-
    xsid yvscdi id cdivnon cuv undpxvcuv souv ocic kdcnyopsc:
    Lfid yid ndii: ILio udcuonc, i0spcidc, Nndccidc 8,Ai-
    iou cnc ypnnnc, idpc, ndpuccidc, kokkcn, noiouscidc,spu-
    0pc, cscvou 8 dvsooyicl, Lfid yid svniksc: ILio ypnnnc,
    nvsuovikokkoul, Lfid yid osc siiko kivvou kdi siiksc yso-
    ypdiksc nspioxsc: ILio yid dsvo, v0pdkd, xospd, nndccid A,id-
    nuvikn syksdcid,nviyyicikokko, xospd, ood, syksdcid Jick-
    8orne, cuosin nupsc, kcpivo nupscl, Lnisysvd sfid yid zo s-
    ov: ILio yid cov kuccdposydo,sio uvcdvo io cnc ypn-
    nnc, N|v, yid cn voo cou Lyme, yid do0svsisc dn ndpoicd, yid pocdl.
    unspcutu: npxsi id syn noikid souv yid sc cic niksc
    kdi yid ssiiksusvsc nspincosic kdi siiksc ysuypdiksc nspioxsc, sv
    isyscdi spsuvd yid cnv ndpdoksun souv svvcid os do0svsisc, kdi-
    vopisc n n, nou docouv cnv dv0puncncd.
    I31I
    h XIUIIkh 1UN 19o AI0NA: h UIA U 1hN AI0h
    1h 0 I1hMh
    Mcous u0o, ksvtupxo Nunosv, Nov Asuvpo, ununntpou
    nntpu, 1cokn Op|vvu
    ldzpikn Ixon dvsnioznou A0nvov
    kon: N nspiypdn cuv ysyovcuv nou ouvscssodv ocnv dvncun cnc
    xsipoupyiknc kdi n dvdop cuv npuconopidkv s0uv nou sspdv
    v0non ocov cosd duc. N dnooxn kdi sdpoyn vscspuv s0uv
    dondc -dvciondc, kd0c kdi cnc dvdio0nodc s0sos cic osic yid cnv
    uononon nio nspnokuv xsipoupyikv snsosuv. N dvdiopyvuon
    kdi n dvd0ion cuv voookosidkv xpuv kdi n kd0ispuon cnc voon-
    suciknc iicncdc uc sndyysdcoc, onynos os dkn ouc couc cosc
    cnc xsipoupyiknc sniocnnc, dpxik ocnv |dd kdi snsicd ocnv Ayyd
    kdi cnv |spdvd. hpuconpoi idcpo 0ssuodv couc oyxpovouc cosc
    cnc xsipoupyiknc: 6updkoxsipoupyikn, kdpioxsipoupyikn, vsupoxsipoup-
    yikn, xsipoupyikn o0dooyd, yuvdikooyd-disucikn, ndocikn xsi-
    poupyikn, xsipoupyikn koiic, op0onsikn, ucopivodpuyyooyd kdi dy-
    ysioxsipoupyikn. Ui kdivocosc cou 2ou ioo cou 19ou divd niopyn-
    odv cic dndpdcncsc npono0sosic nou sspdv sndvocdon ocov 20o di-
    vd kdi kd0ispuodv cn xsipoupyikn uc dvdnondoco spoc cnc idcpiknc
    npdkciknc.
    I32I
    h U1UU0h 1h -UMU2IU OAAAAIMIA: NA UMNA
    IIA MIA UOA10 IAI1UMNh IAUkh, M IIU1h OIkh
    I1UIA, AOUINIA kAI kAINIkh IkUNA
    tsuvnouo nntpn, stpou kup|ko, kuoyspkn nntpn
    L0vik kdi kdnoiozpidk dvsnioznio A0nvov - ldzpikn Ixon.
    kon tn spyucu svdi n ndpouodon idc iidcspd svidspouodc
    sninoknc cnc -0ddoodidc, cnc oocsonpuonc, n onod cd cssucdd
    xpvid ndpouoiscdi os oosvd dudvsvo nooooc 0ddoodiikv
    do0svv. hpksicdi yid d idnocuon cuv cssucduv scv, nou sxsi npo-
    oskosi co svidspov nov spsuvncv, cd dnocssodcd cuv ss-
    cv cuv onouv ndpdc0svcdi kdi oxoiovcdi isoik. |idcspd covo-
    vcdi oi iidicspcncsc cnc "0ddoodiiknc oocsonpuonc" oov dop
    ocnv sniniooyd, ocn uoikn iocopd, ocnv nd0oysvsid kdi ocnv kivi-
    kn sikvd cnc voou, os oykpion s co oin nn0uo.
    |k-Ms0oo: N sknvion cnc spydodc dc doocnks os ocoixsd nou
    npokncouv dn cnv dvdoknnon oxsciknc snviknc kdi is0voc idcpi-
    knc iioypddc kdi dp0poypddc, dn cn idikcudkn idcpikn, sv s-
    ydoc ykoc nnpoopiv npospxscdi dn cic dvdkoivosic kdi cd npdkci-
    k uv cuv ndykoouv ouvspuv 0ddoodidc cnc cssucddc 8scdc.
    Anotsscutu: N oocsonsvd kdi n oocsonpuon ouykdcdsyovcdi nsov
    ocic doiksc sninoksc cnc 0ddoodidc, snnpsovcdc ondvcik cnv noi-
    cncd unc cuv do0svv. Moovci no onsd cnc oociknc voou oun-
    ncouv s nn yvuoc sosvd, n oocsonpuon ocouc 0ddoodiikoc
    sdvsi nosc iidicspcncsc: Ldvscdi s ondvcik unn snncuon,
    os vsdpn nikd Ioocsonsvd dkn kdi os cod kcu cuv 20 scvl, oxsv
    soou kdi ocd o d kdi dop kupuc ocn onovuikn ocnn kdi oco
    ioxo. hd0oysvscik ouoxscscdi kupuc s svokpivooyik npondcd
    nuc o unoyovdioc, o I.., o uno0upsosiioc, kdi o unondpd0upsosiio-
    c, d kdi s cnv diooinpuon, cnv iiond0n dosocoupd kdi cic xdn-
    sc cisc Nb nou ouvosouv cn voo. Lnonc, uc svd d0 ouscsxouv
    kdi ysvsciko ndopyovcsc. Akn uc kdi n kivikn sikvd svdi iiou-
    od, kd0c cd oocsonopucik kdcydcd kdi co svcovo yoc ndpouoio-
    vcdi dpksc onvid ocnv kdcnyopd ducn cuv do0svv. Jsoc, yvscdi dvd-
    op os ouykskpisvsc kiviksc spsuvsc Lnvuv kdi Lupunduv Msooysio-
    yuv, d kdi ocn iyvuon kdi ocn 0spdnsd cnc oocsonpuonc, nuc
    ducsc idopvovcdi sod dn co npod cnc 0ddoodidc.
    unspcutu: N -ouyoc 0ddoodid, s cov ouvsxc dudvsvo
    soo po nikdc cuv do0svv, svdi d vooc nou idpkc ssooscdi
    kdi ouxvcdcd dc sknnoosi. Junik ndpsiyd dnocss n xdpdkcnpioci-
    kn sninokn cnc oocsonpuonc, cnc onodc n ispsvnon sxsi svcd0s
    ondvcik kdc cnv cssucdd skdscd spvovcdc oco uc vsd sosvd.
    198
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I33I
    ANUUAOUIN1IkUI MhXANIMUI 1U AkXA0h IA8h1h 1U-I:
    INIkh ANAA1Ikh UIIIh M 8Ah 1A NU1A UMNA
    tsuvnouo nntpn, kuoyspkn nntpn, stpou kup|ko,
    Avuyvctono0ou Mupu
    L0vik kdi kdnoiozpidk dvsnioznio A0nvov - ldzpikn Ixon.
    kon tn spyucu: Avducikn nspiypdn cuv ducovoouv nxdviov
    nou ouscsxouv ocnv nd0oysvsid cou odkxdpn idncn cnou | I|DDM-
    1l, nuc duco idopvovcdi sod dn cd cssucdd spsuvncik kdi
    kivik sosvd. Ixndcik idkpvous 6 ocid dvncunc cnc voou
    kdi ndpouoious isoik cd ysyovcd nou skcuooovcdi os k0s oc-
    io.
    |k-Ms0oo: hpdydconoin0nks dvdoknnon cnc oxsciknc snviknc
    kdi svnc dp0poypddc kdi iioypddc cnc cssucddc sncdscdc. Ind-
    vciksc snonc nnpoopsc dvcn0nkdv dn co uik siikv svokpivo-
    oyi kv-i dncooyi kv i s0vv ouvsp uv, nou npdydconoi n0nkdv
    kdc cnv id xpovikn nspoo.
    Anotsscutu: Jd npodcd sosvd kdcdcooouv cov |DDM-1 dvd-
    od nsov ocnv kdcnyopd cuv ducovoouv vooncuv. N sykdcocdon
    cnc voou, npono0scsi: Idl Iuvsxn ndpdovn cou skuciko-npoknci-
    ko dicou s dnocssod ouvsxn sk0son ducodvciyvuv ocd dvoookdv
    kccdpd, Il Aouon snicnuv cuv ducodvciyvuv kdi Iyl Avdcponn cnc
    iooppondc cnc dvoxnc ducodvciyvuv.
    Lou, cd ocid dvncunc cnc voou, dkoou0ov oxndcik cnv snc
    osip: I1l |svscikn sudio0nod, xupc pdocikn ducodvood: hpooiops-
    cdi dkpisocspd o poc "idncoyvuv" yvuv, oxsciosvuv unosin-
    svuv yvuv n suoyvuv, kd0c kdi cuv dvciyvuv DP3 kdi DP4. I2l
    Lkucik snsioid. Avdspovcdi oi oi sxpi onspd yvuoco skuciko
    ndpyovcsc kdi o nxdvioc npknonc cnc voou. I3l N ndpouod pd-
    ociknc ducodvoodc s uoiooyikn skkpion ivoouvnc. hn0uoo du-
    codvcioucuv ICF|CA, |CSA, kuccdpocoik svdvci cuv vnoiidkv kucc-
    puv, |AA |gU cnoul kdi vsd ocoixsd yid cic oxscisvsc s ducoc id-
    yvuociksc okidosc. I4l hpoosucikn kdcdocpon cuv -kuccpuv s
    suon cnc skkpionc ivoouvnc. Iuscoxn cnc kuccdpiknc kdi cnc xui-
    knc dvoodc. I5l kivik sknoc idncnc. I6l hnpnc kdcdocpon -kuc-
    cpuv kdi dnoppsouod ndvcsnc ssin ndpdyuync C-nsnciuv.
    unspcutu: U |DDM-1 nn dn cd sod cnc skdscdc cou `60 ouoxsc-
    o0nks s ducovoosc ispydosc. Inspd, n op0cncd cnc dnsuc ducnc
    0supscdi didioncncn, sv oi vscspsc sscsc isioouv o kdi
    d0cspd ocouc dvooo-nd0oysvscikoc nxdviooc cnc voou, spvo-
    vcdc oco uc sdipscik svidspovcd ocoixsd s sod npdkcikn ond-
    od os idyvuocik kdi 0spdnsucik snnso.
    I34I
    M1A8UAIMU/AXAkIA - ANUUUIh1IkU 1hMA -
    NUAIIIUINh: 1A 1IA IA Ah 1h A1INh
    tsuvnouo nntpn, kuoyspkn nntpn, stpou kup|ko,
    Avuyvctono0ou Mupu
    L0vik kdi kdnoiozpidk dvsnioznio A0nvov - ldzpikn Ixon.
    kon tn spyucu: Icnv ndpood spydod dvdous cic iooyiksc
    posic cnc sncvnc, kd0c kdi couc nxdviooc s couc onoouc n op-
    vn ducn oxscscdi s opiosvsc nd0ooyiksc kdcdocosic. |idcspd
    covscdi co ysyovc ci n sncvn s ouvsscdi dnoksiocik kdi vo s
    cnv ndxuodpkd, nuc niocsucdv sxpi kdi co csoc cnc skdscdc cou'90,
    d kdi s sc sicoupysc, nuc dnosikvouv npodcsc sscsc.
    |k-Ms0oo: Ui nnpoopsc nou dvdspovcdi ocnv spydod dc, nposp-
    xovcdi dn dvdoknnon cnc snviknc kdi is0voc idcpiknc dp0poypd-
    dc kdi iioypddc cnc cssucddc nsvcdscdc, dn cn idikcudkn id-
    cpikn, d kdi dn cn ouvspydod dc s cnv |dcp kd kdpn Avcuvd, n
    ouvpon cnc onodc unnps nocin.
    Anotsscutu: N sncvn svdi d ouod nou ndpyscdi oco inn ioc
    kdi syivs yvuocn co 1995, yid cn pon cnc ocov uno0do Idvopsioy-
    voc ponl, kd0c kdi yid cnv ndpsdon cnc ocn p0ion cou svspysid-
    ko ioouyou snicdxvovcdc co scdoio kdi duvovcdc cnv kdcdv-
    uon svspysidc. Ms ducv cov cpno 0supn0nks uc opvn nou npou-
    oosi dn cnv ndxuodpkd Idivsvo sncivo-dvcoxnc.l Lkcc uc dn
    cd dvucspu ocoixsd syivs yvuoc ci yid cn vsd ducn ouod unpxouv
    unooxsc kdi os nooc ouc iococ, nuc svdi cd vsodvdncuoos-
    vd cpixosin Isndyuyn vsodyysioysvsoncl kdi kccdpd cou dvooonoinci-
    ko ouocndcoc Inodndoidoc, idopononon, svspyononon, ku-
    puc cuv J-sokuccpuvl. Lninsov dvscdi vd nspiopsi cn pon cnc
    svoysvoc ivoouvnc Ioxscikc d0c ivoouivodvcoxnc - unspivoou-
    ivdidc - odkxdpnc idncnc cnou-||l. Lvdi oinv npodvnc n kivi-
    kn ondod ducv cuv supncuv, iidcspd iocd os 0spdnsucik sn-
    nso. Jsoc, skcc dn cnv ndpouodon uv cuv sxpi onspd yvuocv
    nxdviov posuc cnc sncvnc ocd iopd kccdpd-ocxouc, yvscdi
    dvdop ocic oxsciksc s ducnv spsuvsc nou supsuc dvouv xpd,
    ocd sxpi ociync dnocssodcd kdi ocic npoooksc nou sxous dn cic
    sscsc ducsc.
    unspcutu: N vso-dvdkdu0nod opvn sncvn, sxvsi vd idpd-
    dcsi nspioocspouc dn svdv ondvcikoc pouc ocov dv0pnivo op-
    ydvio. Nscspd sosvd cn 0souv vd unsiospxscdi os o kdi nspio-
    ocspsc uoiooyiksc sicoupysc n nd0ooyiksc kdcdocosic, ysovcdc
    s dioiood yidcpoc idpuv siikocncuv yid cn sovcikn 0spdnsd
    svc syou dpi0o vooncuv. Lvcocoic, oi npoooksc dc dn cic
    oxsciksc sssic npsnsi vd isnovcdi dn sscposnsid.
    I35I
    IXUNh NUkINUAUIIkh UIIIh 1h AXAkIA:
    UI NUkINIk IA1AAX 0 AI1IA 1h AXAkIA,
    AAAA kAI 0 AOUOIUAUIIkA AkUAUOA 1h NUU
    tsuvnouo nntpn, stpou kup|ko, kuoyspkn nntpn,
    Avuyvctono0ou Mupu
    L0vik kdi kdnoiozpidk dvsnioznio A0nvov - ldzpikn Ixon.
    kon tn spyucu: Icnv ndpood spydod npoosyyous cnv noundpdyovci-
    kn voo cnc ndxuodpkdc dn cnv oncikn yuvd cnc oyxpovnc Lvokpivooydc s
    okon vd kdcdsous noo ocsv ouoxscscdi o koc ducc cnc idcpiknc s cn
    ouykskpisvn vooooyikn ovccncd, coo os snnso diciond0oysvsidc oo kdi os
    snnso nd0ouoiooyikv sndkoo0uv.
    |k-Ms0oo: |id cn isknspduon cnc spydodc dc doiocnkds os nnpoo-
    psc npospxsvsc dn dvdoknnon cnc oyxpovnc idcpiknc dp0poypddc, dn
    ssiiksusvn iioypdd, kd0c kdi dn is0vsc ndvsniocnidkoc idikcud-
    koc cnouc. Lou, iidcspd nocin oc0nks n ouvspydod dc s cn i-
    kcupd cou hdvsniocnou A0nvv, Lvokpivoyo kd Poncn L., d kdi s cov
    Lvokpivoyo-idcpooyo kovAvpvn Xp.,oi onooi dc ndpsxdv uik nposp-
    xsvo dn cic nio npodcsc is0vsc, kiviksc kdi spydocnpidksc sscsc sn cou
    0sdcoc.
    Anotsscutu: N ndxuodpkd dnocss dvcikssvo sscnc cnc Lvokpivoo-
    ydc os o doikoc cosic: IAl Icov cosd cnc diciond0oysvsidc cnc voou,
    nou opiosvsc svokpiviksc n vsupo-svokpiviksc idcdpdxsc dvscdi ci ou-
    oxscovcdi diciooyik s cnv dvncun cnc ndxuodpkdc. Iuykskpisvd, dvd-
    scdi o poc cuv uno0ddikv ksvcpuv cou kopsoo kdi cnc nsvdc kdi nc
    duc scdouv cn sicoupyd couc kcu dn cnv snpdon cnc yuknc, cnc
    ivoouvnc, cuv kdcsxodivv, cnc sncvnc, cuv kopcikosiv kdi uv ou-
    oiv. Lninsov, diyc svokpivik voondcd sninskovcdi s cnv dvncun cnc
    ndxuodpkdc, n onod iocd ouxv dvsi iidcspouc xdpdkcnpsc II. Cush-
    ing, no0upsosiioc, noyovdioc, no0ddik voondcd, Avsnpksid UN
    k.dl I8l Icov cosd cuv sninokv nou sdvovcdi os do0svsc s unspov
    poc. L dvdspous couc nxdviooc sod dn couc onoouc iidcspd sv-
    okpivooyik npondcd ndpouoiovcdi os ondvcik dpi0 ndxuopkuv.
    Upiosvd dn duc svdi n idcdpdxn ocnv ndpdyuyn kdi oco scdoio cuv
    uscikv opovv, idcdpdxsc cnc snvou posuc, n sccuon cnc UN, n
    dvcocdon ocnv ivoouvn, o unspivoouivioc, n uodvoxn ocn yukn kdi co
    ovpoo Peaven.
    unspcutu: Icd ndoid cnc noundpdyovciknc nd0oysvsidc cnc ndxuodpkdc,
    ondvcik spio kdcddvouv nosc svokpiviksc kdi vsuposvokpiviksc
    idcdpdxsc, oi onosc pouv diyc diciooyik yid cn voo ducn. An cnv n
    spi, nn0oc svokpivikv dvudiv sxsi dnosixcs ci osovcdi ocnv ndxu-
    odpkd, sv svd ikpcspo spoc ducv pouv ocs diciooyik kdi ocs
    sdvovcdi uc sndkou0d cnc voou.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    199
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I39I
    h M1AIMA1Ikh kA1A1Ah kAI h kAIAIIIAkh NUU:
    X1Ih M 1U AkXA0h IA8h1h
    Avuyvctono0ou Mupu, tsuvnouo nntpn, stpou kup|ko,
    kuoyspkn nntpn
    L.k.dvsnioznio A0nvov - ldzpikn Ixon.
    Iuvsxc duvscdi o dpi0c cuv dnocssocuv nou dnosikvouv ci n
    scdysudcikn kdcocdon svdi svdc ondvcikc ndpyovcdc nou ouvcs-
    s ocnv dvncun cnc d0npooknpuvonc. Icic nspincosic n ndpnc
    odkxdpn idncn, oi ndpyovcsc kivvou yid dvncun d0npookn-
    puvonc, oi onooi nspidvouv cd snnsd cuv iniuv, co oocnd
    nnnc cou ddcoc kdi co svo0nidk oocnd, nopov vd cpononoin-
    0ov kdc cn scdysudcikn kdcocdon. N ndpdyuyn idc osiuciknc
    svcdonc svdi o nio koivc poc id soou cou onoou n cpon nops
    vd snispsi ducsc cic scdosc. Icouc do0svsc s odkxdpn idncn
    duc cd divsvd nopov vd snyn0ov dn cn scdysudcikn unsp-
    yukdi d.
    I37I
    1A AXIUNA 8AA1IkA INNh1IkA k11AA
    kuno0poyou Ispy|o
    kon tn spyucu: Iuyksvcpuon cssucduv iioypdikv sos-
    vuv nvu ocd Apxsyovd 8docik |svvncik kccdpd kdi svssxnc ss-
    cn cou kkou unc kdi cuv sicoupyiv couc ocd dv0pnivd spud.
    |k ku| s0oo|: 8iioypdikn dvdncnon os sniocnoviksc iio0n-
    ksc, internet, npodcd nooisusvd p0pd os idcpik kdi iooyik
    nspioik.
    Anotsscutu: Apxik, yvscdi kd0opioc cnc npossuonc cuv Apxsyo-
    vuv 8docikv |svvncikv kuccpuv kdi id dvdoknnon cou kkou unc
    couc, sxpi cnv scdcponn couc os pid ysvvncik kccdpd coo oco
    ppsv oo kdi oco 0nu. Icn ouvsxsid snyscdi o nouvdoc xdpdkcn-
    pdc couc sou sscnc cnc kdcocdonc s0uuonc cuv yoviuv couc.
    Tnsicd yvscdi dvdop ocnv nopsd kdi cic osic scdvocsuonc couc
    dn cnv sniocn uc cic ysvvnciksc dkpoosc. kdc cn scdvdocsucikn
    couc nopsd sscvcdi oi scdosc cnc npooknonc couc os pid
    cnc Lukuccpidc 6ssidc Uuodc, oi scd couc dnsniposic kdi n
    cdxcncd scdvocsuonc couc ocic iopsc osic, kd0c kdi oi io-
    psc csxviksc dnsikvionc couc. Jsoc, yvscdi dvdop ocnv sykdcocdon
    couc ocic ysvvnciksc dkpoosc kd0c kdi ocic dvudsc nou npok-
    ncouv cdv cd Apxsyovd 8docik |svvncik kccdpd sykdcdocd0ov dn
    0oc os suyovdiksc 0sosic.
    unspcutu: Jd Apxsyovd 8docik |svvncik kccdpd idpddcouv
    cov kpio po kdc cd npid ocid cnc spuiknc unc yid cnv odn
    dvncun cuv ydscv. Lnonc, dnocsov svd svidspov nso yid sv-
    ssxsocspn spsuvd.
    I36I
    ANUIk1A kA1AIMA1A
    Mupt|vuo Avpsu, Xutn0sopou Ospo, Mnsn Ivvn, Mtcn
    uct0|o, 1kn Avuctc|o
    hdp cic npoouc nou sxouv onsiu0s ocnv dvciscnion cuv kdcdy-
    cuv, cd dvoikc kdcydcd ndpdsvouv svd oodp npnd ocnv kd0n-
    spivn op0ondiikn npn. N ouvsxnc dnon cuv kdkosuv unnc svsp-
    ysidc cd cssucdd scn kdi n ssin ocnv dvciscnion cuv noucpdud-
    civ scscpss cov dpxik ocxo cnc dvciscnionc cuv dvoikcv kdcdy-
    cuv nou ncdv n iouon cnc unc cou do0svoc. Inspd ocxoc cnc
    dvciscnionc svdi n ovcon dvkcnon cnc nnpouc sicoupyikcncdc
    cou cpdudcio0svcoc oksouc. |id vd sxous svd kd dnocssod, cd
    dvoixc kdcydcd npsnsi vd dvciscuniocov dpxik ocov cno cou dcu-
    xndcoc kdi vd dkoou0nosi sykdipn scdop oco ksvcpo dvciscnionc
    yid cnv opiocikn 0spdnsd. N dnoocsipusvn snson kdi n npooupivn dki-
    vncononon cou kdcydcoc ocov cno cou dcuxndcoc dvscdi vd nd-
    ouv kd0opiocik po ocnv nopsd cuv dvoikcv kdcdycuv. Ui nxdvi-
    ksc nosic kdi o skcsvnc xsipoupyikc kd0dpioc, n sykdipn dvciscni-
    on ni0dvv dyysidkv dv, n ocd0spononon cou kdcydcoc kd0c
    kdi n npnn cnc syovnc svdi oi doiksc dpxsc cnc svovoookosid-
    knc povcdc cuv diouvdik ocd0spv do0svv s dvoikc kdcyd-
    cd.
    I38I
    1U5IkUAUIIkA UMNA O1UU1A11Ik0N OAMAk0N
    ouspnouo uyyso, sp|k Otn, kuntuvn upvto
    ldzpikn Ixon L.k..A.
    kon: N ndpoxn siodyuyikv yvosuv oov dop ocd ucopdkd-
    uconpoocdcsucik oksuodcd kdi n dvdoknnon sniniooyikv s-
    osvuv, oxscik s nncnpiosic dn uconpoocdcsucik pdkd nou
    dopov cnv Ld.
    |k ku| s0oo|: Tyivs dvdoknnon cuv cpsxovcuv sosvuv, d
    kdi xpnoiononon kd0ispusvuv nnyv, nuc ouyypdcuv coikoo-
    ydc. Msscn0nks snonc co dpxso cou ksvcpou nncnpiosuv INoo. hd-
    uv h. 8 A. kupidkol.
    Anotsscutu-unspcutu: N nioupyd svc dksou yid svd uco-
    pdko npsnsi vd nspidvsi cd snc ocoixsd: dl cnv cduccncd cnc
    ouodc, l cic uoikoxniksc iicncsc cnc, yl cn iooyikn cnc pon, l
    s0ouc dvuonc, sl sscsc coikokivnciknc kdi coikcncdc ocov v-
    0puno kdi cd 0ndocik, ocl ssyxo unosicuv, l ounspiop oco
    nspiov, nl oikocoikooyiksc sscsc. Icnv Ld ocd csn cnc s-
    kdscdc cou '80 sxds id k0scn ncon cou nooooco nncnpiosuv
    dn uconpoocdcsucik pdkd. Jo nooooc duc svdi nsov 3,267
    oco ovoo cuv nncnpiosuv cnc xpdc I2001-o sooc poc ocd 25 xp-
    vid sicoupydc cou ksvcpou nncnpiosuv svdi 4,17l kdi n nsiond
    cuv nncnpiosuv osscdi os opydvouoopik, dkoou0osvd dn
    inodcd kdi idviokcvd.
    200
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I40I
    AIkU8Ak1hIIU 1U A0U
    Mukpunu ou
    kon tn spyucu: N sscn cnc onc, cou scdoioo kdi cnc nd0oyvou
    ponc cou N.py|ori, o poc cou oco ydocpouskddkcuik skoc kdi ocn ysvs-
    on cou ydocpiko kdpkvou, n iyvuon cnc ounc dn duc kdi oi oyxpovsc
    0spdnssc skpuonc cou.
    |k ku| s0oo|: Xpnoionoin0nks n cpsxouod snvikn kdi svn iioypdd,
    npdkcik ouvspuv, p0pd dn sniocnovik nspioik kdi sikovoypdik uik
    dn idikcudkoc cnouc.
    Anotsscutu: hpksicdi yid gram dpvncik ikpodspio dkcnpio sync ys-
    vsciknc scspoysvsidc. Mscdscdi sou cnc ocodcoocodciknc n cnc konpdvo-
    ocodciknc oo. N ikdvcncd dnoknonc cou ocoxou dnoscdi ocnv svcovn
    kivncikcnc cou, ocnv conikn dnon cou pN Ioupsonl, ocnv dvcocdon ocn
    dyokuccpuon kdi ocnv ndpdyuyn opuv npooknonc. Ms dvciyovik sps0i-
    o snysi skkpion ididocv kdi csik syovn cou sni0nou kdi cou xopou
    Iydocpcid kdi skocl, nspioocspo svcovn oco vcpo. Lninsov npokds sv-
    voyovikn kdcdocpon sou cnc dnssu0spuonc opuv, nuc ss0spsc psc ou-
    yvou, NU, kuccdpocovsc kdi uooinosc. Jnv dpxikn dcpod idsxscdi svcs-
    pikn scdndod. U dpxikc ssyxoc uonsnciko do0svn yvscdi s dvddkcn s-
    0oo n.x. okidod oupdc ocnv dvdnvon n ssyxoc dvciyovikcncdc konpvuv. Is
    svooknnon unoovcdi ooi sv dvcdnokpvovcdi os xopnyn0sod dyuyn n
    unocponiouv cdxcdcd sc cn idkonn cnc. N 0spdnsd skoync svdi o ouvud-
    oc svc dvdocosd cnc dvcdc npucovuv s uo dvciiocik Ikdpi0poukvn
    n doukivnl uo opsc cnv nspd yid id couxiocov sod.
    unspcutu: N ouxvcncd dvxvsuonc cou snikvuvou N.py|ori ndpdsvsi un-
    n, uc pokscdi os ncucikn nopsd yu scuonc cuv ouv0nkv uyisivnc. N
    dnocuxd skpuonc dnoscdi kupuc ocnv dvncun dvcoxnc. Ui csxviksc opid-
    knc iooydc dvdsvscdi vd dionoinoouv vsouc 0spdnsucikoc ndpyovcsc nuc
    dvdocosc nxdviov npooknonc, xnsiocddc, oupsonc k.c..
    I41I
    Mh M8A1IkU MhXANIkU AIMU
    koc Xpncto, kunoupn tu|uv, 8ovkn uvoun, Apuvtn
    Ivvn, unuono0ou Xupuunu
    kon: Ikonc ducnc cnc spydodc svdi n ndpouodon cou n snsdciko nxd-
    viko dspioo uc oyxpovnc s0ou unoon0nonc cnc dvdnvonc, n kdcsin
    cuv nsovskcncuv cou, kd0c kdi n ispsvnon cuv kdcdocosuv sksvuv ocic
    onosc kcu dno cic kdcnsc npono0sosic nops vd xpnoionoin0s.
    |k-Ms0oo|: |id cnv nnpn skncun cnc spsuvc dc xpnoionoinods oyxpo-
    vn iioypdd kdi dp0poypdd dn sykupd idcpik nspioik kd0c kdi nnysc
    cou idikcou.
    Anotsscutu: Jo kpio nsovskcnd cou n snsdciko nxdviko ds-
    pioo svdi n dnouyn cnc idounvuonc n onod oxscscdi s nosc
    sninoksc nuc cpdudciooc cou ocdcoc, cou puyyd, cou puyyd,
    cuv uvncikv xopv. Akn n idounvuon isukovsi cnv svion
    svovoookosidknc nvsuovdc kdi ndpnd npokds uoopd kdi
    yxoc ocov do0svn o onooc duvdcs vd inosi kdi vd cpds.
    idniocods cnv ndpn ouykskpisvuv kdcdocosuv-svssuv ocic
    onosc nops vd sdpoocs kd0c kdi cd kpicnpid nou npsnsi vd nnpo-
    vcdi dvd nspncuon.
    * kdc' dpxnv 0supscdi 0spdnsd skoync yid co ovpoo nvoidc ocov
    nvo nou n sdpoyn ouvsxoc 0sciknc nsonc ICPAPl kdcd cnv ip-
    ksid cnc vxcdc ocd0sponois cnv iddccncd cou puyyd.
    * Lnonc svskvucdi os dvudsc cou 0updkiko coixdcoc nou ku-
    pdpxn 0son sxsi n kuookouon.
    * Ldipscikn xpnoicncd sxsi ocnv unoon0non cnc dvdnvonc os vsu-
    pouk voondcd, nuc ocnv nououscid, cn oupiyyousd, cnv
    nyid udcpoikn oknpuvon, k.d.
    * An id svsin svdi n xpvid dnopdkcikn nvsuovon0sid IXAhl
    nou onspd sdpscdi kdc'okov yid ysc psc nspnouc ocov
    nvo, os ouvido s cnv ouvcnpncikn 0spdnsd, scivovcdc ond-
    vcik cd dnocssodcd.
    * Jd cssucdd xpvid sxsi dpxosi vd xpnoionoiscdi snicuxc, os sni-
    sysvouc do0svsc s osd dvdnvsuocikn dvsnpksid.
    * Lninsov xpnoionoiscdi ocov dnoyddkcio dno cov dvdnvsuocn-
    pd Iweaningl, ocs vd nscxous cdxcspn kdi dodsocspn soo
    dno cov dvdnvsuocnpd.
    unspcutu: U n snsdcikc nxdvikc dspioc dnocss id oy-
    xpovn s0oo unoon0nonc cnc dvdnvonc s iycspsc dvsni0ncsc svsp-
    ysisc kdi dnossiysvn xpnoicncd os id osip kdcdocosuv sni-
    puvonc cnc dvdnvsuociknc sicoupydc. N xpnon cou dvdsvscdi vd sns-
    kcd0s cd snsvd xpvid kdi os sc dvoysc kdcdocosic.
    I42I
    IAOIM UkIMAI IIA 1UN AIXU 1h IXU
    10N ANAN1Ik0N M0N
    8ovkn uvoun, Apuvtn Ivvn, koc Xpncto, kunoupn tu-
    |uv, unuono0ou Xupuunu
    kon: Ikonc cnc spydodc svdi n nspiypdn s0uv ssyxou cnc ioxoc
    cuv dvdnvsuocikv uv. N sicoupyikn kdcocdon cuv dvdnvsuocikv
    uv kdi n yvon cnc svdi no ondvciksc os vsupouksc nd0nosic scs
    yid cn iyvuon, scs yid cnv ndpdkoo0non cnc ssinc couc. Lnonc
    xpnoissi ocnv nposyxsipncikn skcnon cnc sicoupydc cnc dvdnvsu-
    ociknc dvcdc, kd0c kdi ocd ndoid ndpdkoo0nonc voonsuosvuv
    os ML6.
    |k-Ms0oo|: |id cnv spydod xpnononoin0nks uik dn noois-
    osic spsuvncv os idcpik nspioik kdi dvcocoixn iioypdd.
    Anotsscutu: N ioxc cuv dvdnvsuocikv uv nops vd skcin0s s
    cov sicouyik ssyxo cnc dvdnvonc, dnsc, npoxupnsvsc, kd0c kdi s
    dnsikoviociksc okidosc.
    Is ci dop co sicoupyik ssyxo cnc dvdnvonc n xdnn ucikn xupn-
    cikcncd IvCl, xdnn oikn nvsuovikn xupncikcncd IJLCl, n dnon
    cou unosinsvou ykou IPvl, nopov vd ouv cnv unod duvd-
    dc cuv dvdnvsuocikv uv.
    Ui dnsikoviociksc okidosc nspidvouv cnv dkcivoypdd 0pdkoc,
    ocnv onod nops vd ndpdcnpn0s vooc cou svc n kdi cuv o niidpdy-
    cuv, kd0c kdi cnv skcnon cnc kivncikcncdc cou idpydcoc kdc cnv dvd-
    nvon s cnv ouon cnc dkcivooknnonc kdi cuv unspnxuv.
    Icic dnsc okidosc kdcdcooovcdi n scpnon cnc syiocnc ocdciknc
    sionvsuociknc IM|Pl kdi sknvsuociknc IMLPl ocodciknc nsonc, s0ooi
    n snsdciksc.
    Ui npoxupnsvsc okidosc dnocsov s0ouc nio ov0scsc kdi sns-
    dciksc. U ssyxoc yvscdi kdc cn ipksid dnconc sionvonc dn cn
    cn Iokidod Sniffl. Is ducnv scpvcdi n pivikn ISN|Pl, ocodcikn ISn-
    iffPmol kd0c snonc n oioodyikn ISniffPoesl kdi ydocpikn ISniffPgasl
    nson. An cic o cssucdsc unooyscdi n ididpdydcikn nson
    ISniffPdil. N idididpdydcikn nson IPdil unooyscdi kdi kdc cn
    syiocn sionvsuocikn n sknvsuocikn npoon0sid svdvci dnopdysvou
    dspdyuyo IPdimaxl. Lkcc ducv uc unpxouv s0ooi nou sv dndi-
    cov cn ouvspydod cou do0svoc. Aucsc svdi o nskcpikc n dyvncikc
    sps0ioc cou psviko vspou kdi n scpnon cnc ndpdysvnc s ducv
    co cpno Pdi.
    Jsoc kdi n sscn cnc kivncikcncdc cou 0updkiko coixdcoc nops vd
    osi dpkscsc nnpoopsc yid cn sicoupyd cuv dvdnvsuocikv uv.
    unspcutu: Iunspdodcik yid cov ssyxo do0svv s dvsnyncn
    onvoid svskvucdi npoosyyion s okidosc dudvsvnc nouno-
    kcncdc, sv yid cnv ndpdkoo0non do0svv s ssioosvd vsupo-
    uk npondcd npocivcdi oi dnsc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    201
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I43I
    NMUNIkh 1Ah
    upucksukou Ispyu, Xutnuxup| N|kuo, Isvvnut ou-Avt|nn,
    Mvtupn |pnvn
    kon tn spyucu svdi n ndpouodon vsuv sosvuv cnc nd0oys-
    vsidc, idyvuociknc npoosyyionc kdi 0spdnsdc cnc nvsuoviknc unspcdonc.
    N nvsuovikn dpcnpidkn unspcdon svdi id diouvdikn dvudd nou
    csik onys oco 0vdco yu sic kdpidknc dvsnpksidc. N npuco-
    nd0nc opn cnc voou s yvuocn diciooyd npsnsi vd idxupscdi
    dn cn opn sksvn nou npokncsi sucspond0c yu nvsuovikv kdi
    sunvsuovikv idcdpdxv. N nd0ooyik dunsvn nvsuovikn dpcn-
    pidkn nson kdi nvsuovikn dyysidkn dvcocdon dnocsov cd doik xd-
    pdkcnpiocik yvupodcd ducnc cnc voou. Akn xdpdkcnpscdi dn cnv
    dvdidpuon cou coixdcoc cuv dyysuv nou dnoscdi sv spsi ocnv
    dnon cnc nvsuoviknc dyysidknc dvcocdonc Lnonc oi idcdpdxsc cnc
    conc cou ouyvou ocd cpixosin, cnc sicoupydc cuv iovcikv iduv
    d kdi cnc ov0sonc cuv conikv dyysiopdocikv ndpdyvcuv ocouc
    nvsovsc nopov vd ououv ocnv nd0oysvsid cnc nvsuoviknc
    unspcdonc. hpodcd, scdsic ocd yovid 8MPP2 kdi ALk-1 sxouv
    dvdkdu0s os do0svsc s npucond0n nvsuovikn unspcdon. Auc cd
    yovid dnocsov sn cnc unspoikoysvsidc cou JUF- unooxsd kdi n
    dkspdicncd couc svdi ondvcikn yid cn idcnpnon svc uoiooyiko
    nvsuoviko cvou kdi onc. kivik n nvsuovikn unspcdon dpxik
    sdvscdi s n siik ouncdcd, nuc onvoid, ocn0dyxik svo-
    xndcd kdi onsd sic kdpidknc dvsnpksidc. N oyxpovn 0spdnsu-
    cikn npoosyyion cnc nvsuoviknc unspcdonc kupuc nspidvsi nspiopi-
    o cnc uoiknc pdocnpicncdc, dkpc ipksidc dvcinnkcikn 0spdnsd
    kdi 0spdnsd s dyysioidocdcikoc ndpyovcsc. Ui dvdocosc iduv
    dosocou svdi n nio dnocssodcikn dkpc ipksidc 0spdnsd s co vd
    scivsi cd ouncdcd kdi cnv diouvdikn kdcocdon ocouc do0s-
    vsc s npucond0n nvsuovikn unspcdon. N kdcspn kdcdvnon cnc nd-
    0oysvsidc cnc nvsuoviknc unspcdonc sxsi uc dnocssod cnv dioyn-
    on ndpdyvcuv, nuc oi npoocdydvsc, nou nopov vd dvdocpsouv
    cnv unspndod cuv nvsuovikv dyysidkv kuccpuv kdi vd onynoouv
    ocnv onio0oxpnon cnc nvsuoviknc dyysidknc unspcpodc kdi dvdid-
    puonc. N dkpc ipksidc 0spdnsd s snonpoocsvn Inpoocdyd-
    vn |2 n npoocdkukvnl scivsi cn uvdccncd oknonc, cnv diou-
    vdikn kdcocdon kdi cnv sniuon ocouc nspioocspouc do0svsc s npu-
    cond0n nvsuovikn unspcdon. hdpd duc, os do0svsc s oodpn nvsu-
    ovikn unspcdon oi dvsni0ncsc svspysisc svdi koivsc kdi n sniuon xi
    coo ikdvonoincikn I557 ocd 5 xpvidl os dkpc ipksidc 0spdnsd s
    snonpoocsvn. Auco oi do0svsc dnocsov svsin yid xsipoupyikn
    nioupyd svc dvoydcoc oco sookonik ipdyd Ib|ade ba||oon
    atria| septostomyl kdi yid scdoxsuon nvsuvuv.
    I44I
    kAIAkh MM1UXh 1h MA1UIh AOI1IA -
    N01A UMNA
    Mnsptc| nntp|o, unuyspyou N|kuo
    kon: hdpouodon kdpidkv dv ocn psudcosin dp0pcid kdi vsucs-
    puv sssuv ocn ouoxscion cnc s d0npucuon kdi kdpidkn npooon.
    Anotsscutu: N Psudcosinc Ap0pcid IPAl dnocss id xpvid, ouscpikn,
    noudp0pikn, d kdi ouocndcikn syovn voo nou npoosi kupuc
    cov dp0pik usvd cuv ikpv dp0posuv. hpoosi kupuc yuvdksc s dvd-
    oyd 3/1 npoc couc vpsc. Lvdi uvdcv uc, vd ouvosscdi kdi dn sudp-
    0piksc ouocndciksc sknosic. Ui kdpidksc sknosic cnc PA ouvocdvcdi os:
    1l hspikdpcid, sdvscdi oco 10-507 cuv do0svv s PA, iidcspd sksvuv
    s psudcosin oid kdi nops vd onynosi os kdpidk sninudcio kdi
    ouucikn nspikdpcid,
    2l 8dion0sid, iidcspd cnc dopciknc kdi cnc icposiouc,
    3l Icsdvidd dpcnpcid,
    4l idcdpdxsc dyuyicncdc,
    5l Muokdpcid Isdipscik onvidl,
    6l kdpidkn npooon kdi spdyd.
    hpodcsc sscsc sxvouv ci yuvdksc s PA sxouv o opsc duns-
    vo kvuvo yid kdpidkn npooon dn yuvdksc xupc PA. Lninpoo0scuc
    yuvdksc s PA yid couxiocov 10 xpvid sxouv cpinoio kvuvo yid
    kdpidkn npooon dn yuvdksc xupc. Ico ysyovc duc ssxovcd po
    idpddcouv opiosvd kccdpd kdi pid nou nupoocov dvciposic
    ducodvoodc onyvcdc os d0npucuon kdi idpuon d0npudciknc
    nkdc. Icnv kdcnyopd ducn nspidvovcdi: dvdd J-sokccd-
    pd, dkpoyd, kccdpd nou skpouv MNC pid Isvo0nidk kdi sd
    uik kccdpdl, kd0c kdi C-dvcipod npucsvn ICPPl, osiusvn LDL
    Inpokdvcdc skuon anti-oxLDL dvcioucuvl, n NSP 60/65 npucsivn
    Iskovcdc ducodvooodvcpdonl kdi n 8
    2
    -yukonpucsivn | I82UP|l.
    unspucu: N PA sou idikdoiv ducodvoodc npokds kdpidksc
    doiosic, nosc opsc snikvuvsc yid cn un. Ui cssucdoi ouoxsci-
    oo cnc voou s cnv ssin cnc d0npudciknc idikdodc kdi cnc kdp-
    idknc npooonc kd0iocov ouvscn cnv nn sni0scikv scpuv yid cnv
    npoocdod cnc kdpic ocouc do0svsc s PA, ocs vd dvciscuniocov oi
    ndpyovcsc kivvou yid ocsdvidd voo.
    I46I
    AUIM05I UOOAAM0N
    kutco0n uuyysu, koucoupn nntp|o
    U kivikc yidcpc ouxv kdscdi vd dvciscunosi nspiocdcik do0svv
    s oisic o0dv. Lvdi odsc ci oi o0do svdi iidcspd sund-
    0sc os oisic dn noikouc oioyvouc ndpyovcsc nuc dkcnpid,
    kncsc, ndpoicd kdi ioc. N spydod ducn dnookons ocn ouvoncikn nd-
    pouodon cuv kupiocspuv ikpoopydviov nou npooouv cnv ns-
    pioxn cou o0do.
    N spydod svdi onsvn s on cnv kdccdn cuv ikpoopydviov
    Idkcnpid, kncsc, io, ndpoicdl sv yvscdi ouvoncikn dvdop ocic
    kupicspsc kiviksc sknosic nou npokncouv dn cn oun, kd0c
    kdi doik ocoixsd yid cn iyvuon kdi cn 0spdnsd cuv oisuv du-
    cv,. Xpnoionoin0nks snvikn, dyyikn kdi ydikn iioypdd syku-
    puv ouyypdsuv nou dvdspscdi ocnv nd0ooyd cuv o0dv kd0c
    kdi ocn ikpoiooyd cuv ndpdyvcuv sksvuv nou sxouv cn uvdccncd
    vd npokdov o0diksc oisic.
    Icxouc cuv nd0oyvuv ikpoopydviov dnocsov oxsv d cd si-
    coupyik cndcd cou o0do. hoo s ikpoopydvioo npoo-
    ouv cducxpovd nodnoc ocxouc ocnv supcspn su0id kdi
    svo0id nspioxn, s dnocssod vd idcdpooscdi ouxv n sicoup-
    yikcncd cou o0do uc svidou dio0ncnpou opyvou. Jd ouncdcd
    cd onod dnoppsouv coo dn svconiosvsc oo kdi dn ouocndciksc
    oisic nuc n oin svdi ouvn0uc snuvd npokdov svcovn u-
    oopd ocov do0svn.
    kd0ocdcdi odsc ci n d0cspn yvon kdi snsuon cuv iidcspuv io-
    oyikv kdi opooyikv xdpdkcnpiocikv cuv ikpoopydviov nou
    ovouv cov o0d svdi kdi npsnsi vd svdi kd0opiociknc ondodc
    yid cnv npnn, cn iyvuon kdi cn 0spdnsd. |vupovcdc oo co uvd-
    cv nspioocspd yid co oioyvo ndpyovcd duvovcdi coo n sudio0n-
    od cnc iyvuonc oo kdi n dnocssodcikcncd cnc dyuync.
    I45I
    UUN1INIkU IXIMA kAI MIkUIIh
    8vvu Oso0pu
    Lnifsnov soc L: kovzdkioznc L., Ln. kd0nynznc dv. A0nvov
    Mikpoisouon opscdi n ooc dkcnpuv, uypv kdi xnikv ouoiv
    dvsod ocnv oovcikn ouod kdi onoionnocs spdkcik uik. N ndpn
    cou ocpdcoc nou nioupyscdi ocd coixdcd cuv piikv ounvuv
    kdc cnv xni konxdvi kn snsspydo d ovoscdi oovci vi k sn xpi -
    odISmear Layerl. Auc dnocsscdi dn oovcvn, unosdcd noi-
    ko ioco, npucsvsc, oovcodociksc dnousc, kccdpd cou ddcoc
    kdi spiksc opsc dkcnpid. Icnv kivikn npn sxsi six0s ci o kdcs-
    poc ouvudoc yid cnv ddpson cou svdi n svd xpnon unoxupi-
    ouc vdcpou INdUC|l kdi di0usvoidivocscpdoiko osoc IL.D.J.A.l.
    Avdspscdi cd cssucdd xpvid kdi n xpnon cuv Lasers yid cnv snicuxn
    dnokpuvon cou. Jo Smear Layer svdi xddp ouvsssvo s cd coix-
    dcd cnc oovcvnc cuv piikv ounvuv, kdi sv dnocss nnpn pdy
    ocnv sooo cuv dkcnpuv ocd oovcivoounvpid. An cnv n nsu-
    p co Smear Layer pd odv uoikc pdyc ocnv npooknon kdi iso-
    uon cuv updcuv spdnc cuv piikv ounvuv sod ocd oovcivo-
    ounvpid. N ddpson cou ocnv kivikn npn soxssi cov kvuvo cnc
    sndvduvonc cuv oovcivoounvdpuv sv dnocxsi coo n spdn
    cuv piikv ounvuv oo kdi n spncikcncd cnc uiknc dnokdcocdonc.
    202
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I47I
    IUIUM1IA
    kou nupv
    Icn iioypdikn ducn spydod, ndpouoiscdi n sdpoyn cnc s0ou
    cnc spyooniposcpdc dsvc sv uc idyvuociko spydsou os kdpio-
    oyiksc kdi nvsuovooyiksc nd0nosic, nuc snonc kdi uc spydso skc-
    nonc cnc ikdvcncdc/ uoiknc kdcocdonc svc d0ncn s on cnv skc-
    non ndpdscpuv nuc co dvdspio kdci kdi n syiocn nponn
    ouyvouIvo2maxl. |vscdi dvdop ocic uoiooyiksc npoodpoysc cou
    opydvioo kdc cnv oknon kdi snosvuc cnc kiviknc ondodc cuv
    nopiocuv cnc ouykskpisvnc s0ou os ouykskpisvsc nd0nosic In.x.
    doknoioysvsc o0d knl nou nops vd xpnoionoin0s kdi uc idopo-
    idyvuocik kpicnpio. hdpnd kdi os dvcindpdon s cnv dvcpdon
    kdi cd dvdsvsvd dnocssodcd cuv scpnosuv ducv os d0ncsc, i-
    kdiooyscdi n oosvd kdi supcspn sdpoyn cnc s0ou coo os do0s-
    vsc oo kdi os d0ncsc, do oi scpnosic yvovcdi os id uvdikn kdc-
    ocdon Io sscdsvoc scs cpsxsi, scs nondcsl nou nops vd npoo-
    ioposi, scs co scpo cnc snipuvonc cnc uoiooyiknc unc Inou svdi
    snonc uvdiknl svc n.x kdpiooyiko do0svoc, scs co scpo cuv
    npoooksvuv sniosuv svc npucd0ncn. Ikonc snosvuc cnc nd-
    poonc svdi vd ndpouoiosi cnv okidod kd0ducn kd0c kdi cn iccn
    cnc xpnoicncd coo ocnv kivikn npn oo kdi oco xpo cnc d0ncid-
    cpiknc.
    I48I
    AN1IM10Ih kAI10N kAk00N 1U O0AkIkU 1UIX0MA1U
    sp|k O., Askku I.
    kon: Ikonc cnc ndpoodc spydodc svdi vd ndpouoiosi cd oyxpovd
    sosvd kdi cic cosic ocn dvciscnion cuv kdcdycuv cuv nsupv
    kdi cou ocspvou kdi cou xddpo 0pdkd.
    |k: Jo uik npon0s dn supsd dvdoknnon cnc unpxouodc iio-
    ypddc, dn nou sx0nkdv cd ounspodcd.
    Anotsscutu: Jd kdcydcd cuv nsupv svdi n nio ouvn0iosvn kku-
    on oco 0updkik coxud. Iuxvcspd oudvouv ocic nsupsc 4-9 s k-
    pid svcnion cnv socncd cou nsupiko cou. N 0vnoicncd os ni-
    kiusvouc duvsi npd no kdi cvsi os do0svsc nvu dn 80 scv co
    207.N 0spdnsd ocoxssi ocnv suon cou nvou kdi cnv dnouyn dcss-
    kcdodc sv n dkivncononon cou noxovcoc ni0updkou dvcsvskvucdi
    U xddpc 0pdkdc If|ai| chestl sninsksi co 10-207 cuv oodpv kdk-
    osuv cou 0pdkd. Is dnsc opsc dvciscunscdi s dvdynod, xopn-
    ynon ouyvou kdi kd0nspivn pivocpdxsidkn dvdppnon. Is dpisc uc
    kdkosic dndicscdi ocd0spononon nou snicuyxvscdi s nxdvikn uno-
    ocnpin cnc dvdnvonc n s xsipoupyikn snsdon.
    unspcutu: N dvciscnion cuv ksiocv kdkosuv cou 0updkiko
    coixdcoc kdi cuv sninokv couc svdi ouxv idcpik npnd kdi ou-
    vn0uc dndics dn d sod sdposvd 0spdnsucik scpd.
    I49I
    8UIXIkU AOMA 1A AIIA: OIkh I1UIA kAI IXUNA UMNA
    1hN OAMAk1Ikh AN1IM10Ih kA1A hAIkIA
    sp|k O.
    kon: Ikonc cnc ndpoodc spydodc svdi vd ndpouoiosi cd oyxpovd
    sosvd ocnv uoikn ssin cnc voou s cnv nikd kdi cic oyxpovsc
    cosic ocnv 0spdnsucikn dvciscnion.
    |k: Jo uik npon0s dn supsd dvdoknnon cnc unpxouodc iio-
    ypddc, dn nou sx0nkdv cd ounspodcd.
    Anotsscutu: Jo ndiik poyxik o0d svdi id vooc s ouvsxc
    dudvsvn ouxvcncd, dpcncd kdi 0vnoicncd. Icnv Ld sxsi c-
    osi co 107 cuv ndiiv oxoiknc nikdc s dunciksc cosic. Icnv psikn
    nikd dnoscdi ouxv os ioysvn oun, sv ocnv ndiikn oxscscdi
    kpid s cnv dspyd. Jo o0d sddvscdi oco 30-507 cuv ndiiv
    Isiik dyopivl kdc cnv snsd d ouxv. sndvsdvscdi ocnv svn-
    ikn un. Jo soc cou dpkou kdi n ouoksun xopnynonc sdpccdi dn
    co ocio dpcncdc cou o0dcoc kdi cnv nikd cou do0svoc. kpid
    pdkd yid cnv kdcdnosnon cou ndiiko o0dcoc svdi cd ocsposi-
    n, oi
    2
    isyspcsc, n xpoovn, n vsoxpon, n 0souvn k.n.
    unspcutu: Jo poyxik o0d ocd ndii dnocss ouvsxc ioyko-
    svo npnd siik ocic dvsncuysvsc xpsc. N kdcdvnon cuv ido-
    pv nou kdc nikd, kdi n npoodpoyn cnc 0spdnsdc dvoyd, svdi on-
    dvcik ocoixso cnc snicuxnsvnc dvciscnionc cou.
    I50I
    5UAAIkA M1AIUMNA NUhMA1A
    kuunku uvoun
    1
    , Xutn Ispy|o
    1
    4. Ooiznzsc ldzpiknc Ixonc dvsnioznou A0nvov
    Md dn cic oxpovsc ociysc nou sdkoou0s vd cddvouv skdco-
    pid dv0pnuv dv cov koo svdi cd Isoudik Mscdisvd Noond-
    cd II.M.Nl. Ms cov po I.M.N. voscdi n sksvn n kdcnyopd cuv voon-
    cuv nou scdovcdi sou osoudiknc sndnc,s kdcsxouod kupdpxn
    0son co ovpoo snkcncnc dvooooyiknc dvsnpksidc IN|vl kdi cic xd-
    uidksc oisic. Av iocd,dvdoyio0s kdvsc ci n ioon cuv vo-
    oncuv ducv sdpccdi kdi dn ouc ndpyovcsc-nuc n opucikn,
    koivuvikn n oikovoikn oc0n-ccs svdi skod dvcinnc nuc co np-
    nd kd0ocdcdi sdipscik nouoxisc.
    Ikonc cnc spydodc dc svdi n pcid kdi sncospnc ndpouodon uv
    cuv vooncuv kdi cuv ndpdyvcuv nou cd npokdov kd0c kdi cnc sni-
    iiooyiknc couc kdcdvonc.
    Avducikcspd dnocssodcd kdi sncospsocspn dvuon, 0d yvsi kdc
    cn ipksid cou ouvspou.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    203
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I51I
    AIUANAUOhh: AkUIUN1AI 1UA ANh1IkA XUAIA
    MIA MOUU NX0 A5ANUMNh. IkAIA h AIkA,
    kuoyspkn nntp|o, stpou kup|ko, tsuvnouo nntp|o
    kon tn spyucu: N inodvdppnon, id npodcn dvdkun I1974 Fisch-
    er/1978 |||ouzl svdi n ddpson cou snovou, dv0skciko ocn dicd kdi cnv okn-
    on nouc Ikupuc knpovoikol. ho ouxv ocd MML kdcdyyssc spxovcdi oco
    uc oxscik s cn s0oo kdi cic sninoksc cnc. Ikonc cnc spydodc svdi n spn-
    vsd cnc diciooydc couc kdi id npoosyyion ocnv op0cncd couc.
    |k-Ms0oo|: Apxsd MML, iioypdd kdi dp0oypdd, svn kdi snvikn,
    idukcidkn ndocikn xsipoupyikn.
    Anotsscutu: N inodvdppnon xpnoionois ndisc kdi vssc csxviksc Ixdpd-
    kcnpiocikc o dpi0c cuv kdcdxupnsvuv ndcsvcuv dv xsipoupy ocnv Aspi-
    knl.
    Ms0oo|: hdpdooidkn Iuypnl, JuMLSCLNJ, unspnxoi |nc kdi ||nc ysvic kdi unspn-
    xoi |||nc ysvic.Jd npondcd nou npokncouv ouxvcspd dopov scsyxsipn-
    ciksc uoopsc. Ui kvousc nou xpnoionoiovcdi sxouv idopscik sys0oc
    kdi uik kdcdoksunc.
    Mikpcspsc os sys0oc IJumescent l sxouv iycspsc dioppdysc pd kdi
    scsyxsipnciksc ousc, d sydcspn kdcdocpon iocikv kdi inu-
    v kuccpuv kdi sdid do0svsocspo dnocssod. N xpnon cuv ikpcs-
    puv dndics nspioocspo xpvo, nou ouvsnyscdi o` svd syo voooko-
    so sydcspn ipksid xpnonc cuv xsipoupysuv kdi nspioocspd so-
    d, yi' duc supcspd sdpscdi os ikpcspd idcpsd, nou uc sv
    nopov vd unoocnpouv dpisc ossc sninoksc I0poosoik snsi-
    oid, kdpidkn dvdkonnl. Ui sydcspsc os kvousc uocoo sv
    svdi skdncsc kdi sv nopov vd xpnoionoin0ov os do0svsc s i-
    kp conik npnd ndxuodpkdc.
    Icn s0oo s cnv |n kdi ||n ysvi unspnxuv sxouv ndpdcnpn0s icpnon
    vspo, xonxou kocnc, vsupooyiksc sninoksc kdi sxouv dvdsp-
    0s nspiocdcik yid unsp0spdvon kdi pnn uiko dn cic kvousc sod
    oco A.|oc. hdpdcnpovcdi ouxv oykid Iseromas, ouoysc uypol, ou-
    sc oco spd Iend hitsl dn cnv soo cnc kvoudc kdi sykddcd. N |||n
    ysvi nou np0s npodcd dn cnv |cdd svdi no dkpin Io sonioc
    koocsi oo svd upi oco ksvcpo cnc A0nvdcl, oi kvousc sxouv syo
    sys0oc 5 mm Isv co idvik sys0oc svdi 3 mml, sxsi nspiopiosvo
    dpi0 xpnosuv, o FDA nioupys npnd ocnv dvdyvpion cnc d
    uc sxsi siosi cic sninoksc cuv npoysvsocspuv.
    Lnonc, npondcd dopov cnv dvdio0nod Ion cou k|einl, cic dsp-
    ysc ocd siik ge|, cic nskcpouciksc idcdpdxsc kdi cnv dvdid Idv ddi-
    ps0ov >3000 m| nouc s ddl. hspd dn cd ikp uoiooyik npon-
    dcd Iond, ousc yid spikoc nvsc, dvudsc knv kdcoc, unsp-
    yxpuonl dvdspovcdi soik snsioid Issin oknonc kdi xpou
    ocd syd voookosd, d sykdipn dvciscnionl kdi oisic Isy-
    sc kivikscokod nspiocdcik, nioupyd dv0skcikv ikpouvl.
    Aoi do0svsc dvciscunouv snid ocic vssc okidsvsc csxviksc
    Isuperficia| |iposuctionl, os npondcd sod oco xsipoupyso IPUPP 8LA-
    NkLJl kdi ocn scsyxsipncikn dyuyn Inyoc, ssin oknonc, idcponl.
    unspcutu: N ndxuodpkd cuv Lnvuv ndiiv kdi snuv Iniksc
    ocic onosc nioupyovcdi cd inokccdpd l sxsi cd sydcspd nooooc
    ocnv Lupnn, ysyovc nou ouvsnyscdi cn oyoupn snskcdon cnc s0-
    ou cd snsvd xpvid Iidvikc do0svnc ocd 35l.u/s, CJ, MJ kdi nidkn
    kspd s sucspiknc odipiknc nsonc dio0ncnpd 0d on0noouv.
    I52I
    A1UMA1 NUAIkOAAIIk AIMUAII
    Io0c|u k., sccux h., 8o0yupn ., uxutoupn ., oun k.
    Nsupoxsipoupyikn kivikn dvsnioznou lodvvvov
    Aioncosvn ndpdsvsi n dvciscnion cuv do0svv s svondps-
    yksdiiksc dioppdysc kupuc noisc dn ducsc xpnouv xsipoupyiknc
    kdi noisc ouvcnpnciknc dvciscnionc. hdpouoious cnv snsipd dc
    dn cnv dvciscnion 12 do0svv s svondpsyksdiiksc dioppdysc
    isyvuosvsc s CJ- syksou sys0ouc dn 3- 6 cm kdi UCS dn 15 - <8.
    Doi oi do0svsc ncdv unspcdoiko, kdi 3 dn ducoc sndoxdv dn odkxd-
    pn idncn. Ui 8 dn ducoc dvciscuno0nkdv xsipoupyik Iunividkn
    kpdviocod kdi ddpson cou didcdcocl npcn od, kdi 4 ouvcnpn-
    cik, scspn od. o dn ducoc kdcsndv kdi oi o sxdv unon-
    0s os 0pouon yid spdyd Isvdc dn k0s odl kdi sxdv onsd
    dpsdc idcdpdxnc cou ocssxouc. Doi oi do0svsc dvsncudv os knoio
    d0 icdon cou koiidko ouocndcoc. Is 3 do0svsc cnc npcnc o-
    dc cono0scn0nkdv svokoiidko kd0scnpsc cnou camino kd0c kdi os
    2 do0svsc cnc scspnc odc yid iocnd 3 nspv. koiionspicovdi-
    kn ndpoxscsuon cono0scn0nks os svd do0svn dn cnv scspn od
    nou sxs cono0scn0s camino, sv svdc oc cnc idc odc ssps dn
    nddicspd s dicdc upoksou. An cnv npcn od UCS < 13 sys-
    0oc dn 3-6cm kdi oi 7 kivnconoin0nkdv ypnyopd sod ocic snsvsc 3 s
    5 nspsc ndpouoiovcdc vsupooyikn scuon. An cnv scspn od
    1 kivnconoin0nks os 15 nspsc UCS 15, sys0oc <3cm, 1 os svion nvd
    UCS 9 kdi sys0oc 5cm kdi svdc sv op0ooccnos yu idcdpdxv
    cou ocssxouc UCS 12, sys0oc 4cm. Iunspdodcik kdcdnyous
    ci dl do0svsc s UCS 14-15 kdi dicud sxpi 3cm syiocn iscpo
    dvciscunscdi ouvcnpncik, l do0svsc s UCS dn 13 kdi kcu n/ kdi
    dicud dn 3cm kdi vu xpnsi xsipoupyiknc dvciscnionc yl do0svsc
    nou pokovcdi os kudcn kdcocdon s onsd dpsdc idcdpdxnc
    cou ocssxouc sv suspyscn0nkdv dn xsipoupyikn dvciscnion. Lnonc
    oi do0svsc nou dvciscunovcdi xsipoupyik kivnconoiovcdi ypnyopd
    kdi sxouv iycspsc sninoksc kdc cnv ipksid cnc voonsdc couc.
    I53I
    XIUIIkh 1hN UXh 1U IUkA1h
    o|t|k Ivvn, Mxu Ispy|o
    ldzpikn Ixon dvsnioznou A0nvov
    N spydod ducn doxoscdi s cn sscn cuv xsipoupyikv npsuv nou
    dvdv xpd cnv snoxn cou |nnokpcn, doisvn kupuc ocd idou-
    0svcd ouyypdcd cou iou, d kdi os dvdopsc scdysvsocspuv ouy-
    ypdsuv nou doxon0nkdv s cic iksc cou idcpiksc csxviksc. An cnv
    spsuvd nposkus ci xsipoupyiksc npsic yvovcdv os d cd dvdcoik
    spn cou dv0pnivou odcoc. |idcspn npooc sxs ouvcssocs ocnv
    dvcpnon cou kpdvou, ocn xsipoupyikn dvciscnion cuv dioppoiuv
    kdi cuv ndpdspikv oupiyyuv, ocn dvcdn kdcdycuv kdi ocn disuci-
    kn. Lkcscdsvn dvdop yvscdi ocd spydsd cnc snoxnc, nou ndp cnv
    dnn kdcdoksun couc, ncdv sxpnocd kdi dnocssodcik. Jd snicsyd-
    cd cou |nnokpcn, d kdi co spyo cou uc ovoo, dnocssodv ondvci-
    kn ndpdkdcd0nkn yid couc yidcpoc nou dkoo0nodv.
    I54I
    kkUA0MA 2Nkk hAIkA ANA: AUIAh I1A1IkU
    U AN1IM10I1hk 1U A.I.N. hAkAIU kh1h
    5skupkn A|kutspvn
    1
    , Muvku uvoun-nntp|o
    1
    , Auc|0|tkn
    kv/vo
    1
    , Axtcn 8ucs|o
    1
    ,Mupuykoukn uvuy|tn
    1
    , Xuk|ukn
    Ispy|o
    2
    4. Ooiznznc.-zpid ldzpiknc, 2. Avdnnpoznc kd0nynznc Xsipoupyiknc ldzpiknc
    Ixonc dv.iou kpnznc
    kon: hdpouodon nspiocdciko Icase reportl skkondcoc 2enker.
    |k: Tvdc do0svnc nikdc 94 scv s kdn ysvikn kdcocdon nou npo-
    on0s oco k.. Incsdc ndpdnovosvoc yid svcovn uokdcdnood os uyp
    kdi ocsps. hdpdns0nks oco hA.|.N.N. yid nspdicspu dvciscnion.
    Ms0oo: Ico k.. syivs idyvuocikc ssyxoc s ydocpoypdvn.
    Ico hA.|.N.N.: 1l hposyxsipncikd: Uioodyoypnd kdi dvoscpd oioo-
    you. 2l Xsipoupyikn snsdon: Anocuxd ddpsonc s kdnco dpuy-
    yooknio, oncs dnsdoo0n n ivoin cou skkondcoc s ouppdnci-
    k nxvnd JA.
    Anotsscutu: U do0svnc kdc cnv siodyuyn sxs svcovo npnd Ioxs-
    v nnpn duvddl ocnv kdcnoon. Msc cn xsipoupyikn snsdon cd
    ouncdcd unoxpnodv nnpuc kdi o do0svnc, sc dn odn scsy-
    xsipncikn nopsd 6 nspv, sn0s cou voookosou.
    unspcutu: N ivoin cou skkondcoc 2enker s ouppdncik n-
    xvnd cnou JA nops vd unokdcdocnosi sc xsipoupyiksc s0ouc
    sdpsonc, cdv ducsc dvcsvskvuvcdi n dnocuyxvouv.
    204
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I56I
    TXU8IUAUIIkh UIIIh 1h ANUkXIA NkvUSA
    8uvn Mupu, Mut|nvuou Mupu, Avpsou Avtvn, 1cn 8ucs|o
    N anorexia nervosa dnocss onspd cn scspn os ouxvcncd dicd 0dv-
    cou dn' sc cic uxidcpiksc do0svsisc. N ndpdooidkn 0spdnsucikn dvci-
    scnionIkupuc s uxdvduciksc s0ouclsv svdi dnocssodcikn
    iuc ocd osd ocid cnc voou. Ico p0po yvscdi dvdop ocic oyxpo-
    vsc dnsic yid co koivuvik-noiciocik statusIo poc cuv M.M.L.l, yid
    co oikoysvsidk nspiov, yid cn xdnn ducoskcnon cou dcou k.d.
    Akd yvscdi id ovcon dvdop os id osip sscv nou npdydco-
    noin0nkdv os ud kdi os ncspsc nou sndoxdv dn anorexia nervosa
    kdi dnosikvouv id yoviidkn ouoxscion cnc do0svsidcIn onod uc
    sv svdi dnucd sdkpiusvnl.
    hdpnd, snixsipscdi oco p0po, d ovon uv cuv dvdspsvuv
    ocn iioypdd d0noidkv kdi iooyikv idcdpdxv nou sdvo-
    vcdi ocnv do0svsid. Inspd svdi kd0oik dnoskc nuc oi do0svsc nou
    noxouv dn anorexia nervosa ndpouoiouv id nn0pd idcdpdxv
    nuc duvdd ouyksvcpuonc, sdccusvn dvcnn, ouvdio0ndcikn
    doc0sid k.d. Lnixsipscdi id iooyikn npoosyyion cuv ouncucuv
    ducv s sosvd cnc vsupoiooydc kdi kupuc s on cic doiosic
    os snnso ouvsuv kdi vsupoididocv. Jsoc dvdspovcdi oi oy-
    xpovsc 0spdnsuciksc npoonciksc s sdon os vssc svddkciksc s0-
    ouc nou npocsvouv 0spdnsucikn npoosyyion cou do0svoc s cn xpnon
    cnc csxvnc n uv noiciocikv ndpdscpuv. Jducxpovd uc dvds-
    povcdi kdi nosc uokosc kd0c kdi dvcippnosic nou dopov ducsc cic
    0spdnsuciksc dnsic.
    I55I
    NA UMNA 1h IAIN0h kAI OAIA 1h kA1AOAITh
    Nu 8ucs|o, Nku hu, 1cn kv/vo, Mut|nvuo nntpn
    Icic idcdpdxsc cnc i0sonc, cducxpovd s cnv svddyn ocn i0son
    kdi ocnv dvcnn ndpouoiovcdi id noikid uoiooyikv dvudiv
    nou yvovcdi svcovd sdvsc kupuc ocnv kdc0in. Ui do0svsc svsxscdi
    vd sdvoouv npoosucikn dnon n sccuon cou pouc couc Ixupc
    scdon cuv idicncikv ouvn0sivl. Is opiosvsc nspincosic sdvs-
    cdi idcdpdxn ocn ipksid cou nvou Ioi do0svsc sv nopov vd
    koin0ov n cn vxcd sv oi koiovcdi 12-18 psc cnv nspdl.
    Akn svdi ni0dvv vd sdviocov kdi onsd idvonciknc skncuonc
    snonc kdi uoik ouncdcd nuc vducd ksddyd, onvoid, npo-
    ocod dpksc ouxv ouvosouv cnv kdc0in. Jducxpovd sxsi ndpdcn-
    pn0s svdc dpi0c sicoupyikv-dvdcoikv doiosuv Inuc n.x. oi
    sc ocov dpiocsp scunido o n oi doiosic ocd doik yyyid.
    Is ci dop cnv nd0oysvsid cnc voou oi ysvsciko ndpyovcsc svsxscdi
    vd idpddcoouv po ocic idcdpdxsc i0sonc.ocspd dno sninio-
    oyiksc sscsc Ios oikoysvsisc, ioucl ndpd cic ioxupsc svssic yid
    ouoxscio ysvscikv ndpdyvcuv-idcdpdxv i0sonc unpxsi duvd-
    d dvsinc knoiou yoviou n set yoviuv nou vd oxscovcdi s kd-
    cdocosic nuc ovonoikn n inoikn kdc0in. Iunnpudcik kdi
    co nspiov idpddcsi diciooyik po kdi scoi idopvscdi co
    kcu0i iypdd:
    Luysvnc ndpyovcdc
    npoounikcncd
    vspuon xuon
    nspiov
    Is ci dop cic oyxpovsc 0spdnsuciksc npoonciksc, ducsc dopov kdi-
    vopiouc dpdkooyikoc ndpyovcsc .scoi svdc uxodpdkooyikc
    ndpyovcdc svsxscdi vd pd os svd "cosd" nou svdi dvspcncoc cnc
    vsupoxniknc idcdpdxnc nou npokds cnv dppocid, d vd npokds
    ddysc nou dvciocd0ouv cnv dvudd. Akn oco p0po yvscdi dvd-
    op os vsd kivik nsipdcd nou dnosikvouv ci oi do0svsc dvci-
    pov idopscik ocd iopd 0spdnsucik oxndcd. Miocd svdi nio
    0scik cd dnocssodcd ouvn0uc dn ouvudo uxo0spdnsdc kdi dp-
    dkooyiknc dyuync.
    I57I
    1XAI INOIIAk MA2 IINCIDN1ALUMASI:
    !0 UXI kAI 1UU 1XAI
    unupun O.
    2
    , Osopou .
    1
    , Mupvou-1ousskn M.
    1
    4. Lpydoznpio Odpdkooydc ldzpiko Tndzoc A..6., 2. k.Y. Toozu-
    ou, s.I.Y uziknc Mdksovdc
    Ms cov po incidenta|oma nspiypscdi n cuxduc dvsupioksvn snivs-
    piidkn d os ispsvnon uv nd0nosuv. Jo incidenta|oma ndpou-
    oiscdi sc cn xpnon cou doviko kdi dyvnciko cooypou s ou-
    xvcncd 0.36-4.367. Ico sov s cn scuon cuv dnsikoviocikv s0-
    uv dvdsvscdi dnon cnc ndpdnvu ouxvcncdc.
    Ikonc cnc spydodc ducnc svdi dpxik vd isukpivosi cnv cdivnon
    cuv cuxduv snivspiidkv dv, vd snionvsi couc ndpyovcsc nou
    kd0opouv cnv kdkon0sid couc, vd isukpivosi cnv idopoiyvuon couc
    kdi, csoc, vd ndpouoiosi cnv 0spdnsucikn kdi idyvuocikn npoosyyion.
    Jd ounspodcd nou npokncouv svdi ci, oi cuxdsc snivspiidksc
    sc sv svdi coo onvisc kdi ci dnocsov ykouc cuv onouv n
    ouxvcncd 0d duvsi s cnv npoo cuv scv. N npoosyyion cuv ykuv
    ducv npsnsi vd snsksi nosc idcpiksc siikcncsc. N xsipoupyikn dvci-
    scnion svskvucdi os ykouc >3 sk., sv oi ikpcspoi ykoi dndicov
    ouvidosvn dvciscnion.
    I58I
    h MMhNUAh kAI UI IOAN 1h IAI 1U kAIAIIIAkU
    1hMA kAI IIAI1A 1hN A1hIAkh Ih
    Moukn Mup|usvu, Mupkuvtvn 8uc||kn
    ldzpikn Ixon LkA
    Doo co npookio unc duvscdi coo nodndoiscdi kdi o dpi0c
    cuv yuvdikv nou pokovcdi ocn on cnc snvnduonc s cd iidcspd
    xdpdkcnpiocik nou ducn ouvsnyscdi yid cov dv0pnivo opydvio. Iko-
    nc ducnc cnc spydodc svdi n ouoyn sosvuv oxscik s cnv sn-
    pdon cnc snvnduonc oco kdpidyysidk, s knoid iidcspn s-
    0uvon ocov cosd cnc dpcnpidknc nsonc, kd0c kdi s cic ni0dvsc suspys-
    ciksc sniposic cuv dpkuv nou xopnyovcdi uc 0spdnsd unokdc-
    ocdonc. hnyn nnpoopiv dnocssodv noiksc spydosc nou sxouv n-
    ooisucs os nspioik svokpivooydc dv cov koo, kd0c kdi co id-
    kcuo.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    205
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I59I
    A5IUAUIhh 10N IXUN0N AIkUNI1Ik0N MOU0N
    1hN IAIN01Ikh INhh 10N AUIM050N 1U UUUIh1IkU
    8Oh kAI AIIA
    Ot|n N., Mvtuku A., M|xunn N., Mnto I., Tuxn ., Xp|ctono0ou A.,
    U|kovou I.
    Tnd Ynspnxov, dvsnioznidk Akzivooyik Lpydoznpio A6, N.
    AXLA.
    kon: U okonc cnc sscnc ducnc svdi n dioynon kdi isppxnon
    cuv dnsikoviocikv s0uv ocnv idyvuocikn npoosyyion cuv oisuv
    cou ouponoinciko os psn kdi ndii.
    |k ku| s0oo: Msscn0nkdv dvdpoik 60 ndii nikdc 20 nspv
    sxpi 12 xpovv, s kivikospydocnpidk supndcd oupoounc. Is
    ouc couc ikpoc do0svsc isvspyn0nks dpxik unspnxoypdikc ssy-
    xoc sv 45 ssyx0nkdv kdi s power dopp|er. Aviood kuocsooupn0po-
    ypdd isvspyn0nks os 42 dn cd ndii kdi unspnxokuocsoypdd os 45.
    Aiooyn0nks n idyvuocikn uvdccncd, n xpnoicncd, cd nsovskcn-
    dcd kdi cd siovskcndcd cnc k0s s0ou kdi nioupyn0nks dypi0-
    oc yid cnv op0ooyikcspn sdpoyn couc.
    Anotsscutu: Jo unspnxoypnd dvssis cnv ndpn icdonc oco
    nusokdukik oocnd uc kdi cnv kdcocdon cou vspiko ndpsyxd-
    coc. Ms cnv power dopp|er csxvikn isyvo0nodv sukpivsocspd socsc co-
    niknc vspcidc. N dkcivooyikn dviood kuocsooupn0poypdd isvsp-
    ysco yid cov dpxik ssyxo cnc kuocsooupncnpiknc ndivpnonc sv n
    unspnxokuocsoypdd yid couc sndvssyxouc ducnc.
    unspucu: N sdpoyn cuv oyxpovuv dnsikoviocikv s0uv ou-
    si ondvcik ocnv ispsvnon cuv oupooisuv cnc ndiiknc ni-
    kdc, dnokdncsi cd dcid kdi cic sninoksc couc, xupc vd sk0scsi couc
    ikpoc do0svsc os sysc osic iovcouodc dkcivoodc.
    I60I
    U5IA kUIAIA 0 01h khA0h 1h NUU CkUPN
    Iupyu|vn Avtvn, A|vupo0tco nntpn
    ldzpikn Ixon LkA
    kon: Ms dopn nspiocdcik osdc koidc, nou dnosx0nks vooc
    Crohn ispsuvcdi n osd koid uc sninokn cnc voou Crohn.
    |k-Ms0oooyu: hpksicdi yid vpd 33 scv s ss0spo A.A. nou
    ndpouodos yoc kcu koidc kdi onso 8|umberg ocn si koiidkn
    xpd kdi sionx0n npoc ispsvnon. U ndpdkivikc ssyxoc ssis scpid
    Asukokuccpuon s nouoponupnvik cno. hdpnd xpnoionoin-
    0nks n unpxouod dp0poypdd kdi is0vnc iioypdd. Tdon 0n-
    ks os is0vsc nooisosic osdc koidc uc sninoknc cnc voou Crohn.
    Anotsscutu: Ayu duvddc idopoiyvuonc isvspyn0nks spsu-
    vncikn dndpocod nou ssis syovn yko cou cuo s svconi-
    osvn sskuon. N icpnon nou onynos os osd koid svconicdv
    nnoov cnc sisocuiknc ddc. |svikcspd uc sninoksc cnc voou
    Crohn nou onyov os osd koid dvdspovcdi n pnn oupiyyuv kdi
    dnoocncuv, n dioppdyd cnc nspicovdknc koicncdc kdi co coik
    sykoo.
    unspcutu: N osd koid nops vd dnocssosi sninokn os un-
    ocpud voou Crohn, yid duc dndicscdi n sypnyopon cou idcpo.
    I61I
    NUkINIk IAI 1UN IkOAAU kAI h Xh A10N
    M 1h MIOUA
    A0uvuc|n Aupo, kup|ko N|kuo, Mnpttn N|kuo, nupnouo
    Ispy|o
    U syksdoc uocdcdi xniksc kdi oiksc scdosc uc dnvcnon ocic ddysc
    cou nspiovcoc. Upvsc dn cd snivspid cov 0uposin kdi cic yovsc
    ndouv svd ondvcik po o' ducnv cnv npoodpoyn, yidc co svokpivik o-
    ocnd ssyxscdi dn cov syksdo sou cnc unuonc. Aucc o ssyxoc snicpsnsi
    os nspidovcik sps0odcd vd pu0ouv cnv skkpion cuv opovv.
    Ui opoviksc sniposic oudvouv kdc cn ipksid sudo0ncuv nspiuv cnc
    dvncunc, cnc svniknc unc, kdc cn ipksid uoiooyikv svokpivikv k-
    kuv kdi kdc cn ipksid cnc idikdodc cnc ynpdvonc. Idv dnocssod ducv
    cuv posuv ocic kuccdpiksc idikdosc, ocn pon cuv yoviuv kdi ocov ssyxo
    cnc skkpionc couc dn nspidovcik sps0odcd, oi ocsposisc kdi oi 0uposii-
    ksc opvsc pouv ocov syksdo ndpsxovcdc cn ovdikn ikdvcncd cnc ndoci-
    kcncdc cou syksou kdi cnc ounspiopc cou dcou.
    N yvon cuv sniposuv cuv opovv ocn sicoupyd cou syksou svdi coo
    ndi oo kdi n id n svokpivooyd. Xdpdkcnpiocik sxsi dvdsp0s nspdd, co
    1849, kdc co onoo o suvouxioc uv Inuc kkopscl sxs uc dnocssod on-
    dvciksc ddysc ocn ounspiop couc, sv n scdcsuon cuv pxsuv ocd
    suvouxiosvd duc d dvcsocpss cic nponyosvsc ddysc.
    Jssucdsc spsuvsc npoospouv cn uvdccncd vd dvdkdous nspioocspd
    yid cnv snpdon cnc vsupiknc pdocnpicncdc ocnv skkpion cuv svokpivv ds-
    vuv kdi, dvciocpuc, cnv snpdon cuv opovv ocn sicoupyd cou vsupiko
    ouocndcoc kdi ocn ounspiop.
    I62I
    UU1A AUOMIA OAMUIh AIMU 1UMA M 1UMA
    M1A5 AIIAMA1I0N IIA
    Muyy|pn Ispy|o
    1
    , unuono0ou ovkn
    2
    , kounn M|t|n
    1
    ,
    Mupyuptou Apyupn
    3
    , Ik|u Mupu
    4
    4. Ooiznzsc, 2. ldzpc, 3. Avdio0noioyoc Avdn. isu0vzpid LIY, 4. kd0nyn-
    zpid Avdio0noiooydc A6
    Apiozozssio dvsnioznio 6soodovknc
    kon: N kdpionvsuovikn dvduoyvnon IkAPhAl osi usc. U ocd
    s ocd dspioc IIIAl dnocss ondvcik spoc cnc kAPhA ici dpx-
    si dsouc. xupc cnv dvykn sonioo. Jnv cssucdd skdscd uc
    unpxsi id pvnon sdpoync cou IIA yu cou ou scoonc voon-
    cuv. Jd nooooc pvnonc sdpoync IIA scd sndyysdciv uysdc
    dnocss co okon ducnc cnc sscnc.
    |k ku| s0oo: 88 yidcpo idpuv siikocncuv, 46 voonsucsc kdi
    44 oicncsc idcpiknc ouscsxdv ocnv spsuvd. Jouc ncn0nks vd dndvcn-
    oouv dvvud kdc noo 0d spodv d]IIA kdi sucspiksc ounisosic,
    ]Mvov ounisosic yl Mvov IIA, ]Jnocd dn cd o kdi os 5 uno0scik
    osvpid IIl. I1 os svdv vpd 40 scv kdovcusvo I2 os svdv vpd 35
    xpovv s dd ocnv nspioxn cou ocdcoc I3 os svd kopicoki 6 scv nou
    dn cov nspyupo dvscdi ci svdi dodn I4 os svdv vpd 70 scv
    kdi I5 os svdv yscovd nou svdi oouioc.
    Anotsscutu: hooooc 0sciknc kdi dpvnciknc dnvcnonc ocnv sdpoyn
    IIA scd sndyysdciv cnc uysdc dvovcdi ocov nvdkd.
    I1 I2 I3 I4 I5
    |idcpo NA| 54 I61,37l 26 I29,57l 74 I84,097l 46 I52,27l 28 I31,87l
    UX| 34 I38,67l 62 I70,47l 14 I15,97l 42 I47,77l 60 I68,17l
    Noon- NA| 16 I34,77l 2 I4,37l 36 I78,27l 10 I21,77l 10 I21,77l
    sucsc UX| 30 I65,37l 44 I95,67l 10 I21,77l 36 I78,27l 36 I78,27l
    Goicncsc NA| 24 I54,57l 12 I27,27l 28 I63,57l 20 I45,47l 20 I45,47l
    |dcpiknc UX| 20 I45,47l 32 I72,67l 16 I36,37l 24 I54,57l 24 I54,57l
    unspucu: Akn kdi scd cuv sndyysdciv uysdc svdi dunsvd
    cd nooooc dnpo0udc sdpoync IIA.
    206
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I63I
    UU1A AUOMIA OAMUIh AIMU 1UMA M 1UMA
    M1A5 MAOh10N kAI AOAh10N
    Muyy|pn Ispy|o
    1
    , unuono0ou ovkn
    2
    , kounn M|t|n
    1
    ,
    Mupyuptou Apyupn
    3
    , Ik|u Mupu
    4
    4. Ooiznzsc, 2. ldzpc, 3. Avdio0noioyoc Avdn. isu0vzpid LIY, 4. kd0nyn-
    zpid Avdio0noiooydc A6
    Apiozozssio dvsnioznio 6soodovknc
    kon: N kdpionvsuovikn dvduoyvnon IkAPhAl osi usc. Indvcik s-
    poc cnc doiknc unoocnpinc cnc unc svdi kdi o dspioc ocd s ocd IIIAl.
    Dcdv n kAPhA dpxsi xupc kd0uocspnon dn ndpsupioksvouc cd nooooc
    sniuonc duvovcdi. Tcoi os ov cov koo yvscdi npoon0sid sk0nonc cnc
    kAPhA kdi os nocsc. Jd cssucdd xpvid uc unpxsi id pvnon sdpoync
    cou IIA yu cou ou scoonc vooncuv. Jd nooooc pvnonc sdpoync
    IIA scd noicv dnocss co okon ducnc cnc sscnc.
    |k ku| s0oo: 50 d0ncsc kdi 62 d0ncsc nou sxdv skndisucs ocnv sdp-
    oyn kAPhA ouscsxdv ocnv spsuvd. Jouc ncn0nks vd dndvcnoouv dvvud
    kdc noo 0d spodv d]IIA kdi sucspiksc ounisosic, ]Mvov ounisosic yl
    Mvov IIA, ]Jnocd dn cd o kdi os 6 uno0scik osvpid IIl. I1 os svdv vpd
    40 scv kdovcusvo I2 os svdv vpd 35 xpovv s dd ocnv nspioxn cou oc-
    dcoc I3 os svd kopicoki 6 scv I4 os svdv vpd 70 scv, I5 os svdv oou-
    io kdi I6 os svdv o couc.
    Anotsscutu: Jd nooooc 0sciknc kdi dpvnciknc dnvcnonc ocnv sdp-
    oyn IIA dvovcdi ocov nvdkd.
    I1 I2 I3 I4 I5 I6
    Md0ncsc NA| 16 I327l 2 I47l 22 I447l 2 I47l 18 I367l 30 I607l
    UX| 34 I687l 48 I967l 28 I567l 48 I967l 32 I647l 20 I407l
    A0ncsc NA| 30 I48,37l 16 I25,77l 40 I64,57l 6 I9,67l 54 I877l
    UX| 32 I51,67l 46 I74,37l 22 I35,47l 56 I90,47l 62 I1007l 8 I137l
    unspucu: Jd nooooc sdpoync IIA o' svd o n o' svd ndi svdi syd-
    cspd os oxson s cic sc kdcnyopsc 0ucuv.
    I64I
    IIUO0h 1U DNA kAI NhAIkI0h
    Opykou-Mucoupou ., Ispynouo I., I|uvvuk A., kunspn .,
    kvctuvtvou ., Mntn I.
    Lpydoznpio Isviknc Biooydc, ldzpiko Tndzoc, A..6.
    N svnikuon osscdi os nooc ndpyovcsc, svokuccpiouc kdi su-
    kuccpiouc. |vscdi ouoopsuon kdcdocpov os ouocndcd ksii, nuc
    nndp, vsp, svcspo nou snidpvouv cic sicoupysc cou opydvioo.
    Iuncscdi n dvikdvcncd sniip0uonc cou DNA, kdi n doc0sid cuv yovi-
    uv. |ovid pu0ouv cnv svnikuon nupoocvcdc n dpdvonoivcdc
    d. Jd yovid age1 kdi daf2 ps0nks ci oxscovcdi s cn dkpoicn-
    cd. npxouv ooicncsc scd cnc daf2 kdi cou unooxsd cnc ivoou-
    vnc cou dv0pnou. Jo yovio FUXL2 ocov v0puno snonc svoxonoiscdi N
    ouoopsuon kkuv DNA ocouc uokncsc dvscdi nuc sicoupys uc
    "po svnikuonc". N "dvciypdikn ynpdvon", n ysvscikn p0ion cnc
    kuccdpiknc idpsonc kd0c kdi n dnon cuv SNPs npsnsi vd snnpsouv
    cn ipksid unc.
    N okpuvon cuv csospv, s cnv npoo cnc nikdc, sivsi cnv ocd-
    0spcncd cuv xpuooucuv kdi, skcc uv, onys os xpuoouiksc
    dcunsc kdi sksvsc os do0svsisc, nuc o kdpkvoc. Jo icoxovpidk DNA
    ndpouoisi dunsvsc sc kdi sssic cncuv, os svnikius-
    vouc iococ. U syoc dpi0c piv ouyvou, nou ndpyscdi kdc cov
    uoiooyik scdoio, kdcdocpssi co DNA. Avciosiucik npsnsi vd
    kdcdocpsouv cic psc ouyvou, vd snipdvouv cnv kdcdocpon cuv
    opuv kdi ouc, kdi cov pu0 cnc svnikuonc. Apdvsc icoxovpidk
    DNA, ssin dnvcnonc cuv kuccpuv svdvci sukuccdpuv n svokuccd-
    puv coivv, kdi sc scdosc svdi uvdcv vd duvouv cnv npoi-
    0son cuv dcuv os do0svsid.
    Nsupik ocssxidd kccdpd npooiopo0nkdv ocov syksdo. Avdysvvnon
    ioco ndpdcnpn0nks ocnv kdpi sc dn kdpidkn npooon. Msscsc
    oikoysvv do0svsiv 0d on0noouv ocn isukpvion cnc idikdodc cnc
    svnikuonc. N oknon, n p0ion cou pouc, n idcnpnon cnc dc cou
    odcoc, o nspiopioc cuv 0spuv svdi ondvcik yid cnv idcnpnon
    cnc p0ionc cou uoiooyiko scdoioo kdi cnv dkpoicncd.
    I65I
    IUNIIAk AAAAI, IAAUAOI kAI AIONIIU OANA1U
    Ispoy|vvn Ivvn, unukn Ivvn, 1c|vtn Mupu
    Ooiznzsc ldzpiknc Ixonc dvsnioznou kpnznc
    Yns0uvoc kd0nynznc: Bpdc .L., isu0uvznc kdpiooyiknc kiviknc
    dvsnioznidko Isviko Noookosou Hpdksou
    N isyspoicncd cou kdpidko kuccpou svdi co dnocssod idc sncnc
    iooppondc dvsod os sknoucik kdi sndvdnoucik iovcik psdcd.
    Jd ivcd scdkivovcdi sod n su dn co kccdpo sou siikv npucsvv, cuv
    iduv, oi onooi xdpdkcnpovcdi dn sniskcikcncd yid k0s iv kdi dn cov
    kdcno xpovio oco voiyd kdi oco ksoio couc. Inspd yvupous os
    sydo d0 kdi cd yovid nou ssyxouv cd dvcocoixd iovcik psdcd.
    N cducononon cnc opidknc onc cuv iovcikv iduv, s0sos cic osic yid cn
    0supd ci ysvsciko ndpyovcsc su0vovcdi yid cnv nskcpikn doc0sid cuv do0svv
    s kdpidksc dppu0sc. Ui dvudsc ocn ysvscikn skpdon cuv yoviuv onyov
    ocn uosicoupyd cuv iduv-"iduon0sisc".
    Ikonc cnc spydodc svdi vd dnoo0ov s odnvsid nnpoopsc oxscik s
    cnv nd0ouoiooyd cuv iduond0siv, cnv kivikn couc ispsvnon, cn oxson
    couc s cov divio 0vdco kdi csoc cn 0spdnsucikn couc npoosyyion.
    |k ku| s0oo|: Xpnoionoin0nks uik kupuc dn cn idikcudkn idcpikn kdi
    dn cnv unpxouod iioypdd kdi dp0poypdd.
    sp|sxsvo: Ui kpisc yvuocsc iduon0sisc svdi: Iil co ovpoo Long
    0J kdi Iiil co ovpoo 8rugada.
    Jo ovpoo Long 0J IL0Jl svdi id vooc nou xdpdkcnpscdi dn ndp-
    cdon cou 0J idocndcoc kdi un kvuvo yid kdkon0sic koiidksc dp-
    pu0sc. Ldvscdi uc ouyysvsc Iyu scdsuv ocd yovidl n sn-
    kcnco Iyu kdpidknc dvsnpksidc n nnc dpkuvl.
    Jo ovpoo 8rugada dop idcdpdxsc cnc onc 1 cnc sndvdnuonc
    kdi onys ouxv os divio 0vdco, sdicdc koiidkv dppu0iv. Us-
    scdi os cpsic scdsic cou yoviou SCN5A nou kuikonois couc id-
    ouc Nd. knpovoscdi uc ducooudcikc snikpdcv xdpdkcnpdc.
    unspucu: N kdcdvnon cnc nd0ouoiooydc cuv iduond0siv dno-
    css cnv on yid cnv dvncun 0spdnsucikv ocpdcnyikv coo os dp-
    dksucik oo kdi os yoviidk snnso.
    I66I
    h OAIA 1h NMUNIkh OUM8UM8UAIkh NUU
    outtn Acnucu
    ldzpikn Ixon L0viko kdi kdnoiozpidko dvsnioznou A0nvov
    Ikonoc cnc spydoidc svdi vd idnpdydcsucsi 0sdcd nou dopouv cnv
    0spdnsucikn npoosyyion cou ouvpoou cnc nvsuoviknc sonc sics
    duc idpdsi osuc sics xpoviuc kdi vd dvdsisi co 0spdnsuciko xsipi-
    oo cuv dcouv nou svdi unonid yid cnv sknuon cou kivikou ouv-
    poou. ispsuvuvcdi o pooc cnc 0poouciknc dyuync o pooc cuv
    xdnou opidkou dpouc nndpivuv, n idpksid voonsidc kdi n npou-
    dkcikn dyuyn s dvcinnkcikd. hdpdci0svcdi cd cssucdid sosvd nou
    dopouv ocnv dpdksucikn, snsdcikn kdi xsipoupyikn dvciscunion
    cou osuc nspiocdcikou yivscdi ouykpicikn dvcindpd0son cuv kdoikuv
    nndpivuv svdvci cnc ouocndcikd xopnyousvnc 0poouciknc dyuync
    kdi nspiypdovcdi oi svsisic oi dvcsvsisic kdi n xsipoupyikn csxvikn
    kd0uc kdi n ouon couc ocnv sciuon cou csikou npoookiou sni-
    iuonc. Lnionc yivscdi skcsvnc dvdopd oco ouvpoo cnc xpovidc 0po-
    osoiknc nvsuoviknc unspcdosuc kdi ocd sosvd nou kd0iocouv
    nsov nio skuocikn dn ci oco ndps0ov cnv snioyn cnc nvsuoviknc
    0poosvdpcnpskconc. Avdspovcdi oi ndpdyovcsc nou sninskouv cnv
    scsyxsipncikn 0vncocncd kdi idopuvouv cnv npoyvuon. Jsoc dvd-
    ncuooovcdi oi ouv0nksc sdpoync dpdksuciknc npoudnc, n sdp-
    oyn cuv svduikuv icpuv kdi npodvdyysscdi n kukoopid vsuv
    dpdksucikuv ndpdyovcuv nou dvdsvscdi vd unokdcdocnoouv cov poo
    cuv xdnou opidkou dpouc nndpivuv nuc oi dvdocosic cnc dvci-
    0poivnc me|agatran, xime|agatran.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    207
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I68I
    NUNUkINI UIkUI 1U IA1N1IkU 1hMA1U
    nupnouo 8|o, Avuyvctou 1n, kuutono0ou Iupuu|
    L0vik kdnoiozpidk dvsnioznio A0nvov
    Ikonc cnc spydodc svdi vd ouyksvcposi d cd vsd sosvd ypu
    dn cn iyvuon kdi cn 0spdnsd cuv vsuposvokpivv ykuv cou ydocps-
    vcspiko ouocndcoc. Lnonc yvscdi id pdxsd dvdksdduon ypu
    dn cnv cdivnon kd0uc kdi cnv nd0ouoiooyd couc.
    N spydod ocnpx0nks os snvikn kdi svn iioypdd, nuc snonc kdi
    os p0pd nou dvdncn0nkdv sou cou idikcou.
    Ui vsuposvokpivsc ykoi cou ydocpsvcspiko ouocndcoc dnocsov id
    npknon yid cn xsipoupyikn kdi cnv svokpivooyd cou sovcoc. Ms-
    xpi onspd n iyvuon kdi dvciscnion couc ouvdvcoodv dpkscsc u-
    okosc. Nsd sosvd uc cd cssucdd xpvid sxouv osi ondvcikn
    0non ocnv sykdipn kdi ouocn dvciscnion couc. sosvd cd onod
    syivs n npoon0sid vd ouyksvcpu0ov kdi vd kdcdypdov os ducn cnv
    spydod, dnocsvcdc id xpnoin nnyn nnpoopiv xi vo yid co
    oicncn d kdi co oyxpovo yidcp.
    I67I
    AUIAh I1A1IkU: 1hMA1IkU kAhUMA
    o|uvtn Mupu, 1cuykupkn Ispyu, upun tutn, su0spou |pnvn,
    |nspo Ospo
    N spydod n onod odc unoous npdydcsscdi cnv vooooyikn ovccncd cou
    Iuocndciko Iknpospdcoc. Aopn yid cnv snioyn cou 0sdcoc duco unnp-
    s n voonsd ocnv |'hh cou NN6A I0JNP|A yuvdkdc do0svoc s svidspouod
    ouncudcooyd, yid cnv onod kdcniv 15spnc ispsvnonc cs0nks n iyvuon
    cou Iuocndciko Iknpospdcoc.
    N ip0puon cnc ndpouodonc sxsi uc snc: dnocsscdi dn cic ndpdkcu
    svcncsc:
    1 Lniniooyd-Aiciooyd-hd0oysvsid: snixsipscdi nspiskcikn dvdo-
    p ocd uc cpd yvuoc sniniooyik sosvd kd0c kdi ocouc ni-
    0dvoc diciooyikoc ndpyovcsc kdi nd0oysvscikoc nxdviooc cnc
    voou.
    2 kivikn Likvd: yvscdi ndp0son uv cuv ni0dvv kivikv skn-
    osuv kdi sninokv cou "I.I".
    3 iyvuon 8 idopikn iyvuon: nspidvsi s0ouc 8 kpicnpid
    iyvuonc 8 idopoiyvuonc cou "I.I" dn id nsid vooncuv.
    4 hopsd, hpyvuon 8 6spdnsd: dvdspovcdi cd ocid ssinc cnc
    voou, npoyvuociko skcsc kd0c 8 cd uc cpd xpnoionoiosvd
    0spdnsucik scpd.
    Ico csoc k0s 0sdciknc svcncdc dvcindpdc0svcdi cd ocoixsd nou nd-
    pouoiocnkdv s cd supndcd kdi cd kivik xdpdkcnpiocik cnc do0svoc
    nou dnocssos cnv dopn yid cnv spydod ducn.
    I69I
    AAIUN1 kAI IA1AAX 1h AIMU1Ah 1h XIUIIkh
    Avuyvctou 1n, nupnouo 8|o, kuuvtono0ou Iupuu|
    L0vik kdnoiozpidk dvsnioznio A0nvov
    kon: Ikonc cnc spydodc svdi n ndpouodon uv cuv sosvuv
    oov dop ocd dioocdcik npondcd nou npokncouv oco nso cnc
    xsipoupyiknc.
    N on kdi n nd0oysvsid cuv nponcuv diocdonc dndicov d osi-
    p dn svspysisc, oi onosc 0d ndpouoidocov dvducik, kdi 0d dopov
    cd 3 ocid idc syxspnonc: cnv nposyxsipncikn, cnv isyxsipncikn kdi cnv
    scsyxsipncikn nspoo. Is kd0sd dn ducsc cic nspiouc, o xsipoup-
    yc, ouxv os ouvspydod s cov didcoyo, kdscdi vd:
    - vd diooynosi nposyxsipncik cnv diocdon os do0svsc s yvuoc
    dioocdcik ssdcd
    - vd dvciscunosi id dnposvn dioppdyd
    - vd npousi dn cnv sv cu 0si sikn 0puon couc do0svsc
    uno kivvou
    - vd 0spdnsosi cnv scsyxsipncikn 0puon
    |k-Ms0oo|: Iuyypdcd nd0ooydc kdi xsipoupyiknc, kd0c kdi vs-
    cspd sosvd, nooisusvd os p0pd cuv iocoosuv cou |nternet,
    ocd syd site MLDL|NL kdi MLDSCAPL
    Anotsscutu-Ms0oo|: N diocdon dnocss svd ksdio cnc nd0o-
    oydc nou svdi sod ouvudosvo kdi ouvsssvo s cnv xsipoupyi-
    kn. Ui svspysisc yid cnv npnn kdi dvciscnion cuv dioocdcikv npo-
    ncuv nopov vd sdpoocov uc npuckod oco xpo cnc xsi-
    poupyiknc, nvcd s cnv ouvo skcnon cou didcoyou idcpo.
    I70I
    h kAINIkh A5IA 1h kUAUkUhh 1h INAIkUAUIIA
    kutckn Nkn
    B Iuvdikooyikn kivikn, l0kPATLl0, 6soodovkn.
    Ikonc cnc spydodc ducnc svdi vd skcin0ov cd supndcd dn cnv ko-
    nooknnon kdi cnv snioknnon cuv su ysvvncikv opyvuv os sucspi-
    koc do0svsc.
    N ndpood sscn npdydconoin0nks cn xpovikn nspoo 2000-20002 ocd
    sucspik idcpsd cnc 8` |uvdikooyiknc kiviknc cou voookosou |hhU-
    kPAJL|U 6soodovknc.
    Lsco0nkdv 140 yuvdksc nikdc dn 30 suc 75 scv s kupdpxd ou-
    ncdcd yoc, kvno, do0nd kdoou kdi uondpsvsid. konooko-
    nik dvsups0nkdv snnsd kovudcd os 6 yuvdksc I4,287l, sk ysvscnc
    vn scncuonc os 3 I2,147l, n siiksc syovsc cou knou os 38
    I27,147l kdi uoiooyik supndcd os 93 I66,427l yuvdksc. hdpdcnpn0n-
    ks unspoxn cnc konooknnonc svdvci cnc dnnc yuvdikooyiknc sscd-
    onc os nooooc 337.
    Iunspdodcik n konooknnon ndpouoisi syn kivikn xpnoi-
    cncd ocn iyvuon kdi 0spdnsd cuv nd0nosuv cou knou kdi cou cpdxn-
    ou ocnv kd0nspivn idcpikn npdkcikn.
    208
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I71I
    Akh kAI kANh 0NU OAIMUNh
    kuutono0ou Iupuu|, Avuyvctou 1n, nupnouo 8|o
    Ikonc cnc spydodc svdi vd ndpouoidocov cd ndpdkcu: kivikn sikvd,
    npoid0soiko kdi nd0oysvsciko ndpyovcsc, spydocnpidkn iyvuon, id-
    opikn iyvuon, 0spdnsd, sninoksc kdi npodn, s iidcspn dvd-
    op os d cd kdivopyid sniocnovik sosvd oxscik s co 0sd
    duc.
    Xpnoionoiovcdi ocoixsd dn cnv snvikn kdi is0vn iioypdd, kd0c
    kdi dn cssucdd p0pd nou nooisovcdi oco medscape.
    I72I
    1P AkUACP UF A A1IN1 S0FFkINU FkUM CPkUNIC PA1I1IS
    I8- or C-I
    Damaskos D|m|tr|os, kostare|os D|m|tr|os, e|ekas Spyr|don,
    kots|ou Stamat|a
    1
    4. Associated Professor of lnternaI Medicine, emocritus University of Thrace
    Jhe purpose of this project is to investigate the best way to approach a patient after
    he has been diagnosed with chronic hepatits I8- or C-l. Jo do so we searched the
    most recent bib|iography in order to form he most appropriate protoco| we shou|d
    hereafter fo||ow with these patients. Uur aim is to find the best procedure we
    shou|d fo||ow in order to avoid deterioration of the disease and the appearance of
    its possib|e comp|ications Isuch as hepatic cirrhosis, hepatoce||u|ar cancer hepatic
    fai|ure e.t.c.l by means of a thorough fo||ow up from the moment of the diagnosis
    and for the rest of the patient's |ife.We wi|| a|so refer to the criteria tha shou|d be
    met in order to reach the initia| diagnosis, the parameters of physica| and bioche-
    mica| examination and the prognosis of the patient.
    I73I
    hA1UNMUNIkU NUMU AOUOIUAUIIA, kAINIkh IkUNA,
    OAIA
    kctupso nntp|o, ucko nntp|o, ktc|ou tuutu
    1
    4. Avdnnpozpid kd0nynzpid d0ooydc 6
    Jo nndconvsuovik ovpoo dnocss ondvcikn sninokn cnc kppu-
    onc nou kdcdsikvsi cn ysvikcspn snncuon cnc nndciknc uosicoup-
    ydc os sunndcikoc iococ. N yvon cnc nd0ouoiooydc cou nndco-
    nvsuoviko ouvpou, n onod ouvsscdi ocsv s cd snnsd co NU
    oco dd kdi cnv unodid, on0 cov kivik yidcp oco vd snynosi cd
    dvciksisvik kdi spydocnpidk supndcd cou do0svoc, kdi vd 0sosi scoi
    sukocspd cn iyvuon coo cou ouvpou duco oo kdi cnc kppu-
    onc. Lnonc n sndpknc yvon cnc kiviknc ducnc ovccncdc 0d ousi
    ocnv son kivncononon cou yidcpo ocs vd dvciscunosi cnv unoks-
    svn voo, ysyovc nou 0d sciosi nio sod cn ysvikn kdcocdon cou
    do0svoc kdi kdc' snskcdon cnv npyvuon cou. Lninpo0scd 0d coviocs n
    dvdocpsicncd cnc voou n onod snioudvsi oxsv cducxpovd s
    cnv 0spdnsd cnc kppuonc Ikupuc sc dn scdoxsuon nndcocl.
    I74I
    MA1h 10N I0N 1U AI-1 kAI IOANh X1Ih
    1U M 1A IA UI1AIUAh, 1NFa, IL1, vUF kAI A1INh
    INAIk M 0UOkIkh IIh IIA IvF
    2uxupn I., 2uxupn O., 1oou| A., Acnuknouo 8., N|kostto N.
    Lpydoznpio Ouoiooydc, ldzpikn Ixon, As(dvponon, ..6
    kon: 0 dvdocosdc cou svspyonoincn cou ndoivoyvou IPA|-1lsxsi
    dvixvsu0s ocd uo0udkik uyp yuvdikv nou uocdvcdi uo0nkikn is-
    yspon os npypdd |vF kdi sxsi dvdsp0s ci ouoxscscdi dpvncik s
    cnv skdon cnc suoudciknc yovionononc.
    Icnv ndpood spydod sscn0nkdv cd snnsd cou PA|-1 oco dd kdi cd
    uo0udkik uyp yuvdikv un uo0nkikn isyspon, os oxson s cd snns-
    d oiocpdinc,JNFa, |L1, vLUF kdi sncvnc.
    |k ku| Ms0oo|: sydcd ddcoc kdi uo0udkikv uypv sn0nodv
    dn 53 yuvdksc, 20-42 scv, oi onosc unon0nkdv os uo0nkikn isysp-
    on ocd ndoid kkuv suoudciknc yovionononc. Icd sydcd dd-
    coc o nspsc npiv cnv uond scpn0nkdv oi cisc cnc oiocpdinc,
    ocd sydcd ddcoc kdi uo0udkikv uypv nou sn0nodv cnv nspd
    cnc uondc scpn0nkdv oi cisc oiocpdinc, PA|-1, JNFa, |L1, vLUF
    kdi sncvnc.
    Anotsscutu: Is d cd sydcd dvixvs0nks PA|-1. Icd sydcd dd-
    coc, ps0nks ci ouoxscscdi 0scik s cov ndpyovcd JNFa Ir0,416,
    p0,004l. sv ps0nks ocdciocik ondvcikn ouoxscion scd cou PA|-1
    kdi cuv unoonuv ndpdyvcuv, oco dd n ocd uo0udkik uyp. sv
    ps0nks ouoxscion cou PA|-1 s cnv skdon kkuv suoudciknc. Aun-
    svd snnsd PA|-1 ps0nkdv ocic kocsc I16,6267+1,30353l os oykpion
    s cd uo0uki d nou nspi s xdv pi d uokccdpd I13,8162+3,06787,
    p0,03l.
    unspucu: U PA|-1 sv svdi dnocssodcikc npoyvuocikc ndpyuv
    cnc skdonc cuv kkuv suoudciknc kdi cd snns cou sv sdpcvcdi
    sod dn: oiocpdin, |L1, vLUF kdi sncvn. Jd snnsd oco dd cou
    PA|-1 kdi JNFa ouoxscovcdi, svsxosvuc uc snnpsovcdi kdi dn
    d ouocndcd kdi pydvd nspdv cuv uo0nkv. Lvdi dvdykdd n nspdi-
    cspu ispuvon cnc oxsonc cou PA|-1 s ouc ndpyovcsc nnnc-ivo-
    uonc oi onooi sxsi dvdsp0s ci snnpsovcdi dn cn pon cuv ocs-
    posiv opovv.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    209
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I75I
    AOUOIUAUIIA 1h kI0h:
    U UAU 1U A1UIU k11AU
    ucko nntp|o, kctupso nntp|o, ktc|ou tuutu
    1
    4. Avdnnpozpid kd0nynzpid d0ooydc 6
    Ms sosvo cov dudvsvo sninodo cnc nndccidc kdi cnv sdpon
    cnc kdcxpnonc dko, dvdsvsvo svdi n sscn cnc nd0ouoioo-
    ydc cnc kppuonc vd dnokc iidcspn dpcncd. Lvdi yvuocn coo n nd-
    0ooyodvdcoikn sikvd oo kdi o cpnoc s cov onoo pouv oi iopoi
    snidpuvciko ndpyovcsc s csik dnocssod cnv kppuon cou nndcoc.
    Ikonc cnc spydodc ducnc svdi vd kdcdssi co po cou docsposioc
    nndcokuccpou uc koiko onsou ocnv ssin cuv dv cnc kppu-
    onc. N yvon cnc sicoupydc cou iidcspou duco kuccdpiko nn0u-
    oo cou nndcoc on0 ocnv kdcspn kdcdvnon cnc uoiknc iocopdc
    cnc voou kdi dvoysi vsouc pouc ocnv npoon0sid dvciscnionc cnc.
    I76I
    UIUOAIU 8Akk11
    upn 8., 8sp|u k., I|uvvcn A., M|n k., kuptn I.
    A dvsnioznidkn d0ooyikn kivikn ..6.
    U oiooyoc 8arrett, vooc cnc sonc nikdc, dnocss id nd0ooyikn
    snkcncn kdcocdon kdc cnv onod co uoiooyik noocio ndksc
    sni0nio dvcikd0ocdcdi dn ssiiksusvo scdndocik kuivpik sni-
    0nio. 6supscdi ci dnocss npoodpoocikn dvcpdon ocnv ndivp-
    non ydocpiko nspisxosvou ocov oiooyo. N ouxvcncd cnc voou
    sxsi dun0s cnv cssucdd skdscd. Icnv dnon ducn ouvscssos iid-
    cspd n ouscoxn cou pdxsoc cndcoc cou oiooyou 8arrett. N i-
    yvuon c0scdi s svookoniksc iosc kdi ndpouoisi dpkscsc uoko-
    sc, nou csvouv vd sdsouv vscspsc svddkciksc csxviksc nuc n
    8rush cyto|ogy kdi oi svookoniksc onciksc csxviksc. N kivikn ondod
    cou oiooyou 8arrett syksicdi xi vo oco ci ondvcikn dvdoyd cuv
    do0svv ndpouoisi sninoksc d kdi oco ci dnocss cov nsov on-
    dvcik npoid0soik ndpyovcd yid cnv dvncun uondodc kdi ds-
    vokdpkivdcoc cou oiooyou os ouxvcncd 0,57 scnouc. Iyxpovsc
    sscsc sniikouv vd kdcdvonoouv cnv kdcnn ducn cou oiooyou
    8arrett os dsvokdpkvud oco opidk snnso ocs vd nscxouv cnv
    nsov dnocssodcikn npnn cou. Msxpi ccs n 0spdnsd cou oioo-
    you 8arrett nspidvsi cnv kdcdocon cou ndivpoovcoc osoc dp-
    dksucikc, cnv dvcindivpoikn syxspnon kd0c kdi cnv nsov oy-
    xpovn 0spdnsd dnoknonc-ssinc cou oiooyou 8arrett.
    I77I
    k11AUIN1Ikh MA1h 1h IAh 1U NAMU
    1U AN1IkAkINIkU CAM1U kAI 1h U1A11Ikh 1PUL
    1A X0MU0MA1A AMOUk11A0N ANO0U IN vI1kU
    ktc|ou ., unuxpnctou O., Mnoy|utn ., A|u|pn O.
    Lpydoznpio Isvsziknc, Tnd ldzpiknc As(dvpononc, ..6
    kon tn nupo0cu spyucu ncdv n kuccdpoysvscikn sscn nou s-
    dvouv ocd xpuoodcd kdispysiv nspispikv sokuccpuv
    dv0pnou o dpdksucik ndpdoksuodcd n Campto Icamptothec-
    ins, CAMl kdi n Lthyo| IAmifostine, LJNl cd onod xpnoionoiovcdi ocnv
    0spdnsd kdc cou kdpkvou.
    |k ku| s0oo|: N LJN id0scsi kuccdponpoocdcsuciksc iicncsc ocn
    0spdnsd kdc cou kdpkvou, sv sninsov sdvsi ondvciksc dvcis-
    cdocdciksc kdi dvciscd-dioyvsc sniposic. N CAM sxsi dvcikdpkivikn
    pon supsuc odcoc dvdocsovcdc cnv DNA conoioospon | kdi
    npokdvcdc ioxupsc sc kdi 0pdosic ocn inn sikd cou DNA. Jd
    nsipdc dc npdydconoin0nkdv os kdispysisc nspispikv so-
    kuccpuv dv0pnou kdi n pon cuv ouykskpisvuv dpkuv sscn0n-
    ks s cn scpnon cuv sninsuv cuv xpudciidkv dvcddyv ISister
    Chromatid Lxchanges, SCLsl uc skcn souv dv oco ysvscik uik.
    Lninsov diooyn0nkdv cd snnsd cou icuciko skcn IMl kdi cou
    skcn pu0o nodndoidoo IPhl uc sikcv kuccdpocoikcncdc
    kdi kuccdpo-ocd-cikcncdc dvcocoixd.
    Anotsscutu: Jd supndcd cnc ndpoonc spydodc ssidv ci unpxsi
    npoocdcsu-cikn pon cnc LJN svdvci cnc dnciknc ponc cnc CAM ocd
    xpuoodcd cuv sokuccpuv in vitro.
    unspcutu: Gdvscdi ci n xpnon cnc LJN ocnv dvcikdpkivikn 0spdnsd
    nops vd npoocdcsosi cd kccdpd dn cic dvsni0ncsc sniposic cuv
    iopuv dvcikdpkivikv nuc n Campto.
    I78I
    N01A UMNA 1hN AI1IUAOUINIA 1h AkUI0h
    Xpucoxou ., U|kovou N., upucksuun X., M|xsn M., 2ncou X.,
    O|ssyko A.
    ldzpikn Ixon L. k. dv. A0nvov
    N odpkosuon svdi d nououocndcikn vooc. N kivikn cnc nopsd
    noiksi, dn cnv douncudcikn voo s ducdcn don, sxpi cnv npoo-
    sucikn ouocndcikn voo s dvsnpksid idpuv opyvuv, nou nops
    vd onynosi dkn kdi oco 0vdco.
    N diciooyd cnc svdi yvuocn. kd0nspiv yvovcdi sscsc yid vd ps-
    0ov oi ndpyovcsc nou onyov ocnv svion cnc. Txouv svoxonoin0s
    ysvsciko, dvooooyiko, oioyvoi kdi nspidovciko ndpyovcsc. |o-
    vid nou kuikonoiov dvciyvd cou sovoc ouocndcoc iocooudc-
    cncdc dvscdi vd ndouv ondvcik po. Lnonc n idcdpdxn cuv dvo-
    oooyikv nxdviov nops vd onynosi ocnv dvncun cnc voou.
    npxouv svssic nou svoxonoiov ikpoopydviooc nuc co ukod-
    kcnpio cnc udcuonc, ioc kdi xdid. Lnonc n ouxvcspn svi-
    on cnc os knoid sndyysdcd, nuc ocic voooksc kdi couc nupoos-
    ocsc onynos ocnv un0son ci svdc nspidovcikc ndpyovcdc su0-
    vscdi yid cn voo.
    hdp cic noupi0sc spsuvsc nou sxouv yvsi nvu ocnv diciond0oysvsid
    cnc odpkosuonc, sv sxouv ps0s ikdvonoincik ocoixsd nou vd dno-
    sikvouv cnv su0vn svc dn couc ndpdnvu ndpyovcsc. N snikpdco-
    od non svdi ci os cod s ysvscikn npoi0son, d noikid dn
    nspidovcikoc ndpyovcsc nops vd nupoocnosi cnv svdpn cnc v-
    oou.
    210
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I79I
    Ik1 OAIMUNh 1UN kNUMNU AA
    upucksuun X., M|xsn M., U|kovou N., Xpucoxou ., 2ncou X.,
    8.uv|, I.su0sp|ou, .Ipssv|tn
    ldzpikn Ixon L. k. dv. A0nvov
    txo: Ayu cou ci cd cssucdd 10 xpvid unnps d skpnn svids-
    povcoc ocnv sscn kdi dvuon cuv ouocdcikv cou sknvssvou dspd
    uc cpno ndpdkoo0nonc cnc syovnc kdi cou osiuciko stress ocouc
    nvsovsc, n ndpood spydod sxsi uc ocxo vd dvdssi cn xpnoicncd
    cnc dvuonc cou sknvssvou dspd ocn iyvuon kdi ndpdkoo0non
    cuv nvsuovikv nd0nosuv.
    |k ku| s0oo|: |id cnv dvncun cou 0sdcoc npdydconoin0nks i-
    ioypdikn spsuvd ocnv ndykoid dp0poypdd. |id co okon duc,
    xpnoionoin0nkdv osic sosvuv cou idikcou, kd0c kdi iopsc
    snviksc iio0nksc.
    Anotsscutu-unspcutu: Ui nspioocspsc sscsc sxdv sniksvcpu-
    0s oco sknvssvo NU, d npodcd dvdkd0nkdv kdi xpnoionoin-
    0nkdv kdi d ncncik dspid ICU, di0vio, nsvcviol. Lninpo0scd, no
    svoysvn ouocdcik Isoodncsc syovnc, kucokvsc, osiucikl
    nopov vd dvixvsu0ov oco ounkvud cou sknvssvou dspd, dvo-
    yovcdc vssc npoonciksc yid cnv dvuon cou. N dvxvsuon kdi scpnon
    cuv sikcv syovnc cou sknvssvou dspd nops vd on0nosi ocnv
    idopikn iyvuon kdi ndpdkoo0non nov nvsuovikv nd0nosuv,
    nou xdpdkcnpovcdi dn syovn kdi osiucik stress, nuc svdi yid
    ndpsiyd co o0d, n xpvid dnopdkcikn nvsuovon0sid IXAhl, oi
    poyxskcdosc, n kuocikn vuon. Ui cisc svdi idyvuociksc yid co ovpo-
    o cuv dkvncuv kpooov, cnv kuocikn vuon kdi cn ixucn ndvpoyxio-
    cid.
    unspucut|k, nopos vd nos ci n dvuon cou sknvssvou
    dspd svdi d n snsdcikn csxvikn yid cnv skcnon cnc syovnc,
    d unpxouv svssic ci nops vd sxsi ondvcikn 0son ocn iyvuon
    kdi 0spdnsd nvsuovikv nd0nosuv sovcik. Ancspoc ocxoc svdi
    n dvncun cnvcspuv kdi nio diniocuv dvducv, nou 0d nopov vd
    xpnoionoin0ov os voookoso kdi dpycspd ocnv dvncun npoouni-
    kv ouoksuv ndpdkoo0nonc yid iiucikn xpnon dn couc do0svsc.
    I80I
    NUMU A5hMNh NUkUIAIAkh Ih
    NUMU kUIAIAkU IAMIMA1U
    2ncou X., U|kovou N., M|xsn M., Xpucoxou ., upucksuun X.
    ldzpikn Ixon L. k. dv. A0nvov
    kon: Icxoc cnc ndpoodc spydodc svdi dl v' dnodoiocs noioi do0s-
    vsc kivuvsouv dn co ovpoo l n cducononon cou ouvpou sou
    spydocnpidkv-kivikv ndpdscpuv yl v' dvdyvupiocov cd ouocndcik
    nd0ouoiooyik sndkou0d cnc svokoiidknc unspcdonc l vd ps0s
    os noi onso n dnon cnc svokoiidknc nsonc dpxsi vd yvscdi d-
    ncikn ndpyovcdc svd npdydcik ovpoo koiidko idspodcoc sl
    v' dndvcn0s noio svdi co kpoio snnso cnc svokoiidknc nsonc nou
    dndics 0spdnsucikn ndpsdon ocl vd o0ov ocoixsd yid cn idxspion
    ocn ovd svcdciknc 0spdnsdc IML6l l vd o0ov nnpoopsc yid cnv
    sykdipn npsn kdi npnn ni0dvv nponcuv, ndpsxovcdc ou-
    xpvuc nnpoopsc yid cnv isdyuyn cnc dnoounisociknc koiioconc
    kdi cn idxspion cnc "dvoixcnc" koiic nl vd kdu0ov dvsspsvncsc
    nspioxsc cou ouvpou kdi vd o0ov sovciksc onysc.
    Ms0oo-|k: |id cnv dvncun cou 0sdcoc npdydconoin0nks iio-
    ypdikn spsuvd ocnv ndykoid dp0poypdd.ik cnc sscnc dnocs-
    ov npodcsc dvdkoivosic kdi ocoixsd dno co xpo cnc idikcudknc
    idcpiknc svnspuonc. |idcspd xpnoid yid cnv sdyuyn ounspdocuv
    ncdv cd spydocnpidk nsipdcd nou dvdspovcdi ocic sscsc.
    Anotsscutu-unspcutu: 1. Anosx0nks svdc unc d0c ou-
    oxscionc dvsod ocnv kuocikn kdi ocnv sod scpnsvn svokoiidkn
    nson os syn noikid svokoi-idkv nisosuv sxpi kdi cd 70 mmNg 2.
    npxsi svcovn oxson scd svokoiidknc ns-onc, ydocpiko svvo-
    yviou pN IpNil, dunsvnc svcspiknc idnspdccncdc IJrans|ocationl kdi
    cnc sndkou0nc nodnnc opydviknc dvsnpksidc kdi 0dvcou 3. N su-
    on cnc ondxviknc didciknc ponc kdi n osuon cou svcspiko svvoy-
    vou skivov os xdncspsc koiidksc nisosic, no npiv oi sknosic
    cou ouvpou yvouv kivik sdvsc 4. Jo kpoio snnso nou n
    svokoiidkn nson yvscdi svokoiidkn unspcdon svdi 20-25 cm N
    2
    U 5. N
    cpid cnc uno0spdc-osuonc-nd0ooyiknc nnnc ddcoc d s cn
    ouxvn sninokn cou ouvpou, dv sv iop0u0s sod ocn ML6, onys
    oco 0vdco.
    Msovt|ks poont|ks: 1. Jo ovpoo sndvdicuonc npokncsi cdv
    n svokoiidkn unspcdon dvdkouiocs dncod 2. U poc cnc xpvidc
    dunsvnc svokoiidknc nsonc ocnv nd0oysvsid cnc voonpnc ndxuodp-
    kdc kupuc os oxson s cov syksdik suo-yko kdi cnv svokpdvid-
    kn unspcdon 3. Ui svokpdvidksc dnoppu0osic ocd ndoid cou ouv-p-
    ou sxouv nspiypds sndpkc 4. Upiosvsc nsupsc cnc nposkddc n
    skddc nopov v'dnoo0ov ocnv svokoiidkn unspcdon 5. U poc
    cou ouvpou ocnv nd0o-ysvsid cnc vskpuciknc svcspokocidc 6. N npi-
    n dnoounson, nou doscdi ocnv kuocikn nson kdi oco pNi, svdi snu-
    snc ocn suon cnc voonpcncdc kdi 0vnoicncdc dn co ovpoo 7.
    U poc cuv n xsipoupyikv s0uv ocn suon cnc svokoiidknc ns-
    onc os n dndpdcncn koiiocon 8. N nson cnc oupoxou kocnc svdi
    npoyvuocikc skcnc cnc svcspiknc ioxdidc.
    I81I
    IAAUI IUN10N kAI MUkAIAkh AI1UIIA
    kuunku uvoun
    1
    , kupuo0 Mupu
    1
    , koupsn 1u|pxn
    1
    , ko0kou
    nntpu
    1
    , Xutn Ispy|o
    1
    4. Ooiznznc.zpid ldzpiknc Ixonc dvsnioznou A0nvov
    Jo 0sd cnc spydodc dc svdi n sscn cnc ynpdvonc os snnso dvciv
    kdi kdvdiv ivcuv cnc kdpic. N sscn ducn dnocss s0uvon sp-
    ydodc nou snicssocnks s dopn cn sscn cou dvciksisvou cnc u-
    oiooydc cnc dvncunc kdi ynpdvonc.
    An cd kdvid ivcuv os duc nou onspd svdi nspioocspo sscns-
    vd kdi spsuvncik npoosyyisvd, svdi cd kdvid ivcuv dosocou, cd
    onod uocs- ivcd dosocou- idpddcouv cov kupicspo po ocn
    uokdpidkn ouocon.
    Ui scdosc couc os oxson s cnv nikidkn ynpdvon, dnocsov co dvci-
    kssvo cnc sscnc dc, cd s dnocssodcd cuv spsuvv dc 0d ndpou-
    oidocov kdc cn ipksid cou ouvspou.
    I82I
    1UUI Ah 10N MUOUIUN0N UI0N
    kuunku uvoun
    1
    , kuoo0cn Xpucuo0u
    1
    ,
    kuno0poyou Ispy|o
    1
    4. Ooiznznc.zpid ldzpiknc Ixonc dvsnioznou A0nvov
    An cd dpxdicspd kidc xpvid svd dn cd nsov 0ssin sniocno-
    vik d kdi ioooik spucndcd nou snpsns vd dndvcn0ov, ncdv co
    nuc svdi uvdcv dn svd dn kdi iou ov0sco "kdcdoksdod"
    In.x. svd duyl vd dvdncooovcdi oknpd onokd nioupydc, ov-
    0scoi kdi nounokioi opydvioo.
    N spydod dc doxoscdi s co nuc opiosvsc ouosc kdi uoiko ndpyo-
    vcsc-n.x. dkcivood, 0spcncd kn.- nopov vd snnpsouv cn opo-
    ysvson iocv kdi opyvuv.
    Jd dnocssodcd, nou ni0dvc 0d svdi dvcocoixd s duc nou 0d sni-
    oudvouv ocov v0puno, 0d ndpouoidocov kdc cn ipksid cou ouvs-
    pou.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    211
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I83I
    INIk MA1 8AIMN 1hN UOAAk1Ikh OAIA
    M AIINh 1h A1hIAkh 1Ah kA1A 1h IAkIA
    1h IkMUNh
    A|y|vntou A., ousvono0ou .
    dvsnioznidkn Mdisuzikn kdi Iuvdikooyikn kivikn BL0A Tiioopd
    Poudvdc.
    kon: Nd dnosous ci kdc cn ipksid cnc sykuoovnc nops vd
    sknu0s nd0ooyikn dpsi dpcnpidkn unspcdon IAl, sdicdc dns-
    niposuv dyysioidocdcikv npoocdydvivv PU12 kdi dyysioouond-
    ocikv JxA2 kdi dyysiocsvovnc ||, n onod nops vd npon0s s cn
    xopnynon donipvnc.
    |k ku| s0oo: Msscnods cnv snpdon ikpv osuv donipvnc
    os 23 sykusc yuvdksc s A npocosdvisvn ocnv sykuoovn kdc
    cn ipksid cou 2ou kdi 3ou cpnvou cnc knonc. N sscn dc doocnks
    ocnv snpdon cnc donipvnc os ikpsc osic ocnv dyysioouondocikn
    npoocdkukvnc JxA2, nou 0d nopoos vd ssys cnv dnon cnc dpcn-
    pidknc nsonc.
    Anotsscutu: N donipvn os ikpn on 40-50 mg/nspd nops vd o0s
    odv dvcinpoocdydvik dvci JxA2, uc 0spdnsd ocnv A cnc sykuoovnc
    kdi dpycspd odv nponncikn 0spdnsd yid cnv ocd0spononon cnc dpcn-
    pidknc nsonc ocic udoiooyiksc cisc sxpi cov coksc.
    unspcutu: N donipvn os ducn cn on I40-50 mg/nspdl scivsi
    cn pon cou ddcoc ocn ncpondkouvcidkn kukoopd kdi sdccvsi
    cnv dvcocdon cuv odikv dpcnpiv, kci nou sxsi sdkpiu0s kdi s
    Dopp|er. Lnonc, npodvsi cnv kd0uocspnon cnc svoncpidc dnonc
    s cnv npoun0son ci n 0spdnsd 0d sdpoocs dsouc do yvsi n
    iyvuon cou npondcoc.
    I84I
    P O0AkUkUhh 1h IAIN0h NUhMA10N
    1U ANAN1IkU 1hMA1U
    2oyontn O., kutctou M., kupuk0p|ou ., kupuy|uvvou .,
    Xotouuvn X., Iukn ., kovtuk|tn O.
    Movd fpoyxookonnosov, vsuovooyikn kivikn A6
    N 0updkooknnon sdpocnks yid npcn op npiv 70 xpvid ocn 0spd-
    nsd cuv udciuv unsukocikv ouoyv kdi s cn scuon cuv
    csxvikv kdi cuv nxdvncuv sxsi yvsi nsov d no xpnoin s0ooc
    ocn iyvuon d kdi cn 0spdnsd vooncuv cou nvsovd kdi cnc
    unsukociknc koicncdc. N csxvikn yid vd sdpoocs dndics cnv ndpn
    nvsuo0pdkd n unsukociknc ouoync idopscik o kvuvoc nioup-
    ydc poyxonsukociko oupiyyou dn cnv cpon cou nvsovd svdi
    syn. Is nspncuon nou n s0ooc npsnsi vd sdpoocs os do0svsc
    xupc nvsuo0pdkd n unsukocikn ouoyn ccs nioupyscdi csxvn-
    cc nvsuo0pdkdc kdi snsicd sdpscdi n s0ooc. Ui nspincosic nou
    xpnoionoiscdi n 0updkooknnon svdi: 1. Aucdcoc nvsuo0pdkdc
    Iiyvuon unonsukocikv kocsuv, idnocuon cnc kdcocdonc cou
    coixudciko kdi ondxviko unsukcdl 2. Dykoi cou 0updkiko coix-
    dcoc kdi cou soduou Iidnocuon cnc onc kdi cnc 0sonc cou ykou,
    nn iodcl 3. hsupiciksc ouoysc Idvdppnon cou nsupiciko
    uypo, siodyuyn dspd kdcspn dnsikvion kdi idxupioc cou coixud-
    ciko dn co ondxvik unsukcd, nn ioiv, nsupson, ouu-
    oiuonl, 4. hspispiksc nvsuoviksc sc Inn ioivl. 5. Iuon
    ocn diciooyikn iyvuon cuv ixucuv isouv nvsuovond0siv. Jd
    cssucdd xpvid n kdoikn 0updkooknnon dvcikdcdoc0nks dn cnv
    unoon0osvn s vcso 6updkooknnon Ivideo Assisted Jhoracoscopy,
    vAJSl kdi npodcd okiocnks co niskdnco 0updkooknio nou kd-
    0ioc cn s0oo sxiocd snsdcikn kdi iidcspd idyvuocikn.
    I85I
    UOh Xhh 10N "200N 1U IA1hIU" 1hN IA1Ikh NA
    kouy|outn Asuvpo, Mnu uvuy|tu, kouy|outn Avpsu, Mupv-
    ou-1ousskn Mupu
    Lpydoznpio Odpdkooydc, ldzpikn Ixon, A..6.
    Jd d spydocnpou svdi dndpdcnco "spydso" k0s spsuvncn kdi dc
    on0ov ocnv dnkcnon yvosuv nou dpycspd 0d sdpoous os dv-
    0pnouc.
    Ikonc cnc spydodc dc svdi n svnspuon ouv, n sniocnovikn dvd-
    ykdicncd snisi, 0d doxon0ov n doxoovcdi s cov nsipddcio
    os d, ndpo nou yvscdi npoon0sid dvncunc svddkcikv s0-
    uv ocs vd nspiopiocs ducc o nsipddcioc.
    N oxscikn Noo0sod ocnv Ld, os svdpvion s cnv L.L., npoond0s
    vd osi cd npondcd nou osovcdi kupuc ocnv yvoid cou sniocn-
    oviko koou, ocic ypdsiokpdciksc idikdosc d kdi ocnv ssin
    kdcnnc unoonc.
    N ouvspydod ouv snskovcdi ocn xpnoiononon uv yid nsipddci-
    koc okonoc 0d sciosi n/kdi 0d sniosi cuxv npondcd, ici n
    npoocdod couc dn n cnv sniocnovikn od d kdi dn cov kcn-
    vdcpo uc svspyncik cnc soc dnocss unoxpsuon dc.
    I86I
    XIUIIkh AN1IM10Ih 1AMA1Ik0N kAk00N
    1U AXU N1U
    ununouo 8., 2utuy| A., uvuy|tnouo N., unuy|vvn .,
    unuo|xskn M., Anocton ., Xupu0tn N.
    A' pondisuzikn Xsipoupyikn kivikn A..6.
    Noookoso AXLA 6soodovknc
    Jnv nponyosvn skdscd dvciscunocnkdv xsipoupyik ocnv A' hpo-
    ndisucikn Xsipoupyikn kivikn cou A.h.6. 8 do0svsc s cpdudciksc kd-
    kosic cou ndxsoc svcspou.
    Lnc dn couc do0svsc ducoc ncdv vcpsc kdi 1 yuvdkd.
    Ui 5 dn ducoc sxdv dvoikc cpddcd cd onod osovcdv os csvovcd
    kdi vooovcd pydvd kdi os nupoo no, sv oi unoinoi 3 sxdv
    ksiocsc kdkosic.
    Ui ouvunpxouosc kdkosic ncdv dvoysc cnc dicdc nou npoksos cov
    cpdudcio. Icic ksiocsc kdkosic ouvunnpxdv pnsic nndcoc, kdcyd-
    cd cuv oocv cnc skvnc, sv ocic dvoikcsc oi kdkosic dopoodv ony-
    xvd, cd onod pokovcdv ocnv nopsd cou cpdudcovcoc opyvou n cuv
    ncuv.
    N svcnion cuv ksiocv kdkosuv cou ndxsoc svcspou ncdv co sykpoio
    ko os 2 nspincosic kdi co oiyosisc os 1. Ui dvoikcsc kdkosic do-
    poodv oco op0, ocn si koikn kdnn, oco cu kdi oco kdciv ko.
    N xsipoupyikn dnokdcocdon cuv ksiocv kdkosuv cou ndxsoc svcspou
    syivs s skcon cou cpdudciosvou cndcoc cou ndxsoc svcspou kdi
    ocic 3 nspincosic. Is 2 dn cou do0svsc syivs csikocsikn dvdocuon
    os npco xpvo xupc cn isvspysid npoudkciknc ocodc, sv ocov
    ov do0svn syivs csikn oiyosioocod kdi dnokdcocdon cnc ouvs-
    xsidc cou ndxsoc svcspou os scspo xpvo.
    Icic dvoikcsc kdkosic cou ndxsoc svcspou syivs vsdpononon cou cpd-
    dcoc kdi ouppdn xupc npoudkcikn ocod os 3, os 1 syivs vsdponon-
    on kdi ouppdn, npoudkcikn ocod kdi dnokdcocdon os scspo xp-
    vo kdi os 1 syivs skcon cou cpdudciosvou cndcoc, csikn oiyosio-
    ocod kdi dnokdcocdon os scspo xpvo.
    N scsyxsipncikn nspooc unnps os ouc kdn.
    Iunspdvscdi nuc kdc cic ksiocsc kdkosic cnc koidc uvdc vd ndpd-
    cnpn0ov cpdudcioo oco ndx svcspo oovci sv svdi ouxvo kdi
    ouvunpxouv s sc kdkosic cuv koiidkv onyxvuv. N dvciscni-
    on cuv ksiocv kdi dvoikcv kdkosuv cou ndxsoc svcspou uvdc vd
    yvsi os svd n os o xpvouc dvdyuc cnc dpcncdc kdi cnc svcnionc
    cnc kkuonc.
    212
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I87I
    ANAkUhh I1A1Ik0N M kIA IAIN0h NUINU ANU5IA,
    U NUhA1hkAN TXIA1IkU 1MhMA
    NUNUUkUMIAkh NUhAIA
    uvuy|tou-U|kovou A., U|kovou k., Xp|ct|uvnouo k.
    +uxidzpikn kivikn diiov kdi Lnfov I..N. lnnokpzsio 6so.viknc
    kon: Ikonc cnc spydodc svdi n kdcspn kdcdvnon cnc voou oco
    ndoio cnc snviknc npdydcikcncdc.
    |k - Ms0oo: Jo uik cnc sscnc npospxscdi dn co cnd svovo-
    ookosidknc voonsdc cou +uxidcpiko Jndcoc hdiiv 8 Lnuv cou
    |nnokpcsiou |.h.N. 6soodovknc. hspidvsi 12 kopcoid 11-17 scv
    nou voonscnkdv s kpid iyvuon vsupoysvoc dvopsdc kdc co
    xpovik iocnd 1992-2000.
    Anotsscutu: 0c npoc cnv nikd svdpnc idniocvscdi ci oco 58,37
    cou sydcoc Isnc codl oi do0svsc ncdv suc 13 scv. Lkucik dcio
    unpxsi os nooooc 66,77 Ioxc codl nou idniocvscdi ci kdc 757
    Isi codl npksicdi yid oxoik ouv, kdc 507 Insvcs codl idni-
    ocvscdi ondvcikc dnoxupioc kdi oco 507 Icsoospd codl dunsvo
    poc odcoc. Lniondvous ci ocic nspioocspsc nspincosic dvds-
    povcdi nspioocspoi dn svdv skuciko ndpyovcsc. Ico 757 cou syd-
    coc Isvvsd codl ocic oxsosic yovsuv unnpxdv ouykpoosic nou uc
    kdc 58,37 Isnc codl sv skpovcdv dvoixc.Doov dop ocd dcoi-
    k xdpdkcnpiocik cuv do0svv idnioc0nks cssio0npd, uokosc uc
    npoc cnv koivuvikcncd kdi piocsc oxoiksc sniosic. Jo 66,77 ndpou-
    ods idcdpdxsc uc npoc cnv sikvd cou odcoc.
    unspucu: Ico syd nou sscn0nks idnioc0nks ci oov dop
    co o cd kopcoid unspcspov ondvcik. Icic nspioocspsc nspinc-
    osic unpxsi skucik dcio, xdpdkcnpiocikn on cnc oikoysvsidc kdi ou-
    ykskpisvd ocoixsd ocnv npoounikcncd cuv snuv.
    I88I
    h hMIUIIA kAI h ANA15h 10N hN0N U10h 1I IOI
    kAI 1I AUOI
    Nsvnouo A., sny|vvn X., Mncu O., 8spvpo M., 8spvpo N.
    ldzpik znd A..6.-B0p0ondiikn kivikn A..6.
    Yns0uvoc kd0nynznc: Nsvnouoc I.., Avdn.kd0nynznc
    Ui sniuoidko n sucspoysvsc nupnvsc oocsuonc sdvovcdi ocn s-
    yn nsiond couc sc cov coksc os idopscik xpovik idocnd-
    cd o kd0svdc.Ikonc cnc spydodc ducnc svdi n sscn cnc svionc kdi
    ssinc cuv ndpdnvu nupnvuv ocic sniosic cuv sninkuv oocv ocd
    vu kdi kcu kpd.
    Msscnods couc nupnvsc ducoc os dkcivoypdsc cou dpxsou cnc 8`
    Up0ondiiknc kiviknc cou A.h.6., os iopsc niksc. hdpdcnpnods ci
    n svion cuv sucspoysvv nupnvuv oocsuonc idspsi dvoyd s
    cnv nikd kdi co skococs oocov. kdc kdvvd sdvscdi svdc nupnvdc
    os k0s snuon s sdpson cnv vu kdi kcu snuon cou pdxiovou, cd
    scdkpnid, cd scdcpoid kd0c kdi cic dyysc cnc kpdc xsipc kdi
    cou kpou noc. hdpdcnpnods snonc cnv idopscikn dkcivooyikn
    sikvd ocouc iopouc nupnvsc os idopsciksc niksc. Icdidk oi su-
    cspoysvsc nupnvsc oocsuonc duvouv os sys0oc kdi kdcddvouv,
    s cnv npoo cnc dvncunc, sydcspo spoc cnc xvpivnc snuonc
    suc cou, oco csoc cnc dvncunc, ouvoocsu0ov s cn scuon.
    hdpouoious cd dnocssodcd cnc sscnc ducnc ici n yvon cnc
    nioupydc kdi ssinc cuv ndpdnvu nupnvuv svdi doikn npon0s-
    on, yid cn ouocn iyvuon kdi cnv scsnsicd dvciscnion dc kkuonc,
    ocic siikcncsc cnc Akcivooydc kdi Up0ondiiknc.
    I89I
    h I1UIA 1U NUUkUMIU AAIA
    I"kU1AIMANIU-1IAN1AOAAIU"I
    A0ovn Nsktp|o
    1
    , Mnupy|tu A|kutspvn
    2
    , kupukucn Ivvn
    3
    4. 2sznc oiznznc Tndzoc ldzpiknc A..6., 2. Tssioizn oiznzpid
    Tndzoc ldzpiknc A..6., 3. ldzpc
    Ms cnv npoocopd cou vd xvscdi ocd 0n cuv divuv, skivvcdc ouc
    ccs nou o ndcspdc cnc idcpiknc |nnokpcnc pus ocn 0soodikn yn co
    nspno doknnso cou kdi dpycspd snssys ducnv dkpic cn yn yid vd
    oksnosi co od cou, n iocopd cou |sviko hspispsidko Noookosou
    cnc Apiodc "koucinvsio-Jpidvcdsio" dpxsi s cn 0ssuon cou
    ocd csn cou Gspoudpou cou 1889, xpn ocnv npucooud kdi cn pd-
    ocnpi ono non svc snpou, svc ncpono cn, svc ouoouvou
    kdi svc npxou...
    ...|id vd nsposi sod dn id noucpdxn nopsd ndpnn s ducnv
    cnc ndcpdc dc kd0' n cn ipksid cou snonc noucpdxou divd nou
    ic cssuos, ounnpvovcdc 100 kdi nsov xpvid ouvsxoc unc kdi
    npooopc...
    ...kdi, dodc, dcsvovcdc cov vsd xiiscd nou nn skvnos s dioio-
    od kdi npooncikn, scoio vd dvciscunosi cic vssc npoknosic kdi vd
    ouvsxosi vd npoospsi od nspioocspd nops oco 0soodik nn0u-
    o...
    I90I
    kAkINUII UIkUI k0AhkUIU AUOh
    ununouo 8., 2utuy| A., uvuy|tnouo N., unuy|vvn .,
    unuo|xskn M., Anocton ., Xupu0tn N.
    A' pondisuzikn Xsipoupyikn kivikn A..6.
    Noookoso AXLA 6soodovknc
    hdpouoiovcdi 6 nspincosic do0svv s kdpkivosin yko ocn okun-
    kosin dnuon nou dvciscunocnkdv xsipoupyik ocnv A' hpondisuci-
    kn Xsipoupyikn kivikn dn cov |dvoupio cou 1990 suc co skspio cou
    2002 kdi yvscdi dvdoknnon cnc npodcnc is0voc iioypddc.
    Ui kdpkivosisc ykoi svdi id iidcspn opooyik cn ykuv cou
    ydocpsvcspiko ounvd. N iooyikn couc ounspiop svdi iycspo
    sni0scikn dn cd dvcocoixd dsvokdpkivdcd, sxouv svokpivsc iicn-
    csc kdi svdi dpksc onvioi. N ouxvcspn 0son svcnionc couc oco yd-
    ocpsvcspik ounvd svdi n okunkosinc dnuon. N iyvuon ducv
    cuv ykuv svdi ouvn0uc cuxdo xsipoupyik n iocooyik spnd sc
    dn okunkosiskcon, kd0c sv npokdov siik ouncdcd. Jo
    kdpkivosisc ovpoo svdi n ouxvcspn ouocndcikn couc sknuon, n
    svion kdi n svcdon cou onoou svdi dvoyn s co sys0oc, cnv svc-
    nion cou ykou kdi cnv ndpouod scdocosuv, ocoixsd kd0opiocik yid
    co oxsido cnc op0cspnc 0spdnsuciknc dvciscnionc.
    Ui iksc dc nspincosic skn0nkdv s ouncudcooyd osdc oku-
    nkosicidc kdi unon0nkdv os okunkosiskcon. N iyvuon cou
    kdpkivosioc cs0nks s cnv iocooyikn sscdon. Is 2 dn ducoc, sc
    co dnocssod cnc iocooyiknc sscdonc kdi yu cou sys0ouc cou ykou
    I> 2 sk.l dnodoocnks n isvspysid sic nikoskconc. Is kdvsvdv
    dn couc do0svsc dc sv ndpdcnpn0nks scocdon ocs kdi dvncun
    cou ouvpou.
    Doi oi do0svsc svdi sv un, ss0spoi voou kdi ndpdkoou0ovcdi
    sc cnv syxspnon.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    213
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I91I
    kUAIkU NA1IUh1IkU 1IIU kAI AMM1h 1UOIA
    1U MUkUIAIAkU IAOAIMA1U 1I XUNI NMUNUAOI
    1cuupou 8., uuo0 8.
    1
    , Ospsn .
    1
    , hcuu M.
    1
    , Xoupuvn A.,
    Aykouxusn Nsct.
    4. snzosznc oiznzpid ldzpiko zndzoc A..6.I
    vsuovooyikn kivikn Apiozozssou dvsnioznou 6soodovknc,
    Noo. I. dndvikoou'.
    Ikonc cnc ndpoonc spydodc ncdv n sscn cnc dvdnvsuociknc sicoup-
    ydc kdi o npooiopioc cuv sninsuv cou koniko vdcpioupnciko ns-
    nciou cou nodcoc IS-ANPl kdi cuv nxokdpioypdikv ILchol ndpd-
    scpuv cnc sic koidc os 49 cod I35 do0svsc s xpvid nvsuovikn
    kdpd kdi 14 pcupscl.
    Jd dnocssodcd ssidv:
    1. Anon cuv civ cou S-ANP oco 597 cuv do0svv, nou oxscscdi ocd-
    ciocik ondvcik s cnv unspcpod cnc sic koidc oco Lcho, xi
    uc kdi s couc skcsc cnc dvdnvsuociknc sicoupydc.
    2. Aoscpn unspcpod cou sookoiidko idpydcoc IASNl oco
    567 cuv do0svv, nou oxscscdi ocdciocik ondvcik s cnv unsp-
    cpod kdi cnv dnon cnc idscpou cnc sic koidc oco Lcho, cnv
    dnon cnc PCU
    2
    kdi cnv sccuon cnc FLv1.
    3. N cin cou ANP sv oxscscdi ocdciocik s cnv ASN.
    Iunspdvous ci:
    1. N dnon cnc cinc cou koniko vdcpioupnciko nsnciou dnocss
    dinioco skcn unspcpodc cnc sic koidc cnc kdpic ocic xp-
    visc nvsuovon0sisc.
    2. N doscpn unspcpod cou sookoiidko idpydcoc dnocss
    sninsov ondvcik d dvspcnco ndpyovcd npoyvosuc cnc d-
    pcncdc cnc xpvidc nvsuoviknc kdpdc kdi skcn cnc uvdsvnc vd
    dvdncux0s npooonc uosicoupydc cnc dpiocspc koidc.
    I92I
    h AI1IUAOUINIA 1h NUU AL2PIMk
    Iuvvn U.
    1
    , kuuvtn .
    2
    4. Tnd ldzpiknc A..6., 2. Tnd Biooydc A..6.
    N vooc A|zheimer dnocss d skuiocikn n0non cou k.N.I. kdi cnv
    kupicspn opn voidc, nou xdpdkcnpscdi dkpookonik dn cnv dcpo-
    d cou syksou kdi ikpookonik dn cic yspovciksc nksc kdi cic
    vsupoviidksc ouooudcosic. hdp cic skcscdsvsc spsuvsc cuv cssu-
    cduv scv ndpdsvsi yvuocn n dkpinc diciond0oysvsid cnc voou. Ms-
    piko dn couc ondvcikcspouc ndpyovcsc dvncunc voou svdi oi
    snc:
    - N svdn0son cou -duosioc ocov oxndcio yspovcikv nd-
    kv.
    - N 0poion cuv dvuuv c-npucsvv os vsupoviidksc ouooudc-
    osic
    - N ouscoxn syovuv ndpdyvcuv
    - N sccuon cnc xoivspyiknc pdocnpicncdc yu cnc skionc cuv
    vsupvuv kdi cnc dvsnpksidc oco svuo xovn dkscuocpdvosp-
    on
    - N sndyuyn ss0spuv piv yu osiuciko stress oi onosc ou-
    ouv os sc npucsvv, iniuv kdi vouksvikv osuv kd0c kdi
    ocnv ouoopsuon duosioc
    - N ouon cnc dnoinonpucsivnc L4, uc ndpyovcdc kivvou, ocnv
    dnon cuv iviuv duosioc kdi cuv yspovcikv ndkv
    - N ndpouod ysvscikv dvudiv ocd xpuoodcd 1, 14, 19 kdi 21
    - N idcdpdxn cnc vsupondocikcncdc dn ndpyovcsc nuc oi c-npu-
    csivsc, co -duosisc kdi n dnoinonpucsivn L
    I93I
    UAMUOIMU DNA kAI AhUOUIkh
    uvuy|tnouo I., o0ntkn I., kupuctutnpu I., Aunpnouo A., ktcn
    u.
    Ms cnv npoo cnc nnpoopiknc sniocnnc kdi cnv dvncun iidcspd
    cou idikcou kdi cn nioupyd os duc |dcpikv 8osuv sosvuv
    IData8asesl oi sniocnovsc kdcp0uodv vd dnokuikonoinoouv co dv-
    0pnivo yoviud. N npknon onspd svdi n ounnpuon ducnc cnc
    npoon0sidc s cnv spson cuv DNA nouopiov cou dv0punvou yo-
    viidcoc. Ikonc cnc spydodc svdi vd kvous dvdop ocnv npoo
    nou sxsi onsiu0s os ducv cov cosd kd0c kdi vd sous cn ouvsi-
    oop cou Ah6.
    npxouv nn osic sosvuv oco |nternet nou snicpsnouv dvcddyn
    nnpoopiv scd cuv idpuv spydocnpuv ndykoouc dvsod ocic
    onosc sxupous cnv NUv8ase. Ui kdcdypdsc nspidvouv nou-
    opiooc ouscspouc n ouvssvouc s do0svsisc. Iunspidvo-
    vcdi nnpoopsc oxsciksc s cov nn0uo, k0s siodyuyn ndpouois-
    cdi d s cnv dkoou0d nou cnv nspisi kdi cn oxson cnc s ysicovi-
    k xdpcoypdnsvd yovid. Lnonc unpxouv spydsd on-|ine spsuvdc.
    N idikdod yvscdi ducodconoinsvd n niducodconoinsvd yid cov
    ssyxo koivv odcuv dn cnv nnyn cnc nnpoopdc. Icxoc svdi n
    nioupyd svc ksvcpiko 0nodupo yvosuv yid cov ssyxo cuv nou-
    opiov oxscisvuv s cnv npoi0son-svion nd0ooyikv di-
    vocnuv. Jsoc covous ci s cn nioupyd ducv cuv osuv so-
    svuv kdi cnv siopon cuv nnpoopiv ducv dvoysi o poc yid dp-
    dksucikn spsuvd s on cd ocoixsd duc.
    I94I
    U khMUNA 1U 8US1UN 8AI kUAI0I
    kotcvn Mupvu, ko0tpu Mupu, Msvtscou svn, oto0nvn M|xun,
    k0pko Mupyuptn, kunstvo Ispy|o
    I' 0p0ondiikn kivikn A6 - ldzpso okooonc
    U knsvdc cnou 8ostonID88l svdi ducc nou xpnoionoiscdi supcs-
    pd yid cn ouvcnpncikn 0spdnsd cnc okouonc kdi n xpnon cou svskvu-
    cdi k_1oik yid snisivosvsc okoiosic 20-40.
    Icnv ndpood sscn diooyn0nks n scuon nou snicuyxvscdi ocic
    okoiuciksc kdnsc yuvdc sydcspnc cuv 40, s cnv sdpoyn cou
    knsvd cnou 8oston.N scuon s ouvcnpncik sod cou okoiuci-
    ko kupcdcoc sniix0nks scs yidc cd ndii kdi co nspiov couc
    sv n0sdv vd xsipoupyn0ov, scs sv dvdovn cou xsipoupysou.
    Iusx0nkdv ocoixsd dn co Lucspik |dcpso Ikouonc oxscik s 76
    okoiucikoc do0svsc I62 kopcoid kdi 14 dypidl s soo po nikdc
    kdc cnv npcn sscdon oco |dcpso, cd 12.51 xpvid I7-16 scvl.
    An couc 76 do0svsc oi 42 I55.267l sxdv si 0updkik npucond0sc kp-
    cud, oi 2 I2.637l dpiocsp 0updkik, oi 15 I18.437l si 0updkooouik
    kdi oi 18 I23.687l dpiocsp 0updkooouik.
    N son cin cuv oipv cnc okouonc nou idnioc0nkdv kdc cnv npcn
    sscdon s scpnon sn cnc dkcivoypddc s cn s0oo Cobb ncdv 47.34,
    s ikpcspn unooyisvn cin ducn cuv 40 kdi dvcspn ducn cuv 75.
    An cd sosvd nou ousx0nkdv dn cnv kdcdypdn cnc ndpdkoo0n-
    onc cuv ndiiv, sndpkn kp0nkdv kdi sn0nodv unn ocouc unooyi-
    ooc, od dvdspovcdv os ndpdkoo0non cuv do0svv yid xpovik i-
    ocnd oo n sydcspo cuv 10 nvv dn cnv dpxikn sdpoyn cou D88.
    Lnosvuc, s soo xpvo ndpdkoo0nonc couc 28.47 nvsc Idn 10 suc 80
    nvscl, unooyocnks ci n son cin oipv cuv okoiucikv kdnuv
    kdc cnv csikn sscdon npiv cnv ddpson cou D88 ncdv 35 Idn 9 suc 60l.
    Ikonc cnc ndpoodc sscnc svdi n dioynon cnc idopc cuv oko-
    iucikv kdnuv dn cnv dpxikn sxpi cnv csikn sscdon. N ouvoikn
    ip0uon ncdv kdc soo po 12.87 . U sooc poc cnc noooociddc 7
    ip0uonc cou okoiuciko kupcdcoc s cnv sdpoyn cou knsvd,
    ncdv 27.147. N syiocn ip0uon okoiuciko kupcdcoc nou ndpdcnpn-
    0nks ncdv kdc 80.437 Idn dpxiksc 46 os csiksc 9l.
    An cn sscn nposkus ci dn cnv sdpoyn cou knsvd cnou
    8oston 0d nopoos vd sdx0s suspyscik dnocssod os snisysvsc
    nspincosic okoiosuv vu cuv 40.
    214
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I95I
    OAIUX0MUk110MA
    kup|nou ., vu 2., ouo0n I., I|o I.
    A d0ooyikn kivikn A6, AXLA 6soodovknc
    Jo dioxpuokccud svdi ykoc nou dvdncooscdi dn cd xpudivik
    kccdpd cou uso cuv snivspiuv, dnssu0spvovcdc ocnv kukoo-
    pd sysc noocncsc kdcsxodivv. Anocss onvid dicd unspcdonc
    kdi sdkoou0s vd idsysi dkd kdi onspd cnc iyvuonc. Andvc-
    cdi oco 0.05-0.1 7 cou unspcdoiko nn0uoo, soou kdi ocd o d.
    Jo 107 cuv dioxpuokuccucuv svdi oikoysvn.
    Jd kivik supndcd cnc voou nuc n unspcdon, n ksddyd, co do0n-
    d ndv kdi oi siposic dnoovcdi ocnv ocd0spn n id-snouod
    skkpion vopdpsvdvnc, dpsvdvnc kdi vcondvnc.
    N ioxnikn iyvuon cnc voou doscdi ocnv dvspson dunsvuv sni-
    nsuv cuv kdcsxodivv kdi cuv scdoicv couc oco nod kdi ocd
    opd, sv os onvisc nspincosic xpnoionoiovcdi uvdiksc okid-
    osc nuc cd test kovivnc kdi youkdyvou.
    N svcnion cuv ykuv yvscdi s dovikn n dyvncikn cooypdd kdi sni-
    sdivscdi s oniv0npoypnd s M|8U-|123.Is sdipsciksc nspincosic
    yvscdi skskcikc kd0scnpidoc cnc kcu konc kdi siydcond.
    6spdnsucik yvscdi xsipoupyikn ddpson cou ykou, do nponyn0s
    dpdksucikn nposcoidod s dnoksiocsc d kdi dps-vspyikv uno-
    oxsuv.
    Ikonc cnc ndpouodonc svdi n dvdoknnon cnc iioypddc yid co
    dioxpuokccud, sv sdon 0d o0s ocic vssc csxviksc iyvuonc
    cnc voou.
    I96I
    1AMA1Ikh h5h MIOU MAUAI0MA1U INOIIU
    ICAS kUk1I
    O|nnou .k., ununouo 8., Auysp|v ., kounn ., tou A., 1pyku
    A., o .
    Lpy.sipddziknc Ouoiooydc, ldzpikn Ixon dvsnioznou A0nvov
    dv.d0ooyikn kivikn, ldzpiknc Ixonc, dvsnioznou 6pknc
    B' Xsipoupyikn kivikn Noookosou Aoknnsou' Bodc
    Jo usonud snivspiou dnocss kdon0n yko cou snivspiou,
    dnocsscdi dn dyysiopi0n inn ioc, svdi syou ouvn0uc sys-
    0ouc kdi scspnsupo. Iuvn0uc svdi douncudcik kdi n iyvuon cou
    yvscdi cuxdd n yid ispsvnon dio0ndcoc pouc kdc cn vspikn xpd.
    idyiyvokscdi s dovikn cooypdd kdi sv ddipscdi xsipoupyik ndp
    vo soov co sys0c cou svdi sydcspo dn 10cm.
    hspiypdn nspncuonc: Ao0svnc nikdc 62 scv idkoscdi ocd JLh, sc
    dvdspsvn ncon dn oc s sikvd kdcdnndc, diouvdikn doc-
    0sid. An cnv kivikn sscdon sv nposkudv odn ocoixsd ndp vo
    d nnid oondon kdc cnv dpiocsp nyid koiidkn xpd. An cov kivi-
    kospydocnpidk ssyxo sv nposkudv ondvcik supndcd skcc dn
    cin didcokpcn: 337. N dkcivoypdd koidc svdi xupc iidcspd supn-
    dcd. U do0svnc unoscdi snsiyvcuc os spira| CJ koidc dn cnv onod
    npokncsi svd cspocio dicud ocnv nspioxn cou AP vspo kdi svdc
    ykoc s xdpdkcnpiocik usoindcoc. U do0svnc unon0nks os xsi-
    poupyikn snsdon, kdc cnv onod syivs ndpoxscsuon cou dicudcoc,
    idodocnks n iuoicncd cou vspo kdi ddips0nks o dioppdyov
    ykoc s co oocoixo snivspio. N scsyxsipncikn nopsd cou ncdv dvs-
    nnskcoc kdi o do0svnc sn0s cou voookosou cnv 4n scsyxsipncikn
    nspd.
    Iunspdodcik dvdspous ci co usonud cou snivspiou dv
    kdi kdon0nc ykoc nops vd nioupynosi dnsinciksc yid cn un cou
    do0svoc kdcdocosic, kdi nvcocs npsnsi vd co sxsi kdc vou o xsipoup-
    yc os ossc nspincosic nou dopov cn vspikn xpd.
    I97I
    ANI IAUk M1A AAAUkUIkh XUAUk1k1UMh
    O|nnou .k., 1pyku A., O|nnou I., o .
    Xsipoupyikn kivikn, I0Nk 0i Ayioi Avpyupoi'
    Xsipoupyikn kivikn Noookosou Aoioov H Ayd Bdpfpd'
    Avdio0noiooyik Tnd, A0NA 0 Ayioc Iffdc'
    N dndpookonikn xookuocskcon svdi ysvikc dnoskc ci dnocss
    snsdon skoync yid cnv ddpson cnc xonxou kocsuc. Lvdi s0o-
    oc skon, dvdndpdyyin, s no nsovskcndcd, nuc ikp xp-
    voc voonsdc, cdxsd sniocpon cou cdo0vsoc ocnv spydod, kdi sxi-
    ocsc sninoksc. Lxouv dvdsp0s kdc kdipoc iopsc sninoksc nou
    oxscovcdi s cnv snsdon, oi ouvn0socspsc dn cic onosc svdi n di-
    oppdyd, co dicud, n xoppoid.
    Ikonc cnc ndpoodc spydodc svdi n ndpouodon o onviuv snokv
    sc dndpookonikn xookuocskcon.
    hspiocdcik 1o: Ao0svnc o onooc sxs unon0s os dndpookonikn xo-
    okuocskcon sndvspxscdi sc 2 scn s un nupsc. Is CJ Akk ndpd-
    cnpscdi onio0onspicovdk dnocnd ocnv nspioxn cou L ocn, co onoo
    idvoyscdi kdi idniocvscdi ci osscdi os susys0n xoi0o.
    hspiocdcik 2o: Msc dndpookonikn xookuocskcon nioupyd sus-
    ys0ouc didcdcoc ocnv ooukn kdi nyid koiidkn xpd kdc ouvs-
    xsid ioco, dn cn 0son cnc nnc cou odo. idnioc0nks ci co
    dicud osicdv os dioppdyov dyyso cou sninou co onoo si-
    on0s svcc cnc dnovspuonc cou op0o koiidko uc.
    Iunspdodcik dvdspous ci ndp co ysyovc ci n dndpookonikn
    xookuocskcon svdi dodnc s0ooc nops vd ndpouoidocov on-
    visc sninoksc. |id duc dndicscdi iidcspn npoooxn kdi scoicncd yid
    dvciscnion.
    I98I
    XIUIIkh AN1IM10Ih kUIAIU1h1A
    O|nnou .k., ununouo 8., Auysp|v ., kounn ., tou A., 1pyku
    A., o .
    ldzpikn Ixon dvsnioznou A0nvov, ldzpikn Ixon 6pknc, B' Xsip.yikn
    k. Noookosou Aoknnsou' Bodc, Xsipoupyikn kivikn, I0Nk 0i
    Ayioi Avpyupoi'
    hspiypovcdi 6 nspincosic do0svv s uokoiicncd nou dvciscun-
    ocnkdv xsipoupyik. Ui 2 dvciscunocnkdv snsiyvcuc kdi oi 4 skskcik.
    Ui 3 ncdv vpsc kdi oi 3 yuvdksc, nikdc 35 suc 74 scn. Jouc do0svsc
    ducoc dvoyd s cnv svcnion cnc idcdpdxnc couc kdcdcds os o
    osc.
    N npcn od nspisdvs 3 do0svsc s idcdpdxsc cnc kivncikcncdc
    cou ndxsoc svcspou Idcsoc Nirschprung, ondxvikn uon0sid k..n.l.
    Is svdv sk cuv do0svv ouvunnpxs idcdpdxn kdi ocnv soo Iovpoo
    ondociko nusiko soucl, sv os svdv dkn ouvunnpxs sydop0.
    Icn scspn od nspin0nodv 3 nspincosic s npondcd ocnv so-
    o cou ndxsoc svcspou. Lvdc sk cuv do0svv sndoxs dn ovpoo kd0-
    ou cou nspivsou kdi svis oodpn uokoiicncd d kdi dkpcsid.
    Ui unoinoi 2 do0svsc unsspdv dn npncuon cou op0o.
    N xsipoupyikn dvciscnion cnc npcnc odc nspisdvs: Idl uoi-
    kn koskcon kdi sisoop0ikn dvdocuon I1 do0svncl, Il oikn npukco-
    koskcon s idcnpnon cou npukciko oiykcnpd, kdcdoksun nk0ou
    kdi sisonpukciknc dvdocuonc I1 do0svncl, Iyl ocov 3o do0svn s nd-
    pon oondon cou noop0iko uc, isvpyn0nks uoikn koskcon,
    csikn sisoocod kdi svvsc oupyyio os dvdovn cnc opiociknc nd-
    0ooyodvdcoiknc idyvosuc.
    Icn scspn od oi do0svsc s npncuon cou op0o unsn0nodv os
    op0onnd, sv co ovpoo kd0ou dvciscuno0nks s post-ana| repair.
    Iunspdodcik, n uokoiicncd ouvsnsd kivncikv idcdpdxv cou
    ndxsoc svcspou nops vd dvciscunio0s xsipoupyik s ikdvonoincik
    dnocssodcd, do npcd sscn0s ikdvonoincik n svcspikn kdi oi-
    ykcnpidkn sicoupyd.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    215
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I99I
    h AAAUkUIkh XIUIIkh 1hN AN1IM10Ih
    1h IA1UUIUOAIIkh AAINUMh0
    O|nnou .k., 1pyku A., O|nnou I., o .
    Xsipoupyikn kivikn, I0Nk 0i Ayioi Avpyupoi'
    Xsipoupyikn kivikn Noookosou Aoioov H Ayd Bdpfpd'
    Avdio0noiooyik Tnd, A0NA 0 Ayioc Iffdc'
    N dndpookonikn dvciscnion cnc |Uh dvscdi ci ouvosscdi dn i-
    kpcspn voonpcncd kdi 0vnccncd, dn odc iycspo nvo kdi sius-
    vn iocikn kdcdocpon os oxson s cnv dvoikcn dnokdcocdon
    |k-Ms0oo: Is xpovik iocnd 5 nvv npdydconoin0nkdv 5 d-
    ndpookoniksc snsosic os do0svsc s ydocpooioodyikn ndivpn-
    on n ssyxsvn dpdksucik. 3/5 do0svsc ncdv vpsc kdi 2/5 yuvd-
    ksc, nikdc 37 suc 62 scv. U sooc xpvoc nnc knoiou cnou dpd-
    ksuciknc dyuync ncdv 4817 nvsc. 'Uoi oi do0svsc sxdv d nd0ooyi-
    kn oioodyoydocpooknnon s 2ou kdi 3ou d0o oioodycid xupc
    onsd uondodc, kdi n ouvo nd0ooyd dn nsncik, nndp,
    xonpd, nykpsdc. kdi oi 5 do0svsc unon0nkdv os kukocspn nnpn
    0oondocikn, oi 3 os cunikn Nissen, kdi oi 2 os Nissen cpononoinsvn
    kdc Posseti. Ms ysvikn dvdio0nod kdi sc cn nioupyd nvsuonspico-
    vdou, cono0scovcdi S trocurs, 3 cuv 10mm, kdi 2 cuv 5mm. Msc cn id-
    con cou sooovoc sninou, ndpdoksuscdi n nspioxn cuv oksv
    cou idpydcoc. Jo scspo nd svdi n kivncononon cnc ydocpooioo-
    dyiknc ouonc s n xupcidcon 2 n 3 pdxsuv ydocpikv dyysuv.
    Akoou0s n oykion cuv oksv cou idpydcoc s 1 n 2 n dnoppo-
    noid pdcd kdi kdcniv n sknson cnc 0oondociknc.
    Anotsscutu: N ison ipksid cnc snsdonc ncdv 108 snc I90 suc
    165l kdi o sooc xpvoc scsyxsipnciknc voonsdc cuv do0svv 4 nspsc.
    kdd sninokn sv ndpdcnpn0nks.
    unspcutu: N dndpookonikn dvciscnion cnc ydocpooioodyiknc
    ndivpnonc dvscdi od d s0ooc oyikn, dvdndpdyyin kdi dod-
    nc. sv dnocss d vsd xsipoupyikn s0oo, d d vsd o npoons-
    donc kdi n dd cnc kdi cd dnocssodc cnc ioid cnc kdooiknc xsi-
    poupyiknc, sv ovosscdi dn odc ikpcspo xpvo voonsdc kdi
    cdxcspn sndvdop cou do0svn ocic ouvn0sic pdocnpicncsc.
    I100I
    ANM8Ah I AU1XIA XIUIIkh AN1IM10Ih Ak0U
    kUAI1IA, M UAOIA IA1hhh 1h IkA1IA
    O|nnou .k., ununouo 8., Auysp|v ., kounn ., tou A., 1pyku
    A., o .
    Lpy. sipddziknc Ouoiooydc, ldzpikn Ixon dvsnioznou A0nvov
    dv. d0ooyikn kivikn, ldzpiknc Ixonc, dvsnioznou 6pknc
    B' Xsipoupyikn kivikn Noookosou Aoknnsou' Bodc
    Is xpovik iocnd 3 scv, dvciscuno0nkdv 5 do0svsc s oodpsc sni-
    noksc nponyousvuv sisop0ikv n sisodkcuikv snsosuv, os 3
    ksvcpd. hpksicdi yid 3 yuvdksc kdi 3 vpsc, nikdc 29-72 scv, s ioco-
    oyik snisdiusvn skn kocid. An ducoc 2 sspdv sisod-
    kcuikn dvdocuon s pouch, 2 sisop0ikn dvdocuon, kdi 1 xdnn
    sisop0ikn dvdocuon s nku0o.
    N svsin cnc sndvsnsosuc ocouc do0svsc s nponyosvn sisod-
    kcuikn dvdocuon ncdv nusikn onn In2l, oxdin vskpuon In1l
    kdi uosicoupyd cnc nk0ou In1l. Ui o do0svsc s xdnn sisop-
    0ikn dvdocuon s nku0o unsspdv dn unocponn cnc voou sninsy-
    svn s uosicoupyd cnc nk0ou, sv oi 2 do0svsc s sisop0ikn dvd-
    ocuon ndpouoddv dpi unocponn cnc voou.
    Is 3/5 kdcsocn uvdcn n npdydcononon idc sisodkcuiknc dvdoco-
    osuc s nku0o, sv ocouc 2/5 cpononoin0nks n nddi nku0oc. N
    voonpcncd kdi cd sicoupyik dnocssodcd ncdv ouvn s cd is0vn
    iioypdik sosvd.
    N ndpoodc sscn unosikvsi ci n dnocuxd idc nponyosvnc sns-
    donc sv dnokssi unoxpsucik cn nioupyd idc nc vsdc nk-
    0ou, ci ndp cnv ddpson svc oxscik ondvciko cndcoc siso, co
    sicoupyik dnocssod svdi ikdvonoincik, kdi csoc ci cd csxvik npo-
    ndcd cuv okouv sndvsnsosuv, nuc n ooc cnc nk0ou
    scd cou ispo ooco kdi cou knou n cnc kocsuc svdi uvdcv vd
    dvciscunio0ov.
    I101I
    ANIA I10h kAkUhOU 5AAAAIh
    NUU UAAAA0N 5U100N
    O|nnou .k., 1pyku A., ssptn N., O|nnou I., o .
    Xsipoupyikn kivikn, I0Nk 0i Ayioi Avpyupoi'
    Xsipoupyikn kivikn Noookosou Aoioov H Ayd Bdpfpd'
    Avdio0noiooyik Tnd, A0NA 0 Ayioc Iffdc'
    0p0ondiikn kivikn, I0Nk 0i Ayioi Avpyupoi' kdi A0NA Mszd('
    Ui soocosic dnocsov co ouxvcspo cno kdon0ouc ykou cuv oocv.
    Ui doiosic cnc voou svdi ouvn0uc ovnpsic kdi dvdncooovcdi id
    ocn scuon cuv dkpv oocv. hodnsc soocosic ndpdcnpovcdi
    os cod s ysvscikn npoi0son Iducoouikc snikpdcov cnocl.
    hspiypdn nspncuonc: Ao0svnc, nikdc 24 scv, npoospxscdi oco |.U.N.k.
    "Ui Ayioi Avpyupoi", s ioxidyd kdi iykuon ocnv ono0id su sni-
    vsid cnc sic kvnnc. Ico iocopik dvdspscdi n ndpn voou nod-
    nv soocosuv ocnv oikoysvsid cou do0svoc. An cov dkcivooyik
    ssyxo cd supndcd ncdv: Ann Akcivoypdd: Lvconosic xovpoysvv
    soocosuv ocd pdxivid ooc, cd npidd kdi cic nsupsc, Iniv0npoyp-
    nd Uocv: Ldpc dunsvn ouyksvcpuon cou pdiodpkou ocic
    nsupsc kdi syn ouyksvcpuon ocd ooc cnc kvnnc oudcn s voo
    nodnv soocosuv. Mdyvncikn Jooypdd: Lusys0nc xupokdcd-
    kcncikn sspydod s dvooioysvoc svcosuc ondcd ocic J1 kdi J2 dko-
    ou0sc, ocn si kvnn.
    Lv ouvsxsd o do0svnc unon0nks os iod id sncnc svnc IFNAl
    npoksisvou vd cs0s iyvuon. Jo dnocssod cnc iodc unssis cnv
    ndpn kdkon0ouc sspydodc. An cov ssyxo nou npdydconoin0nks,
    yid ocdiononon cnc voou, s unooyiocikn cooypdd kdi oniv0ipo-
    ypnd oocv sv nposkus ndpouod dnodkpuosvuv scdocosuv.
    Movdik spnd ncdv n suidspiodcikn svcnion cou ykou.
    kdc cn pksid cnc xsipoupyiknc snsdonc socn cdxsd iod, n onod
    dnsn 0scikn kdi onynos os npido dkpucnpido cou do0svoc.
    unspcutu: Auc co nspiocdcik unosikvsi ci, k0s socuon xpsi-
    scdi ouocndcikn ndpdkoo0non, kdi ci socuon s kivik n spyd-
    ocnpidk xdpdkcnpiocik kdkon0sidc npsnsi vd ddipscdi piik.
    I102I
    S0kUICAL 1kA1MN1 UF 1kA0MA1IC PAMUkI1UN0M
    k|r|az|s Ch., F|||ppou D.C.
    2nd pt of Surgery, 0eneraI State HospitaI of Nice, Pireus, St.
    PanteIeimon'
    Surg. ept. of Agii Anargirii, kifissias 0ncoIogicaI HospitaI
    Jhe rupture of intrabdomina| organ fo||owing b|unt abdomina| trrauma
    can cause haemoperitoneum. Jhis is a |ife threatening situation which has
    to be so|ved immediate|y.
    During the decade 91-01, 148 patients came to our department, suffering
    from rupture of intrabdomina| organ and haemoperitoneum, fo||owing
    b|unt trauma. From them, 129 patients had been operated, whi|e 19 pati-
    ents had been fo||owed up conservate|y. Conservative treatment was done
    on patients suffering from sp|enic, hepatic and rena| rupture on stage |
    and ||.
    Among the patients we confronted, 122 underwent operation, whi|e the
    rest 26 were intensive|y fo||owed up by conservative methods. A|though
    the haemoperitoneum was of sma|| vo|ume on the |ast group of patients,
    7 of them presented haemodynamic instabi|ity even though they treated
    with crysta||oids and b|ood. Un the tota| 129 patients I877l underwent
    operative treatment and on|y 19 I137l conservative one IJab|e 1l. Jhe
    chosen operative procedure is presented on Jab|e-2.
    From the patients who underwent operation, 6 suffered postoperative|y
    from suppuration of trauma, 3 from recurrent hemorrhage I 1 patients re-
    operated 3 times and died due to septic shockl and 11 died due to mu|tip|e
    injury and shock or/and concomitant diseases and genera| hea|th status
    of |ow reserve Imorta|ity rate 8.57l. From the patients who fo||owed up
    conservative|y, 4 deve|oped i|eus and 2 thrombocytosis. Jhere were not
    deaths on the |ast group of patients.
    We can conc|ude that, according to internationa| references and the stud-
    y of our patients, conservative fo||ow up of haemoperitoneum can be ac-
    ceptab|e and safe as practice on|y on patients with posttraumatic stabi|i-
    ty. |t's very important that every |ifethreatening injury of intrabdomina|
    organs has to be exc|uded.
    216
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I103I
    AIOh1Ik U1IMhI 1h AAhNIkh kUIN0NIA
    ANO0UMUOIkh MA1h
    tsu A., tsu ., ununouo X., unupun .
    Lnifsnov kd0nynznc: Izsdc A. Lnkoupoc kd0nynznc A..6.
    Mid kdn svion kdi svd opo xdyso dnocsov svd no kd
    sio yid cnv svdpn idc ouvdvdocponc. kd0nspivc, ocouc oovcid-
    cpikoc xpouc, kdcdoksuovcdi n scivovcdi xiisc xdysd.
    6snods, oinv, vd idniocoous noisc svdi oi ndpscpoi nou snn-
    psouv cnv dio0ncikn svc xdysou kdi dc onyov oco vd co xdpd-
    kcnpoous odv iycspo n nspioocspo updo dn svd o.
    Lnisds, oinv, iopd xdysd, ocd onod unnpxs id idopscikn
    oxson scd cuv onyv ypdv cic onosc 0supos odv cnv dpxics-
    kcovikn kd0onynon kdc cnv ovcdn cuv csxvncv ovciv idc UU.
    Lni0uvcdc vd sxous oo co uvdcv svd koiv ovoo ndpdscpuv os
    k0s un sscdon xdyso, snsspydocnkds nidk cnv k0s sikvd
    cpononoivcdc cnv un kpon ndpscpo, sniikovcdc vd idniocoou-
    s cnv snpdon nou n ovdikn ducn ddyn 0d npokdoos n xi ocnv
    dndon cou 0sdco Ikpicol.
    Upiosvsc nspincosic cic kdcdoksuods dn dpxnc os nspicosic UU,
    sv knoisc sc kdcdocosic cic "uypdods" nidk.
    kcu dn k0s sikvd cono0scn0nks svdc dovcdc dpi0c kdi, oco syi-
    oco cuv nspincosuv, n spcnon: "noi sikvd npocics odv oopcs-
    pn" n "odv nsov uoikn".
    Ui dndvcnosic kdcdypnkdv kdi ps0nks co nooooco npocnonc cnc k0s
    sikvdc kdi kdc ouvsnsid n snpdon cnc k0s ndpdscpou.
    An co dpxso kdcdypdnc cuv dndvcnosuv npooiopo0nks co 7 nooooc
    npocnonc nou scuxs n k0s spcnon kdi co xdpdkcnpiocik nou ducn
    sknpoounoos.
    Ms cov cpno duc kdcdypnkdv oi doiksc dpxsc yid cnv on svc
    dio0ncik ndpdskco xdysou.
    I104I
    1A 01A 40 XUNIA I1914-1954I AI1UIIA 1h IIUNUMIkh
    hIA 1A XUAIA
    unn ., Xp|ctono0ou-Astp .
    lozopd ldzpiknc, ldzpik Tnd A..6.
    Jo nspiov oco onoo ouvd0poovcdi cd ndii, co oxoso, dnscss-
    os svd iidcspo nso npondcioo yid cic kpdciksc unnpsosc, couc
    idcpoc d kupuc cic Lnvsc ncspsc kdc cnv snoxn cou soonos-
    ou. 0ocoo, sxpi co 1914 sv unnpxs snono pydvo nou vd spiv
    yid cnv npoocdod kdi cnv npodyuyn cnc uysdc cuv d0ncv.
    Icn iioypdd, dvdspovcdi sncospc oi dpoicncsc cnc oxsciknc
    nnpsodc nou ip0nks. |id co okon duc kd0opovcdi sndkpic oi
    unoxpsosic npoc couc vsdpoc d0ncsc cuv idcpv oi onooi sniopco-
    vcdi snonc s cov ssyxo cuv ouv0nkv nou snikpdcov oco nspiov
    ndn cic kcipidksc, oxoiksc sykdcdocosic.
    kpid pydvd cnc unnpsodc svdi oi oxodcpoi, oi onooi ouvsnikoupo-
    vcdi dn cic snioksncpisc voooksc, 0soc nou nponnpxs cnc Ixoid-
    cpiknc nnpsodc. Icd syxsipid kdi nspioik cnc snoxnc nspiypovcdi
    s0ooi npnnc, iyvuonc kdi dvciscnionc cuv do0svsiv, nou snnc-
    cdv kupuc couc d0ncsc. An cnv Ixoidcpikn nnpsod opovcdi dkd
    sndkpic oi npono0sosic cic onosc npsnsi vd nnpov oi kcipidksc sykd-
    cdocosic, s ocxo nvcd cn idcnpnon n kdi nosc opsc cn scuon
    cnc uysdc cuv d0ncv. Jsoc, ouoidocik po ocnv kdn sicoupyd
    cou 0soo cou oxoicpou sndis kdi n ouvspydod s couc iokovcsc
    kdi couc yovsc.
    I105I
    1UUO1hh MO1MA10N IA8h1IkU AONI
    tpto A0uvc|o, Ikuv tutn, 1cn Xpncto
    8doikn npon0son yid cnv cono0scnon sucsucuv dnocss n nn
    svc nnpouc idcpiko iocopiko. Tcoi spiksc opsc, o oovcdcpoc kd-
    scdi vd dnodoosi yid cnv cono0scnon n n sucsdcoc os do0svn,
    nou noxsi dn d dn cic o opsc iiond0oc odkxdpouc idncn
    Icnou | n cnou ||l.
    Ms cnv ndpood spydod snixsipscdi id dvdoknnon cnc is0voc i-
    ioypddc ypu dn co dv n cono0scnon svc cscoiou sucsdcoc
    sxsi ni0dvcncsc sniuonc ocnv ocodcikn koicncd svc cscoiou do0s-
    vn.
    Msc cnv sscn 24 iioypdikv dvdopv, ounspdvous ci o c-
    nou | odkxdpnc idncnc dnocss dnucn dvcsvsin yid cnv cono0s-
    cnon sucsucuv.
    Avc0scd, sc cnv oykpion cuv noooocv snicuxdc do0svv s cnou ||
    idncn os oxson s cov ysvik uyin nn0uo kdcdsikvscdi ci n
    n0non ducn dnocss oxscikn dvcsvsin. hpsnsi vd ouvunooyscdi n
    dpcncd cnc voou, n nikd cou do0svoc kdi kupuc n ikdvcncd duco
    vd pu0si cd snnsd yuknc oco dd. N siusvn duvcikn kdi snou-
    ucikn ikdvcncd cuv idncikv do0svv kd0ioc dvdykdd cnv duns-
    vn dvciiocikn kun nposyxspncik kdi scsyxsipncik kdi cnv sniocd-
    svn ocodcikn uyisivn.
    I106I
    h Xhh 1h A5h1Ikh UMUNh 1h OAMAkUIIh IDUINUI
    unn Osopu
    1
    , Annu .A.
    2
    4. ldzpikn Ixon LkA, 2. Lpy. spiyp. Avdzoiknc dv. A0nvov
    kon: N dvdoknnon cnc oyxpovnc iioypddc kdi dp0poypddc
    oxscik s cn pon cnc rhUN uc ndpyovcd doping ocouc d0ncsc kdi cnv
    dioniocd cuv s0uv dvxvsuonc cnc sv si cuv Uunidkv Ayvuv
    cou 2004.
    |k ku| Ms0oo|: Xpnoionoiscdi n is0vnc dp0poypdd kdi iioypd-
    d cuv cssucduv scv.
    Anotsscutu: Jd dnocssodcd dn cnv snpdon cnc xopnynonc rhUN
    svdi dvcikpousvd. knoisc sscsc dvdspouv ci pd suspyscik ocnv
    dnoon cuv d0ncv os dvc0son s sc nou unoocnpouv ci onys
    os dnon cnc uknc dc xupc uc dvcocoixn dnon cnc dnoonc,
    sv ouyxpvuc dvdspovcdi oodpsc kdi snikvuvsc ndpsvspysisc. Txouv
    y vsi nosc npoon0si sc yi d cn ni oupy d svc di ni ocou dopi ng
    contro|, n.x. s cn scpnon cuv |UF-1, |UF18P-2. |UF18P-3 kc., d s
    dod dnocssodcd.
    unspcutu: Aioncscdi coo n dnocssodcikcncd cnc rhUN ocnv
    dnoon cuv d0ncv oo kdi n dioniocd cuv s0uv dvxvsuonc cnc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    217
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I107I
    MAA1UNINh kAI kAkINU
    unn Osopu
    1
    , Annu .A.
    2
    4. ldzpikn Ixon LkA, 2. Lpy. spiyp. Avdzoiknc dv. A0nvov
    kon: N dvsin cnc ounspiopc cnc sdcovvnc ocnv dvciscnion
    cou kdpkvou kdi cuv dvsni0ncuv svspysiv dn cn 0spdnsd cou.
    |k ku| Ms0oo|: Avdokonovcdi oi sssic, nuc ducsc dvdspovcdi
    ocnv snvikn kdi svn iioypdd kdi dp0poypdd cuv cssucduv scv.
    Anotsscutu - unspcutu: Ui spsuvsc unosikvouv ci n sdcov-
    vn svdi svdc ioxupc dvciosiucikc ndpyovcdc, nou sxsi pon os d
    cd kccdpd cou opydvioo kdi ci ni0dvcdcd ouscsxsi ocn p0ion
    cou dvooidko ouocndcoc. Iuvd s id osip sscv n sdcovvn
    ni0dvv vd svdi oykoocdcikc ndpyovcdc kdi vd ouscsxsi ocnv npo-
    ocdod cou opydvioo dn cnv kdpkivoysvson. Jssucdd kdcdo-
    vcdi npoon0sisc ocs vd dionoin0ov ocn 0spdnsucikn oi dvciosiuci-
    ksc kdi dvooocpononoinciksc cnc iicncsc.
    I108I
    MAA1UNINh kAI NUMU A1AAN1Ik0N 1h0N I11 LAUI
    unn Osopu
    1
    , Annu .A.
    2
    4. ldzpikn Ixon LkA, 2. Lpy. spiyp. Avdzoiknc dv. A0nvov
    kon: N sscn kdi n ndpouodon cnc 0spdnsuciknc ddc cnc sdcov-
    vnc oco divsvo jet |ag.
    |k ku| Ms0oo|: Avdokonscdi n oyxpovn snvikn kdi svn iio-
    ypdd kdi dp0poypdd.
    Anotsscutu - unspcutu: N sdcovvn skkpvscdi dn co kuvpio.
    0c inio pio sxsi cn uvdccncd vd idnspv couc iococ cou kNI.
    6supscdi ci ouscsxsi ocn p0ion cuv kipkiuv pu0v. kdc cd in-
    nsipucik cdid ndpdcnpscdi svd divsvo yvuoc uc jet |ag. I' duc
    idcdpooscdi o nvoc kdi ndpdcnpscdi sccuon cnc nvsudciknc ikdv-
    cncdc kdi knuon. 6supscdi ci osscdi os dnoouyxpovio cuv kipk-
    iuv pu0v os oxson s cnv conikn pd kdi os ssin nvou. N xopnyn-
    on sdcovvnc dvscdi ci sdssi cd ouncdcd duc, yidc on0
    ocov sndvdouyxpovio cuv kipkiuv pu0v ocnv conikn pd. Lnonc,
    ouncscdi o poc cnc ocn scuon cnc kiviknc sikvdc cuv ndoxvcuv
    dn snoxikn ouvdio0ndcikn idcdpdxn Iseasona| affective disorderl , nou
    ndpdcnpscdi kupuc os kdcokouc cou opsou niodipou.
    I109I
    AIII0h 1U N01IAIU MAU - A1hIA ADAMkIWIC2:
    MIA 01h UIIIh
    Annu .A.
    1
    , Io0u .
    2
    , Asovpou .A.
    3
    , Acnuknouo .
    4
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc:
    Nziopd O., Iidvvpn M., Asovou A., Ziopn X.
    4. Lpy. spiyp. Avdzoiknc dv. A0nvov, 2. ldzpc
    3. Akzivooyik Lpy. Adiko' Noookosou, 4. kd0. kdpioxsipoupyiknc
    Is id npoon0sid vd iducoous cnv ioxdid cou Nucidou uso os
    iopsc snsosic Idyysioxsipoupyiksc, kdpioxsipoupyiksc, vsupoxsi-
    poupyiksc knl, npoond0os vd sscnoous cic piiksc dpcnpsc cou
    vucidou uso os svd syo dpi0 ncucuv nou dnocsov syd
    cou snviko nn0uoo.
    Jo syd dnocsov ncdcd dn cnv |dcpoikdocikn nnpsod A0nvv
    kdi co Lpydocnpio hspiypdiknc Avdcoiknc cou hdvsniocnou A0nvv.
    Icnv |dcpoikdocikn nnpsod A0nvv yvscdi sncospnc ndpdoksun cuv
    kuv cnc koiidknc dopcnc ocov onio0onspicovdk xpo, sv oco Lp-
    ydocnpio hspiypdiknc Avdcoiknc n s0ooc ounnpvscdi dn nscd-
    skcosc kdi syxosic okidypdikv xpuocikv. Icxoc svdi n dvdku-
    n cuv piikv dpcnpiv, nou ounnpvouv cnv dicuon cou NM dn cic
    vucidsc dpcnpsc oco dvcocoixo snnso kdi cnc sync piiknc dpcnpdc
    IAdamkiewiczl.
    Icnv ndpouodon ducn 0d dvdu0ov cd npcd dnocssodcd cnc ss-
    cnc ducnc os 45 cod. Is d cd cod cou sydcc dc dvixvscnkdv
    nspioocspsc cnc idc piiksc dpcnpsc, sv ocd 30 dn duc unnpxs sy-
    n piikn dpcnpd.
    Jd dnocssodcd duc 0d dvdu0ov nspdicspu kdi 0d ndpouoidocov
    sncospc. Ui ndpdcnpnosic ouvsxovcdi kdi ndpdovcdi s cd is-
    0vn vskpocoik kdi kivik sosvd cnc iioypddc.
    I110I
    AIII0h 1U 1UMAXU
    Annu .A.
    1
    , Muupovc|o k.
    2
    , 1c|pvn Xp.
    2
    , A|uckotn 8.
    2
    ,
    unukctu I.
    2
    , Ik|ckn I.
    3
    , Xpucv0ou Xp.
    2
    , kuuvtnouo A.
    2
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc:
    ikoc N., Ipkd L., dndonupn ., Mdn l., spuoivknc H., Luzd(d L.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. 0ovzdzpoc
    Icnv ndpood spydod dvdspdocs ocnv dyysuon cou ocoxou kdi
    iidcspd ocic ndpddysc nou ndpouoiouv n si kdi dpiocspn ydocpi-
    ksc dpcnpsc. kdc cn ipksid cnc spydodc sscnods sncospc cnv
    skuon cnc koiidknc dpcnpdc, cov cpnod Na||er kdi couc snispouc k-
    ouc, uc npoc cnv skuon couc, yvon xpnoin yid cov xsipoupy cnc
    nspioxnc, iidcspd cdv npksicdi vd npos os skcscdsvsc cosc kdc
    cic snsosic ocnv koid.
    N ndpood spydod syivs oco spydocnpio cnc |dcpoikdociknc nnpsodc
    A0nvv nvu os 200 ncdcd kdc cn ipksid cnc |dcpoikdociknc ssc-
    osuc cnv cssucdd sdscd kdi dnocss cnd sync spydodc nou
    sxsi odv 0sd cic ndpddysc cuv ovouv kuv cnc koiidknc dop-
    cnc. An cd 200 ncdcd, 108 nodv vcpsc kdi 92 yuvdksc. Andpdcncsc
    npono0sosic yid cnv snioyn cou uiko ncdv: dl vd ncdv svniksc I.o.
    53 scnl, l vd n sspdv kdkosic n snsosic ocnv koiidkn xpd, kdi yl
    vd n sndoxdv dn koiidk voondcd.
    AI hdpddysc cnc sic |docpiknc Apcnpdc I|Al:
    N kdoikn yvon ci n |A npospxscdi dn cnv koivn nndcikn dpcnpd
    dvciocoixs vo os 96/200 nspincosic, sv ocic unoinsc nspincosic n
    dyysuon yvscdi uc snc:
    1l N |A npospxscdi dn cov si ko cnc iuc nndciknc dpcnpdc I18/
    200l,
    2l N |A npospxscdi dn cov dpiocsp ko cnc iuc nndciknc dpcnpdc
    I36/200l,
    3l N |A npospxscdi dn co ixdo cnc iuc nndciknc dpcnpdc I20/200l,
    4l N |A npospxscdi dn co sodo ko, cdv dnooxscdi os cpsic k-
    ouc n iuc nndcikn dpcnpd I30/200l.
    AI hdpddysc cnc Apiocspnc |docpiknc Apcnpdc IA|Al:
    N kdoikn yvon ci n A|A, n onnvikn dpcnpd kdi n koivn nndcikn dp-
    cnsd skovcdi dn cnv koiidkn dpcnpd svdi ouxvn kdi dvciocoixs os
    172 dn cic 200 nspincosic, sv ocic unoinsc nspincosic n dyysuon
    yvscdi uc snc:
    1l N A|A skscdi d s cn onnvikn dpcnpd, sv n koivn nndcikn dpcn-
    pd skscdi vn cnc I6/200l,
    2l N A|A skscdi kdc' su0sdv dn co npo0io coxud cnc koiidknc
    dopcnc I16/200l,
    3l Ui cpsc koi cou cpnod Na||er skovcdi dn koivo s cnv vu
    sosvcspid dpcnpd I4/200l,
    4l N A|A skscdi vn cnc, sv oi oi o koi dn koivo s cnv
    vu sosvcspid dpcnpd I2/200l.
    Nd onsioous ci os 24/200 nspincosic, dn cnv A|A skscdi snikou-
    pikn nndcikn dpcnpd.
    218
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I111I
    I1UIkh ANAUMh 1h MA1h 1U AIkA1U
    kAI 1U AkXA0U IA8h1h
    Asovpou .A.
    1
    , Ik|ckn I.
    2
    Iuvspyoznkdv oi oiznzsc: dnn 6., Ziopn X., Iidvvpn M.,
    Indvkn O., Nziopd O.
    4. Akzivooyik Lpydoznpio Adko' Noookosou
    2. Xsip. 0ovzdzpoc
    Jo nykpsdc svdi svdc dsvdc s inn sicoupyd. N yvon knoiuv
    ocoixsuv yid co nykpsdc nn unnpxs ocnv dpxdd kvd. 6supsco no
    ondvcik pydvo kdi yi' duc co dnokdoodv nn cnc unc Iming
    menl. U de Uraaf ncdv ouc o npcoc nou svcpnos ocn sscn cou nd-
    ykpsdcoc, kdi ocn sicoupyd cou. Xd-pdkcnpiocik svdi co spyo "Disputa-
    tio medica de natura et usu succi pancreatici". cdv d0ncnc cou Sy|vius
    kdi 0supoos co nykpsdc "g|anduca cong|amerata". U ndykpsdcikc n-
    poc ps0nks dn cov 1.U. Wirsung co 1631.0 Wharton 0spnos cn on cou
    ndykpsdcoc ndpoid ' ducn cuv oidoyvuv dsvuv kdi ci dnokpu-
    vs svd unoci0ssvo skkpid dn' co nsyd cou nvsuovoydocpiko. U
    8oerhave co 1745 dvdsp0nks socoxd oco ndykpsdcik uyp. Jo 1869
    nooiscnks id idcpin dn cov P. Langerhans, nou nspisxs id npcn
    dvd-op ocd vnoid kuccpuv oco od cou ndykpsdcoc, nou idopo-
    noiovcdv dn cd kccdpd cou ioco. Jo 1893 o Laguesse, nou sxs uno-
    ncsu0s cn ondvcikn sv-okpivn couc sicoupyd, cd ovdos "vnoid
    cou Langerhans". Md s cov L. Nedon doxon0nks s cnv soucspikn sk-
    kpion cuv vnouv cou Langerhans. U Pavcon sxs 0supnosi cnv skkpion
    ndykpsdciko uypo uc dvcpdon cnc uskddkcuiknc svvouc
    spvnc, onou oi 8ay|iss kdi Starting ssidv ci n oskpscvn siik
    isyspsi co nykpsdc. hpodcd, dnosx0nks ci co svokpivsc kdi co
    sukpivsc cnd cou ndykpsdcoc sv svdi dvspcncd, d ouvsovcdi
    sicoupyik kdi ci dd pssi dn cd vnoid ocov sukpivn dsvd.
    Ui psc cnc kiviknc dvdyvpionc cou odkxdpn idncn skivov ocd
    0n cuv divuv. 0c npcn nspiypdn cou, 0supscdi ducn nou ps0nks
    oco diyu-ncidk xsipypdo "hnupoc Lbers". Jo vod, uc, "idncnc"
    dnoscdi ocov Apscdo. Jo 2 .x. divd o |dnvc unoocnpsi ci o
    idncnc npokdscdi dn knoid vspikn duvdd sv cnv id nspoo
    dvdopsc yvovcdi kdi ocnv Anu Avdcon. Icov 6 .x. divd onsivscdi
    npooc do dvdyvupscdi n knpo-voikcncd cou voondcoc, n vsu-
    pikn cou on kd8c kdi svssic yid ous-coxn cou nndcoc ocn voo.
    I112I
    XAUOUU 5AMNh
    Annu .A.
    1
    , Asovpou .A.
    2
    , A|uckotn 8.
    3
    , Io0u .
    3
    ,
    Muupovc|o k.
    3
    , kuuvtnouo A.
    3
    Iuvspyoznkdv o ldzpoikdoznc kozodznc O. kdi oi oiznzsc:
    Nziopd O., dxuknc N., nou A., Msiooonoou M.,
    snnopn B., didvkou I.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko Noookosou, I3I ldzpc
    |id cnv kdcspn skcnon kdi spnvsd cuv Asdyysioypdiv n uv
    dkcivooyikv sikvuv kdi cnv kdcspn yvon cou siko ndpouoi-
    ous cn opooyd kdi cic ndpddysc cnc Xuopou sdsvnc. N
    sscn npdydconoin0nks ocnv |dcpoikdocikn nnpsod A0nvv Ikdc-
    niv oxsciknc sidcl dn co Lpydocnpio hspiypdiknc Avdcoiknc kdc cnv
    cssucdd 5scd, os 112 ncdcd I63 dvpv, 49 yuvdikvl nou sxdv dks-
    pdio co kukoopik kdi sv sndoxdv dn nd0nosic nou vd snnpsouv
    co sik. Msc co csoc cnc vskpocoiknc sscdonc dvdncoods ocov
    onio0onspicovdik xpo cn xuopo sdsvn ocnv kdvovikn cnc 0s-
    onIU1l. Msscoods cov cpno oxndcioo, cn opooyd kdi cic id-
    ocosic cnc cnv kdcdypds kdi ucoypdds. Icnv dvc0scn nspncu-
    on snskcsvds cic cosc sxpi cnv dnokun kdi dvdyvpion cnc. Jd
    dnocssodcd 0d ndpouoidocov ocn ipksid cou Iuvspou.
    I113I
    UkAIIA kAI MAXAAIAIA A1hIA
    Annu .A.
    1
    , kop k.
    2
    , A|uckotn 8.
    2
    , kuunku O.
    2
    ,
    spsstn Xp.
    2
    , 1cupn Xp.
    3
    , Xpucv0ou Xp.
    2
    Iuvspyoznkdv o ldzpoikdoznc Asuknc X. kdi oi oiznzsc:
    kdpdvou A., kkkdnc I., Ikoknc ., konoziznc ., dnodc M.,
    Mdn l., Mxdoc M., Isopynouoc .
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov, 2. ldzpc,
    3. Akzivooyik Lpydoznpio Adko' Noookosou
    Is id supsd sscn cuv dpcnpidkv ndpddyv ocov snvik nn0u-
    o sscods co oxndcio cuv dpcnpidkv ocssxv nou skovcdi
    dn cnv unoksio kdi cn doxdidd dpcnpd, xpnoin yvoon yid zouc
    snsfdzikoc dkzivoyouc. Lscods 150 ncdcd oco spydocnpio cnc
    |dcpoikdociknc nnpsodc A0nvv.
    Lociods co svidspov dc ocnv skuon cnc kcu 0upsosioc, cnc
    unspncidc kdi cnc sykpoidc cpdxniknc dpcnpdc. Is svd 6,67 cuv nspi-
    ncosuv dc oi cpsic dpcnpsc sxdv koivn skuon. Ui oi ouvudoo
    cdivon0nkdv uc dkoo0uc:
    A. npxsi svd ocssxoc kdi sv ouscsxsi co nsupduxsvik ocssxoc
    I81,3 7l
    npxsi 0upsoduxsvik ocssxoc oxndcisvo dn cnv kcu 0upsosi-
    n, unspncid kdi couc sykpoiouc kouc cou dio Ikdoikn yv-
    onl, 33,37
    N sou docikn dpcnpd skscdi dn co 0upsoduxsvik ocssxoc, 9,37
    Jo ocssxoc oxndcscdi dn cnv kcu 0upsosin kdi cnv unspncid
    dpcnpd, 26,67
    Jo ocssxoc oxndcscdi dn cnv kcu 0upsosin, cnv unspncid kdi
    cnv sou docikn, 6,67
    npxouv o ocssxn nou oxndcovcdi dn cnv kcu 0upsosin s cnv
    unspncid kdi cnv sykpoid cpdxnikn s cnv sou docikn, 2,67
    npxouv o ocssxn dn cnv kcu 0upsosin s cnv sykpoid cpdxni-
    kn kdi cnv unspncid s cnv sou docikn, 47
    8. Iuscoxn cou nsupduxsviko ocssxouc I127l
    N sykpoid cpdxnikn s co nsupduxsvik ocssxoc I67l
    Jo nsupduxsvik ocssxoc skscdi dn cnv sou docikn I27l
    Jo nsupduxsvik ocssxoc s cnv unspncid dpcnpd I1,37l
    N kcu 0upsosinc s co nsupduxsvik ocssxoc I1,37l
    Jo nsupduxsvik ocssxoc s cnv kcu 0upsosin kdi cnv unspncid
    dpcnpd I1,37l
    Ixscik s cn doxdidd dpcnpd co 127 cuv ncucuv dkoou0oodv co
    doik npcuno. Ui idopsc nou pnkds cdivon0nkdv uc dkoo0uc:
    A.Upiosvoi koi oxndcouv ocssxn I487l
    N nyid 0updkikn dpcnpd kdi n 0updkoppdxidd oxndcouv koiv ocs-
    sxoc I11,37l
    N nyid 0updkikn dpcnpd oxndcsi koiv ocssxoc s cnv unoncid
    dpcnpd I9,37l
    N unoncid dpcnpd kdi n ono0id nspionusvn pdxivid I9,37l
    Ui o nspionsvsc pdxivisc oxndcouv koiv ocssxoc I187l
    8. Apcnpsc cou vu kpou nops vd npospxovcdi dn cn doxdidd dp-
    cnpd I21,37l
    N sv cu 0si pdxivid npospxscdi dn cn doxdidd dpcnpd I11.,37l
    Mid sninonc pdxivid dpcnpd npospxscdi dn cn doxdidd dpcnpd
    I5,37l
    N sv cuv 0si pdxivid dpcnpd npospxscdi dn cnv ono0id nspionus-
    vn I4,67l
    |. Liiksc nspincosic I18,67l
    npxouv snikoupiko koi oco 0updkik coxud I5,37l
    Xupiocn skuon cnc nspionsvnc uondciddc kdi cnc 0updkoppdxiddc
    I5,37l
    N 0updkoppdxidd dpcnpd svdi ikpn sv ouykposi s cnv nyid 0updki-
    kn I2,67l
    N ono0id nspionusvn dpcnpd skscdi dn cn pdxivid dpcnpd I5,37l
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    219
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I114I
    XI AAINUMU AAIIIkU N. - kA10 OUIU A1.
    Annu .A.
    1
    , Asovpou .A.
    2
    , A|uckotn 8.
    3
    , Io0u .
    3
    ,
    Muupovc|o k.
    3
    , kuuvtnouo A.
    3
    Iuvspyoznkdv o ldzpoikdoznc kozodznc O. kdi oi oiznzsc:
    Nziopd O., dxuknc N., nou A., Msiooonoou M.,
    snnopn B., didvkou I.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, I3I ldzpc
    Icd ndoid idc skcscdsvnc sscnc cnc dvdcoiknc cou cpdxnou spsu-
    vnods cic iioopsc cuv oxsosuv cou ndvpoou dpuyyiko s cnv
    kcu 0upsosin dpcnpd, yvon xpnoin yid couc xsipoupyoc cnc nspio-
    xnc, couc dvdio0noioyouc kc.
    N sscn syivs ocnv |dcpoikdocikn nnpsod A0nvv cd cssucdd scn os
    900 cpdxnouc I470 vcpsc kdi 430 yuvdkscl kdc cn ipksid cnc vskpoco-
    iknc sscdonc, ndpnd s cn sscn uv opucuv cnc nspio-
    xnc cou cpdxnou.
    Jd dnocssodcd sxouv uc snc:
    1 Jo ndvpoo dpuyyik vspo nopsscdi npooc dn cnv dnoxi-
    on cnc kcu 0upsosioc dpcnpdc 258/900 I28,67l.
    2 Jo ndvpoo dpuyyik vspo nopsscdi nou dn cnv dnoxion cnc
    kcu 0upsosioc dpcnpdc 298/900 I33,17l.
    3 Jo ndvpoo dpuyyik vspo nopsscdi dvsod dn cnv dnoxi-
    on cnc kcu 0upsosioc dpcnpdc
    d Mnpooc dn cov kcu ko 174/900 I19,37l
    hou dn cov kcu ko 159/900 I17,67l
    4 Jo ndvpoo dpuyyik ssnsi Iskscdi dn co nvsuovoydocpi-
    kl n ndivpoov ndvpoo dpuyyik 11/900 I1,27l
    U syoc dpi0c cuv sscn0svcuv cpdxnuv kvsi diniocd cd nooo-
    oc cnc ndpnc cuv iioopiv. N yvon ducn svdi iidcspd xpnoin,
    dv cn ouoxscoous s cnv ndpn poyxoknv, cuv kdpkvuv cnc nspio-
    xnc, cic snsyouosc cpdxsioocosc n cnv snskcdon cov kdc cic yvd0o-
    xsipoupyiksc snsosic Ispikn n piikn cpdxnikn skokdnl.
    I115I
    AAAAAI 10N A1hI0N 1U AIkA1U
    Annu .A.
    1
    , kop k.
    2
    , A|uckotn 8.
    2
    , 1c|pvn Xp.
    2
    , kuunku O.
    2
    ,
    Ik|ckn I.
    3
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc: oizikc l.,
    Mxdc I., kopn L., Iidvvpn M., kdpdvou A., Mdn l.,
    Aunspnouoc N., Asfoc M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. 0ovzdzpoc
    N inn spuoysvscikn npossuon cou ndykpsdcoc snys kdi co nsp-
    noko cnc dyysuonc cou. |i'duc n yvon cuv ndpddyv cuv dpcnpiv
    svdi yvon no ondvcikn yid couc doxoosvouc s cn sscn, sns-
    dcikoc dkcivoyouc kdi couc doxoosvouc s cnv dyysioypdsd
    cnc nspioxnc, kdi cn 0spdnsd cou ndykpsdcoc.
    N sscn dc syivs ocnv |dcpoikdocikn nnpsod A0nvv os 200 dv0pni-
    vd ndykpsdcd I108 dppsvuv kdi 92 0nsuv dcuvl sc co nspdc cnc
    vskpoconc. Jo syd ncdv cuxdo, kdi dnoksocnkdv vo cd ncdcd
    vskpv nou sndoxdv dn nd0nosic cou ndykpsdcoc.
    Jo nykpsdc dpsscdi dn nooio kcuo dpcnpidkv kuv nou nposp-
    xovcdi dn: dl cnv koiidkn dopcn kdi l cnv vu sosvcspid dpcnpd.
    hdpdcnpnods kdi 0d ndpouoioous cn nioupyd:
    A. cuv hpoo0uv cuv,
    8. cuv Unio0uv cuv,
    |. cnc Pdxiddc hdykpsdciknc dpcnpdc nou svdi onoudd cpoopoc
    dpcnpd,
    . cnc Lykpoidc hdykpsdciknc,
    Lniondvous, csoc, cnv nopsd cnc Innviknc dpcnpdc nou nops vd
    nopsscdi:
    1. Ico vu xsoc cou ndykpsdcoc I887l,
    2. Unio0ondykpsdcik I107l,
    3. Lvondykpsdcik I27l.
    Ui ndpddysc 0d ndpouoido0ov oxndcik kdc cnv dvncun cnc spyd-
    odc.
    I116I
    AAAAAI 1h k1Ikh A1hIA
    Annu .A.
    1
    , Asovpou .A.
    2
    , kuunku O.
    3
    , Ik|ckn I.
    4
    , Mun A.
    3
    , Asku
    A.
    3
    , ssvu k.
    2
    Iuvspyoznkdv n ldzpoikdoznc Mdpidvvo I. kdi oi oiznzsc: Mxd L.,
    Ikdpdykvn L., Mndkoyivvnc k., kiosoyou X., Iidvvnouoc A.,
    Aunspnouoc N., Asfoc M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc,
    4. 0ovzdzpoc
    Icnv ndpood spydod dvdspovcdi cd dnocssodcd cnc sscnc cnc
    kuociknc dpcnpdc, nou syivs oco spydocnpio cnc |dcpoikdociknc nnps-
    odc A0nvv nvu os 200 ncdcd kdc cn ipksid cnc |dcpoikdociknc
    sscosuc cnv cssucdd sdscd kdi dnocss cnd sync spydodc
    nou sxsi odv 0sd cic ndpddysc cuv ovouv kuv cnc koiidknc
    dopcnc. An cd 200 ncdcd cd 108 nodv vcpsc kdi cd 92 yuvdksc. Jd
    nopodcd dc cd kdcdcds uc snc:
    Al kAAU|
    1 kuocikn dpcnpd, n onod dnooxscdi ocn ouvsxsid os npo0id kdi
    ono0id.:
    d n kuocikn dpc. npospxscdi dn cov si ko cnc iuc nndci-
    knc dpc. I87/200l,
    n kuocikn dpc. npospxscdi dn ko cnc sic iuc nndciknc
    dpc., nou npospxscdi dn cnv vu sosvcspid dpc. I26/200l,
    y n kuocikn dpc. npospxscdi dn cnv dpiocspn iuc nndcikn dpc
    I12/200l,
    n kuocikn dpc. npospxscdi dn co ixdo cnc iuc nndciknc dpc. I21/
    200l,
    s n kuocikn dpc. npospxscdi dn cnv iuc nndcikn dpc. Inpiv ixdocs
    ocouc o k-oucl I5/200l,
    oc n kuocikn dpc. npospxscdi dn cnv koivn nndcikn dpc. I6/200l,
    n kuocikn dpc. npospxscdi dn cnv ydocpouskddkcuikn dpc.
    I7/200l.
    2 kuociksc dpcnpsc. Ui o kuociksc dpcnpsc Inpo0id, ono0idl skovcdi
    vsc couc:
    d skovcdi voi couc dn cov si ko cnc iuc nndciknc
    dpc. I29/200l,
    o npo0ioc koc skscdi dn cnv dpiocspn iuc nndcikn
    dpc. kdi o ono0ioc dn cnv si iuc nndcikn dpc. I3/200l,
    y o npo0ioc koc dn cnv ydocpouskddkcuikn dpc. kdi o
    ono0ioc dn cn si iuc nndcikn dpc. I2/200l,
    oi o koi skovcdi xupioc dn cnv dpiocspn iuc nndci-
    kn dpc. I2/200l,
    s ndpn cpiv kuv sv ndpdcnpnods, ndpo nou nspiyp-
    scdi ocn is0vn iioypdd.
    8l 6LIN JNI kIJ|kNI APJNP|AI
    d N kuocikn dpcnpd sv idocdupvscdi s cov koiv nndcik npo
    I151/200l,
    N kuocikn dpcnpd nopsscdi snpoo0sv cou koivo nndciko n-
    pou I43/200l,
    y N kuocikn dpcnpd nopsscdi nio0sv cou koivo nndciko npou
    I6/200l.
    220
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I117I
    AAAAAI 1I A1hI 10N 0 INNh1Ik0N UIAN0N
    1U OhAU
    Annu .A.
    1
    , kop k.
    2
    , A|uckotn 8.
    2
    , kuunku O.
    2
    ,
    spsstn Xp.
    2
    , 1cupn Xp.
    3
    , Xpucv0ou Xp.
    2
    Iuvspyoznkdv o ldzpoikdoznc Asuknc X. kdi oi oiznzsc:
    kdpdvou A., kkkdnc I., Ikoknc ., konoziznc .,
    dnodc M., Mdn l., Mxdoc M., Isopynouoc ., kdyspou L.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. Akzivooyik Lpydoznpio Adko' Noookosou
    Ms ducn cn sscn dc, doxon0nkds s cic ndpddysc cuv dpcnpiv
    cuv sou ysvvncikv opyvuv cou 0nsoc, yvon xpnoin yid couc xsi-
    poupyoc cnc nspioxnc.
    N spsuvd sds xpd oco Lpydocnpio hspiypdiknc Avdcoiknc cou hdvs-
    niocnou A0nvv kdi ocnv |dcpoikdocikn nnpsod A0nvv,os 200 nc-
    dcd, cnv cssucdd cscpdscd.
    Ui dpcnpsc cuv sou ysvvncikv opyvuv, svdi: n uo0nkikn, koc cnc
    koiidknc dopcnc, kdi n ncpidd dpcnpd, koc cnc sou dyovou dpcn-
    pdc, n idvon kdi n nopsd cuv onouv, svdi co dvcikssvo cnc sscnc
    dc.
    Iuvoncik, cd dnocssodcd, ncdv:
    1. A|MAJ0IN JNI 0U6NkNI
    dl dn cnv uo0nkikn dpcnpd I76/200l
    l dn uo0nkikoc kouc cnc ncpiddc dpcnpdc I5/200l
    yl kdi dn cic 2 dpcnpsc I119/200l
    2. A|MAJ0IN J0N 0A|0|0N
    dl dn odniyyikoc kouc cnc ncpiddc dpcnpdcI113/200l
    l dn odniyyikoc kouc cnc uo0nkiknc dpcnpdcI64/200l
    yl kdi dn cic 2 dpcnpscI23/200l
    3. A|MAJ0IN JU h6MLNA JNI MNJPAI
    dl dn cn ncpidd dpcnpdI173/200l
    l dn kouc cnc uo0nkiknc dpcnpdcI27/200l
    Jd dvducik dnocssodcd 0d ndpouoidocov kdc cn ipksid cou ou-
    vspou.
    I118I
    AAAAAI 1hN kA1Akh 1U AU1IkU 1U5U
    Annu .A.
    1
    , kop k.
    2
    , A|uckotn 8.
    2
    , 1c|pvn Xp.
    2
    , kuunku O.
    2
    ,
    Ik|ckn I.
    3
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc: oizikc l.,
    Mxdc I., kopn L., Iidvvpn M., kdpdvou A., Mdn l.,
    Aunspnouoc N., Asfoc M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. 0ovzdzpoc
    Jo dopcik co skcsvscdi dn cnv skuon cou sio pdxiovoksdi-
    ko ocssxouc sxpi cov ocsio ovsoo. Txsi nkoc 5-6 skdc. kdi
    spoc, ocnv dpxn sv 2,5-3 skdc. kdi oco csoc 2-2,5 skdc. Icnv nopsd cou
    skovcdi co si pdxiovoksdik ocssxoc dn' nou skscdi n s-
    i unoksid dpcnpd kdi n si koivn kdpucd dpcnpd, n dpiocspn
    koivn kdpucd dpcnpd kdi n dpiocspn unoksid dpcnpd. Icnv kdooikn
    ducn dvdcoikn nspiypdn dvciocoixs vo co 687 cuv nspincosuv cnc
    sscnc dc Io Anson dvdspsi ci os 1000 nspincosic vo co 657 dvci-
    ocoixs ocnv kdooikn nspiypdnl. Icn sscn dc, nou syivs nvu os 500
    dopcik cd I279 ppsvsc kdi 221 0nsicl, ndpdcnpnods dvudsc uc
    npoc cn 0son kdi uc npoc cn idkuon:
    A. 0c npoc cn 0son: Jo dopcik co supokscdi nspnou 2,5 skdc. dn cn
    odyn cou ocspvou. Is nscspo ndpdoksdod co dopcik co sup-
    okscdi 3 skdc. dn cn odyn cou ocspvou.
    8. 0c npoc cnv skuon kdcdcds cic ndpddysc uc snc:
    1. Avudsc uc npoc cn idkuon:
    d. Tkuon cnc dpiocspnc koivnc kdpucdc dpcnpd dn co si
    pdxiovoksdik ocssxoc I97l,
    . N dpiocspn koivn kdpucd dpcnpd skscdi dn co pdxiovo-
    ksdik ocssxoc I7,57l,
    y. npxouv 2 pdxiovoksdik ocssxn I27l.
    2. Tkuon cnc onovuiknc dpcnpdc dn co dopcik co:
    d. N dpiocspn onovuikn dpcnpd svdi npocssucdoc koc cou
    dopciko cou I17l,
    . N dpiocspn onovuikn dpcnpd svdi cssucdoc koc cou
    dopciko cou I17l,
    y. N dpiocspn koivn kdpucd dpcnpd skscdi dn co si pd-
    xiovoksdik ocssxoc I17l.
    3. Tkuon cnc kdccdcnc 0upsosiiknc dpcnpdc Iimal dn co dopcik
    co I117l.
    4. Asc ndpddysc:
    d. N dpiocspn unoksid dpcnpd skscdi npiv dn cnv dpiocspn
    koivn kdpucd dpcnpd I17l,
    . N si unoksid dpcnpd skscdi vn, sc cnv si koivn
    kdpucd dpcnpd I17l.
    I119I
    AAOUII AN: 1U NUMUIAMMA, h Oh
    8 UI AIOMUI AN
    Annu .A.
    1
    , Asovpou .A.
    2
    , kuunku O.
    3
    , Ik|ckn I.
    4
    , Mun A.
    3
    , Asku
    A.
    3
    , ssvu k.
    2
    Iuvspyoznkdv n ldzpoikdoznc Mdpidvvo I. kdi oi oiznzsc: Mxd L.,
    Ikdpdykvn L., Mndkoyivvnc k., kiosoyou X., Iidvvnouoc A.,
    Aunspnouoc N., Asfoc M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc,
    4. 0ovzdzpoc
    |id cn ouocn skcnon kdi dvspson cuv ndpd0upsosiv dsvuv npsnsi
    o siikc vd yvupsi co uoiooyik sys0oc kdi cic ni0dvsc skconsc 0s-
    osic cuv uoiooyikv unsppi0uv dsvuv. Icd ndoid idc supcspnc
    sscnc spsuvnods kdi couc ndpd0upsosisc dsvsc ocnv |dcpoikdoci-
    kn nnpsod A0nvv.
    Msscnods couc ndpd0upsosisc dsvsc scd0dvcid os 942 cod nou sxdv
    ns0vsi dn dicsc 0dvcou oxscsc s ndpd0upsosiikn n vspikn voo.
    Jo uik dc dnocssodv 574 vpsc kdi 368 yuvdksc nou vskpocon0nkdv kdc
    cnv okcdscd 1988 - 1996 ocnv |dcpoikdocikn nnpsod A0nvv.
    Is 47 nspincosic I57l unnpxs svdc sninsov Insncocl dsvdc, sv os 19
    nspincosic I27l oi dvsups0svcsc ndpd0upsosisc ncdv cpsic. Is 324 nspi-
    ncosic sn ouvou 3796, unnpxdv skconoi dsvsc dl svo0upsosiiko
    7, l svocpdxniko 79 kdi yl svo0updkiko 152 oco dvcspo soo0up-
    kio kdi 86 oco kdccspo.
    Ui kcu dsvsc ncdv ouvn0uc sydcspoi kdi dpcspoi dn couc vu.
    hdpnd ocn ouncnon yvscdi ouoxscion cou sys0ouc s cnv nikd
    kdi co o.
    N yvon ducn nops dkd vd on0nosi co xsipoupy cnc nspioxnc ocnv
    dvspson svc ndpd0upsosiiko dsvdcoc kdi ocnv npoocdod cuv
    ndpd0upsosiv kdc cic 0upsosiskcosc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    221
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I120I
    AMO0MA1A N1UIMNA 1h 1UMA1Ikh kUIAU1h1A
    kAI 1h 1UMA1UINAOUU0Ikh IUXh
    U|kovou X.
    0ovzidzpikn Ixon zou A..6
    kon tn spyucu: N spydod dnocss id ovcon iioypdikn dvd-
    oknnon oxscik s cd sdcd nou ndpouoiovcdi ocnv ocodcikn
    koiocncncd kdi cnv ocodcoyvd0ikn nspioxn. U oovcdcpoc sniscdi
    vd yvupsi cnv kivikn sikvd cuv sucuv kd0c svdi uvdcv k-
    noioi do0svsc vd ncnoouv iyvuon yid npcn op dn ducv kdi uoi-
    k n sykupn iyvuon kdi svdpn 0spdnsdc ououv ocnv kdcspn
    npyvuon couc.
    Jd sdcd ndpdooidk xupovcdi ocnv voo cou NUDUk|NINNl kdi
    ocd n NUDUk|N sdcd IMNAl, cd onod n Nodgkin idkpvovcdi os
    8-kuccdpiknc dpxnc kdi J-kuccdpiknc dpxnc. Iuxv ,os nooooc nspnou
    257 cou ouvou cuv n Nodgkin sucuv dvdncooovcdi os su-
    sdsviksc nspioxsc.
    Jd sdcd svdi oi nio ouxvo n sni0nidko kdkon0sic ykoi cnc
    ocodciknc koicncdc kdi cnc ocodcoyvd0iknc nspioxnc kdi dvcinpoou-
    nsouv cnv cpcn ouxvcspn od kdkon0siv ocnv nspioxn ducn sc
    co dkdv0okuccdpik kdpkvud kdi couc kdkon0sic ykouc cuv oisoy-
    vuv dsvuv.
    Mnopov vd npoon0ov cod onoidonnocs nikdc d ocnv ou-
    vcpincikn couc nsiond oi do0svsc svdi cod npoxupnsvuv ni-
    kiv. Lvdi uvdcv vd dvdncux0ov os onoionnocs onso cnc sv yu
    nspioxnc d nio ouxv dvdncooovcdi ocov dkcio cou Wa|deyer.
    N doikn ocoixsinc n s cnv onod sknvovcdi svdi un opn
    ykou, scspnsupd n docsponspd. Iuxvn svdi kdi n svion s-
    kosuv ocnv snivsid cou ykou.
    noksisvik svoxndcd ouvn0uc sv ouvosouv cnc sc, ndp vo
    co do0nd cnc uokdcdnooidc cdv cd sud svconscdi ocov dkc-
    io cou Wa|deyer.
    kdc cnv xpovikn ociyn cnc iyvuonc n nsiovcncd ducv cuv su-
    cuv kdcdcooscdi ocd ocdd | kdi || Icdivnon kdc Ann Arborl.
    Ms sdpson couc oisoyvouc dsvsc, nou cd sdcd svdi ouvn0uc
    xdno d0o kdkon0sidc, n nsiovcncd cuv sv yu sucuv
    svdi soou n uno d0o kdkon0sidc.
    |ocooyik nops vd ndpdcnpn0s onoioonnocs cnoc d nio ouxvc
    svdi o cnoc dn ixucd syd kccdpd. Lnionc nops vd ndpouoid-
    ocs o onoioonnocs dvooodivocunoc d o nio ouxvc svdi cnc 8-
    kuccdpiknc dpxnc.
    N npyvuon cnc voou cou Nodgkin svdi ouvn0uc kdn sv cuv uv
    svdi dnpsncn. Jd J-kuccdpiknc dpxnc 0supovcdi nio kdkon0n dn cd
    8-kuccdpiknc dpxnc.
    I121I
    ANA1UMIC IMkSSIUNS UF 1UU1PLSS 0k 1AW 1AkN
    WI1P vAkIU0S IMkSSIUN MA1kIALS
    kuz|ca 8.
    Student of MedicaI FacuIty of BanjaIuka, epartment for entistry
    Introduct|on: Anatomic impression is reproduction of ora| cavity tissue
    with passive and |oosen mucous membrane taken with various impression
    materia|s.
    Method and mater|a|s: 3 anatomic impressions from the same patient were
    taken, in 3 different impression materia|s:gypsumIcase |l, thermop|astic
    massIcase ||l, and irreversib|e hydroco||oid a|ginate massIcase |||l. Prepara-
    tion of working mode|s with hard gypsum was conducted in |aboratory.
    8ehavior of impression materia|s and qua|ity of the mode|s were monitor-
    ed.
    kesu|t: Ana|yzing the 3 cases the fo||owing resu|ts were determined:Case |
    showed negative characteristics of imperssion:it is uncomfortab|e for pa-
    tients, it is britt|e and breakab|e whi|e pu||ing the spoon out of patient's
    mouth, as we|| as whi|e |etting free the pressure of the working mode|.W-
    orking mode| is a precise negative of the tissue of a tooth|ess upper jaw.-
    Case || is not practica| for working with patients for its thermop|astic
    characteristics, and for incapabi|ity of the mass to come into undermined
    parts of the jaw. Jhe fina| mode| does not precise|y present status of the
    mucous membrane of the upper jaw.Case ||| is practica| for working with
    patients,it is of p|easant consistence, taste and hardens in short time.Wo-
    rking mode| of this impression shows sufficient preciseness of a|| anatomic
    detai|s of the upper jaw.
    Conc|us|on: |t can be conc|uded that irreversib|e hydroco||oid a|ginate is
    the most suitab|e materia| in modern dentistry for impression of tooth|ess
    upper jaw,the most comfortab|e for patients, the most easi|y manipu|ate-
    d, and precise|y presenting anatomic status of tooth|ess upper jaw.
    I122I
    UIkUI kh0 kAI IOANh 1U Xh M 1U OAU 1U M8U
    koukk|ou O., Osopso .
    kon tn spyucu svdi vd ndpouoiosi sninpo0scsc nnpoopsc oxscik s
    cnv svion ykuv kunosuc ocn ocodcikn koicncd kdi vd sscosi cnv ni0dvn
    couc oxson s co o cou spou.
    Ui ykoi kunosuc svdi sovusvoi ykoi, oi onooi s 0d npsnsi vd ouyxsovcdi s
    co nuoyvo kokkud n cn yuydvcokuccdpikn snoud, dv kdi sdvouv iocoo-
    yiksc ooicncsc. N idop couc syksicdi oco ysyovc ci oi ykoi knonc sivo-
    vcdi os sys0oc n dkd sddvovcdi xupc 0spdnsd sc cov coksc.
    Ldvovcdi ouxvcspd cov cpco s cscdpco nvd kunosuc. Lvdi dvuvoi,
    okoupcspou xpdcoc dn couc ysicovikoc iococ ykoi, cuv onouv n sni-
    vsid svdi ouxv sskusvn kdi spiksc opsc dioppdys. Iuxvcspd svcono-
    vcdi ocd od kdi os opiosvsc nspincosic ocn yood, ocnv unspd, oco sv-
    voyvo kdi ocd xsn.
    Ldvovcdi os ouxvcncd 0,2 s 2,7 coic skdc. Upiosvsc spsuvsc dvdspouv
    ci oi yuvdksc s snousc kunosuc nio ouxv ysvvov dypid. Jo ysyovc duc
    osscdi os opvsc oi onosc nspvov ocn ncspd id soou cnc ndkouvcidknc
    snikoivuvdc.
    I123I
    MA1UAOI I1U 8ANNUIUNU 1h 1UMA1Ikh kUIAU1h1AI
    Mno0no A.
    Yns0uvoc kd0nynznc: TIATI0YAH l.
    ho ouxvn svdi n svion cuv spdcond0siv oco svvoyvo cnc
    ocodciknc koicncdc. N kivikn sikvd ducv cuv nd0nosuv ndpouoi-
    si syn noikid sv nops vd svdi idopscikn n ouxvcncd svi-
    onc ocd o d, vd snnpsscdi dn cnv nikd kdi vd sxsi idopscikn
    npyvuon kdi 0spdnsd. Ikonc ducnc cnc spydodc svdi vd ndpouoiosi
    dvducik cic nspioocspsc ouxv sdvisvsc spdcon0sisc vo-
    vcdc sdon ocnv kivikn sikvd kdi cd ocoixsd nou dvovcdi dn cd
    iocopik cuv do0svv. Idv cscoisc 0d nspiypdov: 1l o odc sixnvdc,
    2l nsiyd, 3l kdon0sc nsiyosisc cuv svvoyvuv, 4l co noou-
    ysc nsuyosisc, 5l co noopo sp0nd, 6l co ovpoo Stevens-
    1ohnson. hdpnd 0d yvsi npoon0sid vd coviocov sksvd cd ocoixsd
    cuv nd0nosuv nou 0d onynoouv ocn idopoiyvuon dn sc nd0n-
    osic cou svvoyvou cou ocdcoc s ndpoisc kiviksc sknosic.
    sosvou, csoc, ci nosc opsc oi ndpdnvu spdcon0sisc sd-
    vovcdi dpxik oco ocd n nops vd dnocsov kdi cnv vn sknuon
    os ouvudo s cnv skon npoosyyion kdi cnv oxscikn dncncd cuv
    sscdocikv s0uv Iiocopik, kivikn sikvd, iocond0ooyikn l unon-
    vsi ci oi svoocodciksc sikvsc svdi ondvciksc yid cn iyvuon. Ms
    co csoc cnc ndpouodonc snous vd kdcdsix0s svd dkn nso nou
    nops vd suokinosi n ouvspydod cou ysviko oovcicpou s cov nd-
    0oyo yidcp.
    222
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I124I
    1UMA1IkA IAAMA1A-Xhh-AU1AMA1IkU1h1A-AOAAIA
    Osoocn Xupuno, Mupyuptn Ispy|o
    Ico snpio idc0scdi nn0pd oovcidcpikv ocodcoiducuv nou
    nposnouv scs ocnv dvciond cou ocdcoc, scs ocnv npoocdod dn
    cnv cspnvd. N ocodcikn uyisivn doscdi oco opcoiod cuv ovciv
    kdi cuv ouvInxdvikc ssyxoc ikpoidkv ndkvl,d os opios-
    vsc nspincosic 0supscdi dndpdcncn n ouvpon xnikv souv.
    Jd ocodcik iddcd idkpvovcdi os o kpisc kdcnyopsc: Avcion-
    ncik 8 0opioxd.
    Ikonc cnc ndpoonc spydodc, svdi vd dvdcpssi ocd iioypdik s-
    osvd yid vd idniocosi:
    1. cnv dnocssodcikcncd cuv svspyv ouocdcikv cuv ocodcikv id-
    ucuv,
    2. cic svsxsvsc ndpsvspysisc cuv oksudocuv os siiksc kdcnyopsc
    do0svv.
    Lnonc, n sscn 0d snskcd0s ocov ssyxo cuv nnpoopiv nou dvdyp-
    ovcdi ocic ouoksudosc cuv npovcuv kdi cnv dioynon cnc do-
    sic couc ouvd s cd is0vn npuckod.
    I125I
    h MIkh ANAIAMUO0h 1U XIAU kA1A 1hN 0IMh
    XIUIIkh AN1IM10Ih 10N XIAUXI1I0N
    Iuvvn I|vvn
    1
    , Mno0c|o 8ucn
    1
    4. Tssioizoc 0ovzidzpiknc, Tnd 0ovzidzpiknc, Apiozozssio
    dvsnioznio 6soodovknc
    spn$n: N uikn sndvdidpuon sxsi uc ocxo cnv sicoupyikn kdi
    dio0ncikn dnokdcocdon cuv xsisooxiociv. |id vd snicsux0s n uikn
    sndvdidpuon svdi dndpdcncn n dkpinc yvon cnc uoiooyiknc
    kdi nd0ooyiknc dvdcodc cnc nspioxnc, nuc kdi cou cpnou dvncunc
    cnc vu yv0ou. Dcdv ous id xsisooxiocd, kdc cnv skcn s son
    spuikn sod, idkncscdi n uoiooyikn ouvsxsid coo cou oi-
    ykcnpd cou ocdcoc, oo kdi cuv ndpdpivikv uv. Auc sxsi odv dno-
    cssod cnv duvdd ovsonc scd cuv npucoysvv kdi sucspoys-
    vv ksvcpuv dvncunc cou kpdvou kdi cnv svion cou xdpdkcnpioci-
    ko npoounsou cnc xsisooxiocdc. N uikn sndvdidpuon kdc cnv
    xsipoupyikn dnokdcocdon cuv xsisooxiociv onys ocnv dnpokoncn
    dvncun cou soou npoonou s cnv dkpin sndvdcono0scnon cuv uv
    ocn uoiooyikn couc 0son. N sndvdcono0scnon nops vd snicsux0s s
    iopsc xsipoupyiksc csxviksc oov dop cnv 0son kdi cnv skcdon cuv
    cov, dvoyd s cnv npoounikn npocnon cou snsdvovcd kdi d-
    vscdi nuc sxsi sv0dppuvcik dnocssodcd. N skcnon uc cuv xsipoup-
    yikv dnocssocuv sv svdi id skon un0son, kd0c unpxouv
    noo ndpyovcsc nou ououv ocnv dvncun cuv yv0uv, nuc n
    ysvscikn npoi0son cuv do0svv, n ikdvcncd cou snsdvovcd, n ni-
    kd ocnv onod yvscdi n snsdon, n xsipoupyikn csxvikn, n nioupyd
    ouv kdi csoc n oxsv nvcd dvdykdd isvspysid op0oovciknc 0spd-
    nsdc. Icn is0vn iioypdd ndpdcnpscdi knoid oxscikn ssin xsi-
    poupyikv dnocssocuv ouvd s cnv ndpdnvu csxikn dnokdc-
    ocdonc. 0ocoo ouvd s ducsc cic sscsc dvscdi ci n uikn snd-
    vdidpuon nops uc svd d0 vd dvdxdicosi cd npondcd dn-
    onc kdi indonc nou nioupyovcdi kdc cnv xsipoupyikn dnokdc-
    ocdon cuv xsisooxiociv. hspdicspu spsuvsc svdi dndpdcncsc ocs vd
    ispsuvn0ov cd dkpin dnocssodcd cnc csxviknc ducnc kdi vd ouykpi-
    0ov sndpkc s dvoyd dnocssodcd uv csxvikv.
    I126I
    NAAIIA 1IMU
    |pn O. kv, kukustco . 8ucs|o, Nto0vn k. A0uvc|o
    N kpid dicd npoossuonc cou do0svoc oco oovcidcpso svdi co yoc
    ocn ocodconpoounikn xpd. Md dn cic nio svidspouosc kdi uoi-
    yvuocsc dicsc nvou svdi n vsupdyd cou cpiou, n onod npokds
    svcovo kdi ndpouoik nvo, nvcocs scspnsupd. N vsupdyd cou
    cpiou uvdcv vd svdi npucond0nc n sucspond0nc. N diciooyd cnc
    npucond0oc vsupdydc cou cpiou sv svdi dnocuc isukpivios-
    vn, sv n sucspond0nc nops vd npokdscdi dn nn0oc opydvik d-
    cid.
    Ikonc cnc npokssvnc spydodc svdi n ndpouodon cnc ouykskpisvnc
    kdcocdonc, n ndp0son cuv snikpdcsocspuv dnsuv yid cic dicsc nou
    cnv npokdov kd0c kdi cuv xdpdkcnpiocikv kivikv sknosv cnc.
    6d dvdsp0ov dkn ocoixsd idopoiyvuonc dn sc nd0ooyi-
    ksc ovccncsc, nuc oi ksddysc kd0c kdi oyxpovn s0oooyd
    0spdnsuciknc dvciscnionc.
    I127I
    h XhIMU1h1A 1h AAIIA kOAAUM1Ikh Ak1INUIAOIA
    1hN UOUUN1Ikh
    2us|p|n A., !t|ou .
    Lnifsnov: lodvvou-Mdpd0iozou l., Lnkoupoc kd0nynzpid, Lpydoznpio
    0p0oovziknc, Tnd 0ovzidzpiknc, Apiozozssio dvsnioznio
    6soodovknc.
    Ikonc cnc ndpouodonc ducnc svdi vd snionvsi cn ouon cnc n-
    yidc ksdoscpiknc dkcivoypddc ocn kd0nspivn op0oovcikn npn.
    |vscdi dvdop ocn ixvoypnon kdi svconio cuv dvdcoikv ocoi-
    xsuv cnc, kd0c kdi cnc s0oooydc ksdoscpiknc dvuonc. Lnonc
    dvdspovcdi oi csoospic doiko ovsc xpnonc cnc nyidc ksdoscpi-
    knc dkcivoypddc: dl hspiypdn cuv dvdcoikv ov cou npoonou
    kdi cuv oovcooksscikv oxsosuv. l Msscn cnc dnonc cou kpdvio-
    npoouniko ounsydcoc. yl iyvuon kdi oxsidoc cnc op0oovci-
    knc 0spdnsdc. l kivikn spsuvd. Iunspdodcik, n ksdoscpikn dkci-
    voypdd dnocss dioyo idyvuocik spydso yid cnv sscn, dv-
    uon kdi snuon nov nponcuv cou kpdvionpoouniko ounsy-
    dcoc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    223
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I128I
    U UAU 1h IA0A 1I AN0MAAI IkAIh 10N UN1I0N
    8n ou
    dvsnioznio A0nvov, 0ovzidzpikn Ixon, Lpydoznpio 0p0oovziknc,
    isu0vzpid: kd0nynzpid Inuponoou M.N.
    N yood svdi svd ioxupcdco uik pydvo co onoo, vcdc sod ocn
    ocodcikn koicncd, dnocss svd uvdik ndpyovcd snnpsdoo cnc
    0sonc cuv ovciv kdi cnc idpuonc cou oxndcoc kdi cnc oxsonc cuv
    oovcikv pdyv.
    Icxoc cnc spydodc ducnc svdi n ndpouodon, osi cnc unpxouodc
    iioypddc, cuv sicoupyikv sniposuv cnc yoodc ocnv oovcikn
    oyksi on.
    N npo0non cnc yoodc svdi id uosicoupyd nou sxs nddicspd
    svoxonoin0s uc ondvcikc ndpyovcdc npknonc ouyksioidkv dvu-
    div. 0ocoo, vscspsc sscsc unoocnpouv ci n npo0non cnc yo-
    odc nops vd svdi id dvdykdd npoodpoocikn kvnon cou opyvou du-
    co os npounpxouosc ouyksioidksc dvudsc.
    Iuykskpisvd, oi diciooyiko ndpyovcsc nou npokdov npo0non cnc
    yoodc svdi oi snc:
    * ouyksioidksc dvudsc kdi iidcspd n npo0id xdooovcd
    * vsupouiksc idcdpdxsc
    * okssciksc dvudsc
    * npupn dnsid vsoyiv ovciv
    * 0ndoc cnc yoodc
    * ocodcikn dvdnvon
    * dkpoyuood
    N npo0non cnc yoodc nops vd sknvscdi kdc cn sicoupyd cnc
    oncs ousi ocn idcnpnon n snisvuon svc npounpxovcoc ou-
    yksioidko npondcoc. Mnops uc vd sknvscdi kdi kdc cn on
    npsdc cnc yoodc, yu cou sys0ouc cnc n yu ndpnc unspcpoi-
    kv duydv, kdi v' dnocss scoi ysvsoioupy ndpyovcd idc dvud-
    dc. I' ducn cnv nspncuon nops vd snnpsosi cn 0son cuv ovciv kdi
    vd npokdsosi ouyksioidksc dvudsc.
    Indod sxsi v' diooyscdi ouoc n snpdon cnc yoodc kdc cn i-
    yvuon kdi cov npoypddcio 0spdnsdc os k0s nspncuon dvuddc
    cnc oyksionc.
    I129I
    UI MUOUIN1Ik 01N 1U U1U I8MI 0 AIkU kAUIh 1hN
    AMh kAATh-UAOU1UMh NUIIA0N kAI UN1I0N
    M AIAAA1U AkUI2IU
    Muv kvctuvtvo, stutn N|kuo,tuup|uv Xpncto
    Jd cssucdd xpvid, sdvocnks syoc dpi0c spsuvv oov dop
    cn xpnon opoysvscikv npucsvv cou ooco Ibone morphogenetic pr-
    oteins, 8MPl ocnv Uovcidcpikn.
    Ui opoysvsciksc npucsvsc cou ooco dnocsov id od idc syd-
    cspnc oikoysvsidc npucsvv yvuocsc uc scdcpsnciko dunciko ndp-
    yovcsc- Itransforming growth factors-l kdi dnocsov co opidk un-
    ocpud nou svdi uns0uvo yid cn idcnpnon cnc ooioocdodc kdi cou
    iooyiko nxdvioo cnc oociknc dvdysvvnonc.
    Jpd sn cnc odc 8MP nou oxscovcdi sicoupyik s co nxdvio
    cnc svdosocuonc dvdyvupocnkdv yid cnv ikdvcncd couc vd npou0ov
    cn ispydod cnc sndvop0uciknc oovcvnc.
    Jo 1994, sdpo0nks nsipddcik os sosc dnokdsic os ni0nkouc n
    npucsvn UP-1 os ouvudo s kodyvo kdi idnioc0nks ci idcn-
    pscdi n ucikcncd cou noo sv ndpnd npou0ov cn ispydod
    sndvop0uciknc oovcvnc os 1-4 nvsc.
    Lnonc os n spsuvd xpnoionoin0nks os noocosc os vcid ok-
    uv oi opoysvsciksc npucsvsc 8MP-2, 8MP-4 kdi o duncikc ndpyo-
    vcdc JUF- os ouvudo s kodyvo.Iunspdodcik, dn cn iio-
    ypdikn dvdoknnon cou 0sdcoc, cd dnocssodcd svdi sv0dppuvcik
    d pokovcdi os dpxik ocio oov dop cnv dnooxn couc oco
    sov uc uik snioync yid son kun kdi noocon coo ocd
    vsoyi vcid oo kdi ocd vid s dindoco dkpoppio vcid.
    I130I
    UAOU1UMh M hAk1UXIUIIkh kAI LASk.
    stutn N|kuo, Mstcku Mupu-|ccst, tuup|uvXpncto
    Ikonc cnc spydodc svdi vd ndpouoiosi cn xpnon cnc nskcpoxsipoupyi-
    knc kdi cuv |aser ocnv noocon. N noocon npocsvscdi uc 0spdnsdc
    skoync os vsoyi kdi os vid s dindoco dkpoppio vcid.
    N csxvikn cnc nooconc s nskcpoxsipoupyikn Innn kdi doocdon s
    nskcpio- e|ectrocoagu|ationl pxios vd xpnoionoiscdi dn co 1967.
    Lpsuvnciksc spydosc cuv Mack et a|-1993, Fishman et a|-1996, L|-Me|igy et
    a|-2001kdi Dean et a|-2002 ssidv sydcspd n ndpoid nooooc sni-
    cuxdc s duc cnc csxviknc cnc opokpsonc. An cn iioypdikn
    dvdoknnon cou 0sdcoc, cd dnocssodcd svdi sv0dppuvcik, dndics-
    cdi uc nspdicspu in vivo spsuvd.
    N xpnon cuv |aser ocnv noocon ovciv ndpouoisi ondvcik nso-
    vskcndcd nuc dnouod nvou, sniskcikcncd, dkpsid ocnv dnokonn
    oknpv kdi ddkv oovcikv iocv, diocdon-sccuon cnc diop-
    pdydc, kdcspo ssyxo cou xsipoupyiko nsou, dnoocspuon kdi dpo-
    nonon cuv dkcivooosvuv snidvsiv. Ui Arrastia et a| co1995 I|aser
    CU
    2
    l, Liu et a| co 1999 I|aser Nd:AUl, L||iot et a| co 1999 I|aser CU
    2
    l, oi
    Niko|opou|os et a| 2000 I|aser ArF Lxcimerl spyocnkdv os dv0pnivd -
    vcid kdi ounspdvdv ci sc cnv dkcivonon- noocon cd vcid
    ncdv douncudcik, idcnpn0nks n ucikcncd cuv noikv iocv kdi
    oxndcocnkdv ysupsc oovcvnc. Is ndpoid dnocssodcd kdcsn-
    dv oi spsuvncsc os vcid uv IShoji et a|, 1985 - |aser CU
    2
    , Wi|kerson
    et a|., 1996- |aser argon k.dl.
    Jd ounspodcd cuv spsuvv s on cd kivik, dkcivoypdik kdi ioco-
    oyik supndcd 0supn0nkdv kdcspd os ouykpicikn dioynon s cd
    ovionoincik updcd Iopokpson-youcdpdsnl. Andicovcdi
    uc nspioocspsc in vivo spsuvsc yid vd xpnoionoin0ov s dosid
    ocnv kivikn npn.
    I131I
    MIIMA UAMUO0N 1IU5II0NIMINkAL 1kIUXID
    AUUkUA1-M.1.AI: NA NAAAAk1IkU AIkU
    IIA 1hN NUUN1IA- IIU1h1 kAI kAINIk OAMUI
    Ikp||tn ou, No0u I|ovu
    Tszdpzoszsc oiznzpisc oovzidzpiknc A..6.
    Ikonc cnc spydodc svdi vd ndpouoiosi svd svddkcik uik dnokd-
    cocdonc nou dop cov cosd cnc svoovcdc, co yd noopuv
    cpiosiuv Iminera| trioxide aggregate-MJAl.Txsi svd sup od kivi-
    kv sdpoyv s kupicspsc cnv dvocpon spdn, cnv son ku-
    n noo, cnv dnokdcocdon idcpnosuv kdi sninsov cnv dvciscni-
    on cuv dnopponosuv kdi kdcdycuv piv, cic noocosc kdi cnv sv-
    oovcikn 0spdnsd os vcid s dindoco dkpoppio. Iuykpiciksc in
    vitro sscsc s d uik Idydd, |PM, Super-L8A,CaIUNl2l,ssidv
    unspoxn cou MJA oov dop cnv npnn cnc ikpoisouonc, cic sy-
    ovsic dvciposic, cn iooudccncd kdi kuccdpocoikcncd. Lninsov,
    co MJA svdi co vo uik nou sxsi cnv ikdvcncd vd npoysi cnv dvdysv-
    vnon cnc oovcvnc kdi oocsivnc, co oxndcio ooco kdi svsxsvd
    cuv iocv cou nspioovcou,sv dndics yid cnv nnn cou nspiov uypd-
    odc. Iunspdodcik, co MJA dvscdi vd svdi svd no unooxsvo sv
    sssi uik yid cnv svoovcd. 0ocoo, unpxsi dvykn yid nspdicspu
    spsuvsc dn dvspcncouc spsuvncsc kdi nspioocspsc nooisosic in
    vivo sscv s ikdvonoincikn ipksid sndvssyxuv.
    224
    9
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    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I132I
    UUN1INIkU IXIMA kAI MIkUIIh
    8vvu Osopu
    Lnifsnov soc L: kovzdkioznc L., Ln. kd0nynznc dv. A0nvov
    Mikpoisouon opscdi n ooc dkcnpuv, uypv kdi xnikv ouoiv
    dvsod ocnv oovcikn ouod kdi onoionnocs spdkcik uik. N ndpn
    cou ocpdcoc nou nioupyscdi ocd coixdcd cuv piikv ounvuv
    kdc cnv xni konxdvi kn snsspydo d ovoscdi oovci vi k sn xpi -
    odISmear Layerl. Auc dnocsscdi dn oovcvn, unosdcd noi-
    ko ioco, npucsivsc, oovcodociksc dnousc, kccdpd cou ddcoc
    kdi spiksc opsc dkcnpid. Icnv kivikn npn sxsi six0s ci o kdcs-
    poc ouvudoc yid cnv ddpson cou svdi n svd xpnon unoxupi-
    ouc vdcpou INdUC|l kdi di0usvoidivocscpdoiko osoc IL.D.J.A.l.
    Avdspscdi cd cssucdd xpvid kdi n xpnon cuv Lasers yid cnv snicuxn
    dnokpuvon cou. Jo Smear Layer svdi xddp ouvsssvo s cd coix-
    dcd cnc oovcvnc cuv piikv ounvuv, kdi sv dnocss nnpn pdy
    ocnv sooo cuv dkcnpuv ocd oovcivoounvpid. An cnv n nsu-
    p co Smear Layer pd odv uoikc pdyc ocnv npooknon kdi iso-
    uon cuv updcuv spdnc cuv piikv ounvuv sod ocd oovcivo-
    ounvpid. N ddpson cou ocnv kivikn npn soxssi cov kvuvo cnc
    sndvduvonc cuv oovcivoounvdpuv sv dnocxsi coo n spdn
    cuv piikv ounvuv oo kdi n spncikcncd cnc uiknc dnokdcocdonc.
    I133I
    XhMA1A 5AI5h 1h IUUN1Ikh NUU
    kouptou Mupu, 8puyku Ispy|o
    Lnifsnov: Todknc A., Lnkoupoc kd0nynznc spioovzooydc,
    ponnziknc 0ovzidzpiknc kdi Biooydc Luzsuzov znc 0ovzidzpi-
    knc Ixonc A..6.
    spn$n: Jo sdoc oco onoo dvdncooscdi n nspioovcikn vooc svdi
    oi nspioovciko ioco od, nspippio, dcvidk ooc kdi o oovcikc
    iocc oocsivn. Lvdi vooc ikpoidknc diciooydc ocnv onod ndpsd-
    vouv coniko, svoysvsc kdi ysviko ndpyovcsc, idkpvscdi os oucid
    nou opscdi uc n syovnc dvcpdon cuv ouv kdi os nspioovcci-
    d nou svdi n syovnc dvcpdon uv cuv nspioovcikv iocv kdi
    xdpdkcnpscdi dn cnv kdcdocpon cou nspippiou kdi cou dcvidko
    ooco. N oucid nops vd nv ssix0s nocs os nspioovccid, sv n
    nspioovccid npospxscdi dn nponpxouod oucid. Xdpdkcnpiocik
    nd0oyvuovik ocoixso cnc nspioovccidc svdi o 0dkoc n. n nd0o-
    oyikn 0uvon cnc ouoovciknc oxionc nou uoiooyik sdvscdi
    uc d oxion scd cou duxsvd cou ovcio kdi cuv ouv 0ouc 0,5-2
    xi.
    N sykdcocdon cnc voou, n scncuon cnc oucidc os nspioovccid
    kd0c kdi n ssin cnc nspioovccidc unnps dvcikssvo nov d-
    kpoxpviuv nsipddcikv sscv. Msxpi onspd sxouv nspiypds cd snc
    oxndcd ssinc cnc nspioovccidc.
    1. Movcso cnc d0iddc ouvsxoc kdcdocponc. N nspioovcikn n
    ndpouoisi ypdikn ssin kdi npoxup dpy kdi ocd0sp s cnv npo-
    o cnc nikdc skcc dv 0spdnsucs sndpkc.
    2. 6supd "sdponc" cnc nspioovciknc nc ouvd s cnv onod n
    vooc ndpouoisi nspiouc svspycncdc kdc cn ipksid cuv onouv
    dvsi xpd kdcdocpon cuv nspioovcikv iocv kdi dpvsidc oncs
    n vooc ndpdsvsi ocoin. N npooon nops:
    Nd dvsi xpd cuxdd os svd coo kdi os onoionnocs onso kdc
    cn ipksid cnc unc cou.
    Nd svdi doyxpovn kdi nodnn oncs unpxouv nspooi nou n npo-
    oon os opiosvd onsd svdi nio ni0dvn.
    I135I
    AN1IAAOh UAUkAMIkh kAI M1AAAUkAMIkh 1OANh
    IIA 1hN AIOh1Ikh kAATh X1U A5UNA.
    AUIAh kAINIkh I10h
    I|ukoun A., sskvo t.
    "Jnocd nio dio0ncik dn co uoik."
    nnpscvcdc cnv ndpdnvu dpxn, d npoo0scikn spydod yid vd svdi
    dio0ncik dnoskcn, npsnsi vd ndpouoisi onciksc iicncsc oo co uvdc
    ndpoisc s ducsc cou ssnovcoc uoiko ovcio nou unokd0ioc.
    Icic scdokspdiksc ocsvsc, n ocid cnc diddvoc noposvnc
    Iopaquel nou cono0scscdi npoksisvou vd kdsi cn okocsivn svi-
    on cou unokssvou scdiko okssco couc, nspiopsi ondvcik cn
    ixuon cou ucc kdi co 0oc niidvsidc couc, sivovcdc dio0nc
    cnv dvcnn cou 0ouc. Lninpo0scd sv npoospsi ikdvonoincikn di-
    o0ncikn kun cou okocsivo xpdcoc cou scdiko okssco, npo-
    kdvcdc uoxpusc ocnv csikn dnokdcocdon nou 0d sdpoocs oco
    xuc ovd.
    An cnv n nsup, cd iopd ookspdik ouocndcd nou kukoo-
    pov, ndpouoiouv-ouvd s spsuvsc nvu ocnv oncikn couc ouns-
    piop-noikou 0ouc niidvsid, odc sydcspo dn duc cuv
    scdokspdikv, kdi sninsov opiosvd s nupnvd unnc did-
    vsidc I|n-Ceraml cn uvdccncd dio0nciknc kunc cou unokssvou xu-
    co ovd.
    Ico kivik nspiocdcik ndpouoiscdi n dio0ncikn dnoon cnc ookspd-
    iknc ocsvnc ouocndcoc |n-Ceram kdi dc scdokspdiknc, sn xu-
    co ovd.
    N snioyn ookspdiko s syn didvsid I|n-Ceraml yid cscoio ns-
    piocdcik ouc dnocss d no kdn on csik.
    I134I
    MA1h 1U X0MA1U, 1h Oh kAI 1h 1Ah 10N UA0N
    kAI AAIUN1 U 1A IAOUUUIUN
    so0n Mup|vvu, kupuct|uvo0 Avuctucu, Mncvu stpo0u,
    1c|vto Ivvn
    Yno znv snfsn zou kd0nynzn: kouni I.
    Ikonc cnc spydodc svdi n sscn cou xpdcoc, cnc 0sonc kdi cnc o-
    ocdonc cuv ouv kdi oi ndpyovcsc nou idoponoiov cd ndpdndvu.
    Jo uoiooyik xpd kudvscdi dn po-d0 po suc sdv. Jo u-
    oiooyik spoc noiksi, dn coo os coo kdi dn nspioxn os nspio-
    xn, dn 1 suc 10 mm. Jd uoiooyik npoonsukcd od svdi oundyn,
    ocikc In nopcokdiol kdi ocsps npoouysvd s co unokssvo ns-
    pioocso, ovcid kdi oocov.
    Ui idkuvosic cou xpdcoc osovcdi ocnv dioodipvn, cnv kdpoc-
    vn kdi ouvn0socspd ocnv svdn0son sdvvnc oco sni0nio.
    N syxpuon ndpdcnpscdi uoiooyik os idopsc usc IPacia| Pi-
    gmentl. Xpudciksc idoponoinosic cou ocodciko svvoyvou sxouv
    ouxv ondvcikn idyvuocikn dd. Is svd syo dpi0 ocodcikv
    nd0nosuv, xpudciksc ddysc nponyovcdi n snovcdi cuv nd0ooyikv
    kdcdocosuv. Lninsov, ddyn cou xpdcoc sdvscdi os nosc
    ouocndciksc nd0nosic Iovpoo Peutz-1eghers, dkdv0ucn sdvosp-
    d, vooc Addison, spu0ndcnc nspiocodcikn xpucuon, xdod,
    oin, sovood, nsypd, udcuon, idncn, A|DSl. Lnonc, uoxpu-
    d npokncsi dn svdno0sosic ddydcoc, conikn sdpoyn vicpiko
    dpypou, dn opiosvsc cposc, knviod, pdkd, xpnon xnikv Ioo-
    vcndocsc, kduvcikl kdi ouocndcikn sndn dpsuv scuv.
    Jo xpd, kd0c kdi n oocdon kdi n 0son cuv ouv, scdscdi os
    oxson s cnv ssin cnc syovnc, cnv nn kdi cnv sykuoovn, cov
    odkxdpn idncn, cnv knpovoikn ivn unspndod, cd nsuyosi-
    n voondcd kdi cov od sixnvd, cic suxdisc, cnv spnncikn kdi ocps-
    ncokokkikn ouoocodccid, cn voo cou Crohn kdi cnv nn dpkuv.
    Aosic npondcoc uoxpudc:
    1. CU
    2
    |aser
    2. spdcik oxsud
    3. gingiva| masks
    4. csxvikn erbium AU |aser
    5. Uingiva| tattoo
    6. Xsipoupyiksc, nskcpoxsipoupyiksc kdi kpuoxsipoupyiksc s0ooi
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    225
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I136I
    1UUO1hh MO1MA10N IA8h1IkU AONI
    tpto A0uvc|o, Ikuv tutn, 1cn Xpncto
    8doikn npon0son yid cnv cono0scnon sucsucuv dnocss n nn
    svc nnpouc idcpiko iocopiko. Tcoi spiksc opsc, o oovcdcpoc kd-
    scdi vd dnodoosi yid cnv cono0scnon n n sucsdcoc os do0svn,
    nou noxsi dn d dn cic o opsc iiond0oc odkxdpouc idncn
    Icnou | n cnou ||l.
    Ms cnv ndpood spydod snixsipscdi id dvdoknnon cnc is0voc i-
    ioypddc ypu dn co dv n cono0scnon svc cscoiou sucsdcoc
    sxsi ni0dvcncsc sniuonc ocnv ocodcikn koicncd svc cscoiou do0s-
    vn.
    Msc cnv sscn 24 iioypdikv dvdopv, ounspdvous ci o c-
    nou | odkxdpnc idncnc dnocss dnucn dvcsvsin yid cnv cono0s-
    cnon sucsucuv.
    Avc0scd, sc cnv oykpion cuv noooocv snicuxdc do0svv s cnou ||
    idncn os oxson s cov ysvik uyin nn0uo kdcdsikvscdi ci n
    n0non ducn dnocss oxscikn dvcsvsin. hpsnsi vd ouvunooyscdi n
    dpcncd cnc voou, n nikd cou do0svoc kdi kupuc n ikdvcncd duco
    vd pu0si cd snnsd yuknc oco dd. N siusvn duvcikn kdi snou-
    ucikn ikdvcncd cuv idncikv do0svv kd0ioc dvdykdd cnv duns-
    vn dvciiocikn kun nposyxspncik kdi scsyxsipncik kdi cnv sniocd-
    svn ocodcikn uyisivn.
    I137I
    1U 1UMA 1U NUINU: OIUAUIIkA kAI AOUAUIIkA hMA1A
    utco0pn A|kutspvn, 1upsvou Mupu
    Lnifsnov soc L: dndyidvvon L.
    N uoiooyikn kdcocdon cuv iocv cou ocdcoc kdi n nd0ooyd cou
    vsoyvo I0-6 nvvl svdi nso yvosuv svidspov yid ndiicpouc kdi
    oovcicpouc.
    Ikonc cnc ndpoonc spydodc svdi vd yvsi dvdop ocd nio ouxv su-
    pndcd nou nops vd ndpouoidocov os vsoyv. Joniksc sknosic,
    kdon0ouc n kdkon0ouc onc, kd0c kdi ouocndcik voondcd vd-
    vcdi vd ndpdcnpn0ov. Iuvd s sniniooyiksc spsuvsc n ouxvcncd
    svionc couc nops vd idspsi dvoyd s co o n cn un.
    Jd ouxvcspd sdvisvd conik supndcd oco ocd cou psouc s-
    vdi: kocsic, kocsic dvdconc, npovsoyi vcid, n unspoikn dvncu-
    n xdivv cou xsouc kdi cnc yoodc, oi oxiocsc iopnc skcdonc kdi
    dpcncdc kdi sksic sc nou nspidvouv 0sc, co kokkud
    Piga-Fede kdi cnv spnncikn ouoocodccid.
    N sykdipn svnspuon ousi ocnv nscuxnsvn idopikn iyvuon.
    M'ducv cov cpno ocsscdi s snicuxd n npknon yidcpv kdi oovci-
    cpuv yid svcnion dvudiv n uv nd0ooyikv ocoixsuv cnc ocod-
    ciknc koicncdc yid cnv uns0uvn dvciscnion couc, npoksisvou vd
    sdodscdi n coo ouoinc noicncd unc.
    I138I
    h IIINh 1h kUMh: 1878-1947
    unupuou N., Xp|ctono0ou-Astp .
    lozopd ldzpiknc, ldzpik Tnd, A..6.
    N uyisivn kdi n kd0dpicncd cou dv0punvou odcoc dndoxnos couc
    idcpoc dn cd npcd dkd iocopik xpvid. kdc cov 19o divd kdi ocd
    ndoid cnc conc nou snikpdcoos yid uio0scnon kdi dvuon cuv sni-
    ocnovikv 0sosuv, nou idcun0nkdv dn couc dpxdouc ouyypdsc,
    dpksco idcpo doxon0nkdv siik s cnv uyisivn uv cuv spv cou
    odcoc, cd pydvd Ikdpi, nvsovsc, ysvvncik kdi dio0ncnpid pydvd
    k.c..l, cd sn, uc kdi cd vxid n cd di.
    Liikcspd, n uyisivn cnc knc, uc dvdnondoco spoc cnc spdcoo-
    ydc, dndoxnos couc ouyypdsc os sc cnc skvosic cnc, dn cnv
    nspinonon kdi cov kdunio, uc cd scpd npodnc kdi dvciscni-
    onc cuv do0svsiv kdi cuv ndpdocuv cnc. Ui idcunosic cuv idcpv sv
    nspiopovcdi dnoksiocik kdi vov os idcpik 0sdcd n 0sdcd uyisivnc
    d sxouv nposkcosic nou dopov kdi ocic koivuviksc oxsosic cuv
    dv0pnuv, oi onosc, ouvd s couc ouyypdsc, 0d nopoodv vd snn-
    psdocov oodp dn "svd piko kdi indp ksi".
    I139I
    IXUNh AN1IM10Ih 1U AIIIUAMU I AAXNUIU
    AIMUAIIA AU h5h ANMA1U
    uvuy|tono0ou k.
    Lnifsnov kd0nynznc: ouvdc L.
    U syksdikc dyysiondooc dnocss ondvcik dcio voonpcncdc kdi
    0vnccncdc sc dn AA dn pnn dvsupodcoc. Joo n npnn oo
    kdi n dvciscnion cou ndpouoiouv oodpsc uokosc. 0c npoc cnv
    npnn, dvdspscdi nuc co soc cnc snsdonc nou 0d snisys yid cnv
    dvciscnion cnc AA -xsipoupyikn n svdyysidkn- sv snnpssi cn ou-
    xvcncd svionc dyysiondoou, ouvd s cd suc cpd sosvd,
    uocoo duc dnosvsi vd csknpiu0s kdi s cuxdionoinsvsc kiviksc
    sscsc. Tvd 0spdnsucik scpo nou ocoxssi ocnv npnn d kdi
    ocnv dvciscnion cou dyysiondoou kdi co onoo sxsi kd0ispu0s ocnv
    kivikn npn svdi n trip|e-N 0spdnsd, Ihypervo|emic, hypertensive, he-
    modi|utionl. hdp uc cnv supsd sdpoyn cnc s kdi dpksc xpvid,
    sv sxsi ouvcdx0s svd ouykskpisvo npuckoo kdi kupuc sv sxouv
    yvsi oi dndpdcncsc cuxdionoinsvsc sscsc nou 0d dnoskvudv cnv
    dnocssodcikcnc cnc. 1ouc n vn 0ssiusvn s0ooc 0spdnsuci-
    knc dvciscnionc cou dyysiondoou svdi n xopnynon cnc vioinvnc,
    idc ouodc - dvcdyuviocn cuv iduv dosocou. Is dv0skcik dyysi-
    ondoo nou sv dvcdnokpvscdi ocd ndpdnvu 0spdnsucik scpd sxouv,
    ouc, svsin oi s0ooi svdyysidknc 0spdnsdc, nuc n dyysiondocikn
    s ndvi kdi n svdpcnpidkn xopnynon ndndspvnc. 0c soxdco 0spd-
    nsucik scpo yid cnv dvciscnion cou no oodpo dyysiondoou
    nou sv unoxups ocs ocnv svdyysidkn 0spdnsd, npocsvscdi n svo-
    koiidkn xopnynon vicponpuooiko vdcpou, s dod, uocoo dno-
    cssodcd.
    226
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I140I
    UU1Ikh MA1h AUkA1A1Ah kA1AIMA10N OAAAII0N
    kAI M1AkAI0N U10N M 01Ikh U1UNOh
    kupukctu ., Muuo0n I., 8uput|n ., Ntu||vu 2., Muo k.
    dvsnioznio 6sooddc
    |cuyyn: N dnokdcocdon cuv kdcdycuv cuv oocv cou xspio svdi
    uoxspnc, s dnsid cou spouc kvnonc kdi uosicoupyd onnc
    kdi pdyo.
    kon: N kdcdypdn cou spouc kvnonc, cnc ikdvcncdc pdyo kdi
    onnc kdi n oykpion cnc uyioc kdi cnc noxouodc kpdc xsipc kd-
    0c snonc kdi n unoksisvikn dioynon cou dnocssodcoc dn couc
    noxovcsc.
    |k ku| Ms0oo: An 1/1/2000 suc 30/3/2001 dvciscunocnkdv 31 kd-
    cydcd ddyyv kdi scdkdpnuv oocv. An duc cd 24 dvciscun-
    ocnkdv s soucspikn oocsoov0son s mini idkdcdydciksc sc, sv cd
    7 s soucspikn oocsoov0son s mini nksc xdno npo. N oocso-
    ov0son syivs s dvdcoikn dvcdn kdi osdo cuv ddkv opuv.
    Is ouvunpxouosc kdkosic cuv ddkv opuv syivs sicoupyikn kdi
    dvdcoikn dnokdcocdon couc. Asod scsyxsipncik scs0n vp0nkdc
    sicoupyiknc 0sosuc kdi ocn ouvsxsid oi do0svsc dkoo0nodv npypd-
    d svspynciknc kdi nd0nciknc kivnconononc. U sooc xpvoc ndpdkoo-
    0nonc cuv do0svv ncdv 6 nvsc I3 s 12 nvscl.
    Anotsscutu: kdc cnv cssucdd sscdon oi do0svsc ndpouoiouv
    spoc kvnonc kn cnc cnc noxouodc MkG p0puonc 90o cnc syyc GG
    95o kdi cnc nu GG 50o oi do0svsc sndvn0dv ocnv dpxikn couc spydod
    os 10-14 sosc. Ico dvucspu xpovik iocnd co 907 cuv do0svv
    skkpivdv cd dnocssodcd piocd suc no kd kdi co 107 kd.
    unspucu: N oo uvdcv ocd0spn oocsoov0son s dvdcoikn dvcd-
    n kdi osdo cuv unspkssvuv ddkv opuv dnocss s0oo sko-
    ync ocnv dvciscnion cuv kdcdycuv cuv dyyuv kdi cuv scdkdp-
    nuv ocnv kpd xspd. Txsi ioxupn svsin ocd svdp0pik ndpddp0pik
    kdi onsiposin kdcydcd yidc npoospsi dvdcoikn dvcdn kdi sv kd-
    0nvsi suysvn dvdcoik ocoixsd.
    I141I
    h MUIAkh 8IUAUIIA 1h kAhNh kA1A AAkA
    Aunp|vkn .
    1,2
    , o0ou M.
    1
    , A|u|pn O..
    2
    4. Tnd Mopidknc Biooydc kdi Isvsziknc, 2. Lpydoznpio Isvsziknc,
    ldzpikn Ixon, nokpzsio dvsnioznio 6pknc
    kon tn spyucu svdi n ispsvnon cnc opidknc iooydc cnc ok-
    puvonc kdc nkdc IIkhl kdi cd vscspd sniocnovik sosvd nou
    dvdspovcdi yid cn voo ducn.
    |k ku| Ms0oo: Icnv ndpood spydod syivs dvdoknnon cnc iio-
    ypddc cuv cssucduv scv kdi ispsvnon os dpxsd cou idikcou. N
    oknpuvon kdc nkdc n iondpcoc syksdouscic, nuc syscdi
    dic, svdi id syovnc do0svsid dnousvuonc cou k.N.I., nou
    0supscdi ducovooo vond. N non ci n Ikh svdi ducovooo vond
    ocnpscdi os opiosvsc ndpdcnpnosic.
    Anotsscutu: Apxik, ndpdcnpovcdi idxusvd sokccdpd kdi dkpo-
    yd ocnv sukn ouod, sv sdvscdi snonc dnon cnc noocncdc cuv
    |gU kdi cuv dkpoyuv ocic nksc. npxsi ouoxscion cnc do0svsidc s
    cd yovid MNC kdi dvscdi ci dvcdnokpvscdi kd os dvoookdcdocdci-
    k pdkd. Ms cnv on0sid spsuvv nou sxouv isvspyn0s os 0ndocik
    s on id do0svsid nou ovoscdi nsipddcik In dspyiknl ducovoooc
    syksdouscic, d unocponiouod do0svsid cnc onovuiknc ocnnc
    kdi cou syksou s ndpoid kivik, iocooyik, dvooooyik kdi ysvsci-
    k xdpdkcnpiocik s cnv Ikh, sxouv cduconoin0s cd ducodvciyvd nou
    svsxovcdi ocnv Ikh, cd onoid svdi n doikn npucsvn cnc usvnc IMP8l, n
    npucsoiniikn npucsivn IPLPl, n yukonpucsivn usvnc cuv oiyo-
    svpokuccpuv IMUUl kdi csoc n d-kpuocdvn. N ducodvood snyscdi
    s cnv on0sid cpiv kupuc ndpdyvcuv cou opidko incioo, cnc iiknc
    uvonc dn ioc nuc cnc idpc kdi o NJLv-1 kdi dn unspdvciyvd.
    Lkcc cuv uv n Ikh sxsi kdi ysvscikn on. Acod nou ndpouoiouv
    cov sysvo dncuno DP2 INLA- DP81*1501-D0A1*0102-D081*0602l svdi
    snippsnn ocnv ouykskpisvn do0svsid, sv ouvoik 19 nspioxsc sxouv
    "svoxonoin0s" ocd xpuoodcd 1, 5, 6, 7, 10, 17, 19. Jsoc, n do0svsid
    nops vd dvciscunio0s s cnv on0sid |FN-, cou ounouspoc 1, cuv
    yukokopcikosiv kdi cpd cssucdd sxouv dvdncux0s 0spdnssc nou
    ocoxsouv cic npucsosc cuv J kuccpuv Isdcivon 8l.
    unspucut|k, n yvon cuv opidkv sosvuv cnc do0svsidc 0d ou-
    vcssosi yid cnv kdcspn dvciscnion kdi npnn cnc.
    I142I
    U OUIh ANA Xh M 1U OAU kAI 1hN hAIkIA
    1UN AAhNIkU AhOMU
    Annu .A.
    1
    , Asovpou .A.
    2
    , A|uckotn 8.
    3
    , Io0u .
    3
    ,
    Muupovc|o k.
    3
    , kuuvtnouo A.
    3
    Iuvspyoznkdv o ldzpoikdoznc kozodznc O. kdi oi oiznzsc:
    Nziopd O., dxuknc N., nou A., Msiooonoou M.,
    snnopn B., didvkou I.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc
    Msscnods co 0upsosin dsvd scd0dvcid os 1004 cd onod snodv cd
    cssucdd 5 xpvid ocnv A0nvd. N sscn syivs ocnv |dcpoikdocikn nn-
    psod A0nvv.
    Jo uik cnc sscnc dnocssco dn 675 vpsc sonc nikdc 58,9 scv
    kdi soou ouc 168,4 sk. kdi 329 yuvdksc sonc nikdc 66 scv kdi
    soou ouc 153,8 sk. Jo soo oik poc cou 0upsosin ncdv 21,1 yp,
    ocouc vpsc kdi 15 yp. ocic yuvdksc. U sooc oikc ykoc ncdv 18 k. sk.
    yid couc vpsc kdi 13,9 k. sk. yid cic yuvdksc.
    Jo oc cuv ov ncdv 5,3 sk. oco si o kdi 4,9 sk. ocov dpiocsp
    o ocouc vpsc kdi dvcocoixd 4,4 sk. si, 4,3 sk. dpiocsp ocic yuvd-
    ksc. Jo ncoc cuv ov ocouc vpsc ncdv 3,2 sk. si kdi 3 sk. dpiocs-
    p kdi ocic yuvdksc 3 sk. kdi 2,8 sk. dvcocoixd. Jsoc co nxoc ncdv ocouc
    vpsc 1,5 sk. si kdi 1,4 sk. dpiocsp kdi ocic yuvdksc 1,3 sk. kdi 1,1 sk.
    dvcocoixd.
    Iuoxscods yko kdi poc s cnv nikd kdi co oc cou dcou kdi cd
    dnocssodcd ncdv: Apvncikn ouoxscion cou ykou cou 0upsosin s cnv
    nikd IP< 0,001l kdi 0scikn s co oc cou dcou IP< 0,005l. N scpnon
    cou pouc ssps ndpoid dnocssodcd.
    N yvon cuv uoiooyikv sys0v cou dsvd cuv su0upsosiikv dc-
    uv nou ouv os nspioxn nou sv svns n poyxoknn 0d on0nosi
    couc yidcpoc vd skcinoouv ouoc cov dsvd cou sscdosvou ocnv
    kivikn npn kdi ocic opooyiksc sscosic Ioniv0npoypnd , uns-
    pnxoypndl.
    I143I
    MA1h 1h AN0 OUIU A1hIA
    Annu .A.
    1
    , 1c|pvn Xp.
    2
    , Asku A.
    2
    , kupuvtvn h.
    2
    , Muupovc|o k.
    2
    ,
    ssvu k.
    3
    Iuvspyoznkdv o ldzpoikdoznc Asuknc X. kdi oi oiznzsc:
    Aivdpozooc ., Iidvvnouoc A., Mdvoc I., kdyspou L.,
    Mnzpoyoyou A., dndxpnozoc A., Lsvn L.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. Akzivooyik Lpydoznpio Adko' Noookosou
    Icd ndoid idc skcscdsvnc sscnc cnc nspioxnc cou cpdxnou os sy-
    d cou snviko nn0uoo spsuvnods cic, nooisc os iioopsc
    kdi ndpddysc, dpcnpsc cou 0upsosin dsvd Ivu, kcu, kdccdcnl,
    kd0c kdi co ixdo cuv koivv kdpucuv.
    N spsuvd npdydconoin0nks os 900 cpdxnouc I470 dvpv kdi 430 yuvdikvl ocnv
    |dcpoikdocikn nnpsod A0nvv kdc cd cssucdd scn. Ui ouv0nksc cnc spsuvdc
    snscpsdv cn isvspysid supsuv dvdcoikv cov kdi cnv kdcspn ispsvnon
    cnc npossuonc cuv dpcnpiv. Apxik, os k0s cpxno yivcdv dvdyvpion kdi
    ndpdoksun cnc vu, kcu kdi kdccdcnc Iimal 0upsosioc dpcnpdc, s cn on0sid
    siiknc csxviknc svdpcnpidknc syxuonc opo, sv oi nspincosic s susys0n unsp-
    cpod kdi kdkon0n vsondod cou 0upsosin sdips0nkdv dn cn sscn. Akoo-
    0nos, os k0s ncd, n ddpson cuv npoo0uv kdi cuv ndyuv uv cou cpdxnou
    kdi o svconioc cou ouc ixdoo cnc koivnc kdpucdc dpcnpdc.
    Jd dnocssodcd cnc spsuvnciknc dc npoon0sidc dnokdncouv cic iopsc
    ndpddysc skuonc kdi nopsdc cuv dpcnpiv cou 0upsosioc. Iuykskpisvd, n
    vu 0upsosinc dpcnpd skscdi:
    1. An cnv koivn kdpucd dpcnpd I56/900 I6,27lI,
    2. An co ixdo cnc koivnc kdpucd c dpcnpd c I128/900 I14,27lI,
    3. An cnv su kdpucd dpcnpd I674/900 I74,87lI,
    4. Is koiv ocssxoc s cnv yuooikn dpcnpd I30/900 I3,37lI,
    5. Is koiv ocssxoc s cn yuooikn kdi npoounikn dpcnpd I12/900 I1,37lI.
    hdpdcnpn0nkdv iopsc ocov cpno skuonc scd cuv dvpv kdi cuv yuvdi-
    kv, kd0c snonc kdi scd nouuv kdi pdxouuv dcuv Ioi ndpdd-
    ysc svdi ouxvcspsc ocd pdxoud codl. U syoc dpi0c dcuv cou sy-
    dcoc dc sdodsi s dpkscn sdicncd cn yvon uv cuv ni0dvv dvdco-
    ikv oxsosuv ocn 0upsosiikn nspioxn, npyd dndpdcnco yid cnv dnouyn cuv
    ouvn0iosvuv sninokv cuv syxsipnosuv 0upsosioc, cnv spikn n piikn cpd-
    xnikn skokdn kc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    227
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I144I
    AAAAAI 1h kOh kAI 1h UIA 10N kAA0N
    1h 50 kA01IA
    Annu .A.
    1
    , Asovpou .A.
    2
    , A|uckotn 8.
    3
    , Io0u .
    3
    ,
    Muupovc|o k.
    3
    , kuuvtnouo A.
    3
    Iuvspyoznkdv o ldzpoikdoznc kozodznc O. kdi oi oiznzsc:
    Nziopd O., dxuknc N., nou A., Msiooonoou M.,
    snnopn B., didvkou I.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc
    Ikonc cnc sscnc ncdv n dvdncnon, n kdcdypdn kdi n ndpouodon cuv
    ndpddyv cuv kuv cnc su kdpucdc, ocoixso nou dnocss xpnoi-
    n yvon yid cnv kdcdvnon kdi snynon cuv sikvuv cuv dnsikoviocikv
    s0uv Idyysioypdscl, kdi co xsipoupy nou snsdvsi ocnv nspioxn
    cou cpdxnou.
    Icd ndoid dc skcscdsvnc sscnc ocnv nspioxn cou cpdxnou, ss-
    cnods kdi ndpouoious cic iioopsc cnc skuonc cuv kuv cnc
    su kdpucdc. N spsuvd npdydconoin0nks os 200 cpdxnouc ocnv |dcpo-
    ikdocikn unnpsod A0nvv. Ui supssc dvdcoiksc cosc dc snscpsdv
    vd sscnoous sncospsidk cov cpno skuonc kdi nopsdc cuv k-
    uv cnc su kdpucdc.
    hdpdoksuods, ndpdcnpnods, kdcdypds kdi ucoypdnods cic
    ndpdcnpnosic. An cnv dvuon npokncsi ci:
    d. N skuon cuv kuv yivcdv xupioc os ouxvcncd 717.
    N skuon cuv kuv yivcdv sc dn oxndcio koivv kuv
    297 s iopsc noikisc.
    kdc cnv ndpouodon 0d ouoxscoous cn ouxvcncd cuv ndpddyv s
    co o kdi co nkoc cou cpdxnou.
    I145I
    h ANO0INh ANA1UMIkh kA1A 1h 82AN1INh UXh
    Asovpou .A.
    1
    , Ik|ckn I.
    2
    Iuvspyoznkdv oi oiznzsc: dnn 6., Pnzn I., Mxdc I., oizikc l.,
    Xdxdpiknc I., Mndikdc .
    4. Akzivooyik Lpydoznpio Adko' Noookosou, 2, Xsip. 0ovzdzpoc
    Tvd dn cd 0sdcd nou dvskd0sv nodv nsd spsuvdc kdi sscnc yid
    couc iocopikoc cnc idcpiknc ncdv kdi n skcsson cnc dvdconc. |idc, sv
    ocnv Adcivikn on oi vskpocosc xi vo sv npdydconoiovcdv, d
    0supovcdv kdi n0ik kooisc Iodcdviocsc, kio ocnv nupl ocnv
    Lnvikn 8udvcivn Avdcon oi dpcupsc sxvouv ci sv ouvsdivs kci
    cscoio.
    N 0son ducn unoocnpscdi dn kssvd 0soyuv, iocopikv kdi oyuv,
    kdi xi yidcpv, nou dnocsov nnyn ocoixsuv kdi sosvuv:
    1l o Msydc Bdosioc kdi o Ipnypioc o Noonc covouv cn ondod cuv
    sniocnovikv dvdcov.
    2l o Luoz0ioc o Avzioxsdc I4oc divdcl snokonoc kdi oooyncnc s-
    xvsi supcncd dvcinsuv npdydciko op0oou kdi sxscdi cnv nsi-
    pddcikn idcpikn spsuvd.
    3l os kssvo cou 6sovn ovdxo I762-818 .X.l dvdspsi ci "co od
    svc dnooccn syivs dvcikssvo sscnc dn yidcpoc, sv un dk-
    d".
    4l os dnondod dn kssvo cou Iusv cou vsou 0soyou dvds-
    pscdi ci "oi idcpo dvscsvdv odcd ocs vd soiksiu0ov s cd sou-
    cspik pydvd cuv vcuv".
    5l o Isopyioc Topvknc. Lncsuyd cnc udvcivnc Nsupodvdcoiknc kdi
    Nsupouoiooydc dnocss n unonuon cnc unpsuc skcc cou kNI
    kdi ou "ddvoc" kdi "uciko" nou vsupvsi cd onxvd.
    Jd ndpdsydcd cuv dvdcoikv yvosuv kdc cnv, uocuxc yo yvu-
    ocn, udvcivn snoxn svdi no. U 0psifoioc o spydivc nspisypds
    cnv kukoopd cou ddcoc ocouc nvsovsc kdi ocouc vspoc dn nd-
    pdcnpnosic nou skdvs s ioncpsc Ikdc cov A. Lucuxinl. U doc o
    Aiynvznc I6oc .X. divdcl yvpis cnv ndpn cuv n ndvpouv d-
    puyyikv vspuv kdi ouviocoos ocouc xsipoupyoc cou 0upsosioc ds-
    vd "syovcsc ndvcdxo cdc cs kdpucdc dpcnpdc kdi cd ndivpoo-
    vcd vspd".
    An cd ndpdnvu dvscdi ci:
    dl n dvdcon cou dv0pnivou odcoc sv ouvdvcoos oodpsc dvcip-
    pnosic dn cnv Avdcoikn Up0on Lkknod kdi ncdv dnoskcn pd-
    ocnpicncd ocouc 8udvcivoc os dvc0son s cn on,
    l cd ncdcd npospxovcdv dn sykndcsc n ouc kdcdikdos-vouc
    os 0vdco,
    yl n dvdcon yivcdv kdc xpsc Iconoypdiknl kdi kdc ouocndcd Iou-
    ocndciknl, kdi
    l okonc cuv dvdcov ncdv n kdcdvnon cnc unc kdi oxsosuc cuv
    opyvuv cou dv0pnou yid vd dvciscunio0ov oi do0svsisc kdi oi
    sc snicuxc.
    I146I
    UI A1hIAkUI XhMA1IMUI 1U hX
    Annu .A.
    1
    , Asovpou .A.
    2
    , Io0u .
    3
    , Ik|ckn I.
    4
    , Mun A.
    3
    ,
    kuunku O.
    3
    , Aouuk I.
    2
    Iuvspyoznkdv o ldzpoikdoznc kdpdkoknc N. kdi oi oiznzsc:
    kdpdvou A., kdpdvou I., Xdxdpiknc I., Xdxdpikn A.,
    Isopynouoc ., iddvznc N., Iidvvpn M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc,
    4. 0ovzdzpoc
    Icd ndoid cnc sscnc cuv dpcnpidkv ndpddyv cuv kpuv sscn-
    ods cic dpcnpidksc ndpddysc cuv dpcnpiv cou vu kpou os 100 nc-
    dcd cou Lpydocnpou hspiypdiknc Avdcoiknc cou hdvsniocnou A0n-
    vv kdc cn ipksid cnc skndsuonc cuv oicncv.
    Icnv npoon0sid dc vd cdivonoous cnv nounokcncd cou nnxu
    oov dop cnv dicuon cou ocnpixcnkds ocnv ndpdoxn ci nopo-
    s vd sxous doikoc cnouc, cuv onouv n spnvsd svdi spuooyi-
    kn. Tcoi sxous cd snc:
    A. "kdvovikn" dicuon cou nnxu Is ndpn kspkiiknc usvidc 8 so-
    ocsnc dpcnpdcl: 817
    1. Dsc oi dpcnpsc cou nnxu idkdovcdi dn cn pdxivid dpcnpd: 687
    2. Dsc oi dpcnpsc cou nnxu idkdovcdi dn cnv sninonc pdxivid
    dpcnpd: 77
    3. N kspkiikn dpcnpd skscdi dn cnv sninonc pdxivid dpcnpd,
    n usvid kdi n soocsn dn cn pdxivid: 47
    4 Dnuc dvucspu s supsd dvdocuon scd pdxividc kdi kspki-
    iknc ocnv nspioxn cou dykvd: 27
    8. Lninonc dpcnpsc cou nnxu : 107
    1. N sninonc usvid dpcnpd unokd0ioc cnv usvid: 47
    2. Lninonc son dpcnpd: 27
    3. Lninonc kspkiikn dpcnpd sninpo0scd cnc kdvoviknc kspkiiknc
    dpcnpdc: 27
    4. N sninonc dpcnpd cou dvcipdxou svdi kovcn kod kdcdnysi oco
    syyc cnd cou nnxu: 27
    |. hdpouod sonc dpcnpdc Ispuk kdcoinol: 97
    1. Tkuon cnc sonc dn cnvusvid dpcnpd d s cn soocsn: 37
    2. Tkuon cnc sonc dpcnpdc dn cnv usvid dkpi dn cnv koivn
    soocso dpcnpd: 27
    3. Tkuon cnc sonc dn cnv koivn soocso dpcnpd: 27
    4. Tkuon dn cnv kspkiikn dpcnpd: 27
    228
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I147I
    hI NhM0h kAI IN0I OUI1h10N IA1Ikh A..O.
    IIA 1hN PIv AUIM05h
    upuscn O.
    1
    , ktcou 8.
    2
    , kup|yk|tn 8.
    2
    , I|yku 2.
    3
    ,
    Ipuut|kono0ou .
    2
    4. Lpydoznpio Yyisivnc Tndzoc ldzpiknc A..6., 2. Ooiznzsc .zpisc
    Tndzoc ldzpiknc A..6., 3. Ooiznzpid I.L.Y.. - Tnd ldzpikov Lpydozn-
    pov T.L.l.6.
    Ikonc cnc spydodc ncdv n ispsvnon kdi n dioynon cuv nnyv svn-
    spuonc, kd0c kdi co snnso doikv yvosuv oicncv idcpiknc yid cn
    N|v oun.
    syd 790 Ivpsc: 54,37, yuvdksc: 45,77l oicncv cnc |dcpiknc A.h.6.
    ounnpuos sykupd dvvuo sniniooyik sco, co onoo nspi-
    dvs cd ocoixsd o, nikd, snvo onouv kdi osip spucnosuv. Jd
    dnocssodcd ssidv ci: dl 0c kupicspsc nnysc svnspuonc yid co A|DS
    n0nkdv kdc osip cd sod diknc svnspuonc kdi cd svnspucik
    uid. l Ui cpnoi scoonc cou N|v svdi sykupd yvuoco dn co
    ovoo oxsv cuv spucn0svcuv. yl 0c osc dunsvnc ni0dvcncdc
    npooonc dn cov N|v n0nkdv kdc osip oi xpnocsc svosuv
    vdpkucikv, oi oo-diuioi vpsc kdi cd cod s nouydiksc
    oxsosic. l Jo 90,27 kdi co 91,37 cou sydcoc yvupsi dvcocoixd, ci
    sv uocdcdi dkn dnocssodcikn 0spd-nsd kdi nponncikc so-
    idoc yid cnv N|v oun.
    Iunspdvscdi, ci oi oicncsc cnc |dcpiknc cou A.h.6. ndpouoi-ouv dio-
    onsucd kd snnso doikv yvosuv yid co A|DS, cuv onouv oi k-
    pisc nnysc svdi cd sod diknc svnspuonc kdi cd svnspucik u-
    id. N ouykskpisvn idnocuon sniondvsi cnv dvykn opyvuonc sii-
    kv skndisucikv osivdpuv, cd onod 0d npoospouv ocouc ouscs-
    xovcsc oicncsc cuv Ixov ysdc csknpiusvsc sniocnoviksc yvosic
    kdi snsipsc yid cnv N|v oun.
    I148I
    U 8AOMU 1UIMU1h1A 1U IA1IkU kAI NUhA1IkU U0IkU
    1hN OAMUIh 1U NUMU IIA 1h M1AOMIh 1h IIA
    ucxun . kvctuvtvo
    1pd koivoviknc ldzpiknc 8 ioknonc Noookosidkov Movov
    Iutp|kn xon |u - 8ouyupu
    kon tn spyucu: N snicuxd cnc scdpp0ionc svc ouocndcoc uysdc
    doscdi coo ocnv ndpoxn dnocssodciknc hpuco0idc Gpovcdc
    ysdc ocouc nocsc, oo kdi ocnv syiocn dnooxn cou dn co idcpik
    kdi voonsucik npoounik.
    Icnv ndpood spydod dvdscdi o d0c scoicncdc coo cou idcpi-
    ko, oo kdi cou voonsuciko npoouniko kdc cnv svdpn cnc sdpo-
    ync cou vou yid cnv scdpp0ion cnc uysdc.
    |k ku| s0oo|: kpicnpio yid cov d0 scoicncdc cou idcpiko kdi
    voonsuciko npoouniko ocnv sdpoyn cou vou yid cnv scdpp0i-
    on cnc uysdc svdi oi ioi oi nocsc nou spxovcdi kd0nspiv os sndn
    s couc sicoupyoc cnc uysdc.
    Icnv ndpood spydod dvdovcdi cd sosvd spsuvdc nou npdydco-
    noin0nks co xpovik iocnd Isncspou-Ukcupou 2001 os cpsic n-
    sic cnc Ldc IA0nvd-6soodovkn-Isppscl kdi o cnc 8ouydpdc
    IIid - Giinnononl, os cuxdd snisysvo koiv do0svv.
    |id cnv spsuvd xpnoionoin0nks onsvo spucndcoyio s dcoiksc
    ouvsvcssic npouno s npouno Iface to facel. Jo oxsido0sv sys0oc
    cou sydcoc dvspxscdi os 500/xpd cod kdi cuv o uv kdi do-
    p ysvik nn0uo vu cuv 18 scv.
    Anotsscutu ku| cunspcutu: An cnv dvuon cuv dnocssocuv
    cnc spsuvdc npokncsi ci co idcpik kdi voonsucik npoounik sv svdi
    scoio vd npoodpoocs ocd vsd sosvd nou snisi o voc yid cnv
    scdpp0ion cnc ysdc.
    Jd sosvd dnosikvouv ci kdc cn ipksid cnc nposcoidodc cou
    voooxsou yid cnv uysd, kdvsc sv suos cnv dndicosvn dpcncd
    ocic npocosic nou kdc kdipoc skdvdv cd 0soik pydvd cuv sniocn-
    vuv uysdc npoc dpid unoupyik pydvd, ' dnocssod onspd vd
    unpxouv cpisc kdi dvcippnosic coo dn co idcpik kdi voonsucik npo-
    ounik oo kdi dn couc dnoc nocsc.
    I149I
    NNUhU1h1A TX00N AIIA 8 Oh8U
    uvuy|tou-U|kovou A., U|kovou k., Xp|ct|uvnouo k.
    +uxidzpikn kivikn diiov kdi Lnfov I..N. lnnokpzsio 6so.viknc
    kon: Ikonc cnc spydodc svdi n sscn cnc ouvoonpcncdc cuv u-
    xosuv kdi cnc dnocssodcikcncdc cnc pdxsdc 0spdnsdc os cnd
    svovoookosidknc voonsdc os |svik Noookoso.
    |k-Ms0oo: ispsuvn0nkdv 66 nspincosic ndiiv kdi snuv I41
    dypid - 25 kopcoidl nou voonscnkdv oco cnd svovoookosidknc
    voonsdc cou +uxidcpiko cndcoc hdiiv kdi Lnuv cou |nnokp-
    csiou |.h.N. 6soodovknc. N voonsd ncdv pdxsdc ipksidc, nspnou
    4-6 souv kdi nspisdvs son ndpsdon os kpon, dpdksu-
    cikn dyuyn, ouousucikn yoviv kdi svnspuon ndiiv kdi snuv
    ypu dn cn voo.
    Anotsscutu: An cd 41 dypid cd 17 sxdv oxiopsvsid kdi 3 dn' duc
    sxdv kdi sdp vonciknkd0uocspnon. An cd 24 dypid s uxucikn
    idcdpdxn n npooiopisvn dic cd 4 ndpouoddv kdi sdp von-
    cikn kd0uocspnon, 1 dpi skcscdsvn idcdpdxn cnc dvncunc, 2 uxd-
    vdykdocikn - kdcdvdykdocikn idcdpdxn kdi 2 kdcd0incikn idcdpdxn n
    npooiopisvn dic. An cd 25 kopcoid cd 7 sxdv iyvuon oxio-
    psvsidc. Icd 3 dn' duc unnpxs sdp voncikn kd0uocspnon. Jd un-
    oind 18 kopcoid sxdv uxucikn idcdpdxn n npooiopisvn dic.
    An duc cd 4 sxdv kdi sdp kd0uocspnon, 1 idcdpdxn sdccudciknc
    npoooxnc - unspkivncikcncd kdi 1 idcdpdxn Asperger.
    unspucu: An ducn cnv dvdpoikn sscn npokncsi ci cd dypid
    sdvouv os sydcspo nooooc oxiopsvikn idcdpdxn kdi sc
    uxosic. Ui ouxvcspsc ouvunpxouosc idcdpdxsc ncdv: voncikn kd0u-
    ocspnon, kdc0in, uxdvdykdocikn-kdcdvdykdocikn idcdpdxn. Is o
    nspincosic ouvunnpxs idcdpdxn cnc dvncunc. N pdxsd voonsd os
    cnd svovoookosidknc voonsdc svdi dnocssodcikn kdi dnos-
    yscdi o ociydcioc kdi n ipudcononon cuv ndiiv.
    I150I
    AI1IA AU1XIA M1A AU UOkh Ikk1UMh
    onouo I., sko0pn N., Iks|u A., utc|uo0pu O.
    Aoknniso Bodc L' 0p0on. Tnd
    N xsipoupyikn cnc knnc Msooonovuou okou si 70-957 dvdkoi-
    on sk cnc ioxidydc sv n xsipoupyikn yid Uoudyd svdi iycspo sni-
    cuxnc.
    hdpouoious 54 do0svsc 30-65 scv nou xsipoupyn0nkdv yid scspn n
    cpcn op sc dn nponyn0sod iokskcon.
    U okonc cnc sscnc svdi vd kd0opiocov oi ni0dvcncsc snicuxdc , sc
    dn sndvdnncikn syxspnon yid knn sooonovuou okou kdi vd
    dvdncn0ov oi dicsc dnocuxdc.
    Jd nposyxsipncik supndcd yid cn scspn syxspnon ncdv:
    * |oxidyd ouvsnsid idc vsdc kM 14 do0svsc
    * |oxidyd yu unocponnc cnc knnc oco io snnso 10 do0svsc
    * Ayu nyidc Nuciddc .Icsvuonc19 do0svsc
    * Aoc0sid yu nponyn0sodc supsdc nscdskconc 4 do0svsc
    * Xupc sdvn dicd ni0dvc yu vuonc 5 do0svsc
    * hodnn piicikn ouvpon yu ykou 1 do0svnc
    * |nnoupiikn ouvpon sc dn dicud 1 do0svnc
    Jo fo||ow-up cuv do0svv svdi dn 1-12 scn kdi cd dnocssodcd cdivo-
    ovcdi uc kd, scpid, kdi ncux ouvd s cn cdivnon Finnegan.
    An couc 54 do0svsc oi 30 sxdv svd kd dnocssod I56,67l, oi 16 sxdv
    scpio I29,47l kdi 8 do0svsc sxdv ncux dnocssod I157l. Is nooooc
    857 oi do0svsc dioynodv uc 0scikn cnv syxspnon.
    Jd kdcspd dnocssodcd s0nodv dn id vsd knn os o snnso,
    sv n unocponn sc dn dkp douncudcikn nspoo suos dnocss-
    odcd ouykpoid s npucoysvn syxspnon.
    N scsyxsipncikn vuon, si cd xsipcspd dnocssodcd. N n dvdkoion sk cou
    nvou sod scsyxsipncik, ondvsi n dvdyvpion cnc nc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    229
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I151I
    UAh1IkU MA1UAUIIkU AIXU 1UN AhOMU 1U X0IU
    NAIA UAU0N kAI1A AU OAUN1 1h ..O.I..
    kounn .A.
    1
    , 1c|yo0nA.
    2
    , Tupotn M.
    3
    , Ispyo0u .
    3
    , punuv|tn
    .
    3
    , 5npocuou 1.
    2
    , kuo0cn k.
    2
    , Ikvu .
    3
    ,
    Iukop0n M.
    3
    , O|tc|pn A.
    3
    , uvtsp 8.
    2
    , Mnv A.
    4
    4. 0nznc ldzpc, 2. ldzpo, 3. Ooiznzsc ldzpiknc A..6., 4. kd0nynznc
    spdzooydc Apoioiooydc ldzpiko Tndzoc A..6.
    Ikonc cnc spydodc ncdv n kdcdypdn uv cuv nspiocdcikv dn cov
    nponncik spdcooyik ssyxo nou npdydconoin0nks oco ovoo
    oxsv cou nn0uoo cou xupio Nspid kdpcodc dn od spd-
    coyuv kdi s0sovcv oicncv idcpiknc-sv cnc L.L.G.|.L.
    |k-Ms0oo: kdc cnv ndpdovn cuv s0sovcv oco xupi, ssco0n-
    kdv nponncik oi nspioocspoi kcoikoi cou ikpo xupio oi onooi s-
    vdi cpcnc nikdc, sv unnpxdv oco xupi yu 0spivnc nspiou kdi csuc
    kcoikoi nou idsvouv os sysc nsic. Iuvoik ssco0nkdv 102
    dn couc 110 viouc n 0spivoc kdcokouc, 62 yuvdksc kdi 50 vpsc.
    Anotsscutu: spdcooyiksc nd0nosic ndpouododv 40 yuvdksc I39,217
    cou ouvou cuv sscdo0svcuv kdi 64,517 cuv sscdo0svcuv yuvdikvl kdi
    19 vpsc I18,627 cou ouvou cuv sscdo0svcuv kdi 387 cuv sscdo0s-
    vcuv dvpvl.idyvo0nkdv noiksc nd0nosic cou spdcoc yid cic onosc
    0nks dyuyn. Jd dnocssodcd kdi n nopsd diooyn0nkdv sc dn
    nvo dn cov dypocik idcp kdi kp0nkdv sndpksc noisc dyuysc sxdv
    o0s. Icic xpvisc nd0nosic sndvdnpooiopocnkdv 0spdnssc s ikdvonoin-
    cik dnocssodcd. Lvidspov ndpouoiouv ouykskpisvd nspiocdcik,
    scs yidc npucodiooyn0nkdv os do0svsc sync nikdc, oi onooi sv
    sxdv npodon os spdcoyo, scs sikvsc nou kp0nkdv uc onvisc.
    unspcutu: An cd nspiocdcik nou dvciscuno0nkdv dvscdi n dv-
    ykn yid cnv ndpoxn cdkciknc povcdc coo yid cd spdcooyik, oo
    kdi yid voondcd uv siikocncuv nspiocdcik dn siiksusvouc yid-
    cpoc nou 0d scddvouv os dnodkpuosvsc nspioxsc dkd kdi s cnv
    npocponn kdi unoocnpin s0sovcikv opydvosuv. hoo dn couc ys-
    povcsc kdcokouc cou xupio, ssco0nkdv yid npcn op ocn un couc
    dn spdcoyo. Mvo s cscoisc npucoousc 0d unpsi d ocoi-
    xsinc ouscoxn uysiovoik dnoksiosvuv nn0uov ocic npuco-
    0isc kdi nponnciksc unnpsosc uysdc.
    I152I
    AOUkUIkh AUkA1A1Ah 10N h50N 1U UOIU XIA1U
    NMU AOAh1. IkI1Ikh MA1h M1A5 IIUNA1IIkU
    1NUN1A kAI UIOI0N MhIAI0N
    Xp|ctoopkn ., Xutnkn ., Xuvts M., kupux|o O., Muo k.
    0p0ondiikn kivikn dvsnioznou 6sooddc
    kon: N oykpion cuv dnocssocuv cnc ndociknc cou npoo0ou xid-
    oco ouvsoou Ih.h.X.Il os uo osc do0svv, ocic onosc xpnoio-
    noin0nks oxsud sniyovdciiko csvovcd n onio0uv npiduv.
    |k ku| Ms0oo|: 35 do0svsc s pnn cou npoo0ou xidoco ouvs-
    oou, dvciscunocnkdv s dp0pookonikn h.h.X.I. Ui do0svsc xupocnkdv
    cuxdd os uo osc. Ud A: oxsud sniyovdciiko csvovcd kdi
    od 8: oxsud onio0uv npiduv. N od A nspisdvs 20 do0s-
    vsc Ivpsc: 17, yuvdksc:3l s soo po nikdc 30 Ispoc:17-44l.N od
    8 nspisdvs 15 do0svsc Ivpsc: 10 yuvdksc:5l s soo po nikdc
    24 Ispoc:16-34l.U ssyxoc cuv do0svv syivs nposyxsipncik kdi scsy-
    xsipncik s kivikn skcnon Iokidod Lachmanl, s siiksc kdksc
    dioynonc cou yvdcoc kdi s siik dp0pscpo cou yvdcoc.
    Anotsscutu: Mscsyxsipncik os ouc couc do0svsc cnc odc A n
    okidod Lachman syivs dpvncikn, n kdkd dioynonc cou yvdcoc
    dun0nks dn 52 os 94 nvcouc, n scpnon s co dp0pscpo ssis ci n
    idop dn co uoiooyik yvdcd ncdvs 1.8 xiiooc, sv 19 dn couc
    20 d0ncsc sndvn0dv ocic d0nciksc couc pdocnpicncsc. |id cnv od
    8 n okidod Lachman syivs dpvncikn os 14 dn couc 15 do0svsc, n k-
    dkd dioynonc cou yvdcoc dun0nks dn 49 os 91 nvcouc, n scpn-
    on s co dp0pscpo ssis ci n idop dn co uoiooyik yvdcd
    ncdvs 2.1 xiiooc, sv 13 dn couc 15 d0ncsc sndvn0dv ocic d0nciksc
    couc pdocnpicncsc.
    unspcutu: Jd dnocssodcd duc sxvouv ci n dp0pookonikn h.h.-
    X.I vsi kd dnocssodcd oov dop cnv ocd0spcncd cou yvdcoc
    kdi cnv snvoo ocic d0nciksc pdocnpicncsc xupc vd unpxouv ido-
    psc scd cuv uo ooxsucuv.
    I153I
    IAIN01Ikh UIIIh NUAUIIk0N AANUAAMA1Ik0N NU-
    M0N
    oun ., Auyoukn ., ouou ., Atcu ., Ipnyop|n N.,
    Muv I.
    Jd ndpdvsondodcik vsupooyik ovpod IhNIl dnocsov onvisc
    idcdpdxsc cou ksvcpiko kdi nspispiko vsupiko ouocndcoc. N skn-
    uon couc dnoscdi ocnv ndpouod kdkn0uv vsondocuv, nou svco-
    novcdi os d pydvd, skcc cou vsupiko ouocndcoc kdi sv s0-
    ocdvcdi os duc.
    U nd0oysvscikc nxdvioc cuv ouvpuv ducv ndpdsvsi os nosc
    nspincosic yvuococ. 0ocoo os opiosvsc opsc hNI sxsi dvixvsu0s
    unc ccoc ouykskpisvuv dvcioucuv ocov op kdi co syksdovu-
    cido uyp do0svv. ho dn cd dvciodcd duc sxouv cduconoin0s
    kdi ps0nks ci ocpsovcdi svdvci ouykskpisvuv dvciyovikv snicnuv,
    nou skpovcdi coo ocd vsondodcik kccdpd, oo kdi couc vsup-
    vsc. |id co yo duc sxsi snikpdcnosi n non ci cd hNI svdi ducovo-
    onc dpxnc.
    Icn 8' Nsupooyikn kivikn cou Noookosou AXLhA isvspyovcdi oki-
    dosc cduconononc kdi ciconononc cuv dvci-vsupuvikv dvciou-
    cuv, ducv ndn nou ocpsovcdi svdvci vsupvuv cou ksvcpiko vsupi-
    ko ouocndcoc. Jd supndcd dn cov spydocnpidk ssyxo kdi n ouoxs-
    cion couc s cnv kivikn sikvd vouv cn uvdccncd yid dodn idyvu-
    ocikn npoosyyion cuv hNI. N dvxvsuon dvci-vsupuvikv dvcioucuv
    dnocss ioxupn svsin ispsuvnosuc svsxsvnc ndpnc vsondodc
    os o pydvo, dkn kdi dv sv unpxouv kiviksc sknosic dn cov
    npucond0n yko.
    Ms sosvn cnv snsipd ci cd hNI nops vd sknvovcdi no vup-
    cspd dn cov npucond0n yko, yvscdi dvspn n ouon cnc iyvuonc
    cuv hNI ocnv sykdipn iyvuon kdi dvciscnion opiosvuv npucond0v
    ykuv, nuc cou ikpokuccdpiko kdpkvou nvsovoc, kdpkvou uo0n-
    kv kn. Is nosc nspincosic sninsov, sv svdi uvdcn n dvciscni-
    on cou ykou, dvciscunscdi kdi co hNI. Jsoc, soou ondvcikn 0su-
    pscdi n ouon ducv cuv spydocnpidkv dvooooyikv okidoiv
    ocn ispsvnon cnc unokssvnc nd0oysvsidc cuv hNI.
    I154I
    UI 8hMA1UU1 kAI UI AINI01 1hN kAIAkh ANAkIA
    I|tn Xp., koucoupn .
    hdp co ysyovc ci n dpdksucikn dyuyn dnocss cnv dpxikn 0spdnsd
    yid couc do0svsc s kdpidkn dvsnpksid, cd cssucdd xpvid npdyd-
    conoscdi ndcocnon Ikonikn kdi npodcd dikoiidknl, d kdi
    cono0scnon svokdpidkv dniviucv yid cnv dvciscnion cnc.
    kon: N dvdoknnon cnc xpnonc cuv ndcoocv Ikoniknc n dikoi-
    idkncl kdi cuv sucsoiuv dniviucv.
    |k ku| Ms0oo: N dvdncnon, s cn on0sid nskcpoviko unooyi-
    ocn, ocnv ndykoid iioypdd IMLDL|NL databasel kdi os nooisus-
    vd p0pd ocoixsuv oxscik s couc ndcocsc kdi couc dniviucsc. hpdy-
    dcono0nks dvdoknnon cnc iioypddc kdi cuv oxscikv p0puv kdi
    cd ocoixsd nou dvsups0nodv ndpouoiovcdi s.
    Anotsscutu: N xpnoiononon cuv ndcoocv yid cn scuon cuv
    diouvdikv ndpdscpuv do0svv s kdpidkn dvsnpksid pokscdi
    un ispsvon. hdpd cd no unooxsvd dpxik dnocssodcd, cu-
    xdionoinsvsc sscsc sv sxouv dnossi nsovskcndcd oxscik s cn
    vDD n cn DDD ndcocnon os do0svsc s oodp ouncdcd kdpid-
    knc dvsnpksidc skcc sdid dn cov konokoiidk ouyxpovio. N
    dikoiidkn ndcocnon dnocss npodcn s0oo yid cnv dvcis-
    cnion cnc ouopnciknc kdpidknc dvsnpksidc os do0svsc s svokoi-
    idkn idcdpdxn dyuyicncdc Inspnou co 307 cuv do0svv csiko ocd-
    oul, n onod sxsi uc dnocssod cnv doyxpovn ouocon cuv koiiv. N
    snicuxnsvn xpnon cuv dikoiidkv ndcoocv sxsi uc dnocssod
    cn oxsv cducxpovn ouocon cuv o koiiv. Ui sucsoioi dnivi-
    ucsc dnossiysvd duvouv cnv sniuon do0svv nou sniuodv dn
    kdpidkn dvdkonn n sxouv iocopik ssvouodc koiidknc cdxukdpdc
    s diouvdikn snipuvon n xdn kod s0nonc.
    unspucu: N scsuon dikoiidkv ndcoocv kdi svokdpid-
    kv dniviucv npdydconoiscdi nsov s snicuxd. Msxpi onspd svd
    ikp nooooc do0svv s kdpidkn dvsnpksid dvscdi vd osscdi
    dn cic csxviksc ducsc. Nssc sscsc 0d dnosouv dv oco sov 0d
    dnocssoouv svd ondvcik no ocnv dvciscnion cnc kdpidknc dvs-
    npksidc.
    230
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I155I
    XNU1UI AOUIUNUI MIkUUIANIMUI U ANIXNUN1AI
    AI1IkU kAI IkAIAkU IU
    Ikku M., Xutnnntpou M., Mn|c|kn A.,
    usvou-kupuy|uvvou ., Asou-uv|n .
    A Lpydoznpio Mikpofiooydc, Tnd ldzpiknc A..6.Mikpofiooyik
    Lpydoznpio I..N.6. AXLA
    kon: Ikonc cnc spydodc ncdv n sscn cuv spydocnpidkv supn-
    cuv os nsupicik kdi nspikdpidk uyp dn do0svsc nou voonscnkdv
    oco |.h.N.6 AXLhA, kdc cnv cpiscd 2000-2002.
    |k-Ms0oo|: Lsco0nkdv ouvoik 248 sydcd nsupiciko uypo
    kdi 67 nspikdpidko uypo. Jd 0psncik uik nou xpnoionoin0nkdv yid
    cnv kdispysid cuv nd0oyvuv ikpoopydviov ncdv dl didcoxo ydp,
    l MacConkey ydp kdi yl Saboureaud, sv yid couc dvdspiouc ikpoop-
    ydviooc: dl6sioyukoikc uc kdi l8N|A. N cducononon cuv ikpo-
    uv nou dvdncx0nkdv kdi co dvciiypdd syivs s co nxvnd v|JL-
    kI8|UMLP|LuXl.
    Anotsscutu: dl hsupicik uyp: An cd 248 sydcd nou ssco0n-
    kdv, cd 37 Inooooc 157l ncdv 0scik. I'duc ps0nkdv cd snc ikpid:
    Pseudomonas aeruginosa kdi Staphy|ococcus aureus os 6 sydcd, Strep-
    tococcus viridans kdi hnkconI-l Staphy|ococcus Isimu|ans, epidermidis,
    sciuril os 5 sydcd, Acinetobacter anitratus os 4 sydcd, Streptococ-
    cus faeca|is kdi Mkncsc ICandida kruseil os 3 sydcd, k|ebsie||a pneum-
    oniae kdi Proteus mirabi|is os 2 sydcd, Streptococcus dvdspioc, Serr-
    atia marcescens, Aeromonas hydrophi|a, Propionobacterium kdi Lnteroba-
    cter c|ocae os 1 syd. N sudio0nod cuv dnoovu0svcuv ikpouv sxs
    uc snc: 1l Jd svcspodkcnpidk ncdv 1007 sudo0ncd os ksdoonopvsc
    3nc ysvic, Ciprof|oxacin, Jobramycin, Jrimethoprim/Su|fa kdi |mipenem
    kdi 757 os Piperaci||in/tazobactam, Jicarci||in/CA, Aztreonam kdi Merop-
    enem 2l N Pseudomonas aeruginosa ncdv 807 sudo0ncn os Piperaci||in/
    tazobactam kdi 607 os Jicarci||in/CA kdi Aztreonam 3l Jo Acinetobacter
    anitratus ncdv 677 sudo0nco os |mipenem kdi 507 os Meropenem 4lU
    Staphy|ococcus aureus ncdv 1007 sudo0ncoc os Lrythromycin, Jeicop|an-
    in, vancomycin, 867 os Jrimethoprim/Su|faISeptrinl kdi 717 os Uentamic-
    in, Uxaci||in kdi Jetracyc|ine 5lUi hnkconI-l Icdukokkoi ncdv 1007
    sudo0ncoi os Jeicop|anin, Jetracyc|ine kdi vancomycin kdi 83.37 os Jrim-
    ethoprim/Su|fa 6lU Lnterococcus faeca|is ncdv 1007 sudo0ncoc os Ampi-
    ci||in, Uentamicin kdi vancomycin
    l hspikdpidk uyp: An cd 67 sydcd nou ssco0nkdv, cd 6 Inooo-
    oc 97l ncdv 0scik. I'duc ps0nkdv cd snc ikpid: hnkconI-l Staph-
    y|ococcus Iepidermidis, sciuril os 3 sydcd, Serratia marcescens, Acine-
    tobacter anitratus kdi Uram I+l dvdspid dkcnpid os 1 syd. N sudi-
    o0nod cuv dnoovu0svcuv ikpouv sxs uc snc: 1lU Staphy|ococcus
    epidermidis ncdv 1007 sudo0ncoc os Jeicop|anin, Jetracyc|ine kdi vanco-
    mycin 2lJo Acinetobacter anitratus ncdv 1007 sudo0nco os |mipenem,
    Meropenem kdi Jrimethoprim/Su|fa.
    unspcutu: dl hsupicik uyp: 1l Ui nio ouxvo nd0oyvoi ikpoop-
    ydvioo svdi o Staphy|ococcus aureus kdi n Pseudomonas aeruginosa. 2l
    Jd ocssxn cou Staphy|ococcus aureus sv sxouv dkn ndpouoiosi kd-
    d dv0skcikcncd os Jeicop|anin kdi vancomycin. Avc0scd, ocnv Uxaci||in
    sxouv 297 dv0skcikcncd, ndn, sxous dio0ncn cnv ndpouod cuv MPSA
    3l Jd ocssxn Pseudomonas aeruginosa ncdv 807 sudo0ncd os Piperaci|-
    |in/tazobactam kdi Amikacin, sv n dv0skcikcnc couc ocd d dvcii-
    kpoidk, kdi siikcspd ocnv |mipenem, ncdv no syn, ysyovc dp-
    ksc dvnouxncik. 4lIndvcikn dv0skcikcncd ocd iopd dvciiocik
    ndpouododv kdi cd ocssxn cou Acinetobacter anitratus. l hspikdpidk
    uyp: 1lU nio ouxvc nd0oyvoc ikpoopydvioc svdi o Staphy|ococcus
    epidermidis 2lJd ocssxn cou Staphy|ococcus epidermidis ncdv 1007 sud-
    o0ncd os Jeicop|anin, Jetracyc|ine kdi vancomycin.
    I156I
    DNA MICkUCPIS
    Opykou-Auupn M.
    1
    , ousp 8., 1n ., Iko0p|u I.
    4. Avdn. kd0nynzpid
    Lpydoznpio Biooyiknc Xnsdc, ldzpikn oxon dvsnioznou lodvvvov
    Ms cnv ooknpuon cnc xdpcoypnonc cou dv0pnivou yoviidcoc
    cs0nks co 0sd cnc dionononc cou ocnv kivikn npn. |id ndpsiyd
    npsn dvcdnkpionc os knoio dpdksucik oxnd n npsn su-
    n0sidc os knoid ysvscikn voo. Auc syivs sikc s cnv siodyuyn cuv
    DNA microarrays n DNA microchips.
    Jd DNA microchips svdi ikp ndkid dn yud n siik nouspn ocd
    onod ocd0sponoiovcdi skdcovcsc xiisc dnouxsc oiyovoukso-
    ciuv oi onosc dvciocoixov os spiksc xiisc dv0pnivd yovid. Mid
    xdpdkcnpiocikn cn sys0ouc svdi svd nn0oc 100.000 idopscikv
    oiyovouksociikv dnouxiv dvciocoixoosc os 3 xiisc dv0p-
    nivd yovid. Jd oiyovouksocid duc ouv0scovcdi in situ soov n
    dnouxd couc svdi yvuocn dn cnv xdpcoypnon scs yoviuv sun-
    0sidc scs yoviuv uns0uvuv yid cnv dnkpion os pdkd In.x. svud
    kdcdoiool.
    cDNA n mPNA dn kccdpd cou do0svoc, ondosvd s 0opouod xpu-
    ocikn, cpsxouv nvu oco DNA microchip kdi nou unpxsi dvciocoixd
    osuv ndpdcnpscdi upiioc. Icn ouvsxsid id dkcvd sisp isyspsi
    cn xpuocikn n onod uoopsi. N sknsnsvn dkcivood ousyscdi
    dn ouvsocidkoc odpucsc sisp. Avoyd s co xpd kdi cnv svcdon
    cnc skcicdi o d0c skpdonc cou ouykskpisvou yoviou ocov k0s
    do0svn. Jd dnocssodcd snsspyovcdi dn ssiiksusvd npoyp-
    dcd oyioiko ionnpoopiknc kdi scoi skcicdi n dvcdnkpion cou
    do0svoc os knoio pdko n n ni0dvcncd svionc sun0sidc nuc
    dvdsp0nks ocd ndpdnvu ndpdsydcd.
    n DNA microchips xpnoionoiovcdi yid cnv iyvuon kdi cn 0spdnsu-
    cikn npoosyyion cnc kdpidyysidknc voou, cou A|DS, opiosvuv opv
    kdpkvou, cnc voou cou A|zheimer, cou idncn kdi dpkscv uv ysvs-
    cik knpovoosvuv do0svsiv.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    231
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I157I
    U UAU 1h ANUU1UXhMIA IkOAh SNDCAN-1I
    1h IAIN0h 1h XUNIA NUMh1I1IA kAI 1h IAOUIkh IAIN0h
    10N NUMh1Ik0N AA1Ik0N AAAUI00N
    kuono I., ks|up A., Mn| M., N|kkn k., Ivvou M.I.
    Lpydoznpio d0ooyiknc Avdzoiknc dvsnioznou 6sooddc
    kon: N syndecan-1 ICD138l svdi id siikn npucsoyukvn cnc kuccd-
    piknc snidvsdc nou skpscdi dn cd ndodcokccdpd. N dvooooco-
    xnikn skcnon cuv ndodcokuccpuv os uik dnososuc cou svon-
    cpou kdi n sscn cnc ondodc couc ocn idopikn iyvuon cuv svo-
    ncpikv nd0nosuv svdi o okonc cnc ndpoodc spydodc.
    |k-Ms0oo: Msscn0nkdv 39 yuvdksc oi onosc ndpouoio0nkdv oco
    sucspik idcpso s ncpoppdyd. Jo uik dnososuc sscocnks ioco-
    oyik kdi n iyvuon nou cs0nks ncdv svoncpikn unspndod I9 nspi-
    ncosicl, svoncpikc nonouc I8 nspincosicl, svoncpcid I10 ns-
    pincosicl kdi n unspndocik/n vsondodcik svoncpio I12 nspi-
    ncosicl. Lnonc ounspin0nkdv 15 nspincosic svoncpou ndvpo-
    ou kunosuc. N dvoooocoxnikn skpdon cnc syndecan-1 sscn0nks os
    cosc ndpdvnc s cn s0oo Lnvision os nxvnd DAuU ducdcnc
    dvoooocoxnsdc. U unooyioc cuv ndodcokuccpuv sc cnv dvo-
    ooocoxnikn xpon syivs dv 10 syd oncik nsd IMUhl.
    Anotsscutu: Is sc cic nspincosic svoncpcidc dvixvs0nkdv nd-
    odcokccdpd os dpi0 sydcspo cuv 10 ndodcokuccpuv/10 MUh.
    Jd n unspndocik svoncpid svidv kdc soo po 0-1 ndodco-
    kccdpd/10 MUh. hdpoouc dvixvs0nkdv sxiocd ndodcokccdpd
    Ikdc soo po 0-1 ndodcokccdpd/10MUhl ocd unspndocik svon-
    cpid. Avc0scd ndpdcnpn0nkdv dpksc ndodcokccdpd I>15ndodco-
    kccdpd/10 MUhl os ouc couc nonosc.
    Ico uik dn cic ndvposc kunosic sv dvixvs0nkdv ndodcokc-
    cdpd. N syndecan -1 uc skpscdi ocnv kuccdpikn spvn cuv kucc-
    puv cou 0dpco kdi ocnv cpooocn. Ad kccdpd cou svoncpiko
    ocpdcoc sv sspddv co CD138.
    unspucu: N dvxvsuon socu kdi sdxocuv ndodcokuccpuv s co
    dvcoud CD138 oco ocpd cou svoncpou isukovsi cnv iocooyikn
    iyvuon cnc svoncpcidc iidcspd os noncsc nspincosic nou n dpi0-
    ncikn skcnon cuv ndodcokuccpuv ocn xpon NL svdi uoxspnc.
    hdpnd dnoksovcdi doiosic uvdcv vd in0ov iocooyik
    cnv svoncpcid In.x snvoppuoidk n npio ndpdyuyik svon-
    cpio, unspndod ocpudcikv kuccpuv knl. Lninsov n ndpouod dpks-
    cv ndodcokuccpuv ocouc svoncpikoc nonosc os dvc0son s
    cnv svoncpikn unspndod 0d nopoos svsxosvuc vd dnocss xpn-
    oio idopoidyvuocik kpicnpio iidcspd os ikp csdxid nspiopi-
    osvou svoncpiko uiko.
    I158I
    IA1Ik 8AI UMN0N 1hN Ak1INUOAIA
    Ayysn Ispy|o
    1
    , Ouvupkn uyyso
    2
    , p. Osopou kup|ukn
    3
    4. Ooiznznc ldzpiknc Ixonc dv. 6sooddc, 2. Ooiznznc ldzpiknc Ixonc
    dv. 6sooddc, 3. Askzopdc ldzpiknc Ouoiknc dv. 6sooddc
    kon: N Akcivo0spdnsd, kupuc yo cnc spcnonc nou sxsi dn no-
    sc oyxpovsc csxvooyiksc sdpoysc cnc |dcpiknc In.x. nidkn dnsi-
    kvionl, sxsi vd usn0s nodnc dn cnv siodyuyn cou nskcpovi-
    ko dksou. Ikonc ducnc cnc spydodc svdi vd dvdssi duc cd os-
    n kdi vd npocsvsi svd ooknpusvo oocnd dndicnosuv Irequiremen-
    tsl yid cov oxsido cou os svd cnd Akcivo0spdnsdc. Ancspoc oko-
    nc ducnc cnc npoon0sidc svdi n svononon cuv idcpikv nnpoopiv
    os svd npoounik kso, o onooc 0d idcnpscdi s' pou unc.
    |k ku| Ms0oo|: U nskcpovikc ksoc sicoupys ocd ndoid dc
    idcpiknc onc sosvuv, nou sdodsi cnv kdcdxpnon, dvspson
    kdi idypdn cuv ocoixsuv, svcc cou voookosidko ikcou. U oxsid-
    oc dc cscoidc onc npono0scsi cov kd0opio cuv dndicnosuv Ire-
    quirementsl oxscik s cic nnpoopsc cou dksou dn k0s cnd cou
    voookosou. |id ducv cov okon, xpnoionoin0nkdv svcunsc psc
    idcpikv iocopikv dn cd voookosd: hh|NA, |nnokpcsio A0nvv, 401
    |INA, Noookoso hduv Ayd Iod kdi 6pioio Noookoso kd0c
    kdi ouvsvcssic dn siiksusvouc dkcivo0spdnsucsc.
    Anotsscutu: U nskcpovikc ksoc svc do0svoc nops vd nspi-
    dvsi ouykskpisvd noypdik ocoixsd, co idcpik iocopik, cnv
    iyvuon cnc voou, cic npdydconoinsvsc sscosic kdi cnv sdpo-
    svn 0spdnsd. Icnv ndpood sscn syivs d npoon0sid kuikonon-
    onc cuv dndpdcncuv sosvuv coo yid cnv 0spdnsd cou do0svoc oo
    kdi yid cnv scsnsicd ndpdkoo0non cou. Jsoc syivs o oxsidoc dc
    osuc sosvuv n onod vdcdi vd idxsipiocs cov sv yu nskcpo-
    vik kso kdi id0scsi cd dndpdcncd spydsd yid cnv skon kdi ypn-
    yopn xpnon cnc.
    unspcutu: |id no xpvid, o xsipypdoc idcpikc ksoc dnocs-
    oos cov vo cpno ouoync kdi dno0nksuonc cuv sosvuv cuv
    do0svv. Ui oyxpovsc dvyksc cnc |dcpiknc npoksodv cnv scssin
    cou dksou s cnv siodyuyn cnc nskcpoviknc cou opnc. Jd snvik
    voookosd pokovcdi ocnv dpxn ducnc cnc npoon0sidc, oncs co 0sd
    dop sod couc sovcikoc idcpoc, oi onooi 0d spydocov os svd
    vso nskcpovik nspiov. N siodyuyn cnc nskcpoviknc opnc sxsi
    ondvcik nsovskcndcd, nou oxscovcdi s cnv skon dvdncnon,
    dvkcnon kdi dosid cuv idcpikv sosvuv, d ouvosscdi kdi
    dn opiosvd siovskcndcd, nou dopov kupuc cic dvdykdicncsc cnc
    sk0nonc cou xsipioo cuv ouykskpisvuv sdpoyv, cnv kuikonon-
    on cnc nnpoopdc kdi cnv ndpouod ouvsxisvnc csxvooyiknc uno-
    ocnpinc.
    I159I
    h AN1IM10Ih 10N AOUI01Ik0N AAMUO00N
    10N kA10 Ak0N 1A AIIA
    kvctuvt|vn I., Mnscku O., Nsvnouo ., unuuc|sou 8.
    kon: N dp0poypnuon nspispiko cnou svdi id dpi ouyysvnc
    n0non nou xdpdkcnpscdi dn cnv dndod cuv uv cuv vu kdi kcu
    kpuv. Ui ndpdoposic nou nioupys iidicspuc ocd ku kpd sno-
    ouv cnv npin kivncononon cou do0svoc n kdcdpyov svcsc cn
    ion cou. Ikonc cnc sscnc ducnc svdi n nspiypdn cuv ndpdop-
    osuv ducv kd0c kdi o cpnoc dvciscnionc couc.
    |k ku| s0oo|: kdc co xpovik iocnd 1985-2000 dvciscunocnkdv
    ocnv kivikn dc 26 ndid I18 dypid - 8 kopcoidl. Ui 18 dn couc ndpdn-
    vu do0svsc iskoo0nkdv ocnv kivikn dc dsouc sc cn ysvvnon couc
    s dnocssod cnv son svdpn cnc 0spdnsdc. Liikcspd yid cn o-
    ykdn cou yvdcoc kdi cn dpi pdionnonod, nou idnioc0nks ki-
    vik os ouc couc ndpdnvu do0svsc, sdpocnkdv iop0uciko yi-
    voi snsooi sxpi cnv nikd cuv 6 nvv. Ui unoinoi 8 do0svsc ndpd-
    ns0nkdv ocnv kivikn dc os sydcspn nikd.
    |id cnv dnokdcocdon cnc pdionnonodc dndicn0nks os ouc couc do0svsc
    sninkuvon cou dxsiou csvovcd kdi ono0iou kvnidou uc, sc0son cou
    npoo0ou kvnidou uc oco su xsoc cou noio, ono0id kdi sou 0udkoconl.
    Lyxsipncikn dnokdcocdon cnc oykdnc cou yvdcoc dndicn0nks os 12 do0svsc
    Ioocsocod cou kcu nspdcoc npidou ooco I4 do0svscl, ono0id 0udkocon
    kdi sninkuvon cuv ono0iuv npiduv uv I16 do0svscl, kdi dp0poicdon s
    oocnd sucspiknc oocsoov0sonc I6 do0svscl.
    Icouc 5 do0svsc ouvunnpxs kdi ouyysvsc sp0pnd ioxou nou dvciscunocnks
    s dvoikcn dvcdn kdi oocsocod ocponc kdi pdicncdc os niksc 10ou kdi
    12ou nvc.
    Anotsscutu: Mscsyxsipncikn ip0uon cuv ndpdoposuv snscs-
    x0n os ouc couc do0svsc. Is svd syo nooooc do0svv I17 do0s-
    vscl sxds unocponn cnc ndpdpuonc kdi dndicn0nkdv npo0scsc sy-
    xsipnciksc snsosic. Doi oi do0svsc kivnconoin0nkdv dovcdc sc
    cov 30o nvd I10 do0svscl n sc cov 36o nvd I16 do0svscl.
    unspcutu: hdp co syo nooooc cuv unocponv, oi onosc idni-
    ocvovcdi sc cnv syxsipncikn dnokdcocdon cuv kcu kpuv ocd ndii
    s dp0poypnuon, ducsc dnocsov cn vn 0spdnsucikn snioyn yid cnv
    koivuvikn svcdn cou do0svoc.
    232
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I160I
    MUIAkUI MhXANIMUI AN1UXh 1h MOIkIAAINh
    1U S1APLUCUCC0S A0k0S
    unuvuctucou |pnvn, Mut0u|ono0ou Ayys|kn, Ikouv|upo0n svn,
    Aou ousvn, Ayysou ku|nn, Ispy|ou Ispyu,
    Muv|tn Avtvn
    Mikpofiooyd, Tnd ldzpiknc dvsnioznou 6sooddc
    Ui dv0skciko ocn s0ikivn Staphy|ococcus aureus IMPSAl ouviocov
    ondvcik voookosidk nd0oyvd ikpid s ndykoid idonop. N
    dvcoxn couc sdvocnks sc cnv siodyuyn nsvikiivv ocn 0spdnsuci-
    kn dyuyn cuv ocduokokkikv oisuv. kpioc nxdvioc dvcoxnc
    cou Staphy|ococcus aureus dnocss co yovio mec-A, nou kuikonois
    cn xdnnc ouvsidc npucsivn P8P 2d n P8P 2'. N npucsivn ducn su0vs-
    cdi yid cn ovson cnc nsncioyukvnc cou kuccdpiko coixdcoc, cdv
    oi unnc ouvsidc uoiooyiksc npucsivsc P8Ps 1, 2, 3 kdi 4 duvd-
    cov vd sicoupynoouv, snsin sosovcdi dn co -dkcdik dvciio-
    cik. Ui dv0skciko ocn s0ikivn Staphy|ococcus aureus ndpouoiouv
    idoponoinosic ocnv dvcoxn, xi vo sdicdc cou yoviou mec-A, d
    kdi uv ysvscikv ocoixsuv kdi nspidovcikv ndpdyvcuv. Jo ysyo-
    vc duc dnocss sov 0spdnsucik npnd kdi n dvuon cou 0d
    snixsipn0s ocnv ndpood spydod.
    I161I
    A1INh: MIA UAAI1UIIkh 01Nh
    Xunou ., Ntsku A., |o0tu I., Mnouvt|o0ku .
    Lpydoznpio sipddziknc Ouoiooydc ldzpiko Tndzoc A6
    Asncvn, npospxsvn dn cnv snvikn sn sncc, ovoscdi id op-
    vn npucsviknc osuc nou ndpyscdi dn co ob yovio. Jduconoin0n-
    ks ysvscik co 1994, sc dn spsuvsc os ndxodpkd novckid nou ndpou-
    oddv ssin cou yoviou duco. hdp co ysyovc ci n sncvn ouvs-
    0nks kdc' dpxnv s cn p0ion cou pouc, onspd dvscdi ci ducn nd-
    si nodn po ocov opydvio. Ikonc cnc spydodc ducnc svdi n
    dvdoknnon cuv sxpi cpd yvosuv yid cn sncvn kdi cn pon cnc os
    uoiooyiksc kdi nd0ooyiksc kdcdocosic.
    N sscn dc ducn ocnpx0nks ocn is0vn iioypdd kdi os nnpoo-
    psc cou idikcou.
    An cn sscn cou ndpdnvu uiko npokncsi ci n sncvn ndpioc
    doik pio-opsd nnpoopdc scd inouc ioco - kNI kdi kdc
    ouvsnsid ouscsxsi: il ocn p0ion cnc nponnc cponc, cou dio0nd-
    coc kpou kdi cou doiko scdoioo, iil ocnv svnuon, cnv uo0ud-
    kioppnd kdi cn ouvcnpnon cnc knonc, iiil ni0dvc oco nxdvio cou
    divosvou cnc syovnc d kdi ocnv spukn dvncun, ivl ocnv
    nd0oysvsid scd uv cnc d0npudciknc voou, cnc dpcnpidknc unsp-
    cdonc, cuv 0poosoikv snsioouv, cou odkxdpouc idncn c-
    nou || kdi cou ouvpou noukuocikv uo0nkv os ndxodpkd cod.
    Insivscdi ci o poc cnc ocnv dno0nksuon cou nouc kd0ioc cn s-
    ncvn uc svdv dn couc ndpyovcsc sksvouc nou idpdciodv ondvci-
    k po ocnv ssin cou souc.
    N nspdicspu sscn cuv nd0ouoiooyikv nxdviov nou ouscsxsi
    n sncvn svsxscdi vd dnocssosi sovcik ni0dvc ouoin ndpyo-
    vcd yid cnv dvciscnion cnc ndxuodpkdc kd0c kdi yid id osip voon-
    cuv oxscisvuv s ducnv.
    I163I
    h AMINU1AIkh IUXh 1-185 1h AU UAII 1hN kAOAh
    10N UAIMMA10N AIU01N0N IN vIvU. h kA8U51AIkh IUXh
    INAI AAAI1h1h IIA 1hN AI0Ih AIIAIMIA
    OIUAUIIkA UN1IkIA kAI UN1IkIA M AAITh AU
    Muvku uvoun-nntp|o, kup|un Aouk, Auc|0|tkn kvctuvtvo,
    kunpuo kup|ko
    N dnoinonpucsivn L Iapo Ll npoysi cov idsoodosvo dn unoo-
    xsc kdcdoio cuv unosicuv cuv inonpucsvv nou nspisxouv
    apo L. N dnocuxd k0dponc cuv unosicuv ducv oxscscdi s unsp-
    inonpucsvdid cnou ||| kdi npin d0npooknpuvon. Icouc dv0pnouc,
    cd snnsd cnc apo L ocov opp ouoxscovcdi s cd snnsd cuv cpiyuks-
    piuv cou oppo, ysyovc nou unonvsi ci n nspoosid apo L nops
    snonc vd snnpssi cd snnsd cuv cpiyukspiuv cou oppo. hpdydco-
    noinods scdop yoviuv sou dsvov os novckid yid vd xdpcoypd-
    noous cic nspioxsc cou opou cnc apo L nou svdi dndpdcncsc yid cnv
    k0dpon cnc xonocspnc kdi cuv cpiyukspiuv in vivo. Asvoo nou
    skpouv apoL3 kdi apoL4 os osic 1-2x109 pfu onynodv os dunsvd
    snnsd xonocspnc kdi cpiyukspiuv oppo os uoiooyik C578L6
    novckid, d sv onynodv os sndvdop oco uoiooyik cuv dun-
    svuv sninsuv xonocspnc oppo os novckid s ssin os apo L Icd
    onod osicdv os sndysvn unscpiyukspididl. Avc0scd, dsvoo
    nou skpouv cnv truncated Issidcikn opnl apoL 1-185 onynodv
    os uoiooyik snnsd xonocspnc oppo os L-/- novckid kdi sv
    npoksodv unscpiyukspidid. N dvuon kdc Northern cou PNA dn
    nndcokccdpd novcikiv nou skpouv coo cnv kdvovikn oo kdi cnv
    truncated Issidcikn opnl apoL ssis ci cd snnsd cou mPNA ioop-
    pondc Isteady-statel cnc uoiooyiknc opnc cnc apo L nou npokdov
    unspinidid kdi cnc truncated Issidcikncl opnc cnc apo L nou
    sv npokdov unspinidid svdi ouykpoid.. Jd supndcd duc s-
    xvouv ci cd divocsik kdcoind 1-185 cnc apo L svdi sndpkn yid cnv
    k0dpon cuv unosicuv inonpucsvv nou nspisxouv apo L dn co
    nndp, sv nspioxsc cou kdpoucsiko 1/3 cou opou cnc apo L svdi
    dndpdcncd yid cnv sndysvn dn cnv apo L unspinidid.
    I162I
    IN01Ikh-MIOUIkh OAIA 1h XI2UONIA
    A. kupuy|vvn, 8. Muupsu
    ldzpikn Ixon dvsnioznou lodvvvov, +uxidzpikn kivikn
    N yvuocikn-ounspiopikn 0spdnsd svdi id dn cic ounnpudciksc ocn dp-
    dko0spdnsd 0spdnsuciksc s0ouc ocnv dvciscnion cuv oxiopsvikv
    uxosuv. Anookons ocouc ndpdkcu ocxouc: 1. Icn s yvuocikoc nxdviooc
    dvciscnion cuv ndpdyuyikv ouncucuv cnc voou. 2. Icn suon cuv dp-
    vncikv ouncucuv kdi cnv scuon cnc koivuvikonononc cou do0svoc. N
    dnocssodcikcncd cnc yvuociknc-ounspiopiknc 0spdnsdc sxsi okidocs os
    osip cuxdionoinsvuv kivikv sscv, os oykpion s cnv ocd0spn npcunn
    povcd nou nspisdvs ouvn0uc vo dpdksucikn dyuyn, sc uxokoi-
    vuviksc ndpsosic n ssin onoidonnocs ndpsdonc. Is oykpion s cov
    o cno povcdc cnc odc ssyxou, oi nspioocspsc nooisosic sxvouv
    ondvcik dunsvn ouxvcncd suv dn co voookoso ocouc do0svsc nou
    unon0nkdv os 0spdnsd s ducn cn s0oo, nuc kdi scuon cnc uxiknc couc
    kdcocdonc d kdi cuv ouvdio0ndcikv ouncucuv, iidcspd sc 18 n-
    vsc, sv oi do0svsc voi0ouv ikpcspn uoopd sdicdc sudio0nosuv n
    ndpdnpncikv isv. N sicoupyikcncd cuv do0svv ocn yvuocikn-ounspio-
    pikn 0spdnsd scivscdi snonc ondvcik, nuc snonc kdi n svdio0nod ocn
    voo kdi n ouvspydod ocn dpdksucikn 0spdnsd. Lv cocoic, nuc onsivsi kdi
    n vn scddvuon oco 0sd, oi nspioocspsc sscsc svdi dvsndpksc oov
    dop oco sys0oc cuv siycuv kdi ocnv uio0scnon koivv kpicnpuv oxscik
    s cnv skdon. Lninsov, n sdpooicncd cnc s0ou nspiopscdi ondvcik
    dn cnv ssin snsipuv 0spdnsucv, skndisusvuv os ducn cnv 0spdnsucikn
    s0oo.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    233
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I165I
    IINNh1Ikh AN1IM10Ih PIv-AUIM05h
    1ctcou O., unupun O., Mupvou-1ousskn M.
    1
    4. Av. kd0. Odpdkooydc
    Lpydoznpio Odpdkooydc ldzpiko Tndzoc A..6.
    Iuvd s cnv hU, nspnou 1600 ndii ovovcdi k0s spd s cov i
    cou N|v kdi nvu dn 907 cuv ndiidcpikv ovosuv npospxscdi dn
    k0scn scoon cou io dn opo0scikn ncspd oco spuo n vsoyv.
    Dcdv n ncspd sv unoscdi os 0spdnsd, co nooooc scoonc noi-
    ksi I15-407l. N nspiysvvncikn sdpoyn dvcipscpoknc dyuync ocnv n-
    cspd nops vd sdccosi cnv scoon kdc 60-707. Lnonc, n xopnynon
    ouvudoo dvcipscpokv dpkuv kdc cnv vsoyvikn nspoo sci-
    vsi cnv npyvuon cou ndiidcpiko N|v. Ui ndpyovcsc kivvou yid cnv
    k0scn scoon cou io svdi co un ncpik iik opco, n oc, n
    ipksid kdi oi sninoksc cou coksco kdi n s0ooc idcponc cou vso-
    yvo.
    6spdnsucik xpnoionoiovcdi d cd idci0ssvd dvoyd cuv voukso-
    ciuv, kd0c kdi dvdocosc cnc npucsonc. N npocsivsvn dyuyn nspi-
    dvsi npoysvvncik cnv xopnynon ioouvnc I2Dvl Ip.o.l, os ouv-
    udo s d dvcipscpok pdkd os cpin n in oxnd, kdc cov
    coksc svosid xopnynon cou oxndcoc kdi ovcon xopnynon oco
    vsoyv Ip.o.l. U cokscc yvscdi s kdiodpikn con kdi dnosyscdi o 0n-
    doc. Icic dvdncuoosvsc xpsc sdpovcdi vo koniksc n-
    osic kdi nd0ncikn dvooononon cou vsoyvo, n dnocssodcikcncd cuv
    onouv dioncscdi.
    Doov dop cnv 0spdnsd cuv N|v-0scikv vsoyvv, sv unpxouv kivi-
    ksc sscsc nou vd undyopsouv ouykskpisvn ndiidcpikn dyuyn. Xopn-
    yovcdi cd id dvcipscpok pdkd s couc svniksc, os cpinn dyuyn.
    Xopnyscdi snonc npoudkcikn dyuyn yid cnv pneumocystis carinii, yid
    ukncidoiksc kdi dkcnpidksc oisic, kd0c kdi yid oun dn CMv.
    I164I
    U M8UAIAMU 0 M1U UAhTh 1h hA1I1IA A
    A|k. I. Mno0ku, uv. I. Mnuuo0ko, O. Xp. ksscn, I. Xp. ksscn
    Lpydoznpio Yyisivnc kdi Lniniooydc
    ldzpikn Ixon dvsnioznou A0nvov
    kon : Icxoi soidoo. Avdop ocd oyxpovd sid kdc cnc nndcci-
    dc A kdi cpnoc xopnynonc. Lkcnon cnc dnocssodcikcncdc cuv souv
    sou ndpouodonc oxscikv spsuvv. Lvssic soidoo kdi soidocik
    npoypdcd kdc cnv nspoo snindc. Avsni0ncsc svspysisc, dvcsvssic.
    |k ku| s0oo| : hpdydconoin0nks dvdoknnon cnc oyxpovnc snviknc kdi
    is0voc iioypddc.
    Anotsscutu : N dnocssodcikcncd cou soou kdc cnc nndccidc A svdi
    95-1007, sv ousi kdi ocnv npnn sucspond0oc ounc dn NAv. Jo
    sio svdi kd dvskc.
    unspcutu : kdcdsikvscdi n ondod cou soidoo ocnv dvciscnion
    cnc nndccidc A. N unn dnocssodcikcnc cou, ikdiooys cnv npo0scn
    ducn dnvn yid co oocnd uysdc.
    I165I
    I167I
    MOANIh U8Ah ANAIMIA 2 AONI M N1UNh
    OUM8Uk11A0h, M1A AU 8AXIA IAkIA OAIA
    M ANAUkLID
    sccx h., Mnoupuvt ., kuunkn 8., Aupu 8., Xo A.,
    Mnoupuvt k.A.
    Aidzooyikn kivikn, ldzpikn Ixon, dvsnioznio lodvvvov
    |cuyyn: Jo Anagre|ide svdi svdc kdivopyioc ndpyovcdc nou sivsi
    cov dpi0 cuv dionscduv kdi xopnyscdi ocnv iiond0n 0pookucc-
    puon kd0c kdi os d usonspndocik ovpod s 0pookucc-
    puon. Is do0svsc s pdxsdc ipksidc 0spdnsd sxouv dvdsp0s ou-
    ncdcd cscoid nuc, ksddysc, do0nd ndv, kdcdkpcnon d-
    coc, ippoisc kdi vducd. Avc0scd svion nnidc n scpidc dvdidc sxsi
    dvdsp0s os dkpc ipksidc 0spdnsd.
    kon: N dvdop 2 nspincosuv do0svv s iiond0n 0pookuccpu-
    on, oi onooi sc pdx iocnd dn cnv svdpn xopnynonc Anagre|ide,
    sviodv oodpn dvdid.
    Ac0svs: Ui do0svsc nou dvdspdocs ncdv svdc vpdc 75 scv kdi d
    yuvdkd 82 scv. Jo ci sndoxdv dn 0pookuccpuon, ncdv yvuoc yid co
    sv vpd npo 3 scv, yid cn s yuvdkd npo 2 scv. kdc co iocnd duc
    kdi oi 2 do0svsc dkoo0nodv 0spdnsd s pououpd os on 1000 mg/
    d, xupc uc vd ndpouoioouv nnpn n spikn son oov dop cov
    dnuco dpi0 cuv dionscduv. Msc cn idkonn ducnc cnc 0spdnsdc,
    oi do0svsc dkoo0nodv 0spdnsd s Anagre|ide os osic cuv 1 mg/d.
    Anotsscutu: 3 kdi 4 nvsc sc cnv svdpn cnc 0spdnsdc, o vpdc kdi n
    yuvdkd dvcocoixd, sviodv oodpn dvdid. Iuykskpisvd n cin cnc Nb ocov
    vpd sdcc0nks dn 14 gr/d| os 8 gr/d| kdi ocn yuvdkd sdcc0nks dn 12 gr/
    d| os 6 gr/d|. Msc cnv ssin ducn isknn sod n xopnynon cou Anagre|ide kdi
    oi do0svsc unoocnpx0nkdv s scdyyosic ounukvusvuv spu0pv dioodi-
    puv. hdpnd syivdv siiksc sscosic dn cd dnocssodcd cuv onouv
    dnoksocnkdv d yvuoc ni0dv dicd dvdidc. uocuxc kdi oi 2 do0svsc
    kdc cn ipksid cnc voonsdc couc kdcsndv. U sv vpdc yu onnc, n s
    yuvdkd yu ioxdiiko dyysidko snsiooou.
    unspucu: N xopnynon cou Anagre|ide ncdv n dicd yid cnv svion ood-
    pnc dvdidc ocouc do0svsc. Iuvd s dpxiksc sscsc nvu ocic sniposic
    cou pdkou, n son cin cnc Nb nscsi kdc 1 gr/d| sc dn 0spdnsd ip-
    ksidc 2 scv. Mscsnsicd sscsc nvu oco io pdko dvdspouv nuc os
    0spdnsd >2 scv, nops vd npokn0s dkd sydcspn ncon cnc Nb. Icnv
    npoksisvn nspncuon, kdi s on cic ndpdnvu ndpdcnpnosic, ssc dvds-
    pous nuc oodpn dvdid nops vd npokn0s kdi sc dn pdxsdc ip-
    ksidc 0spdnsd cnc 0pookuccpuonc s Anagre|ide.
    I166I
    AAAhAIAh U1UNINh kAI 0MA1U1A1INh 1UN IkAINh hNA
    1U IAOAIMA1U 1U AUAIU
    Auc|0|tkn k., unucu ., Ospo0 k.
    1
    4. Av. kd0. Odpdkooydc ldzpiko zndzoc Hpdksou
    Lpydoznpio Odpdkooydc, Tosdc Bdoikov Lnioznov, Tnd ldzpiknc,
    dvsnioznio kpnznc, Hpksio, kpnznc
    kon: Jo vsuponsncio oudcoocdcvn sxsi svoxonoin0s ocnv nd0o-
    uoiooyd cnc kdc0inc. Jd cpikukik dvcikdcd0incik kdi oi dvd-
    ocosc cnc sndvdnponnc cnc ospocovvnc snnpsouv co oudcoocd-
    civspyik oocnd IPa||is, Lur. 1. Neurosci. 14: 763,2001, Prosperini et a|., 1.
    Neurochem. 69:206,1997I. U okonc cnc ndpoodc sscnc dop ocn id-
    skdvon cuv dnsniposuv ospocovvnc-oudcoocdcvnc ocov sni-
    kivn nupnvd cuv doikv ydyyuv syksou dpoupduv.
    Ms0oo: Xpnoionoin0nks n s0ooc cnc syksdiknc ikpoidnuonc,
    in vivo, kdi ispsuvn0nks n p0ion cnc skkpionc oudcoocdcvnc dn cnv
    ospocovvn ocov snikivn nupnvd cou idpydcoc ssu0spuv kivos-
    vuv dpoupduv. Aposviko dpoupdoi pouc 300-350 yp. xpnoionoin0n-
    kdv ouvd s couc kdvoviooc cnc L.L I86/609/LLCl. Msc dn cnv
    dvdio0ncononon cuv nsipddcouv s udvn I10 mg/kg, i.m.l kdi
    upoxupikn kscdvn I100 mg/kg, i.m.l cono0scn0nkdv kd0scnpsc ikpo-
    idnuonc docspnsupd ocov snikivn nupnvd ouvd s cic ou-
    vcscdysvsc cuv Watson kdi Paxinos INAc -AP:1.6,ML:1.5,Dv:-8.2I. Mid
    nspd sc cnv scsuon cuv kd0scnpuv pxios n ouoyn 12 siy-
    cuv, dv 30 snc. kdc cnv ouoyn cou 5ou sydcoc n ospocovvn
    iduconoinsvn os csxvnc syksdovucido uyp xopnyn0nks sou cou
    kd0scnpd. Jd snnsd oudcoocdcvnc os k0s syd npooiopocnkdv
    s pdiodvooooyikn s0oo.
    Anotsscutu: N xopnynon cnc ospocovvnc I250 kdi 125 Ml npoksos
    ocdciocik ondvcikn suon ocnv skkpion cnc oudcoocdcvnc I547 cnc
    doiknc skkpioncl, ocov snikivn nupnvd cou idpydcoc.
    unspcutu: Jd dnocssodcd duc sxvouv ci n ospocovvn pu0-
    si cnv skkpion oudcoocdcvnc ocd doik yyyid kdi unoocnpouv cnv
    isknspduon nspdicspu sscv yid cov npooiopio cou nxdvioo
    sou cou onoou snicuyxvscdi n pon ducn.
    234
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I168I
    1A1hIIk AN1IM10Ih 10N AO0N I20N U5IUNU
    unupun O.
    2
    , Osopou .
    1
    , Mupvou-1ousskn M.
    1
    4. Lpydoznpio Odpdkooydc ldzpiko Tndzoc A..6.,
    2. k.Y. Toozuou, s.I.Y uziknc Mdksovdc
    Ui ss0spsc psc ouyvou IL.P.U.l svdi oi coiko scdocsc cou ou-
    yvou s unn xnikn dvcipdocikcncd. Ui L.P.U. dvcipov s k0s
    ndpdkssvo ocoixso n pio kdi dnoonov svd nskcpvio npokdvcdc
    osuon cou npoon0svcoc opou. N coikcncd cou U
    2
    svdi ouvpcn-
    on cnc pU
    2
    kdi cou xpvou ponc cnc unsposdc.
    Ikonc cnc ndpoonc spydodc svdi, dpxik, vd unsv0uosi couc svoys-
    vsc nxdviooc s couc onoouc co kccdpo npoocdcsscdi dn couc
    coikoc scdocsc cou ouyvou kdi ocn ouvsxsid vd dvdosi cic ocpd-
    cnyiksc 0spdnsuciknc ndpsdonc.
    Jd ounspodcd nou npokncouv svdi ci, oi L.P.U. idpddcouv on-
    dvcik po ocnv dvncun iociknc nc. Ui 0spdnsuciksc ocpdcnyiksc
    nou 0d dkoou0ovcdi oco sov 0d npsnsi vd kivovcdi os cpd snns-
    d: vd npodvouv co oxndcio cuv coikv scdoicv, vd svi-
    oxouv co pu0 dnsvspyonononc kdi vd cpononoiov cnv syovn
    dvcpdon.
    I169I
    NA UMNA 1h NUU 1U AL2PIMk
    8ccn Aouk, 1co0kuo Ipnyp|o, A|kou uuyysu, kutcu spus
    N vooc cou A|zheimer sxsi xdpdkcnpio0s uc d dn cic nio koivsc do0s-
    vsisc cou vsupiko ouocndcoc kdi cd nooooc cnc dvdsvscdi vd duvo-
    vcdi ouvsxc oo cd vsd idcpik snicsydcd 0d duvouv co soo po
    unc kdi oo o nn0uoc, noypdik, 0d sdvsi dudvsvo nooo-
    oc nikiusvuv dcuv. Ui ndpscpoi ducnc cnc dnonc cnc ouxvcn-
    cdc cnc voou svdi noscIkoivuviksc, oikovoiksc, oikoysvsidksclkdi
    sscovcdi sncospc oco p0po. Msxpi onspd sxouv yvsi nosc s-
    scsc yid cnv kdcdvnon kdi cnv 0spdnsd cnc voou, d n oyxpovn
    kivikn npdydcikcncd dnsxsi dpksc dn co dn co vd npoospsi 0spd-
    nsd n dkd kdi d dioyn noicncd unc ocouc do0svsc. Is ,ci do-
    p cd oyxpovd 0spdnsucik sosvd 0d socioous cnv npoooxn dc
    os o spsuvnciksc kdcsu0vosic. Apxik 0d dvdsp0os ocic cssucdsc
    sssic ocn yoviidkn 0spdnsd. Txsi ps0s onspd svdc dpi0c yovi-
    uv cd onod skpovcdi os do0svsc s voo cou A|zheimer.Jsoc 0d
    dvdsp0os nspinncik ocnv kdcs0uvon cnc dvciscnionc s cn on-
    0sid cnc ndocikcncdc cou vsupiko kuccpou kdi cuv vsupikv ikcuvI-
    divsvo use it or |ose itl.Jssucdd sxsi snicsux0s svoxuon cuv vsu-
    pikv ouvsuv in vitro s cn xpnon vsupocpoivv Ivsupikc duncikc
    ndpyuvl.Tcoi snicsovcdi onspd os o cov koo cspocisc npoon-
    0sisc yid cn xpnoiononon cuv vsupocpoivv uc dpdksucikn dyuyn
    ocouc do0svsc s voo cou A|zheimer
    I170I
    U 8AOMU 1UIMU1h1A 1U IA1IkU kAI NUhA1IkU U0IkU
    1hN OAMUIh 1U NUMU IIA 1h M1AOMIh 1h IIA
    ucxun . kvctuvtvo
    1pd koivoviknc ldzpiknc 8 ioknonc Noookosidkov Movov
    ldzpikn Ixon Iidc - Bouydpdc
    kon tn spyucu: N snicuxd cnc scdpp0ionc svc ouocndcoc uysdc
    doscdi coo ocnv ndpoxn dnocssodciknc hpuco0idc Gpovcdc
    ysdc ocouc nocsc, oo kdi ocnv syiocn dnooxn cou dn co idcpik
    kdi voonsucik npoounik.
    Icnv ndpood spydod dvdscdi o d0c scoicncdc coo cou idcpi-
    ko, oo kdi cou voonsuciko npoouniko kdc cnv svdpn cnc sdpo-
    ync cou vou yid cnv scdpp0ion cnc uysdc.
    |k ku| s0oo|: kpicnpio yid cov d0 scoicncdc cou idcpiko kdi
    voonsuciko npoouniko ocnv sdpoyn cou vou yid cnv scdpp0i-
    on cnc uysdc svdi oi ioi oi nocsc nou spxovcdi kd0nspiv os sndn
    s couc sicoupyoc cnc uysdc.
    Icnv ndpood spydod dvdovcdi cd sosvd spsuvdc nou npdydco-
    noin0nks co xpovik iocnd Isncspou-Ukcupou 2001 os cpsic n-
    sic cnc Ldc IA0nvd-6soodovkn-Isppscl kdi o cnc 8ouydpdc
    IIid - Giinnononl, os cuxdd snisysvo koiv do0svv.
    |id cnv spsuvd xpnoionoin0nks onsvo spucndcoyio s dcoiksc
    ouvsvcssic npouno s npouno Iface to facel. Jo oxsido0sv sys0oc
    cou sydcoc dvspxscdi os 500/xpd cod kdi cuv o uv kdi do-
    p ysvik nn0uo vu cuv 18 scv.
    Anotsscutu ku| cunspcutu: An cnv dvuon cuv dnocssocuv
    cnc spsuvdc npokncsi ci co idcpik kdi voonsucik npoounik sv svdi
    scoio vd npoodpoocs ocd vsd sosvd nou snisi o voc yid cnv
    scdpp0ion cnc ysdc.
    Jd sosvd dnosikvouv ci kdc cn ipksid cnc nposcoidodc cou
    voooxsou yid cnv uysd, kdvsc sv suos cnv dndicosvn dpcncd
    ocic npocosic nou kdc kdipoc skdvdv cd 0soik pydvd cuv sniocn-
    vuv uysdc npoc dpid unoupyik pydvd, ' dnocssod onspd vd
    unpxouv cpisc kdi dvcippnosic coo dn co idcpik kdi voonsucik npo-
    ounik oo kdi dn couc dnoc nocsc.
    I171I
    U UAU 1U UUXA Cak 1hN ANIXNh
    1U 50k11AIU A81IU
    Mcous u0o, sp|k Otn, kuntuvn upvto, Opsvto A0uvc|o,
    Mnuuo0tu nntp|o
    ldzpikn Ixon dvsnioznou A0nvov
    N dvdkun cou ouvsssvou s U npucsivsc unooxsd cuv sukucc-
    piuv ivcuv Ca+2 ICao+2l CaP dnoodnvios cn opidkn on nov dn
    cic yvuocsc sniposic cou Cao+2 ocd kccdpd iocv nou idcnpov cn
    ouocnikn ooiocdon cou Cao+2, nuc svdi cd kpid kccdpd cuv ndpd-
    0upsosiv dsvuv, cd vspik kccdpd, oi oocsokocsc kdi oi oocso-
    ocsc, cd xovpokccdpd, cd kccdpd cou svcspou kdi cou ndkovcd.
    Is scdsic cou CaP dnoovcdi nosc knpovoiksc nd0nosic s
    nio ouxvsc cnv oikoysvn undosocioupikn unspdosocidid IFNNl kdi cov
    oodp vsoyvik unspndpd0upsosiio INSNPJl. Lninsov, o CaP skp-
    scdi kdi os kccdpd Ivsupik, sni0nidk, kccdpd cou dko, kccdpd
    cou ndykpsdcocl, cd onod s ouscsxouv ocnv ouocnikn ooiocdon
    cou Cao+2 d pu0ouv noiksc sicoupysc nuc n opovikn skkpion,
    n svspyononon iovcikv iduv, n yoviidkn skpdon, n dnncuon kdi
    o kuccdpikc nodndoidoc.
    Iunspdodcik, o CaP nops vd ndsi ondvcik po ocic vscspsc
    0spdnsuciksc npoosyyosic nov do0svsiv oxscisvuv s cnv unsp-
    n cnv unosicoupyd cou. Ui npcsc spsuvsc yid cn 0spdnsucikn xpnon
    1dosocoincikv1 svspyonoincv kdi dvcdyuviocv cou CaP sxouv sv-
    0dppuvcik dnocssodcd.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    235
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I172I
    IhMIUAUIIkh MA1h kA1AIMA10N IXIU hAIk, 1UUI
    AN1IM10Ih kAI h IAh 1U 1hN UIU1h1A 20h
    Ip$u Iouu, Xou|pu Dyu, kopun N|kuo, u0u nntp|o,
    Muupoovtn Asuvpo
    0p0ondiikn kivikn ..I.N.l.
    kon: N dvdpoikn sscn kdcdycuv ioxou os unspniksc Ivu cuv
    75 scvl do0svsc s on sniniooyik xdpdkcnpiocik, kpicnpid yid
    ouvcnpncikn n xsipoupyikn dvciscnion kdi snpdon ducv ocnv sniu-
    on kdi cnv noicncd unc cuv do0svv scdkdcdydcik.
    |k ku| s0oo|: Msscnods 288 do0svsc, nou sionx0nodv ocnv op0o-
    ndiikn kivikn cou h.h.|.N.|. scd cuv scv 1997 - 2001, s nspicpoxd-
    vcnpio n unoksdik kcdyd ocnv nspioxn cou ioxou. Ui do0svsc duco
    cdivon0nkdv s on co o, cnv nikd, cov cno kdcydcoc kdi cov
    cpno dvciscnionc couc s ocoixsd nou sn0nodv dn cov kso
    k0s do0svoc. Akn kdcdypnkdv cuxv ouvo npondcd uysdc.
    Icn ouvsxsid npooiopocnks n sniuon cuv do0svv ducv scdkdcdy-
    dcik kd0c kdi n sicoupyikn couc kdcocdon s cnsuvikn snikoivu-
    vd nou isvspyn0nks dn cov |dvoupio suc cov Gspoupio cou cpsxo-
    vcoc scouc.
    Anotsscutu: Lvsvnvcd svdc vcpsc I31,57l kdi 197 yuvdksc I68,57l s-
    oou pou nikdc 83,05 scv I75-109l sionx0nodv s iyvuon kdcydcoc
    ioxou kdc cn sscosvn xpovikn nspoo. L ducv 122 I42,367l sxdv
    unoksdik kdi 166 I57,647l nspicpoxdvcnpio kcdyd ioxou. Iuvo
    npondcd uysdc nou snsddv cnv ouvcnpncikn dvciscnion ndpou-
    ododv 78 do0svsc I27,087l sk cuv onouv 25 sxdv unoksdik kdi 53
    idcpoxdvcnpio kcdyd.
    unspcutu: Jd kdcydcd ioxou ocnv cpcn nikd nnccouv nio ou-
    xv cic yuvdksc dn couc vpsc I2,17/1l kdi dopov nio ouxv ocnv
    nspicpoxdvcnpid nspioxn I57,647l. Msydcspo nooooc unoksdikv
    kdcdycuv dvciscuno0nks xsipoupyik I79,517l svdvci cuv nspicpoxd-
    vcnpuv kdcdycuv I68,077l nou dvcikdconcpsi ouc kdi cnv skcios-
    vn sydcspn uvdccncd npuonc cuv cssucduv. Lnisdi0nks n
    yvuocn dn cn iioypdd dunsvn voonpcncd kdi 0vnccncd nou
    ouvossi cd kdcydcd duc kd0c kdi n dpvncikn snpdon couc ocnv
    noicncd unc cuv do0svv.
    I173I
    XhIMU1h1A kAI IAIN01Ikh A5IA 1h FNA MA1U
    IANAUMIkh MA1h UMN0N A.I.N.hAkAIU 1990-2002I - ANAAh
    UMN0N
    Auyouctkn A|k.
    1
    , o|n A.
    1
    , uvuyouono0ou Uup.
    2
    ,
    kuoyspkn A.
    3
    uv| h.
    4
    , 1c|tcn .
    5
    4. Ooiznzsc Tndzoc ldzpiknc dv. kpnznc, 2. Li.vn Isvikn ldzpc,
    dvsnioznidk Isvik Noookoso Hpdksou, 3. Askzopdc d0ooyiknc
    Avdzodc, Tnd ldzpiknc dv. kpnznc, 4. Lnkoupoc kd0nynznc
    Xsipoupyiknc, Tnd ldzpiknc dv. kpnznc, 5. kd0nynznc Isviknc
    Xsipoupyiknc, Tnd ldzpiknc dv. kpnznc
    kon: N ispsvnon cnc sudio0nodc/siikcncdc cnc FNA doco, nuc
    ducn xpnoionoiscdi uc soo ssyxou cou nn0uoo Iscreening testl,
    ocnv hdvsniocnidkn kivikn Xsipoupyiknc Uykooydc cou hd.|.N.Npd-
    ksou kdi oykpion s cd is0vn iioypdik sosvd.
    |k 8 Ms0oo|: Xpnoionoin0nkdv ocoixsd dn cd dpxsd cou hd0oo-
    yodvdcoiko spydocnpou cou |dcpiknc Ixonc Npdksou I1990-2002l,
    cnc hdv.kiviknc Xsipoupyiknc Uykooydc Ihd.|.N.N.l, kd0c kdi cou |d-
    cpsou Mdoco nou sicoupys oco io voookoso dn co 1995. Jd ocoi-
    xsd opydv0nkdv os nskcpovikn on sosvuv kdi dkoo0nos sns-
    spydod couc os N/.
    Anotsscutu - unspcutu: N snsspydod cuv ocoixsuv sv sxsi
    ooknpu0s sxpi cn ociyn ovcdnc cnc ndpoonc nspnnc. |id cov
    yo duc sv nopov vd sdx0ov dodn ounspodcd cn sosvn
    xpovikn ociyn. hdp'd duc, id dpxikn skcnon sxvsi ci cd dnocs-
    sodcd svdi dpksc sv0dppuvcik, xupc duc vd ondvsi nuc sv unp-
    xouv nspi0pid scuonc.
    I174I
    kAMUMAIkh AAIA kAI IUNIIU SUX9
    Mntpoyyou Avuctucu
    ldzpikn Ixon dvsnioznou A0nvov
    kon tn spyucu: N ouoxscion cuv scdsuv oco yovio SUX-9 s
    co ovpoo kdnosiknc uondodc.
    kiviksc nspincosic.
    |k ku| s0oo|: Xpnoionoin0nks n cssucdd snvikn kdi svn i-
    ioypdd kdi dp0poypdd dvdyvupiosvuv ouyypdsuv. Lnonc dvcn-
    0nkdv nnpoopsc dn is0vsc iociossc oco idkcuo.
    spn$n: Jo yovio SUX-9 spscdi ocn vn q24 cou xpuoodcoc 17
    kdi scdsic duco cou yoviou npokdov cn voo cnc kdnosi-
    knc uondodc. Ui nspioocspsc scdsic npokncouv de novo os
    scspuyo opn. N kdnosikn uondod xdpdkcnpscdi dn dvud-
    sc oco oxndcio cou okssco kdi cuv dp0posuv, dykuon cuv
    kpuv, unondod uondcv, sp0puon cou ioxou kdi ndpdpuon
    cnc skvnc. hdpdcnpscdi ikpoyvd0d, ssin nsupv kdi dvdnvsuoci-
    kn dvsnpksid. N vooc ouxv oxscscdi s dvciocpon cou ou kdi
    nops vd knpovoscdi kdc cov kupdpxo cpno s dcsn isioucik-
    cncd. Icnv spydod nspidvovcdi sncospsc nspincosic do0svv s
    k kd0c kdi ucoypdsc nou kdcdsikvouv cd xdpdkcnpiocikcspd ou-
    ncdcd cnc voou.
    I175I
    1U IUNIIU W1-1 kAI 1A NUMA DNS-DkASP, FkASIk kAI WAUk
    Anoctokn scno|vu
    ldzpikn Ixon dvsnioznou A0nvov
    kon tn spyucu: N sscn cou yoviou WJ1 kdi siikcspd n isps-
    vuon cnc oxsonc cuv scdsuv cou yoviou duco s cd ovpod
    Denys-Drash, Frasier kdi WAUP.
    |k ku| s0oo: Jo uik nou xpnoionoin0nks yid cnv vcnon cuv
    nnpoopiv nspidvsi snvikn kdi svn iioypdd kd0c kdi dp-
    0poypdd dvdyvupiosvuv ouyypdsuv. Indvciksc nnpoopsc sn-
    0nodv dn co idkcuo.
    spn$n: Jo yovio WJ1 spscdi oco ikp pdxovd cou 11ou xpuo-
    odcoc kdi skpscdi ocnv dvncun cuv vspv kdi cuv yovuv. Ms-
    cdsic oco yovio duc svoxonoiovcdi yid cnv svion cuv ouvp-
    uv Denys-Drash, Frasier kdi WAUP. Ui do0svsc nou noxouv dn ovpo-
    o Denys-Drash ndpouoiouv dunsvn ouxvcncd svionc ykou Wi-
    |ms, idxssvn sodyysidkn oknpuvon, yovdikn uoysvsod kdi su-
    ospdpoicio. Jd cod s ovpoo Frasier xdpdkcnpovcdi dn
    yovdikn uoysvsod, dvciocpon ou, vspik ovpoo kdi duns-
    vn ouxvcncd svionc yovdodocdcoc. Jsoc, o divcunoc dc-
    uv s ovpoo WAUP nspidvsi svion ykou Wi|ms, dvipid,
    ysvsciksc dvudsc kdi nvsudcikn kd0uocspnon.
    236
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I176I
    OAMUI 1h 8IUNANU1XNUAUIIA 1hN IA1Ikh
    Msstn N.
    1
    , koutcoun A.
    2
    , onotn N.
    2
    , Xntu X.
    2
    , uctnpu A.
    2
    4. Askzopdc, 2. Ooiznzsc, Lpydoznpio lozooydc - Lfpuooydc, ldzpikn
    Ixon, dvsnioznio A0nvov, A0nvd
    kon tn spyucu: N dvdoknnon cuv sdpoyv cnc iovdvocsxvo-
    oydc ocnv |dcpikn. N vdvocsxvooyd sxsi uc dvcikssvo uik n ouocn-
    dcd nou sxouv cic snc doiksc iicncsc: sxouv couxioco id iocd-
    on dn svd sxpi 100 vdvscpd, kdcdoksuovcdi sou idikdoiv nou
    dokov oik ssyxo nvu ocic uoiksc kdi xniksc iicncsc ov
    opidknc kdkdc, kdi nopov vd ouvudocov yid vd xcoouv syd-
    cspsc osc. N on nioupys vdvoosc yid ioskdcopid xpvid kdi
    n iovdvocsxvooyd sxsi uc dvcikssvo cic osc ducsc, cnv dnsn-
    pdon iooyikv kdi csxvncv vdvoouocncuv, kdi cnv kdcdoksun vd-
    voouocncuv nou isnovcdi dn dpxsc ndpoisc s cic iooyiksc.
    |k-Ms0oo|: Xpnoionoin0nks n unpxouod iioypdd kdi dp0po-
    ypdd, s iidcspn sdon os nooisosic cuv o cssucduv scv.
    Anotsscutu: n, vdvodvcikssvd kdcdoksudosvd dn dvpydvd
    uik nopov vd xpnoionoin0ov ocn iodcpikn spsuvd, iyvuon, kdi
    ouc 0spdnsd. 8iooyik csoc nou scpvs cnv ndpouod n svspycncd
    ouykskpisvuv ouoiv yvovcdi ypnyopcspd, nio sudo0ncd kdi nio sus-
    ikcd cdv xpnoionoiovcdi vdvooudcid uc ixvn0scsc. Ndvooudc-
    id nopov vd xpnoionoin0ov yid vd scdsp0ov pdkd sks dkpi-
    c nou xpsiovcdi, dnosyovcdc cic ndpsvspysisc nou ouxv dvdk-
    ncouv dn cn xpnon ioxupv dpkuv.
    unspcutu: N iovdvocsxvooyd 0d svdi svd ioxup spydso yid
    cov idcp oco soo sov. Jsxvnco vdvooiko 0oi nops id spd
    vd xpnoionoin0ov yid snioksun iocv nuc co spd, o xvpoc kdi cd
    ooc - kdi ouc dkd on0noouv do0svsc vd dvdysvvnoouv pydvd.
    I177I
    MUI 1U 8U1UX NA MA kANI IU NU kAI AA IU
    1XIMNU, INAI NA OAINUMNU 10N kAI0N,
    kuoyspkn nntpn, tsuvnouo nntpn, stpou kup|ko
    kon tn spyucu: Ui pucsc cou dv0pnivou npoonou svd ducsc nou n-
    ioupyovcdi dn cov nio kdi cnv nikd kdi ducsc nou nioupyovcdi dn cn
    xpvid oondon cuv uv.Jo 8UJUX Icovn cou kuocnpiou cnc ddvcdoncl
    cic sivsi vovcdc on ocnv dv0pnivn dcdiood. Lnosi cn pon cnc
    Ach kdi cic vsupiksc osic npoc couc sc kdi ousi ocnv ndpuon couc.
    Ikonc cnc spydodc svdi n spsuvd ypu dn co 8UJUX, n dicioynon ypu dn
    cnv svcovn svdoxnon npoc duc kdi n sovcikn cou nopsd.
    |k-Ms0oo|: 8iioypdd, svn kdi snvikn, idukcidkn idcpikn.
    Anotsscutu: N xpnon cou 8UJUX skiv co 1980 kdi ocouc spdcoyouc nsp-
    v co 89. U FDA sykpvsi co 89 cn xpnon cou yid sdpondoo kdi ocpdio sv
    co 2000 yid cn uikn uocovd. Apxsc cou 2002 sykpvscdi yid dio0ncikoc youc
    Icod < 65 scv s k0scsc ypdsc oco sopuol.Lv oi n xsipoupyiksc di-
    o0nciksc ndpsosic sivovcdi Idn 2001 os 2002 kdc 237, uSAl, n xpnon cou
    8UJUX ndpouoisi ocd0spn voo kdi svdi npcn ocic non surgica| snsosic
    Idkoou0ov ikpospdciksc ndpsosic, kodyvo, LASLP, xnik pee|ing l.Ui
    vpsc co xpnoionoiov ouvsxc I1998: 6,17 2001: 13,87 2002 :207 l.Ldp-
    scdi oco sopuo, cic kpsc cuv dciv, co scuno kdi co di. Ispsuvsc dvd-
    spouv cn xpnon cou os sninoksc dn cd sdpd os 0upsosion0siscl. Jo k-
    ococ k0s snoksnc svdi 500-200 sup dvoyd cnv nspioxn sdpoync, n svson
    xpsiscdi 15 snc kdi co dnocssod idpks uc 6 nvsc.Avsni0nncsc svspysisc
    svdi: novoksdoc, dvdnvsuocikn uoxspsid, sdpncuon kdi sdid conikn
    spu0pcncd kdi npnio. sv sdpscdi ocouv sc ypu dn co ocd yidc s
    ducoc is kdi cps.
    unspcutu: Lv kdcdyyssc yid sninoksc spxovcdi oco uc cd cssucdd xp-
    vid, co 8UJUX dioncscdi os n cnv supnn kdi sdid ocnv Ld. Nsd oksu-
    odcd IMyob|oc, Serutoxl nn co dvcdyuvovcdi. Dd sxvouv ci ocouc no-
    oiouc kkouc n xpnon cou sivscdi kdi vssc s0ooi dvciynpdvonc sdpo-
    vcdi. Av npksicdi yid id snspn d, 0d co spous os yd xpvid.
    I178I
    0 AN1IM10I2UN UI MUNAXUI 1U AIIU UU 1hN A01IA,
    1UN UNU, 1h MUNA5IA kAI 1U OANA1U - h MIIA AU 1h Oh1IA MU
    1U AIU1IkU IA1IU 1U AIIU UU
    kupukucn I|vvn
    ldzpc
    kon tn spyucu - |k: Nd ndpouoiosi cn 0supncikn cono0scnon 8
    cnv npdkcikn dvciscnion opidkv kdcdocosuv cnc unc co dv0pnou,
    dionoivcdc cn ovdikcncd cv xdpdkcnpiocikv cv kdcokuv cnc d0u-
    viknc noicsdc.
    Anotsscutu - unspcutu: Icov cno nou k0s ociyn dvciscun-
    ovcdi:
    * n dppocid uc snoksn co 6so - pd suoyd,
    * o nvoc, oudcikc n uxikc, uc dxpiococ ovcpooc co dv0pnou,
    oxsv dndpdcncoc yid cnv uxikn updvon - cssuon - k0dpon
    cou,
    * n ovdi uc npon0son ouoidociknc snikoivuvdc - svosuc s couc
    ouc dv0pnouc kdi s co 6s os svd o snnso,
    * o 0vdcoc nspiyscdi kdi n knsd - sioc dkoou0d yvscdi ndvn-
    ypi, yvscdi npoon0sid dnsic 8 cpnoc unc nuc cd ndpdnvu
    * vd ouykpi0ov s cic yvuocsc os ouc dc dnsic co uciko dv-
    0pnou 8 cnc kdoiknc idcpiknc nou idokdocs ocic idcpiksc oxo-
    sc, kdi
    * snixsipscdi n sdyuyn knoiuv ounspdocuv.
    ...Lvdi ducn dkpic n snsipd nou okod scdspscdi ocouc skcc
    kdi onuonnocs s cn yood nou nsi nio nspd dn uxpoc dpi0oc
    kdi ocdciociksc kdi dkoou0s cn oyikn cnc kdpic...
    I179I
    IA1Ikh 1U AIIUN UU - h I10h 1U IUN1A AIU
    kupukucn I|vvn
    ldzpc
    kon tn spyucu - |k: Nd ndpouoiosi cn 0supncikn cono0scnon 8
    cnv npdkcikn dvciscnion opidkv kdcdocosuv cnc unc co dv0pnou
    sod dn cic ouousc, cnv nspd 8 cn un co niosvou dokncn.
    Anotsscutu - unspcutu: |vscdi npoon0sid oi dnsic 8 o cpnoc
    unc svc n yidcpo, co kdi cou onoou kdcdkucdv k0s spd dn
    sksc snioksncsc, oi nspioocspoi dn couc onoouc, dnoyoncsusvoi
    dn idcpikn kdi yidcpoc, kdcssuydv ocn ououn cou yid knoio ond-
    vcik npnd uysdc, oudciknc n uxiknc, ik couc n knoiou dydnn-
    svou couc npoonou, snovcdc oco 0dd
    * vd dvdu0ov
    * vd ouykpi0ov s cic yvosic cnc kdoiknc idcpiknc, kdi
    * snixsipscdi n sdyuyn knoiuv ounspdocuv.
    ...kovc cou, uc dypocikc idcpc co Ayou Dpouc, nnpd ki sy d0ndcd
    unoovnc, dncncdc, snikoivuvdc, xioop, dv0punic kdi ysvik cnc
    idcpiknc nou s iokscdi os di0sdcpd 8 d0ouosc idokddc, spyd-
    ocnpid 8 0douc...
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    237
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I180I
    h 01Nh MDM2 kAI UI UIkIA AI1UII 1h
    2o|n A., Iuvvou k., Xutn|uvvou k.
    ldzpikn Ixon L.k..A.
    N npucsvn mdm2 dnsnip coo s cnv npucsvn p53 oo kdi s -
    sc kpoisc npucsvsc-pu0iocsc cou kuccdpiko kkou.
    Tvd doik oksoc cuv dnsniposuv cnc npucsivnc Mdm2 s sc
    npucsivsc, svdi duc s cnv npucsivn p53.N Mdm2 npoosvscdi dnocss-
    odcik ocnv p53,cnc onodc cd snnsd os kdcocdon stress cou kucc-
    pou svdi dunsvd, dnsvspyonoivcdc cnv scdypdikn cnc ikdvcncd
    kdi onyvcdc ocnv cdxsd dnonon cnc ocd npucsooucid sou cnc
    oo cnc ouikoucvnc. Ms cn osip cnc n p53 snysi cnv skpdon cou
    yoviou cnc Mdm2, sou svc unokivncn sdpcsvou dn cn pon cnc
    p53 uc scdypdiko ndpyovcd. N svspyononon ducn spiksc opsc y-
    vscdi kd0uocspnsvd, vovcdc ocnv p53 co dndpdcnco xpovik nspi0pio
    vd posi. Asc ni opsc cdxcdcd, xupc uc vd cnv snnpssi s-
    od, sdicdc scd-scdpdocikv cpononoinosuv cnc cssucddc. Ms cov
    cpno duc ouocnvscdi svd ducopu0isvo oocnd dpvnciknc dvpd-
    onc Ian autoregu|atory feedback |oopl, yid cov ssyxo cnc pdocnpicn-
    cdc cnc p53 sod oco kccdpo.
    N ocsvn xupoxpovikn p0ion cnc pdocnpicncdc cnc p53 sod oco kccd-
    po svcsvscdi sninsov dn co ysyovc ci kdi n Mdm2 unksicdi os dnoi-
    konon sou cnc oo cnc ouikoucvnc ocd npucsooucid. hpsnsi
    s vd coviocs ci oi dnsniposic ducsc svdi uvdcv vd snnpso-
    vcdi dn scd-scdpdociksc cpononoinosic ducv cuv o npucsvv,
    nuc uoopuiosic, uc dnvcnon os iopd ondcd.
    N mdm2 skcc dn cnv ondvcikn cnc dnsnpdon s cnv p53, ouvsscdi kdi s
    sc npucsvsc kdi cic svspyonois dvoyd . Ui kupicspsc dn ducsc svdi:
    1. N pPb
    2. Ui L2F1/DP1
    3. N p19APFIocd novckidl kdi n p14APFIocov v0punol oykokdcdocdci-
    kn npucsvn.
    4. N p300Iouvsvspyonoincnc scdypdnc cnc p53l
    N mdm2 sxsi kdi sc pdocnpicncsc , dvspcncsc cnc p53. Indvcikn
    svdi n dvdkun cnc ndpouodc nspioxv kdcdocosuv cou kucc. k-
    kou oco ksvcpik pio cnc mdm2.Lcoi n mdm2 ouvsiospsi oco ocd-
    cnd ocn on U1.Mnops n dvdkun ducn vd spxscdi os dvc0son s
    cnv oykoyovikn pdocnpicncd cnc mdm2 d n mdm2 sxsi id nspioxn
    duconspiopioo cdv n oykoyovikn cnc pon unspskpscdi.
    N ouoidocikn sscn kdi kdcdvnon cuv dnsniposuv cnc Mdm2 s cnv p53,
    nopov vd ououv ocnv dvciscnion kdi ocnv 0spdnsd cou kdpkvou.k-
    pioc ocxoc svdi n dnssu0spuon cnc p53 dn cnv dvdocdcikn pon cnc mdm2
    kdi n sndvdop cnc oykokdcdocdciknc sicoupydc cnc p53.
    I181I
    kN1Ikh Xh, MOUUI kAI AIkA kA1AIAOh
    !t|ou upucksun-tuupo0u
    Ikonc cnc spydodc svdi n ouvoncikn ndpouodon s0uv kdi uikv
    yid cnv kdcdypdn cnc ksvcpiknc oxsonc, idc svvoidc ypu dn cnv onod
    snikpdcs oyxuon kdi idxn ocnv oovcidcpikn opooyd.
    hdpouoiovcdi o s0ooi dvspsonc cnc, ouykskpisvd n csxvikn cnc
    dc xsipc kdi n csxvikn cou dnsupou xsipioo, sv yid cnv kdcd-
    ypdn cnc yvscdi dvdop ocic snc s0ouc : 1l |pdiksc, 2l ksdos-
    cpiksc, 3l Nskcpouoypdiksc, 4l Asosc idouyksioidksc kdcdypdsc
    nsuc. |id cnv sdpoyn cuv idpuv s0uv kdcdypdnc unpxsi
    nn0pd uikv sk cuv onouv cd nspioocspo koiv xpnoionoiosvd
    svdi : 1l 6spondociko cnoi kspiv, 2l Luysvooxd updcd, 3l |-
    oi dnocnuonc, 4l Akpuikn pncvn sv uxp nouspisvn, 5lIii-
    kvsc kdi noudi0spsc.
    Lnonc dvdovcdi cd nsovskcndcd kdi siovskcndcd k0s s0ou
    s nspioocspn sdon ocic sosc idouyksioidksc kdcdypdsc nou
    svdi kdi oi nspioocspo npdkcik xpnoionoiosvsc. Msc dn oykpion
    cuv idpuv uikv kdcdypdnc ndpdc0svcdi cd ocoixsd oov dop
    cic iicncsc kd0svc dn duc, ocs vd snisyscdi o kdcnoc ouv-
    udoc s0ou kdi uiko dvoyd k0s op s cnv iidicspcncd cnc
    nspncuonc kdi cnv kpon cou 0spnovcoc oovcicpou.
    Idv ounspdod 0d syds ci sv unpxsi kdd csxvikn nou vd kd-
    ncsi sc cic nspincosic nou ndpouoiovcdi ocnv kivikn npn. Ui yv-
    osic cou oovcicpou kdi n ouvspydod cou do0svn svdi ni0dvv oi nio
    onoudoi ndpyovcsc yid vd snicxous d dkpin kdcdypdn cnc ks-
    vcpiknc oxsonc. Tcoi, svdi dndpdcncn n yvon nspioocspuv cnc idc
    csxvikv yid vd sxous uvdccncd sdcoksuonc os k0s do0svn kdi
    ouvsnc isukuvon kdi no nspioocspo snicuxd cuv spydoiv dc.
    I182I
    NI5I kAI IMAXA OMA1A 1A UIAMMA1A M8UAIAMU
    1h hA1I1IA 8
    ksscn X.I.
    1
    , ksscn X.O.
    1
    , ukup A.
    2
    , Axtcn 8.
    2
    4. Ooiznzsc ldzpiknc L.k..A, 2. Ooiznzsc ldzpiknc dvsnioznou kpnznc
    Yns0uvoc kd0nynznc: Xdzknc A., Avdnnpoznc kd0nynznc ponnzi-
    knc ldzpikncI
    kon tn spyucu: Ikonc cnc spydodc svdi vd coviocov oi kupicspsc svs-
    sic soidoo cnc nndccidc 8 d kdi vd ndpouoidocov oi kupicspoi npo-
    ndcioo kdi oi vscspsc sssic ocd npoypdcd soidoo cnc nndcci-
    dc 8.
    |k ku| s0oo: Xpnoionoin0nks uik dn cnv unpxouod sniocnovikn id-
    cpikn iioypdd kdi dp0poypdd, kd0c kdi nnpoopsc dn cnv idikcudkn
    idcpikn
    unspcutu: Lvioxuciksc osic cou soou cnc N8v ysvik sv ouvocdvcdi
    yu cnc ipksidc cnc dnocssodciknc npoocdodc 9 xpvid sc cov soid-
    o. N ipksid cnc dnocssodciknc npoocdodc yid couc snouc nou soi-
    ocnkdv kdc cnv vnnidkn n cnv ndiikn nikd npsnsi vd skcicdi. Jd dnocssod-
    cd 0d kd0opoouv cic sovciksc ouocosic yid cnv xopnynon svioxucikv -
    osuv.
    houdvciyovik sid nou svoudcvouv co N8sAg odv svd ouocdcik
    diooyovcdi sn cou ndpvcoc.
    N xpnon ducv cuv souv nops vd dsi cd npoypdcd soidoo
    kdc cnv ndiikn nikd kdi vd kdcdnsi ocnv xopnynon sninpo0scuv osuv
    ouykskpisvuv dvciyvuv. Lvcocoic, duc cd sid 0d isukovouv no
    cnv xopnynon souv kdi 0d sdxioconoinoouv cov dpi0 cuv svsosuv.
    I183I
    U IU 1h AUIIA 0 8IUAUIIkU UAU 1UN 21o AI0NA
    1cupoux svn, kutco0n uuyysu, spukkn N|kuo
    Jo ysyovc nuc 300.000.000 ns0dvdv dn cov i cnc suoyic sod ocov
    20o divd vo, cnv kd0ioc ducocuc id dn cic nio cpodkciksc kdi
    dnsinciksc voouc nou sxsi yvuposi n dv0puncncd. N do0svsid skn-
    vscdi s sou0svucikn ksddyd, nvo ocnv ncn, ssco kdi no
    un nupsc. Jd npcd kkkivd onid sdvovcdi oco npouno kdi
    cd kpd, sdnvovcdi ypnyopd, kdi scdcpsnovcdi os kcdivsc nou
    ysouv uyp. Mcn, ocd kdi dic ysouv uoxspdvovcdc cnv dvd-
    nvon, cd cpixosin oknpdvouv kdi no d ouncdcd sdvo-
    vcdi. Ui skcsc 0vnoicncdc 0vouv co 507.
    kd0c co cssucdo kpood ndpouoio0nks co 1977 kdi o xpvid dpy-
    cspd o hdykoioc Upydvioc ysdc I WNUl nuos sc dn 11xpovn
    npoon0sid cnv sdvion cou io, npodvc sv ouvcpsxsi yoc dvn-
    ouxdc. 0ocoo, siiko spsuvncsc cuv iooyikv nuv niocsouv nuc o
    ic cnc suoyic pokscdi os cpd couxiocov kpu spydocnpid. Msc
    cnv ncon cnc Ioisciknc Tvuonc kdi cn ouvspydod kopuduv sniocn-
    vuv cnc nuc o kanatjian A|ibekov kdi o v|adimir Pasechnik sydcd cou
    io pokovcdi nsov snond os o onsd. Ico ksvcpo yid cov Tsyxo
    kdi cnv hdpsnion cuv Ao0svsiv ocnv Acvcd kdi oco spydocnpio vec-
    tor su dn co Novosibirsk ocn Iinpd. Apxsd dnppncd nspisxouv id
    ocd kpdcv nou ni0dvv uooouv kssvd sydcd io. noocnp-
    scdi nuc n ocd scd uv nspidvsi: |pk, 8psid kopsd, kvd,
    Ain, Ncid Apikn, |opdn kdi hdkiocv . knoid dn cd ndpdnvu kpcn
    svdi noncd yid nsp0dn cpookpdcv kdi ni0dvn npoon0sid dnssu-
    0spuonc cou io yid noicikoc kdi cpookpdcikoc youc.
    sosvnc cnc noiciknc kdcocdonc ocn is0vn oknvn kdi ouoyisvoi co
    ysyovc nuc sv unpxsi yvuocn 0spdnsd yid cov i kdcdnyous oco ouns-
    pdod nuc n dvncun cou soidoo Icou ovdiko cpnou oucnpdcl
    kd0ocdcdi dndpdcncn. Ui N.h.A os ouvspydod s cn Lcdipsd Uravax sxouv
    nn dpxosi cnv ndpdoksun soou. hpsnsi oinv vd yvsi id ndykoid
    ouvcoviosvn npoon0sid, npoksisvou vd n ps0os dvciscunoi s id
    kdcocdon s ouvsnsisc donncsc ocov dv0pnivo vou.
    238
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I184I
    NU1A UMNA 1h OA1Ikh AN1IM10Ih 10N U50N
    1OANIAI0N NUM0N , X0I ANAAh 1U S1 - 1MhMA1U
    k|uy|ukn .
    1
    , kuctp|vkn k.
    1
    , Mv .
    1
    , kukkuskn k.
    1
    ,
    8pu .
    2
    4. Ooiznzsc ldzpiknc dvsnioznou kpnznc
    2. kd0nynznc kdpiooydc ldzpiknc Ixonc dvsnioznou kpnznc
    kon: Icnv ndpood spydod, yvscdi ouykpicikn dvdoknnon cuv dno-
    cssocuv cnc xpnonc cuv oyxpovuv dvcidionscdidkv, dvcinnkci-
    kv kdi dvci0poucikv ndpdyvcuv kd0c kdi cou pou cnc npinc
    sndvdicuonc. hpocsvovcdi vscspoi dvcidionscdidko kdi dvcinnkci-
    ko ndpyovcsc kdi oxndcd ouvudoo ducv.
    Ms0oo: hpdydconoin0nkdv sscsc yid cn dnsin cnc dnocssod-
    cikcncdc cuv dnoksiocv cuv ||b/|||a yukonpucsivv cuv dionscduv.
    Lnonc, os sscsc syivs oykpion cnc dnocssodcikcncdc cuv nndpi-
    vv xdno opidko pouc xupc kdi d s cnv nndpvn, kd0c kdi n
    skcnon cnc ndpdcscdsvnc ponc cuv npcuv. Akn, sscocnks o
    poc dvci0poucikv ndpdyvcuv sonc ponc kd0c kdi cnc npi-
    nc sndvdicuonc. Jsoc, vscspoi 0spdnsuciko ndpyovcsc cs0nkdv
    un sscn yid cnv dnocssodcikcnc couc scs uc ovo0spdnsd n os
    ouvudo s couc nn xpnoionoiosvouc.
    Anotsscutu: Jd abxicimab, tirofiban, eptifibatide sivouv cn 0vnoi-
    cncd n cnv snncuon uokdpidko spkcou, xupc dnon cou kiv-
    vou yid dioppdyd. Jd dnocssodcd cnc oykpionc dvsod ocnv nnd-
    pvn kdi ocic nndpvsc xdno opidko pouc ncdv disysvd, sv
    dnosxcnks n dnocssodcikcncd cnc svonndpvnc os 3 sscsc. hdp-
    cdon xpnonc nndpivv xdno opidko pouc sxpi 90 nspsc ssis
    ondvcikn suon cuv 0dvcuv n cou spkcou ocic 30 nspsc kdi os
    ikpcspo d0, ocouc 3 nvsc. N hirudin svdi dnocssodcikcspn svd-
    vci cnc nndpvnc. sv dnosx0nks n dnocssodcikcncd cnc snsdciknc
    sndvdicuonc svdvci cnc ouvcnpnciknc 0spdnsdc.
    unspcutu: n sscn pokovcdi kdi ouncovcdi ouvudoo cuv
    ndpdnvu ndpdyvcuv nuc nndpvnc kdi ||b/|||d dvdocosuv nddic kdi
    vsdc ysvic kdi p.os dvcinnkcikv. Avdncooovcdi vsoi ndpyovcsc nou
    snipov ocnv nnn sv dvdsxcnks n dnocssodcikcncd cnc konio-
    ypsnc, kdi iocd cnc ndpdcscdsvnc xpnonc cnc d s cnv donipvn.
    I185I
    h MIkh ANAIAMUO0h 1U XIAU kA1A 1hN 0IMh
    XIUIIkh AN1IM10Ih 10N XIAUXI1I0N
    Iuvvn I|vvn
    1
    , Mno0c|o 8ucn
    1
    4. Tssioizoc 0ovzidzpiknc, Tnd 0ovzidzpiknc, Apiozozssio
    dvsnioznio 6soodovknc
    N uikn sndvdidpuon sxsi uc ocxo cnv sicoupyikn kdi dio0ncikn
    dnokdcocdon cuv xsisooxiociv. |id vd snicsux0s n uikn sndvdid-
    puon svdi dndpdcncn n dkpinc yvon cnc uoiooyiknc kdi nd0oo-
    yiknc dvdcodc cnc nspioxnc, nuc kdi cou cpnou dvncunc cnc vu
    yv0ou. Dcdv ous id xsisooxiocd, kdc cnv skcn s son spui-
    kn sod, idkncscdi n uoiooyikn ouvsxsid coo cou oiykcnpd
    cou ocdcoc, oo kdi cuv ndpdpivikv uv. Auc sxsi odv dnocssod
    cnv duvdd ovsonc scd cuv npucoysvv kdi sucspoysvv ks-
    vcpuv dvncunc cou kpdvou kdi cnv svion cou xdpdkcnpiociko npo-
    ounsou cnc xsisooxiocdc. N uikn sndvdidpuon kdc cnv xsipoup-
    yikn dnokdcocdon cuv xsisooxiociv onys ocnv dnpokoncn dvncu-
    n cou soou npoonou s cnv dkpin sndvdcono0scnon cuv uv ocnv
    uoiooyikn couc 0son. N sndvdcono0scnon nops vd snicsux0s s i-
    opsc xsipoupyiksc csxviksc oov dop cnv 0son kdi cnv skcdon cuv
    cov, dvoyd s cnv npoounikn npocnon cou snsdvovcd kdi d-
    vscdi nuc sxsi sv0dppuvcik dnocssodcd. N skcnon uc cuv xsipoup-
    yikv dnocssocuv sv svdi id skon un0son, kd0c unpxouv
    noo ndpyovcsc nou ououv ocnv dvncun cuv yv0uv, nuc n
    ysvscikn npoi0son cuv do0svv, n ikdvcncd cou snsdvovcd, n ni-
    kd ocnv onod yvscdi n snsdon, n xsipoupyikn csxvikn, n nioupyd
    ouv kdi csoc n oxsv nvcd dvdykdd isvspysid op0oovciknc 0spd-
    nsdc. Icn is0vn iioypdd ndpdcnpscdi knoid oxscikn ssin xsi-
    poupyikv dnocssocuv ouvd s cnv ndpdnvu csxikn dnokdc-
    ocdonc. 0ocoo ouvd s ducsc cic sscsc dvscdi ci n uikn snd-
    vdidpuon nops uc svd d0 vd dvdxdicosi cd npondcd dn-
    onc kdi indonc nou nioupyovcdi kdc cnv xsipoupyikn dnokdc-
    ocdon cuv xsisooxiociv. hspdicspu spsuvsc svdi dndpdcncsc ocs vd
    ispsuvn0ov cd dkpin dnocssodcd cnc csxviknc ducnc kdi vd ouykpi-
    0ov sndpkc s dvoyd dnocssodcd uv csxvikv.
    I186I
    IA1AAX 1U NU 0 AUUIA 1h NUU 1U AkkINSUN
    stpou kup|ko, kuoyspkn nntpn, tsuvnouo nntpn,
    Avuyvctono0ou Mupu
    ldzpikn Ixon L.k.dvsnioznou A0nvov
    Ui idcdpdxsc cou nvou dopov co 74-987 cuv ndoxvcuv dn iiond0n
    voo cou Parkinson, s soo dvckcuno ocnv noicncd unc couc. Ui dvu-
    cspu idcdpdxsc dndvcov uc idkonsc cou nvou, ndpdcscdsvn dnvd
    kdi nspnoid unvnd. Nukcoupd, uooksscikn uokdd, uocoviksc
    idcdpdxsc svdi oi kpisc dicsc dnvdc os hdpkivoovikoc do0svsc. 8s-
    did, oi unviksc idcdpdxsc d0iduc ssooovcdi dpvncik, os ouvud-
    o s cnv npoosucikn ssin cnc voou, sv cscoiou souc ouoxscion
    sv unpxsi dvdopik s cnv npoo cnc nikdc Issyxoc 100 do0svv
    s voo Parkinsonl. Lninpoo0scuc, oi idcdpdxsc cou nvou dndvcov kdi
    uc sninokn cnc xpovou 0spdnsdc s Levo-Dopa. N kdc0in n onod
    snonc dndvccdi os cscoiouc do0svsc, idpddcsi dvdiuc dpvn-
    cik po ocnv noicncd cou nvou, xuc uc vd unspcsps cnc nopsdc
    cnc voou kd0ducnc. nvdyuy, npsiocik kdi dvcikdcd0incik nopov
    vd xpnoionoin0ov, sv n svoppivik xopnyosvn soonpsoovn s-
    vdi uvdc vd kdcdocs dnocssodcikn ocnv dvciscnion cnc vukcou-
    pdc.
    I187I
    h IAh AIIIUA1Ik0N UI0N 1U NUOhAIU 1hN kAIAkh
    AI1UIIA kAI U UAU 1U 1h MOUh1Ikh kAIAkh ANAkIA
    kuoyspkn nntpn, stpou kup|ko, tsuvnouo nntpn,
    Avuyvctono0ou Mupu
    ldzpikn Ixon L.k.dvsnioznou A0nvov
    Jo svo0nio svdi o kpioc pu0iocnc cou dyysidko cvou, kd0oov
    dnssu0spvsi dyysiopdociksc ouosc nuc svdi oi: LDPF Isvo0nidkc
    idocdcikc ndpyovcdcl, LDNF Isvo0nidkc unspnoucikc ndpyuvl,
    npoocdkukvn, svo0nvsc kdi LDCF Isvo0nidkc ouondocikc ndp-
    yuvl. Ui cpsic dn ducoc couc ndpyovcsc ILPDF, LDCF, svo0nvscl kdi o
    LDCF nou sdpccdi dn cnv kukouysvon, ndouv ondvcik po ocn
    ouopncikn kdpidkn dvsnpksid. Tvdc syoc dpi0c nsipdcuv kdi
    kivikv spsuvv, nspiypsi cd dunsvd snnsd cuv svo0nivv oco
    nod ocnv ndpdnvu voo. N suon cnc kdpidknc s0nonc, n onod
    ouvcss ocnv sccuon cou scdcpsnciko svou cnc doocspvnc,
    dnocss kdi ducn cnd cou supcspou nxdvioo nou nspiypscdi.
    8sdid, cd ndpdnvu dnocssodcd sv sxouv dkn dnosix0s nnpuc,
    kdi dndicovcdi nspdicspu sscsc nou vd kd0opouv kdc noo oi nxd-
    vioo duco nopov vd ocnpouv cic ndpdnvu nd0ooyiksc ispydosc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    239
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I188I
    I1UIkP ANAUMh 1h MA1h 10N AIII0N
    Asovpou .A.
    1
    , Ik|ckn I.
    2
    Iuvspyoznkdv oi oiznzsc: Pnyd M., iddvzn k., kovn M.,
    Ludyysivknc N., nnzpnouoc I.
    4. Akzivooyik Lpydoznpio Adko' Noookosou, 2. Xsip. 0ovzdzpoc
    Ui dpcnpsc kdi oi ssc ncdv dvcikssvo sscnc dn ccs nou unnps
    svidspov yid cnv dvdcoikn kdi uoiooyikn sscn. N ondod couc,
    sv sv ncdv nvcd kdcdvoncn, ncdv doik spcnd dn cnv dpxn.
    U |dnvc yid ndpsiyd nspisypds cnv dopcn odv svd "kop idipo-
    svo os nooc kouc kdi kdokouc" oi onooi cpooocov co od.
    Icnv dpxn oi sscncsc sv ncdv nvcd oyoupoi yid co dv oi ssc kdi oi
    dpcnpsc sunnpscoodv idopscikoc okonoc, dv kdi ypnyopd dvcin-
    0nkdv ci ounspispovcdi idopscik cdv csvovcdi.
    kdc cnv ndpouodon 0d dvdsp0os isoik ocic yvosic dn cnv
    Lnvikn dpxdicncd, cn |dnvikn ndpoon kdi cn 8udvcivn snoxn , co
    Msoduvd kdi cnv Avdysvvnon kdi siikcspd os ducoc nou nponyn0nkdv
    cou Wi||iam Narvey.
    Jov Lnsokn, cov |nnokpcn, cov Apiococsn, cov Npio, cov Lpdo-
    ocpdco, cov |dnv, cov Montino dei Luzzi,cov Leonardo da vinci ,cov An-
    drea vesa|ious kdi cov Marce||o Ma|pighi.
    I189I
    P 0 AAIUNIU A1hIA kAI UI kAAUI 1h
    Annu .A.
    1
    , Muupovc|o k.
    2
    , 1c|pvn Xp.
    2
    , A|uckotn 8.
    2
    ,
    unukctu I.
    2
    , Ik|ckn I.
    3
    , Xpucv0ou Xp.
    2
    , kuuvtnouo A.
    2
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc: ikoc N.,
    Ipkd L., dndonupn ., Mdn l., spuoivknc H., Luzd(d L.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. 0ovzdzpoc
    N noikioopd ocnv sou dyvio dpcnpd s couc coixudcikoc kdi
    ondyxvikoc cnc kouc svdi no syn kdi svdi okoo vd cdi-
    von0s. Ui yoi dvyovcdi kdi ocnv spuooyikn ssin cuv dyysuv
    cnc nspioxnc. Jo nn0oc cuv snsosuv nou yvovcdi ocnv nspioxn dc
    onynos ocnv dvuon cuv ndpddyv nou sups0nodv cnv cssucdd
    4scd sn 100 ncucuv ocnv |dcpoikdocikn nnpsod A0nvv.
    Ui supssc dvdcoiksc cosc kd0iocoodv uvdcn cnv ndpdcnpnon kdi s-
    ncospn ndpdoksun. An cnv dpxn 0supn0nks yid youc dnonononc
    oknio vd n yvsi ikpion scd cuv nspincosuv nou unpxsi sk-
    0dpd oxndciosvn koivn dyvioc dpcnpd kdi cuv nspincosuv nou o
    ixdoc os sou kdi su dyvio yvscdi no vupc ocnv koiidkn dopcn.
    idkpvds cic dkou0sc nspincosic:
    1. Movn sou dyvioc Ivo svd ocssxocl n onod vsi ouc couc
    coixudcikoc kdi ondyxvikoc kouc, 127.
    2. inn sou dyvioc Iixdocl kdi skuon cuv kuv dn cd uo
    ocssxn, 637. idkpvovcdi unonspincosic
    * Jo ono0io ocssxoc kdcdnysi uc vu youcidd dpcnpd, sv co
    npo0io kdcdnysi uc kcu youcidd kdi sou dioikn, 377.
    * Jo npo0io ocssxoc kdcdnysi uc sou dioikn dpcnpd, sv co
    ono0io vsi cnv vu kdi kcu youcidd dpcnpd, 137.
    * Dnuc ocnv nponyosvn nspncuon, d o ixdoc cou onio0ou
    kou yvscdi sc cnv so cou dn cnv nso i cou unspd-
    niosioc cpndcoc, 137.
    3. Jpixocnon cnc sou dyovou kdi ocn ouvsxsid skuon cuv kuv, 167
    4. idpson cnc sou dyovou os csoospic n kdi nspioocspouc kouc,
    sk cuv onouv sknopsovcdi oi iopoi koi, 117.
    Ui ndpddysc cuv kuv cnc sou dyovou sdpcvcdi sod dn cnv
    noikicncd cnc sou dyovou. |idcspn sscn syivs ocnv 0uposin dp-
    cnpd, n onod didcvsi uc cou sou 0updkiko coixdcoc, sv vsi
    kouc npoc cnv nikn ouon kdi cnv ksdn cou npidou. Ui ndpd-
    cnpnosic ducsc 0d ndpouoidocov sxupioc.
    I190I
    kOh 1h UNAIkh A1hIA I 900 10MA10N
    Annu .A.
    1
    , Asovpou .A.
    2
    , Io0u .
    3
    , Ik|ckn I.
    4
    , Mun A.
    3
    ,
    kuunku O.
    3
    , Aouuk I.
    2
    Iuvspyoznkdv o ldzpoikdoznc kdpdkoknc N. kdi oi oiznzsc:
    kdpdvou A., kdpdvou I., Xdxdpiknc I., Xdxdpikn A.,
    Isopynouoc ., iddvznc N., Iidvvpn M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou, 3. ldzpc,
    4. 0ovzdzpoc
    Ico ndoid cnc isdyuync idc supsdc ypu dn cn Xsipoupyikn Avdco-
    ikn cou cpdxnou, ispsuvnods cov cpno skuonc cnc onovuiknc
    dpcnpdc, ouovcdc scoi ocnv sdxiocononon cuv kivvuv kdc cn
    xsipoupyikn cnc nspioxnc.
    N sscn syivs ocnv |dcpoikdocikn nnpsod A0nvv kdi nspisdvs
    900 ncdcd I470 vpsc kdi 430 yuvikscl. Ui supssc cosc nou syivdv
    kdc cnv vskpocon dc snscpsndv sc cnv ndpdoksun cou dopciko
    cou kdi cuv unoksiuv dpcnpiv vd sscnoous cov cpno skuonc
    cuv onovuikv dpcnpiv.
    kdc cn ocdciocikn dvuon, o cpnoc skuonc kdcdcooscdi uc snc:
    dl Iuvn0nc cpnoc Inpiv co 6upsoAuxsvik ocssxocl 792/900 I887l IIXN-
    MA 1l,
    l An co ixdo cnc k. kdpucdc 36/900 I47l IIXNMA 2l,
    yl Md s co 6A ocssxoc 18/900 I27l IIXNMA 3l,
    l Msc co 6A ocssxoc 36/900 I47l IIXNMA 4l,
    sl An co dopcik co 9/900 I17l IIXNMA 5l,
    ocl An cnv k. kdpucd 9/900 I17l IIXNMA 6l.
    hdpdcnpnods csoc ci unpxsi oxson cpnou skuonc s co nkoc di-
    o kdi co nipio cou cpdxnou In. ndpdcnpnods ci oi ndpddysc
    yvovcdi ouxvcspd si dn dpiocspl. Jsoc cd supndcd ndpd-
    oouv sdp s cd dvdspsvd ocn is0vn iioypdd.
    I191I
    IXAMU kUIN0N kA01I0N
    Annu .A.
    1
    , 1c|pvn Xp.
    2
    , Asku A.
    2
    , kupuvtvn h.
    2
    , Muupovc|o k.
    2
    ,
    ssvu k.
    3
    Iuvspyoznkdv o ldzpoikdoznc Asuknc X. kdi oi oiznzsc:
    Aivdpozooc ., Iidvvnouoc A., Mdvoc I., kdyspou L.,
    Mnzpoyoyou A., dndxpnozoc A., Lsvn L.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. Akzivooyik Lpydoznpio Adko' Noookosou
    kon: Ikonc cnc sscnc ncdv n dvdncnon, n kdcdypdn kdi n ndpou-
    odon cuv ndpddyv cou ouc ixdoo cuv koivv kdpucuv, ocoi-
    xso nou dnocss xpnoin yvon yid cnv kdcdvnon kdi snynon cuv
    sikvuv cuv dnsikoviocikv s0uv yid co xsipoupy nou snsdvsi
    ocnv nspioxn cou cpdxnou.
    |k Msstn-Ms0oo: Icd ndoid idc skcscdsvnc sscnc ocnv nspioxn
    cou cpdxnou, sscnods kdi ndpouoious cic nooisc os iioopsc nd-
    pddysc cou ouc cou ixdoo cuv kdpucuv. N spsuvd npdydconoin0n-
    ks os 843 cpdxnouc ncucuv ocnv |dcpoikdocikn unnpsod A0nvv cd cs-
    sucdd scn. Ui ouv0nksc spsuvdc dc snscpsdv cn isvspysid supsuv dvdco-
    ikv cov. Msc cnv vskpocon kdi cnv ddpson cuv npo0iuv kdi nyiuv
    uv cou cpdxnou svconds cic koivsc kdpucsc.
    Anotsscutu: hdpdoksuods, ndpdcnpnods, kdcdypds kdi ucoypdn-
    ods cic ndpdcnpnosic. An cnv dvuon npokncsi ci o ixdoc yivcdv oco
    oc cou npo0iou dcoc cnc sykpoidc dnuonc: dl cou scspou duxsviko
    onovou os nooooc 1,57, l cou cpcou duxsviko onovou os nooooc
    187, yl cou cscdpcou duxsviko onovou os nooooc 707, l cou nsncou du-
    xsviko onovou os nooooc 87, sl cou skcou duxsviko onovou 17 cuv
    nspincosuv, sv os d nspncuon n kdpucd s ixdcdv.
    unspcutu: kdc cnv ndpouodon 0d dvdsp0os ocic oxsosic cou ouc
    ixdoo s co o, cnv nikd kdi co nkoc cou cpdxnou.
    240
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I192I
    h 8AXIUNIA A1hIA 8 h IUAh 8AXIUNIA A1hIA
    Annu .A.
    1
    , kop k.
    2
    , A|uckotn 8.
    2
    , 1c|pvn Xp.
    2
    , kuunku O.
    2
    ,
    Ik|ckn I.
    3
    , Ospskou .
    4
    Iuvspyoznkdv o ldzpoikdoznc Nvdc L. kdi oi oiznzsc: oizikc l.,
    Mxdc I., kopn L., Iidvvpn M., kdpdvou A., Mdn l.,
    Aunspnouoc N., Asfoc M.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. ldzpc, 3. 0ovzdzpoc, 4. Bioyoc
    Ico ndoio cnc sscnc- cuv dpcnpidkv ndpddyv cuv kpuv sscn-
    ods cic dpcnpidksc ndpddysc cuv dpcnpiv cou vu kpou os 100 nc-
    dcd cou Lpydocnpou hspiypdiknc Avdcoiknc cou hdvsniocnou A0n-
    vv kdc cn ipksid cnc skndsuonc cuv oicncv.
    Icnv ndpood spydod sscods cn pdxivid kdi cnv sninonc pdxivid
    dpcnpd. Lninonc pdxivid kdscdi n suv dpcnpd nou pokscdi snino-
    nc cou soou vspou. Mid cscoid dpcnpd nops vd unokd0ioc cn pdxi-
    vid n vd cn ounnpvsi. |id youc s0oooyikoc 0supnods kd vd
    ous unn ocn sscn dc vo cic dpcnpsc kdi vd dsnoous i-
    kpcspouc kouc. N sninonc pdxivid dpcnpd skscdi ouvn0socspd
    oco syyc cnd cou pdxovd kdi n npdkcikn cnc ondod ouvocdcdi oco
    ysyovc ci ouxv n nopsd cnc onys ocov nnxu, snpoo0sv cnc dnovs-
    puonc cou iksdou pdxiviou. Tcoi nops kiocd vd ouyxu0s s
    sd kdi id svosioc svson vd sxsi os0pid dnocssodcd.
    Ui ndpddysc cic onosc idkpvds ncdv oi dkou0sc:
    A. Mvo id pdxivid dpcnpd: 767
    1. N kdoikn nspncuon cuv iuv cnc Avdcoiknc: n pdxivioc dp-
    cnpd. 8pokscdi nio0sv cou soou vspou, idocduposvn kcu
    dn duc ocov dvcspo pdxovd: 747
    2. U oxndcioc cou soou vspou sv svdi o cunikc ocn doxn,
    d n dpcnpd nspv kcu dn duc: 27
    8. ndpn vo idc pdxividc dpcnpdc: 107
    1. Mid suv dpcnpd snpoo0sv cuv uo piv cou soou vspou: 27
    2. N suv dpcnpd pokscdi nou dn cic psc cou soou vspou,
    d nspv npooc dn duc oco pdxovd: 47
    3. N pdxidd dpcnpd nspv nou dn co soo vspo ocn pdxidd nsu-
    p, d ispxscdi nvu dn co vsupik ko scd uospdci-
    ko 8 soou vspou: 27
    4. sv unpxsi o kdoikc oxndcioc cou soou vspou dn uo
    psc kdi n dpcnpd nspv nvu dn co soo vspo: 27
    |. uo sovd dpcnpidk ocssxn: 147
    1. N doxdidd dpcnpd idipscdi os uo ocssxn sk cuv onouv co
    svd nopsscdi npoo0uc kdi co o onio0uc cuv piv cou soou
    vspou: 57
    2. N pdxivid dpcnpd idipscdi os uo ocssxn, svd sk cuv onouv
    nopsscdi snpoo0sv cou soou vspou: 97
    I193I
    A1hI 1h AXIAIA IOANIA 1h AkA XIU
    Annu .A.
    1
    , Asovpou .A.
    2
    , kuunku O.
    3
    , Ik|ckn I.
    4
    , Mun A.
    3
    , Asku
    A.
    3
    , ssvu k.
    2
    , Ospskou .
    5
    uvspyctnkuv n Iutpo|kuctn Mup|uvvo0 . ku| o| o|tnts: Mxu .,
    Ikupuykvn ., Mnukoy|vvn k., k|osoyou X., I|uvvnouo A.,
    Aunspnouo N., Aso M.
    1. pyuctnp|o sp|ypu|kn Avuto|kn uvsn|ctnou A0nvv,
    2. Akt|vooy|k pyuctnp|o "Auko0" Nocokosou, 3. Iutp,
    4. Uovtutpo, 5. 8|oyo
    kon: Ui kdkosic ocn pdxidd snivsid cnc kpdc xsipc sv svdi
    ouxvsc. |id cnv dnokdcocdon couc uc, cdv ouov, xpsiscdi kdn
    yvon cnc dvdcoiknc cnc nspioxnc, iidcspd s cuv ndpddyv nou
    ouxv unpxouv oco dpcnpidk kcuo cnc nspioxnc, dv kdi n dyysuon
    cuv dkcuv yvscdi kupuc dn couc nddidouc kouc.
    |k sstn-Ms0oo: N sscn syivs oco spydocnpio cnc hspiypdiknc
    Avdcoiknc cou hdv. A0nvv kdc cd cssucdd scn.Jo uik dc dnocss-
    odv 90 ncdcd I180 vu kpdl dn cd xpnoionoiosvd yid cnv oknon
    cuv oicncv. kdc cn ipksid cnc scoidodc cou nnxn kdi cnc kpdc
    xsipc ndpdoksuds cnv kspkiikn kdi usvid dpcnpd, couc pdxidouc
    kdi couc soocsouc kouc. Gucoypdds, kdcdypds kdi csoc
    kdcdxupoods cd sosvd ocov nskcpovik unooyiocn yid vd s-
    yous cd ounspodc dc.
    Anotsscutu: Jd dnocssodc dc cd kdcdcds uc snc:
    1. Ui scdkpnisc dpcnpsc npospxovcdi dn co nou oxndcscdi dn
    dvdocuon cnc kspkiiknc s cn pdxiid soocsd dpcnpd I94/180l
    2. Ui pdxidsc scdkpnisc npospxovcdi dn co nou oxndcscdi dn
    dvdocuon cnc kspkiiknc s cnv usvid dpcnpd I10/180l
    3. Ui pdxidsc scdkpnisc npospxovcdi dn kspkio-usvio co oco onoo
    dvdocovscdi kdi n pdxidd soocsd dpcnpd I52/180l
    4. Ui pdxidsc scdkpnisc npospxovcdi dn co nou oxndcscdi vo
    dn cnv kspkiikn dpcnpd I12/180l
    5. Ui pdxidsc scdkpnisc npospxovcdi dn co nou oxndcscdi dn
    dvdocoosic cnc pdxiddc soocsdc s cnv usvid dpcnpd I8/180l
    6. sv unpxsi pdxido co I4/180l
    I194I
    ANA1UMU-Ak1INUAUIIkh MA1h 10N 8AIk0N IAIIAI0N
    1U 1AIkU IkOAAU
    Annu .A.
    1
    , Asovpou .A.
    2
    , ununouo N.
    1
    Iuvspyoznkdv o ldzpoikdoznc kdpdkoknc N. kdi oi oiznzsc:
    Ludyydivknc N., Pnyd M., Nziopd O., Mxdc I.
    4. Lpydoznpio spiypdiknc Avdzoiknc dvsnioznou A0nvov,
    2. Akzivooyik Lpydoznpio Adko' Noookosou
    Msscnods oco Lpydocnpio hspiypdiknc Avdcoiknc cou hdvsniocnou
    A0nvv cn opooyd cuv doikv ydyyuv cou syksou. U ocxoc
    dc sv ncdv vo n 0supncikn yvon cnc dvdcodc cou syksou, d
    kdi n svsxsvn xpnon cuv sosvuv dc yid ouykposic s cic oyxpo-
    vsc dnsikoviociksc s0ouc.
    Jo uik dc dnocssodv 60 niodpid dv0punvuv syksuv, dn 15
    vpsc kdi 15 yuvdksc. Jd niodpid sc co 0vdco kdi s kdcnn
    snsspydod iscnodv dv 20 os osc osiduv, sykdpouv kdi s-
    cuniduv cov kdi os dpi0 kdi os dnocdon, dv 5 xiiooc scd cuv
    sninsuv idconc s on cd snnsd dvdopc nou xpnoionoiov oi
    oyxpovsc dnsikoviociksc s0ooi, iuc n dyvncikn cooypdd. knoid
    dn cd ounspodcd dc ncdv cd dkou0d.
    U kspkopoc nupnvdc svdi o nounokcspoc os opooyd Iksdn,
    od, oupl kdi ocnv nopsd dn ouc. Anocunvscdi kupuc scd cuv
    osiduv sninsuv LA+5 suc LA+15, cuv sykdpouv LA uc LA+15 kdi cuv
    scuniduv LA-10 suc LA+20. Txsi syiocsc idocosic cnc ksdnc 34
    Iosido LA+10l X 23 Isykpoio LA+15l X 22,5 Iscunido LA+20l xiio-
    oc.
    U dkosinc nupnvdc, s onvosisc oxnd, dnocunvscdi kupuc scd
    cuv osiduv sninsuv LA+10 suc LA+20, cuv sykdpouv LA suc LA+10
    kdi cuv scuniduv LA+20. Txsi syiocsc idocosic 27,5 Iosido LA+15l
    X 39 Isykpoio LA+5l X 22,5 Iscunido LA+10l. Jo duydosisc o-
    nsyd dnocunvscdi kupuc scd cuv osiduv sninsuv LA+5 suc
    LA+20, cuv sykdpouv LA-10 suc LA-20 kdi cuv scuniduv LA suc LA+10.
    kdi ocd cpd snnsd idcov sxsi syioco nxoc ooiospc kudivs-
    vo dn 3,5-11 xiiooc.
    U cdiviosinc nupnvdc dnocunvscdi kupuc scd cuv osiduv snins-
    uv LA+20 kdi LA+25, cuv sykdpouv LA kdi LA+15 kdi cuv scuniduv LA
    kdi LA+20. Ui ksc idypovcdi odc vo ocic sykpoisc idcosc,
    ocd vu0sv cou sninsou dvdopc ILAl snnsd uc co LA+ 15. hspioocs-
    psc sncospsisc yid cn icdn cuv nupnvuv 0d ndpouoidocov.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    241
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I195I I196I
    ANA1UMIkh kAI AAAIUANO0UAUIIkh MA1h 1AOIk0N
    hMA10N AU 1I ANAkAO 1hN AA1IA kU12IA
    uvtun Ayys|kn, kup0u Avpsu
    kon tn spyucu: N kdcdypdn cuv oocv nou ps0nkdv os snc c-
    ouc kdc cic dvdokdsc ocnv ndcsd koci kdi n dv0punooyikn ss-
    cn ducv ocs vd npokouv nnpoopsc nou dopov co o kdi cnv
    nikd 0dvcou cuv dcuv ocouc onoouc dvnkdv oi okssco. Lninsov,
    snixsipscdi id skcnon cnc kdcocdonc cnc uysdc couc doiosvn os
    doiosic nou ndpdcnpovcdi oco okssc.
    |k ku| s0oo|: Jo dvdokdik uik diooyn0nks s on iio-
    ypdd dn id dvdcodc kdi oocsooydc, dv0punooydc kdi nd-
    diodv0punooydc. N spydod nspidvsi sncospsc ucoypdsc dn
    cd supndcd.
    Anotsscutu: idnioc0nks ci oi cdsc svdi uc sn co nsocov ovsc
    kdi xi odiksc kdi oi okssco dvnkouv os cod uv cuv nikiv kdi
    cuv o uv, dv kdi os opiosvouc couc cd iyooc supndcd snicps-
    nouv vo uno0sosic. o okssco ndpouoiouv no nd0ooyik
    ocoixsd nou snicpsnouv id dpn skcnon cnc kdcocdonc cnc uysdc
    cuv dcuv ducv.
    unspcutu: Ms dscnpd cnv skcsvn dvdcoikn sscn cuv cdikv
    supncuv kdi sou cuv sosvuv nou npoospsi n dv0punooyikn
    sscn ducv dn cic sv yu dvdokdsc npokncouv xpnoisc nnpoo-
    psc yid cic ouv0nksc iduonc kdi cnv uysd cou nddicspou nn0u-
    oo, sv kd0ocdcdi uvdcn n ndpdkoo0non cnc ssikciknc nopsdc
    do0svsiv ocnv nspioxn. Jducxpovd, n noypdikn dvuon cou nn-
    0uoo cuv dpxduv vskpocdsuv si nooid ocoixsd yid cic ouvn-
    0sisc kdi cic koivuviksc osc nponyosvuv snoxv.
    h IAh 1h A1U8A1A1INh 1A IA 1U UIkU U5U
    AONI M 01UAOh XUAh1UAAIMIA
    Mut0uou ., Xpnctn ., Mn|vn X., Mnupuktpn ., ssp|n k., |c M.
    hd0ooyikn kivikn cou hdvsniocnidko Noookosou |udvvvuv
    Msscsc ssidv ci cd dunsvd snnsd cou oupiko osoc dnocsov ndpyo-
    vcd kivvou yid cnv svion kdpidyysidknc voou. 0ocoo, oi nd0ouoiooyi-
    ko nxdvioo nou isnouv cn ouoxscion cou oupiko osoc s cn ocsdvidd voo
    sv sxouv nnpuc isukpivio0s. npxouv svssic ci n xopnynon dvciinidii-
    kv ndpdyvcuv, kdi iidcspd cnc divoinpcnc, sivsi cd snnsd cou oupi-
    ko osoc. Avc0scd, o dpi0c cuv sosvuv oxscik s cnv snpdon cuv ocd-
    civv ocd snnsd cou oupiko osoc svdi nspiopiosvoc.
    Ikonc cnc sscnc: H skznon znc snpdonc znc dzopfdozdzvnc ozd snnsd
    oupiko o(soc os do0svsc s npozond0n unspxonozspodid.
    ik kdi s0ooi: Msszn0nkdv 97 unspxonozspodiiko do0svsc I42 vzpsc
    kdi 55 yuvdkscI nikdc 5B,2B,4 szov. Is d zd zod znc ssznc npooiop-
    oznkdv oi inidiiksc kdi oi szdfoiksc ndpszpoi zou opo npiv, kdi 6 kdi 42
    sfosc sz znv xopnynon dzopfdozdzvnc I40 mg nspnoocI. Lninpo0szd,
    os syd opov npooiopoznkdv oi kdodziksc dnskkposic zou vdzpou kdi zou
    oupiko o(soc.
    Anocssodcd: Td snnsd zou oupiko o(soc ouoxszovzdv 0szik s zd snnsd
    znc ivoouvnc kdi zov zpiyukspiov, kdi dpvnzik s zic zisc znc kdodziknc
    dnskkpionc zou oupiko o(soc IFLUAI. H xopnynon znc dzopfdozdzvnc fszoos
    zic zisc zov iniov zou opo, soos ondvzik zd snnsd zd oupiko o(soc, kdi
    sxs oc dnozssod znv d(non zov kdodzikov dnskkposov zou vdzpou kdi zou
    oupiko InvdkdcI.
    hvdkdc
    upstpo| p|v tn 6 s. 12 s. st tn
    0spunsu st tn 0spunsu 0spunsu
    1C 303.156.9 187.944.7 190.145.1 <0.0001
    Img/dLI
    LDL-C 221.753.3 119.740.7 117.339.8 <0.0001
    Img/dLI
    1U 168.379.3 121.257.4 117.057.2 <0.0001
    Img/dLI
    PDL-C 47.812.4 46.810.6 49.520.8 NS
    Img/dLI
    Ivcouvn 9.55.4 10.15.6 10.35.4 NS
    PUMA 2.92.5 3.12.2 3.12.4 NS
    Uup|k o0 5.31.6 4.91.4 4.81.4 <0.0001
    Img/dLI
    F0A I7I 10.67.7 12.17.5 11.75.2 0.01
    FNa I7I 1.10.6 1.51.4 1.40.7 0.01
    sv ndpdznpn0nks ouoxszion szd( zov szdfoov zou sninsou oupiko o(soc
    kdi zov szdfoov zov ziov zov inidiikov ndpdszpov sz zn 0spdnsd.Iu-
    nspdod: H xopnynon dzopfdozdzvnc os unn on fsziovsi zo inidiik
    npo, kdi npokds ondvzikn soon zov sninsov zou oupiko o(soc du(vo-
    vzdc znv dnskkpion zou. Auzn n iiznzd znc dzopfdozdzvnc svdi iidzspd ond-
    vzikn yid znv npnn znc kdpidyysidknc voou.
    I197I
    NANU1XNUAUIIA: U1AN h kAAIkh IA1Ikh AN11AI
    M 1hN 1XNUAUIIA, 1A AU1AMA1A IAOUN I1UIA
    Ot|n uvuy|tn
    1
    , kuo0n svn
    2
    4. Ooiznznc ldzpiknc A' szouc, 2. Lnkoupoc kd0nynzpid Ouoiknc ldzpiknc
    Ansikvionc . Tns - ldzpiknc
    nokpzsio dvsnioznio 6pknc
    kon: Ikonc cnc spydodc ducnc svdi vd sioysi cov oicncn / kd0nyn-
    cn cnc |dcpiknc Ikdi xi vol ocnv Nvo-Lniocnn, svd oosvd dvdncuo-
    osvo nso spsuvdc ocnv Xnsd, cnv Guoikn kdi cnv 8iooyd s snd-
    vdocdciksc sdpoysc os vssc csxvooysc. Lnonc, 0d o0s iidcspn s-
    don oov dop ocic ni0dvsc sdpoysc ocov ko cnc |dcpiknc kd0c
    kdi ocd n0ik indcd sv kdi cdv npokncouv dn ducsc.
    |k ku| s0oo|: |id cnv spydod ducn dvcscdi uik dn cd sydcs-
    pd ndvsniocnid cou koou nou doxoovcdi spsuvncik s co 0sd,
    kd0c kdi dn ipdcd/opydviooc nou unpxouv dnoksiocik yid
    ducv cov okon, nuc co NN| INationa| Nanotechno|ogy |nitiativel, nuc
    snonc id, nspioik, p0pd kdi spsuvsc sykpicuv sniocnvuv dv
    cov koo nou doxoovcdi s cnv vdvocsxvooyd, sv n spydod ducn
    dnocss kupuc kpicikn dvdoknnon os svd ysvikcspo ndoio.
    Anotsscutu: Lvdi nsov odsc ci unpxsi id is0vnc kivncononon
    kdi svd ouvsxc dudvsvo kdi scdkivosvo svidspov cnc sniocno-
    viknc koivcncdc npoc cic kdcsu0vosic nou unosikvsi n Ndvocsxvooyd.
    Av kdi dpksc ocoixsd nou ouv0scouv cnv kdivopyid ducn Lniocnn svdi
    dkd n-uonoinoid, ndp' d duc co 0supncik und0po unpxsi
    kdi iddvscdi ci svdi nsov 0sd xpvou yid cnv npdydcononon couc.
    unspcutu: Ui sssic npoxupov s nd cdx kdi o onspivc yid-
    cpc d kdi ysvikcspd o onspivc v0punoc 0d npsnsi vd ouvsinco-
    noinosi cnv ondvcikcncd cnc Nvo-Lniocnnc kdi cic ddysc nou ducn
    spvsi, scdovcdc ondvcik cov cpno kdi cnv noicncd cnc unc
    dc. Jo viod duc uc sxsi o sic kdi 0d npsnsi vd ouvunooyi-
    ocov sc oi ndpscpoi, kci nou kd0ioc snicdkcikn cnv dvykn yid
    ouvsxn sndypnvnon ocs vd dnosux0ov svspysisc nou 0d npoo-
    ouv cov noicio kdi cic dsc idc ss0spnc kdi nokpdciknc dv0p-
    nivnc unc.
    242
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I198I
    8AXXUNI I10I 10N kA1AIMA10N IXIU
    1hN UIU1h1A 20h 10N AON0N
    kukuskn kvctuvtvo, 1c|yo0n tu|uv, 8upkn Xpucv0n,
    1|opu kv/vo
    Iuvspyoznkdv: kdpzoovkn Mdpd, Mixdkn Nkn, Avpoukn Zdxdpsvid
    ldzpikn Ixon dvsnioznou kpnznc 8 Tnd Noonsuziknc TLl kpnznc
    kon: U okonc cnc ndpoodc sscnc svdi n kdcdypdn, n dvuon
    kdi n dioynon cuv ouv0nkv iduonc, cuv unnpsoiv povcdc kdi
    cou npoypdcoc dnokdcocdonc nou cuyxvouv oi do0svsc s kcdy-
    d ocnv nspioxn cou ioxou, sc cnv so couc dn co voookoso d
    snonc kdi n unsin s0uv scuonc cnc kdc' okov povcdc.
    n0uc sstn ku| s0oo|: Msscnods dvdpoik dn cd dpxsd
    cnc Up0ondiiknc kiviknc cou hd.|.N.Npdksou 40 do0svsc I.o. nikdc
    75,8 scnl, nou co npco 6nvo cou 2001 unsocnodv kcdyd xdnnc svsp-
    ysidc ocnv nspioxn cou ioxou. N spsuvd npdydconoin0nks sou ouvs-
    vcsunc kdi ounnpuonc okidosvou spucndcooyou, co onoo kd-
    csypds ouv0nksc kdi dvyksc iduonc npiv kdi sc co kcdyd nuc
    kdi snincosic ocnv noicncd unc Ixpnoionoin0nks n kdkd SF-36l,
    sv snonc syivs dioynon cuv do0svv os pdocnpicncsc cnc kd0ns-
    pivnc unc s on cnv kdkd 8arthe|. hdpnd, npdydconoin0nks
    ouocndcikn dvdoknnon cnc iioypddc npoksisvou vd ouvoiocov
    csknpiusvd scpd ndpsdonc ocnv nopsd dnokdcocdonc nou d-
    vsi xpd ocd ndoid cnc koivcncdc.
    Anotsscutu - unspcutu: Jo kcdyd cou ioxou svdi ni0dvc n
    nio pddcikn ouvsnsid cnc oocsonpuonc kd0c oxscscdi s ondvcikn
    0vnoicncd - cnc cnc cou 5 s 207 - kdi voonpcncd nou ouvn0uc npo-
    kds uno kocouc voonsd kdi dkpoxpvid dnokdcocdon n onod
    snnpssi oodp cic uoiksc kdi uxooyiksc sicoupysc d kdi cnv
    koivuvikn un cou do0svn. Avdsikvovcdi oi sysc kdi nonsupsc
    dvyksc cuv do0svv s kcdyd cou ioxou kdi co dvsndpksc npypdd
    dno0spdnsdc nou dkoou0ov, sv covscdi n okonicncd ouoidocik-
    cspnc ndpsdonc cuv sv cnc isniocnoviknc odc uysdc nou sp-
    yovcdi ocnv hpuco0id kdi sucspo0id Gpovcd ysdc.
    I199I
    IUAh kkIIkh A1hIA kOUMNh AU 1h 8AXIUNIA A1hIA.
    hMA 10MA. M8UAUIIkh ANA15h kAI kAINIkh hMAIA
    Ntcn k., upucksu I., 1tn 1., Iupyuvn A., on I., 1c|kpu .
    Lpydoznpio spiypdiknc Avdzoiknc, ldzpik Tnd A6
    kdc cn ipksid cuv dvdcov nou isvspyovcdi oco Avdcoso cou |d-
    cpiko Jndcoc cou Ah6 ocd ndoid cnc idokddc cnc Avdcoiknc
    ocouc oicncsc |dcpiknc kdi Uovcidcpiknc ndpdcnpnods oco dpiocsp
    vu kpo ncdcoc yuvdkdc 77 scv cnv ndpouod idc sninonc kspkii-
    knc dpcnpdc nou skucdv dn cn pdxivid dpcnpd 2.5 cm nspnou xd-
    ncspd cou csvovcd cou ndc pdxidou uc kdi nopsusvn uc snino-
    nc pdxivid dpcnpd dpxik sn cd svcc kdi dkoo0uc sninonc kdi sni
    cd skcc cou soou vspou xopnyoos nodn uk kuvd oco iks-
    do pdxivio u. Icn ouvsxsid n dpcnpd spcdv ocov nnxn sninonc
    cnc usvidc dnovspuonc cou iksou kdi scd cou kspkiiko kd-
    ncnpd cou kdpno kdi cou pdxiovokskpiiko uc yid vd scdnsosi
    ocnv kspkiikn dpcnpd Isninonc kspkiikn dpcnpdl.
    N sninonc kspkiikn dpcnpd dvsupokscdi os nooooc 14.277 nooooc
    kdc no uncspo ouykpicik s sksvo cnc sninonc usvidc dpcn-
    pdc nou dvspxscdi os 2.267. kdc cnv spukn indon cuv dpcnpiv cou vu
    kpou oxndcscdi dpxik svd "dovik oocnd" dn co onoo dkoo0uc id-
    nooovcdi oi unoinsc dpcnpsc. Ico cssucdo ocio cnc indonc cuv dpcn-
    piv isvspyscdi dvdocuon scd cnc pdxividc kdi cnc sninonc pdxividc
    dpcnpdc s "dnoppnon" cou ksvcpko cndcoc cnc cssucddc dpcnpdc on-
    cs kdi oxndcscdi n kspkiikn dpcnpd. Icnv nspncuon dc ouvcssocnks ndpd-
    ovn cou ksvcpiko cndcoc cnc sninonc pdxividc dpcnpdc kdi "dnoppn-
    on" cou dvdocouciko kou scd pdxividc kdi sninonc pdxividc dpcn-
    pdc. Auc 0d nopoos vd dnoo0s ocnv "diouvdikn snikpcnon" cou snino-
    nc dpcnpidko ouocndcoc sn cou sv cu 0si ouocndcoc. Auc nops vd os-
    scdi: 1. os ysvscikoc ndpyovcsc, 2. ocn 0son cou spou ocn ncpd, 3. ocic
    npcsc kivnosic cou vu kpou kdi 4. os douvn0n dvncun cou uko ouocnd-
    coc cou vu kpou.
    N yvon cnc ndpouoidsvnc ndpddync svidspsi co xsipoupy kdi ysvik-
    cspd cov kivik idcp yidc n dpcnpd ducn: 1. svdi nspioocspo suucn os
    cpdudciooc, 2. nops vd npokdsosi npondcd kdc cov kd0scnpido
    cnc pdxividc dpcnpdc, 3. nops dv0dosvd vd skn0s uc unopid sd
    oncs unpxsi o kvuvoc svdpcnpidknc syxuonc, 4. nops vd nioupynosi
    npondcd kdc cnv dioynon dyysioypdiv kdi 5. nops vd nioupynosi
    npondcd kdc cn nn uospdcikv kpnvv cou dvcipdxou.
    I201I
    XIAMU MIA hIA 1hAA1Ikh, kAI IkkIMNA
    1hATXIA1Ikh, M1A5 NU IOIkU kN1U IIA
    I01U8AOMIA OUN1IAI kAI MIA kN1Ikh TXIA1Ikh kAINIkh
    I1I1U8AOMIA OUN1IA IIAI
    kkkun tsuvu, Mnukono0ou ou
    kon: N skcnon kdi ndpouodon cou ouvou cuv 0scuv nou do-
    pov cnv puon kdi sicoupyd idc nnpsodc Jnsuxidcpiknc, sou cnc
    onodc 0d ndpsxscdi uxidcpikn ocnpin os hspispik ksvcpo ysdc dn
    ksvcpikn +uxidcpikn kivikn.
    |k ku| s0oo: Msscn0nks vscspn iioypdd dn svd sniocn-
    ovik nspioik, iioypdd s cpsxovcd sosvd dn cnv snsipd
    ocnv Ld, uik dn oxsciksc s Jnsdcpikn nnysc cou idikcou kdi
    iixsipsc onsiosic kd0nyncn. 0c spydso xpnoionoin0nks co Ivoo
    Lpucnosuv NLPMLS.
    Anotsscutu: U oxsidoc sou cuv spucnosuv NLPMLS kdi n supsd
    ioon cuv unnpsoiv Jnsdcpiknc doscdi ocnv uio0scnon npocnuv
    noicncdc nou sdodouv cn oudccncd coo oco csxvik oo kdi
    oco idcpik oksoc cnc unnpsodc. Tcoi, npoosyyocnkdv oi oi ndpyo-
    vcsc nou snskovcdi oco oxsido, kdcdoksun, sdpoyn kdi sicoup-
    yd cnc unnpsodc, ocs ducn vd svdi supsdc dnooxnc.
    unspcutu: N nioupyd Jnsuxidcpikv Movuv ocn xpd dc
    svdi dndpdcncn, do unpxsi idpkc dudvsvn ncnon uxicpou
    sou ikcou cnsdcpiknc. N Jnsuxidcpikn ouvcss ocn odn scuon
    cnc noudpdkdc kdi ocn ouocn xpnon dpkuv dn couc uxik noxo-
    vcsc, ocnv dnon cnc dioniocdc cuv do0svv kdi ocnv dnooxn cuv
    ndpsxsvuv unnpsoiv ocnv nspispsid, ocn sciocononon cuv idyvu-
    ocikv kdi 0spdnsucikv xsipiov cuv ysvikv kdi dypocikv idcpv oov
    dop cnv uxidcpikn povcd, ocn uvdccncd svnspuonc cuv idcpv
    cnc nspispsidc kdi ocn ouvsxisvn idcpikn kdi voonsucikn skndsuon.
    I200I
    UIkUI kh0 kAI IOANh 1U Xh M 1U OAU 1U M8U
    koukkou Osopu, Osopso uvuy|tn
    Ikonc cnc spydodc svdi vd ndpouoiosi sninpo0scsc nnpoopsc oxscik s
    cnv svion ykuv kunosuc ocn ocodcikn koicncd kdi vd sscosi cnv ni0dvn
    couc oxson s co o cou spou.
    Ui ykoi kunosuc svdi sovusvoi ykoi, oi onooi s 0d npsnsi vd ouyxsovcdi s
    co nuoyvo kokkud n cnv yiydvcokuccdpikn snoud, dv kdi sdvouv iocoo-
    yiksc ooicncsc. N idop couc syksicdi oco ysyovc yi oi ykoi knonc sivo-
    vcdi os sys0oc n dkd sddvovcdi xupc 0spdnsd sc cov coksc.
    Ldvovcdi ouxvcspd cov cpco s cscdpco nvd kunosuc. Lvdi dvuvo, okou-
    pcspou xpdcoc dn couc ysicovikoc iococ ykoi, cuv onouv n snivsid
    svdi ouxv sskusvn kdi spiksc opsc dioppdys. Iuxvcspd svconovcdi ocd
    od kdi os opiosvsc nspincosic ocn yood, ocnv unspd, oco svvoyvo kdi
    ocd xsn.
    Ldvovcdi os ouxvcncd 0,2 s 2,7 coic skdc. Upiosvsc spsuvsc dvdspouv
    ci oi yuvdksc s snousc kunosuc nio ouxv ysvvov dypid. Jo ysyovc duc
    osscdi os opvsc oi onosc nspvov ocn ncspd id soou cnc ndkouvcidknc
    snikoivuvdc.
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    243
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I202I
    NU1A UMNA IIA 1A Dk0U-L01INU-S1N1S
    tnvono0ou A., kup|ukou 8., Ntuuncxu M., Muvnouo .I.
    Lpydoznpio Odpdkooydc, ldzpikn Ixon, nokpzsio dvsnioznio 6pknc
    kon: Tvd ondvcik npnd cnc snsdciknc kdpiooydc nou sv sxsi
    dkd dvciscuniocs ikdvonoincik dop cnv sndvdocsvuon sc dn cnv
    cono0scnon cuv dyysidkv vdp0nkuv Istentsl s ocsdvidd dyysiondocikn.
    hpodcd, sxsi npocd0s ci n sndvdocsvuon ducn 0d nopoos vd dvciscu-
    niocs s cn xpnon stents nou sxouv snociocs s pdkd Idrug-e|uting-stentsl.
    N ndpouodon cuv vscspuv sosvuv dn kiviksc sscsc oxscik s duc
    co 0sd svdi o okonc ducnc cnc spydodc.
    |k ku| s0oo: Avdoknnon nooisosuv oco Med|ine kd0c kdi uv nnyv
    oco idkcuo.
    Anotsscutu: Ui kupicspsc ouosc nou sxouv xpnoionoin0s yid cov snocio
    cuv stents svdi co xnsio0spdnsucik ndkicdsn, co dvoookdcdocdcik pdnd-
    ukvn kdi n sds0dvn. Mid osip dn kiviksc sscsc ocic onosc diooyo-
    vcdi cd pdkd duc uc npoc cn dpdkokivncikn, cnv dosid kdi cnv kivikn
    couc dnocssodcikcncd pokovcdi os ssin scs sxouv nn ooknpu0s os
    Lupnn, Aspikn kdi |dnuvd. Icic sscsc ducsc nspidvovcdi oi: SJP|DL, JA-
    XuS |-|v, LLuJLS, ASPLCJ, DLL|vLP, PAvLL, S|P|uS, ACJ|UN, Lv|DLNJ. Lvsikcik
    dvdspovcdi cd snc supndcd: dl n PAvLL ssis ci stents snociosvd s pdnd-
    ukvn svidv 07 sndvdocsvuon svd xpvo sc cnv cono0scnon couc, l n
    JAXuS | ssis ci stents snociosvd s ndkicdsn svidv snonc 07 sndvd-
    ocsvuon svd xpvo sc cnv cono0scnon couc, yl n SJP|DL ssis ci stents sno-
    ciosvd s sds0dvn svidv no xdn nooooc sndvdocsvuonc I13,37l
    6 nvsc sc cnv cono0scnon couc.
    unspucu: An cd ndpdnvu sosvd npokncsi ci n xpnoiononon
    cuv drug-e|uting-stents svdi iidcspd snusnc ocnv snsdcikn 0spd-
    nsd kdi ni0dvv 0d oouv opiocikn on oco npnd cnc sndvdocs-
    vuonc sc dn dyysiondocikn ndpsdon.
    I203I
    A5hMNh kAI ANOk1Ikh AAN1hh OAIA
    M ANANAMNh ANO0INh OUUIh1INh, AON0N
    M ANAIMIA kAI MAUAA1IkU NUMU IMDSI
    Mnoupuvt ., sccx h., kuunkn 8., Aupu 8., X|o A.,
    Mnoupuvt k.A.
    Aidzooyikn kivikn, ldzpikn Ixon, dvsnioznio lodvvvov
    kon: N skcnon cnc snpdonc nou doks n dvdouvudosvn dv0pnivn spu-
    0ponoincvn ocd snnsd cnc dioodipvnc os dvdiikoc do0svsc s MDS.
    Ac0svs-Ms0oo|: Msscnods 47 do0svsc s dvdid kdi MDS. I29 vpsc kdi
    18 yuvdksc nou idyvo0nkdv kdi unon0nkdv os 0spdnsucikn dyuyn ocnv ki-
    vikn dc cd cssucdd 4 xpvidl. 32 dn ducoc sxdv dv0skcikn dvdid IPAl, 4
    sxdv dv0skcikn dvdid s dkcuiosisc spu0poocsc IPAPSl, 2 sxdv dv0skci-
    kn dvdid s nspoosid docv IPAL8l,7 sxdv dv0skcikn dvdid s nspoosid
    docv os sddyn IPAL8-tl, kdi 2 sxdv xpvid usoovokuccdpikn suxdid
    ICMMLl. N son cin cnc Nb nou sxdv oi duco oi do0svsc, npo cnc xopnynonc
    LPU ncdv 10,2 gr/d| ILpoc: 7,6 uc 12 gr/d|l. LPU xopnyn0nks svosuc os
    osic cuv 150 u/kg x 3 opsc/od kdi n dnvcnon cuv sninsuv cnc Nb
    skcin0nks sc dn 12 sosc kdi dv sc dn 6 nvsc dn cnv svdpn cnc
    0spdnsdc. 0c syiocn dnvcnon ocn 0spdnsd opocnks k0s dnon cnc cinc cnc
    Nb sydcspn n on cuv 2 gr/d|, sv uc sxiocn dnvcnon ocn 0spdnsd opocn-
    ks k0s dnon cnc cinc cnc Nb couxiocov kdc 1 gr/d|.
    Anotsscutu: Ms on cd ndpdnvu kpicnpid nou opocnkdv, 32 do0svsc I687l
    dnvcnodv ocn 0spdnsd s LPU. An ducoc, 19 do0svsc I40,47l dnvcnodv
    ondvcik ocn 0spdnsd kdi 13 do0svsc I27,67l dnvcnodv sxiocd. Ui unoi-
    noi 15 do0svsc I327l sv dnvcnodv kd0ou ocn 0spdnsd. Lnonc, dn couc 19
    do0svsc nou dnvcnodv ondvcik ocn 0spdnsd, 18 sxdv PA kdi 1 sxs PAPS. An
    couc 13 do0svsc nou dnvcnodv sxiocd ocn 0spdnsd, 6 sxdv PA, 3 sxdv PAPS,
    1 sxs PAL8 kdi 3 sxdv PAL8-t. Dcdv 6 nvsc sc dn cnv svdpn cnc 0spdnsdc
    dvdsscn0nkdv oi cisc cnc Nb, ndpdcnpn0nks nuc ducsc ndpssivdv isc n
    sdpc dunsvsc os 17 do0svsc dn couc 32 nou dnvcnodv ocn 0spdnsd
    I537l. Ui unoinoi do0svsc, xpsio0nks vd couc xopnyn0s LPU os sydcspsc
    osic cnc cnc cuv 150 u/kg x 4-6 opsc/od.
    unspcutu: Ms on cd ndpdnvu sosvd, ocn 0spdnsd s dvdouvudosvn
    dv0pnivn spu0ponoincvn do0svv s dvdid kdi MDS, vnks nuc 687 cuv do0s-
    vv dnvcnodv ocn 0spdnsd kdi 537 cuv do0svv sxdv idpkn dnvcnon o'ducnv.
    I204I
    IN1Ikh AhOMIAkh IAIA AN0 1A MA1UIAOIkA
    uyypus - psuvnts: uI A|cku Mup|v0n I 1cupoux svn
    N nn0uoidkn spsuvd dnookons s cnv oykpion ysvscikv xdpdkcnpiocikv nou
    nioupyov co dv0pnivo divcuno, ocnv dnsin cnc ysvsciknc snikoivuvdc
    kdi ocnv dvdncnon ouyysvikv oxsosuv scd nn0uov s ovd cnv ysu-
    ypdikn kdcdvon couc. N ndpood spsuvd sscsi co oocnd cuv spdcoyu-
    ikv s cn on0sid cuv sniocnv, cnc ysvsciknc, cnc uoiknc dv0punooydc kdi
    cnc dv0punoysuypddc.
    N spsuvd npdydconoin0nks ocd ndoid cou d0ndcoc "Guoikn Av0punooyd"
    os id od 250 dcuv, oicncv cnc |dcpiknc Ixonc A0nvv, cuv onouv cd
    dkcuik dnocundcd ousx0nkdv kdi sscn0nkdv s nocn ocn iddn
    cuv npoounikv sosvuv. kdcniv syivs cducononon ouvd s couc doi-
    koc spdcoyuikoc cnouc kdi oykpion uc npoc cn ysuypdikn kdcdvon:
    Icnv nn0uoidkn spsuvd iidcspo svidspov ndpouoisi n kdcdvon cuv 250
    dcuv s kdcdyuyn dn cn 8psid, ksvcpikn kdi Ncid Ld. Jd dnocssodcd
    ndpdc0svcdi ocov ndpdkcu nvdkd:
    XNU1h1A 8AIk0N 10N 10N MA1UIAOIk0N 10N Ak1A0N
    hLP|IJPUG|kUI kUAhUL|NI JU5UL|NI
    JhUI 7 JhUI 7 JhUI 7
    8UPL|A LAAAA 44,44 48,88 6,66
    kLNJP|kN LAAAA 50,00 43,00 7,00
    NUJ|A LAAAA 33,18 59,09 7,72
    INUAU 39,75 52,92 7,31
    hdpdcnpscdi dunsvn ouxvcncd cou nspiocpoiko cnou ocnv ksvcpikn L-
    d, cou konosioc ocn Ncid Ld kdi d oxscikn dnon cou coosioc
    kd0c kivodocs dn cn 8psi npoc cn Ncid Ld
    6supn0nks oknio vd yvsi oykpion cnc odc cuv oicncv dn cn Ncid
    Ld s cnv spsuvd ocov nn0uo cnc hsonovvnoou cou kd0nyncn Guoiknc
    Av0punooydc cou L.k.h.A. k. 6. k. hcoiou kdi os ouvspydod s cov npodvdsp-
    0svcd kd0nyncn. N oykpion syivs s on cn ocdciocikn okidod X
    2
    oncs kdi
    idnioc0nks n sykupcncd cuv dnocssocuv cncsscnc.
    Lndyuyik oksncsvoi kdcdnyous oco ounspdod nuc oi iopoi cnoi cuv
    spdcoyuikv noikouv dvoyd s cn ysuypdikn couc npossuon dvcikd-
    concpovcdc cnv noikicncd cuv ysvscikv cnuv. Jo ysyovc duc isukovsi
    cnv cdivnon cuv dv0pnuv os unonn0uooc yid cnv siikcspn kdi dnocs-
    sodcikcspn sscn couc .
    I205I
    U1hI5h IIXIh1Ik0N AUOA0N kA1A 1hN kAIUANAIOhIA M
    1h Xhh 1U IOAMA1IkU Ik1h.
    8spyou|ou M.
    1
    , utpu .
    1
    , Aptsn .
    1
    , kup|ukou 8.
    1
    , 1spcsvou A.
    2
    ,
    Ospn .
    2
    , 8pstkn I.
    2
    4: Ooiznzsc ldzpiknc ..6 2: kdpiodvdio0noiooyikn 0d I..N. As(dvpononc
    U idodcikc skcnc I8|Sl dnocss ndpscpo nou nooocikonois co 0oc
    nvuonc. N sscn oxsiocnks yid vd npooiopiocs n snpdon cou 8|S ocn id-
    ikdod nnc dnoosuv kdi ocouc dvdio0noiooyikoc xsipiooc kdc cnv
    kdpiodvdio0nod.
    Is 68 do0svsc Idopcoocsdvidd ndpkdn 47, dvcikdcocdon ddc 17,
    ndpkdn + dd 4l, xupiosvouc cuxdd os 2 osc, kdcdypnks nd-
    pno iypdd dvdio0nodc dn ndpdcnpncn nou sxs idpkn npodon ocnv
    cin 8|S. Icnv npcn od In32l o uns0uvoc dvdio0noioyoc sv sxs kdd
    svnspuon yid cnv cin 8|S. Icn scspn In36l o ndpdcnpncnc sxs uvdccncd
    vd svnspvsi cov uns0uvo dvdio0noioyo yid cnv cin 8|S, cdv skpivs xpnoi-
    o. Jo dvdio0ncik oxnd kdi co monitoring ncdv id. Avd0nkdv oi kdcdvosc
    8|S, o dpi0c svnsposuv yid cnv cin cou kdi oi svspysisc nou nposkudv. Icd-
    ciocikn dvuon: two-tai|ed/t-test.
    Jd oudcoscpik, unokssvn nd0ooyd kdi xpvoc dopciko dnoksioo sv
    isspdv ocic 2 osc. Icnv A, n cin 8|S 0supn0nks xpnoin dn cov ndpdcnpncn
    os 154 nspincosic I4,81 1,57/ do0svnl. Icnv 8 o uns0uvoc dvdio0noioyoc
    svnsp0nks yid co 8|S os 117 nspincosic I3,251,31/ do0svn, p3.34 L-0,5l. Is
    92 cuv ndpdnvu I78,67l sn0nodv scpd nuc : cicononon cuv dvdio0nci-
    kv I70,67l cuv dyysipdocikv I7,67l, kdi cuv o I11,97l, n d scpd I9,77l.
    N kdcdvosc 8|S IA37,34 10,20 8 37,2 10,0 p0,959l kdi oi kdcdvosc 8|S/
    2enith 8|S/ Nadir sv isspdv ocdciocik Ip0.599 kdi p0,581l. U xpvoc dno-
    idounvuonc ncdv dvoyoc kdi ocic o osc.
    Jo ysyovc ci n nnpoopd 8|S ocn 8 onynos os scpd kdi sccuos cn ouxv-
    cncd nou 0supn0nks usin dnosikvsi cn xpnoicnc cou. 0ocoo, yid sii-
    koc youc kdi nuc dvscdi dn cic ouvoiksc kdcdvosc ocic o osc, -
    okod unoocnpscdi ci n xpnon cou 8|S svdi dndpdcncn ocic snsosic ducsc.
    244
    9
    U
    Lh|IJNMUN|kU INLP|U GU|JNJ0N |AJP|kNI LAAAAI
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I206I
    8IUAIMUUAUIIkUI Ik1 IA1UIX0MA1IkU U5 MOAIMA MUkA-
    IU: UIN01Ikh A5IA IIA 1hN MOANIh kAIAIIIAk0N IUI0N
    stpo kku , svn Xutnv|koou-kotckou, nntp|o I. Xutcspu
    dvsnioznidkn kdpiooyikn kivikn ..6., . . I. N. As(dvpononc
    |cuyyn: hponyosvsc sscsc dnssidv iopsc dioppsooyiksc idcdpd-
    xsc os sniiodvcsc dn o spdyd uokdpou IULMl . hvcuc sv sxsi cskn-
    piu0s dkn, cuxv ouoxscion scd ducv cuv idcdpdxv kdi cnc kiviknc
    skdonc ducv cuv do0svv.
    kon: Ikonc ducnc cnc sscnc ncdv vd skcinosi cn ouoxscion, os sniiod-
    vcsc dn idcoixudcik ULM, scd iodioppsooyikv ndpdscpuv kdi cnc
    kdnnc svionc kdpidyysidkv snsioouv IkALl kdc cnv ipksid ndpdko-
    o0nonc 30 nvv.
    Ms0oo: Uyvcd do0svsc I 55 vpsc l , sonc nikdc 57 14 scn, sniiod-
    vcsc dn idcoixudcik ULM I 45 npo0io kdi 35 kdccspol ndpdkoou0n0nkdv
    yid 30 nvsc. kdcdypcnkdv cd dkou0d kAL: kdpidyysidkc 0vdcoc, ULM,
    docd0nc ocn0yxn, ALL, 0poosoik snsioid. Ui dkou0oi iodioppso-
    oyiko skcsc unooyocnkdv kdc cnv soo dn co Noookoso: ivuoyvo,
    dnucoc dpi0c sukv dioodipuv IAAl, cd snnsd cnc npucsvnc C, n son
    kdcdvon cuv spu0pv dioodipuv I MkLAl .
    tut|ct|kn Avucn: Xpnoionoin0nks co t-test, oi kdnsc sniuonc kdc ka-
    p|an-Meier, kdi n ocdidkn spcnon cou Cox.
    Anotsscutu: 1l Ao0svsc nou sxdv svd couxiocov kAL In24l kdc cnv ip-
    ksid cnc ndpdkoo0nonc cuv 30 nvv, sxdv sydcspo dnuco dpi0 AA,
    Ip<0.01l, xdncspn cin npucsvnc C, Ip<0.01l, kdi xdncspn MkLA Ip<0.01l.
    2lAo0svsc s dpi0 AA > 507 cnc .c sxdv 7 opsc sydcspo kvuvo kAL
    Ip<0.01l.
    3l Ao0svsc s npucsvn C<507 cnc .cl sxdv 8 opsc sydcspo kvuvo kAL,
    sv do0svsc s snnsd>757 sv sxdv kAL Ip<0.01l.
    4l |id cnv MkLA >14.5 ncdv pio idxupioo do0svv s 6 opsc ikpcspo
    kvuvo svionc kAL Ip<0.04l.
    5l houndpdyovcikn dvuon dnssis cov dnuco dpi0 cuv AA kdi cnv cin
    cnc npucsvnc C dvspcncouc npoyvuocikoc skcsc kAL. Ip<0.05l.
    unspcutu: Icnv od cuv do0svv s idcoixudcik ULM nou sscnods
    kdcdsxcnks ouoxscion scd iodioppsooyikv sikcv kdi cnc kdnnc
    svionc kAL kdc cnv ndpdkoo0non cuv 30 nvv.
    I208I
    M8UAIAMUI 1U OUI1h1 IA1Ikh
    1cpnu Ivvu, unyku Ivvn, uvuyono0ou uvuyo0u, tuupnou-
    o n0po, 1c|nu Mupu, Avtvou 8uc||kn, oto nyu, Mnuuo0-
    ko uvuy|tn, kokkpn 2n, ksscn Icn, ksscn Ospo,
    1puxuv kctu, Mno0ku kutspvu.
    Ui soidoo svdi svd dn cd ondvcikcspd snicsydcd cnc iodcpiknc spsu-
    vdc kdi csxvooydc kdi kdcsxouv nposxouod 0son scd cuv scpuv yid cnv
    npoocdod cnc noidc uysdc. hpoocdcsouv co soidsvo coo dn cn
    uvncikn dvncun oiuv vooncuv, ndpsxovcdc cou dcoikn dvood, kdi
    sivouv cn idonop cuv oisuv ocnv supcspn koivcncd s co nxdvio
    cnc ouoyiknc dvoodc.
    Jd sid svdi siiko dvooonoinciko ndpyovcsc Idvciyvdl, nou xupc n
    s sxiocsc dvsni0ncsc svspysisc, npokdov svspyncikn dvooononon isys-
    pouv, ndn, couc duvcikoc nxdviooc cou opydvioo Ixuikn kdi kuccdpi-
    kn dvoodl s dnocssod cnv ndpdyuyn dvcioucuv, nou dc npouooouv
    oik n spik, vid n ndpoik, dn cic do0svsisc nou npokdov oi dvcocoixoi
    nd0oyvoi ndpyovcsc.
    6LMA-IJUXUI JNI LPLNAI
    N ndpood spsuvd sds xpd cov |ovio cou 2002 os dvcinpoounsucik syd
    105 oicncv kdi sxs uc 0sd cnv kdcdypdn cuv soidov cuv oicncv cnc
    |dcpiknc Ixonc A0nvv.
    Icxoc cnc spsuvdc ncdv n sscn cnc soidociknc kunc cuv oicncv kdi n
    nn xpnoiuv nnpoopiv, oov dop ocn isvspysid soidov ou-
    vd s co ouviocsvo oxnd soidoo ocn xpd dc.
    Jd dnocssodcd nou nposkudv dn cnv spydod ncdv cd snc :
    1. nn kun yid couc cnouc souv ndiiknc nikdc kdi xdncspn yid
    couc cnouc s dvdvnocikn on n kdc cnv snsd kdi cnv svnikuon.
    2. Lvnspuon os 0sdcd soidov 1007
    Iuvsnc cd ounspodcd nou nposkudv dn cnv spydod dopoodv oco un-
    snnso svnspuonc cuv oicncv |dcpiknc A0nvdc, oco un snnso ku-
    nc yid couc cnouc souv cnc ndiiknc nikdc kdi oco xdncsspo snnso
    kunc yid couc cnouc souv s dvdvnociksc osic n kdcd cnv snsd kdi
    cnv svnikuon.
    I209I
    kAkINUINh kAI X0MU0MIk AN0MAAI
    1cpnu Ivvu, unyku Ivvn.
    Jic cssucdsc skdscsc sxsi ndpdcnpn0s dioonsucn npooc ocn ysvscikn cou
    kdpkvou kdi n kuccdpoysvscikn sxsi scdcpdns o'svd doik nso spsuvdc. N
    ysvscikn on cuv vsondoiv sxsi spdiu0s kdi oi xpuoouiksc dvudsc 0su-
    povcdi kpoisc ocnv nd0oysvson cou kdpkvou. N cducononon cuv sndvdd-
    dvsvuv kuccdpoysvscikv ddyv sxsi kiviksc sdpoysc ocn iyvuon kdi
    npyvuon n dkd kdi ocnv ndpoxn sikcv yid cic unosidciksc voouc.
    Ikonc cnc spydodc
    Ikonc cnc spydodc ncdv n dvspson nnpoopiv nou ouoxscouv cic xpuo-
    ouiksc dvudsc s cnv oykoysvson.hpydci ps0nks ci :
    * N npodcn dvncun cuv kdivocoikv csxvikv cnc opidknc kuccdpoysvsciknc,
    nou svoudcvouv s0ouc cnc opidknc iooydc kdi cnc kuccdpoysvsciknc , sxsi
    dnocssosi pydvo ndpoxnc vsuv dvcinsuv os no 0sdcd cnc oykoysvsonc.
    * Ui xpuoouiksc dcunsc nops vd svdi dpi0nciksc n oiksc.
    * Lvdi ondvcik v' dvdyvupovcdi kdi vd idkpvovcdi oi nio oxsciksc kuccdpo-
    ysvsciksc dvudsc os k0s unocno kdpkvou, id kdi nops vd onyov os kd-
    cspn kdcdvnon cnc nd0oiooydc cou.
    IMhLPAIMA
    Ui xpuoouiksc dvudsc sxouv ouoxscio0s s cnv dvncun cou kdpkvou dn
    cnv dpxn cou divd , d uc isd sxsi ksposi cnv dnooxn cic cpsic cssucdsc
    skdscsc xpn ocnv npoo nou sxsi snicsux0s ocnv kuccdpoysvscikn kdi Mopid-
    kn 8iooyd. U Dr. Sandberg kdi oi ouvspycsc cou sxouv npossi ci oco soo
    sov n 0spdnsd cuv do0svv s kdpkvo 0d kd0opscdi dn cnv kuccdpoysvs-
    cikn kdi cn ysvscikn cnc do0svsidc, sv nn snous ci oi xpuoouiksc dvud-
    sc oxscovcdi, os iopsc nspincosic, s cn xdnn npyvuon, s cnv ssin
    ykuv os kdkon0sic opsc scs s cnv cducononon cou kdpkiviko cnou.
    I207I
    UkIMAIA Akhh IIUIUM1IAI
    . Isvvnut, I. upucksukou, N. Xutnuxup|
    Ikonc cnc spydodc ducnc svdi n ndpouodon vscspuv sosvuv dvdopik
    s cnv okidod oknonc n kdpiodvdnvsuocikn okidod oknonc n spyoonipo-
    scpd. Lvskvucdi ocn ispsvnon cnc onvoidc, yid cnv skcnon cnc nvsuo-
    viknc sicoupydc kdi yid nposyxsipncikn n scsyxsipncikn skcnon. |idcspn npo-
    ooxn vscdi ocic dvcsvssic nou nops vd sxsi knoioc yid cnv svdpn cnc o-
    kidodc kdi ocd pdkd nou npsnsi vd idkonov npiv cn okidod. kdc cn
    okidod npdydconoiovcdi ouvsxsc scpnosic nuc Nk|, dpcnpidkn nson kdi
    dspid ddcoc. Ui spyoscpiksc ouoksusc nou xpnoionoiovcdi yid cnv oknon
    svdi o kuisvoc ipooc kdi co nondco. Jd npuckod nou xpnoionoio-
    vcdi nspioocspo svdi cou 8ruce kdi cou 8a|ke oov dop cov kuisvo cnncd,
    kdi cou 1ones oov dop co nondco. N skcnon cnc dvdnvsuociknc sicoup-
    ydc npdydconoiscdi s on cnv kdpidkn sicoupyd Isyiocn oknonl, co on-
    so cou dvdspiou ouo Idspid oknonl kdi cov cno cou dspioo. Jsoc,
    diooyovcdi cd ouncdcd nou svdi uns0uvd yid cn idkonn kdi cov nspiopi-
    o cnc oknonc.
    9
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    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    I210I
    MhXANIMU 1h IAh 1U S1kSS 1U ANUUUIh1IkU 1hMA
    .Ipu, .kunvn, .koupu
    kon tn spsuvu: Iuykpicikn dioynon cuv doikcspuv npocsivsvuv
    nxdviov, osi cuv onouv co uxooyik stress sivsi cnv uvd cou opyd-
    vioo.
    |k ku| s0oo: |vscdi dvdoknnon cnc is0voc iioypddc, s sdon
    ocic cssucdsc nooisusvsc spsuvsc oi onosc csknpivouv sndpkc cic i-
    opsc svddkciksc uno0sosic.
    Anotsscutu: Ui snikpdcsocspoi scd cuv spsuvncv nxdvioo, s couc
    onoouc co stress 0d nopoos vd kdcdocssi co dv0pnivo dvooonoincik o-
    ocnd dvscdi vd svdi oi snc: d. Msiusvn svspycncd Nk kuccpuv Iuoiko
    ovscl kdi siusvoc nodndoidoc sokuccpuv yid ndpdyuyn ndod-
    cokuccpuv. . Msuon cuv Nk kuccpuv kdi cuv sokuccpuv oco nspispik
    dd kdi siusvn dnkpion ducv os icoyvd sps0odcd. y. iopsc vsupoxn-
    iksc ddysc nou oudvouv cdv o opydvioc skc0scdi oco stress, nuc n
    svspyononon ioxnikv ov ocov ovd uno0dou-unuonc, n ddyn cnc
    iooppondc scd idpuv vsuponsnciuv kd0c kdi n dnon cou scdoi-
    oo cuv ovodivv 0d nopoodv vd ouvsnyovcdi cnv svcnon cuv ss-
    psiv cou opydvioo kdi cn sydcspn sudio0nod ocic oisic. . N svspyo-
    nonon cuv dvcisyovuv ndpdyvcuv I|L-6, |L-10l nou sivsi cn ouocnd-
    cikn syovn dnkpion IS|PSl. s. Lpsuvcdi o poc cnc |L-1 uc idsoodn-
    co cnc idvcpdonc vsupiko - dvooonoinciko ouocndcoc. Liik spsuvcdi n
    idcdpdxn oco scdoik ovonci cnc oiyyousvnc kdi siikcspd cou koi-
    ko svou oiyyousivonc, sou cou onoou dokscdi n pon cnc |L-1b ocd
    sosin kccdpd ocxouc kdc cn ipksid cnc dvooooyiknc dnkpionc, sdi-
    cdc cou stress. oc. ksvcpik po ocic ioxniksc ddysc nou snispsi co stress
    sxsi n idcdpdxn ocn scdvocsuon kdi kupuc ocnv sniuon cuv sokuccpuv.
    koikc svdi o poc cnc dnncuonc cuv sokuccpuv sou cnc snpdonc
    svoysvv oniosiv cd onod svspyonoiov kdi duvouv cnv skpdon opuv
    FAS ocn spvn cuv sokuccpuv. N dnsnpdon FAS s FAS |igand Inpoo-
    scnc FASl ouscsxsi ocnv dnncuon cuv sokuccpuv kdi pd ocn suon
    cou dpi0o couc. Icn idikdod svsxovcdi kdi cd ovokccdpd vovcdc nvud
    ocd sokccdpd yid dnncuon.
    unspcutu: Ldicdc cnc nounokcncdc cuv ndpdnvu npocsivsvuv
    nxdviov svdi okoo vd ounspvous nuc npdydcik kdcdocsscdi co
    dvooonoincik oocnd dn co stress. Dsc oi ndpdnvu dnsic sxouv cnv npoo-
    ncikn vd snikupu0ov s sninsov sscsc oco sov. N non cnc idcdpdxnc
    ocnv sniuon cuv sokuccpuv svdi n sxpi ociync kdcspd csknpiusvn
    ouykpicik, coo s dvciksisviksc scpnosic oo kdi s nioupyd nsipddcikv
    ovcsuv os novckid.
    246
    9
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    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    h M I 0 I
    9
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    247
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    IAhTI ANA1hMN0N
    ANAkUIN00N AOhNA 2003
    h M I 0 I
    I1hMUNIkh 1AIIA
    OUI1h10N IA1Ikh AAAA
    MA|UI 2003
    Liikn skoon ocd ndoid cou
    9ou I1hMUNIkU NIU
    OUI1h10N IA1Ikh AAAA
    LkJh0IN
    |PAG|kLI JLXNLI AIIANU A..

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