MR# 02-573

INDUCTION (PHASE 1)
Height cm
1 1
1 3
1 5
2 8
2 10
2 12
3 15
3 17
3 19
4 22
5 28
6 35
1 1
1 2
1 3
1 4
1 8
2 9
2 10
2 11
2 12
2 15
3 16
3 17
3 18
3 22
4 23
4 24
4 25
4 26
4 28
5 35
INTERIM MAINTENANCE ( PHASE 3 )
WK Day Date Due Date Given 6-MP PO 60mg/ m2 once daily
X
X
Cyclophosphamide 1000 mg/m
2
I.V. Over 20 mint
WK Day Date Due Date Given
CONSOLIDATION ( PHASE 2 )
X X
X X
X X
X X
WK Day Date Due Date Given VCR 1.5 mg/m2
I.V.Push (max 2
mg)
DAUNO 30mg/m2
I.V. Push
PROTOCOL FOR T-ALL/NHL
Name
1 1
1 8
2 15
3 22
4 29
5 36
6 42
6 43
7 50
8 57
THE M-Phase (PHASE-4)
XRT in case of CNS positive disease.
1 1
1 4
1 6
1 8
2 10
2 12
2 15
3 17
3 19
3 22
4 29
5 30
5 31
5 32
5 33
6 37
6 38
6 39
6 40
7 50 Begin Maintenance
X
X X
X X
X X
DELAYED INTENSIFICATION ( PHASE 5 )
WK Day Date Due Date Given
VCR 1.5mg/ m
2
IV
Push (max 2 mg)
ADR 30 mg/ m
2
IV
Push
WK Day Date Due Date Given 6-MP PO 60mg/ m2 once daily
kg
m
2
X
X
X
INTERIM MAINTENANCE ( PHASE 3 )
6-MP PO 60mg/ m2 once daily Merthotrexate 15mg/ m2 PO once weekly IT MTX
X
X
X
X
X
X
X
X
X
X
X X
X
X
X
X
X
X
X
X
X
Cyclophosphamide 1000 mg/m
2
I.V. Over 20 mint
6-MP PO 60mg/ m2 once daily
Cytarabine 75mg/m
2
IV Push
or s/c
IT MTX
X
CONSOLIDATION ( PHASE 2 )
X*
* For CNS diesase only
X
X
X
X X
X
X
X*
X
X
X
IT -MTX1 year 8 mg 2 year
10mg 3yrs. 12.5 mg
BM
X
BSA
Lasparaginase 6000 iu /m23
times/ week starting day 3
Prednisolon 60 mg/m2 div tid
x 28 days taper day 28 35
PROTOCOL FOR T-ALL/NHL
Weight
X
X
X X
X
X
X
X
X
X
Begin Maintenance
X
X
X
X
X
X
X
6-TG 60mg/m
2
PO
OD
ARA-C
75mg/ m
2
IV Push
IT MTX
DELAYED INTENSIFICATION ( PHASE 5 )
DXM 6 mg/ m
2
POx3 wk taper over
1wk
L-ASP 6000iu/m
2
3
time/week startind day 3
CPM 1000mg/ m
2
IV
over 20 min
X
X
X
X
X
X
X
X
6-MP PO 60mg/ m2 once daily Merthotrexate 15mg/ m2 PO once weekly IT MTX
Wt --------- kg Ht ------- cm BSA ---------- m2
Wt --------- kg Ht ------- cm BSA ---------- m2
Wt --------- kg Ht ------- cm BSA ---------- m2