Supplemental Table-I.

Chemotherapy Schedule
MCP 842-Protocol
Standard Risk (SR) Reg A-B-A-B(Reassessment) A-B then 6months
High Risk (HR) Reg A-B-A-B(Reassessment) A-B-A-B- then 12 months Maintenance daily 6MP &Weekly MTX

Intrathecal (IT) in first 4 cycles. Total 6 Double IT- Hydrocortisone (HCN) and MTX)
Cycles 1&2 – Days 1, 8 Cycles 3 & 4- Day 1 Age dependent IT doses- < 1 yrs - 8mg, 1-1.99yrs -10mg, 2-2.99yrs-12mg, >3 yrs-15mg
Regimen A-CVAC
Cyclophosphamide Days 1,2,3 and 4 IV -Day 1 - 800mg/m2 then Days 2-4- 200mg/m2
Vinblastine Days 1 and 8 IV - 6mg/m2 (max 20mg)
Doxorubicin Days1,2 IV 20 mg/m2, Days 1 and 2
Cytarabine D1- 12hrly- 2 doses IV 500 mg/m2 every 12 hours (a total of 2 doses), Day 1. Infuse each
dose over 3 hours.

Regimen B-VEIM
Vinblastine D1 and D8 6mg/m2 (max 20mg)
Etoposide Days 1, 2 and 3 60 mg/m2 IV
Ifosfamide/Mesna Ifosfamide- 1200mg/m2 IV
Days 1, 2, 3, 4, and 5 Mesna- 400 mg/m2 IV x 4 doses daily (first dose is given with
ifosfamide and then every 3 hours x 3 doses)
Methotrexate(MTX) Days 1, 2 and 3 15 mg/m2, IV
ALCL 99- Protocol
Prephase- AM1BM1AM2BM2AM3AM3
IT Doses- MTX-< 1 yrs - 6mg, 1-1.99yrs -8mg, 2-2.99yrs-10mg, >3 yrs-12mg Ara-c--< 1 yrs - 16mg, 1-1.99yrs -20mg, 2-2.99yrs-
26mg, >3 yrs-30mg HCN- --< 1 yrs - 4mg, 1-1.99yrs -6mg, 2-2.99yrs-8mg, >3 yrs-10mg
Pre-phase
Dexamethasone Days 1-5 5 mg/ m2/day then 10mg/m2/day IV or orally
Cyclophosphamide Days 1,2 IV- 200 mg/m2
Triple IT Day 1 Doses above
Course AM (AM1,AM2,AM3)
Dexamethasone Days 1-5 10 mg/m2
Methotrexate Day 1 MTX 3 g/m2 in 3 hour ---Folinic acid 15 mg/m2 orally or iv.
Intrathecal injection Day 1 Doses above
Ifosfamide ays 1-5 Ifosfamide 800 mg/m2---Mesna (iv bolus 330 mg/m2/dose)
Cytarabine (Ara-c) Day 4,5 IV- 150 mg/m2
Etoposide Day 4,5 IV- 100 mg/m2
Course BM (BM1,BM2,BM3)
Dexamethasone Days 1-5 10 mg/m2
Methotrexate Day 1 METHOTREXATE 3 g/m2 in 3 hour
FOLINIC ACID 15 mg/m2 orally or i.v.
Cyclophosphamide Days 1-5 IV- 200 mg/m2
Doxorubicin Day 4,5 IV- 25 mg/m2
APO- Protocol
Induction (36 days)
Prednisolone(PDN) Daily, for 28 days PO -40 mg/m2/day-Don’t Taper
Vincristine Days 1,8,15 and 22 IV-1.5 mg/m2 (max dose 2 mg) (for patients < 10 kg use 0.05 mg/kg)
Doxorubicin Days 1 and 22 IV-75 mg/m2 IV over 15 minutes (for patients < 10 kg use 2.5 mg/kg)
IT MTX Days 1, 8 and 22
Consolidation- 1-5 cycles (21days-each)
Doxorubicin IV, on Day 1 303 mg/m2 IV over 15 minutes (for patients < 10 kg use 2.5 mg/kg)
6-Mercaptopurine Days 1-53 PO - 6-MP: Mercaptopurine 225 mg/m2
Prednisolone Days 1-5 120 mg/m2/day
IT MTX Day 1 Age dependent IT doses≤ 1.99 yr =8mg, 2-2.99yrs=10mg, 3-8.99yrs=12mg, ≥
15mg
Vinblastine Day 1, 8 & 15 VLB: Vinblastine 6 mg/m2 IV push
6-15 Cycles (21days each)
Vinblastine Day 1, 8 & 15 VLB: Vinblastine 6 mg/m2 IV push
6-Mercaptopurine Days 1-53 PO - 6-MP: Mercaptopurine 225 mg/m2
Prednisolone Days 1-5 120 mg/m2/day
IV MTX Day 1 IV- 60mg/m2
Hydrocortisone (HCN), Methotrexate (MTX), Cytarabine (Ara-c), Prednisolone(PDN),6-MP(Mercaptopurine)