DRUG STUDY

Brand Name Indication Contraindication Adverse

Effect
Nursing
Responsibility
Mechanism of Action
Tramadol
Hydrochlorid
e
-Relief of
moderate to
moderately
severe pain
-Relief of
moderate to
severe chronic
pain in adults
who need
around the
clock
treatment to
extended
period(ER
tablets)
-Unlabeled
uses;
premature
ejaculations;
rest leg
syndrome
-Contraindicated
with allergy to
tramadol or
opioids or acute
intoxication with
alcohol, opioids, or
psychoactive
drugs
CNS:
Sedation
,dizziness or
vertigo,
headache,
confusion,
dreaming,
sweating,
anxiety,
hypotension,
nausea and
vomiting
-Control
environment
(temperature,
lighting) if
sweating or CNS
effects occur
-Ensure that the
patient does not
cut, crush, or
chew ER tablets
Binds to mu-opioids
receptors and
inhibits the reuptake
of norepinephrine
and serotonin;
causes many effects
similar to the opioids
Clonazepam -Used alone or
as adjunct in
treatment of
Lennox
Gaustaut
syndrome,
akinetic and
myoclonic
seizures; may
be useful in
patients with
absence
-Treatment of
panic disorders
with or
without
agoraphobia
-Unlabeled
uses: Periodic
leg movement
during sleep;
hypokinetic
dysathria;acut
-Contraindicated
with
hypersensitivity to
benzodiazepines,
psychoses, acute
narrow-angle
glaucoma , shock,
coma, acute
alcoholic
intoxication with
depression of vital
signs , pregnancy,
lactation


CNS:
transient,
mild
drowsiness
initially,
sedation,
depression,
lethargy,
apathy,
fatigue, light-
headedness,
disorientatio
n, anger,
hostility.

-Monitor
addiction-prone
patients and
carefully
because of their
predisposition
to habituation
and drug
dependence
-Monitor
patient for
suicidal ideation
-Monitor liver
function and
blood counts
periodically in
patients on long
term therapy
-Exact mechanisms
not understood ;
benzodiazepines
potentiate the
effects of GABA, an
inhibitory
neurotransmitter.
e manic
episodes