Ivermectin

Mechanism of action
Ivermectin causes a tonic paralysis of worms, probably by activating
a glutamate-activated chloride channel. This leads to
hyperpolarization of invertebrate nerve and muscle cells,
which causes paralysis. Fortunately, ivermectin does not cross
the mammalian blood-brain barrier.
Clinical use
Ivermectin is effective for treating nematodes.
Adverse effects
Because of its rapid killing effects, an inflammatory response
termed the Mazzotti reaction (itching, rash, fever, swollen
lymph nodes, and arthralgias) may occur as the worms are
eliminated.