Drug Study

Drug Name
Generic
ibuprofen
Trade
Advil

Classificati
on
NSAID

Indications
Mild to
moderate pain
Fever

Mechanism of Action
May inhibit
prostaglandin
synthesis, to
produce antiinflammatory,
analgesic, and
antipyretic effects.

Route/Frequency/Do
sage
PO/ every 4 to 6
hours/ 400 mg

Adverse Reactions

Drug Interaction

CNS: dizziness,
headache,
nervousness
CV: edema, fluid
retention
EENT: tinnitus
GI: abdominal
pain, bloating,
constipation,
decreased
appetite, diarrhea,
dyspepsia,
epigastric distress,
flatulence,
heartburn, nausea,
nonnecrotizing
enterocolitis,
vomiting
GU: acute renal
failure, azotemia,
cystitis, hematuria
Hematologic:
agranulocytosis,
aplastic anemia,
leukopenia,
neutropenia,
pancytopenia,
thrombocytopenia,
anemia, prolonged
bleeding time
Metabolic:
hyperkalemia,
hypoglycemia

Drug-drug
Anticoagulants
Antihypertensive
Aspirin
Bisphosphonates
Cyclosporine
Digoxin, lithium
Methotrexate
Drug-herb
Dong quai,
feverfew, garlic
ginger, gingko
biloba, horse
chestnut, red
clover
White willow
Drug-lifestyle
Alcohol use
Sun exposure

Nursing
Consideration
Check renal
and hepatic
function
periodically in
patients on
long-term
therapy.
NSAIDs may
mask signs
and symptoms
of infection.
Blurred or
diminished
vision and
changes in
color vision
may occur.
Full antiinflammatory
effects may
take 1 or 2
weeks to
develop.

Skin: rash, prutitus