Summer2007Workshop

inBiologyandMultimedia
forHighSchoolTeachers

INTRODUCTION TO STEM CELLS

2007SUMMERTEACHERWORKSHOP
BETHMICK
BELFASTAREAHIGHSCHOOL
BELFASTMAINE
Life Sciences-HHMI Outreach. Copyright 2006 President and Fellows
of Harvard College.

STEMCELLUNIT
LESSONPLAN

INTROLECTURE
PLANARIALAB
WEBSEARCH
3DAYSINCLUDEA
WEEKENDTOGIVE
TIMEFOR
PLANARIATO
REGENERATE
REMEMBERTO
ORDERPLANARIA
AHEADOFTIME

OBJECTIVES

WHATARESTEM
CELLS?
HOWARETHEY
OBTAINED?
HOWCANTHEYBE
USED?
VISUALIZE
REGENERATION
THROUGH
PLANARIALAB

STEMCELLRESEARCH
WHATISITALLABOUT?

http://stemcells.nih.gov/info/basics/
"Image courtesy of NIH resource for stem cell research"

WHATHAPPENSAFTER
MEIOSIS?
WHATDIDMEIOSISPRODUCE?

GAMETES
2N

2N

1N

1N

1N

1N

1N

1N

4HAPLOIDSPERM

1N

1N

1N

1N

1N

4HAPLOIDEGGS

1N

WHATHAPPENSAFTER
MEIOSIS?
WHATDIDMEIOSISPRODUCE?
WHATHAPPENSTOGAMETES?

FERTILIZATION

ImagecourtesyofL.DeVosU.L.B.Biodic
http://www.ulb.ac.be/sciences/biodic/biodic/images/bio_animale/embryologie/fecondation/baefec_01_01.jpg

WHATHAPPENSAFTER
MEIOSIS?
WHATDIDMEIOSISPRODUCE?
WHATHAPPENSTOGAMETES?
WHATSTHEPRODUCTOF
FERTILIZATION?

ZYGOTE
Thefertilizedegg

http://en.wikipedia.org/wiki/Image:Spermegg.jpg#file

WHATHAPPENSAFTER
MEIOSIS?
WHATDIDMEIOSISPRODUCE?
WHATHAPPENSTOGAMETES?
WHATISTHEPRODUCTOF
FERTILIZATION?
HOWDOESAONECELLZYGOTE
BECOMEAHUMAN?

EMBRYOGENESIS
http://stemcells.nih.gov/info/scireport/appendixA.asp
Image courtesy of NIH resource for stem cell research

http://embryo.soad.umich.edu/carnStages/carnStages.html
Image courtesy of Brad Smith, University of Michigan

SO..WHATARESTEMCELLS?
CELLSTHATCAN
MAKEMOREOF
THEMSELVES
CELLSTHATCAN
BECOMEALMOST
ANYCELL
MULTIPOTENT

Stem
cells

http://stemcells.nih.gov/info/basics/
"Image courtesy of NIH resource for stem cell research"

WHEREDOSTEMCELLSCOME
FROM?
EMBRYONIC
BLASTOCYST

ADULT

CORDCELLS
PLACENTA
CHILDREN
ADULTS

EMBRYONICSTEMCELLS

Blastocyst
http://en.wikipedia.org/wiki/Image:Blastocyst_English.svg

http://stemcells.nih.gov/info/basics/
"Image courtesy of NIH resource for stem cell research"

EMBRYONICSTEMCELLSARE
OBTAINEDFROM
INVITROFERTILIZATIONEMBRYOS
THATWERENOTUSED

http://www.news.wisc.edu/packages/stemcells/illustration.html

ADULTSTEMCELLSARE
OBTAINEDINAVARIETYOFWAYS

IllustrationbyMattBohan,2007

STEMCELLSHAVEALSOBEEN
FOUNDINMATUREORGANS

IllustrationbyMattBohan,2007

PROSANDCONSOFEACHTYPE
EMBRYONIC
CELLLINESLAST
ANDLASTAND
LAST
MULTIPOTENT
EASYTOFIND
ETHICALISSUES
WHENDOESLIFE
BEGIN?

ADULT
CELLLINESDO
NOTLAST
NOTMULTIPOTENT
HARDTOLOCATE
NOETHICAL
ISSUES

ANIMATIONS
HOWEMBRYONICSTEMCELLLINES
AREMADE
WHATISASTEMCELL

REFERENCES

http://stemcells.nih.gov/info/scireport/2001report.htm
http://www.ulb.ac.be/sciences/biodic/biodic/images/bio_animale/embryologie/fecondati
on/baefec_01_01.jpg
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.figgrp.3748
http://www.news.wisc.edu/packages/stemcells/illustration.html
http://www.drugs.com/enc/images/images/en/17010.jpg
http://embryology.med.unsw.edu.au/Notes/placenta.htm
http://www.dnalc.org/stemcells.html
http://gslc.genetics.utah.edu/units/stemcells/