CFX01 OPA

Cefuroxime Axetil

20-Oct-09

Medium: 0.07 N HCl

CFX
Concentration
Time
5
10
15
30
45
60

V1
0.010548
0.013873
0.015173
0.016107
0.016460
0.016417

5
10
15
30
45
60

CFX
V3
V4
0.006970 0.009050
0.010940 0.011666
0.013165 0.012756
0.015740 0.014129
0.016203 0.014430
0.016500 0.014528

V5
0.010190
0.014254
0.015852
0.017027
0.016029
0.017086

V6
0.010215
0.014305
0.016031
0.017313
0.017448
0.017440

CxVml
9.4932
12.4163
13.5040
14.2547
14.4848
14.3649

(=amount of active released in the vessel)

8.3147
6.2728
8.1452
9.1710
12.0565
9.7913
10.4411
12.7573
13.8724
11.7169
11.3528
14.1083
15.4583
13.9299
12.5042
15.0689
15.6658
14.2586
12.6984
14.1055
15.7246
14.4375
12.7120
14.9503

9.1935
12.8030
14.2676
15.3220
15.3542
15.2600

5
10
15
30
45
60

CxVs
0.00000
0.05274
0.12211
0.19797
0.27851
0.36081

(=amount of active withdrawn)

0.00000
0.00000
0.00000
0.04619
0.03485
0.04525
0.11355
0.08955
0.10358
0.19148
0.15537
0.16736
0.27882
0.23407
0.23801
0.36783
0.31509
0.31016

0.00000
0.05095
0.12222
0.20148
0.28662
0.36676

0.00000
0.05108
0.12260
0.20276
0.28932
0.37656

5
10
15
30
45
60

Qn
9.4932
12.4691
13.6261
14.4527
14.7633
14.7257

(corrected amount of active released)

8.3147
6.2728
8.1452
9.1710
12.1027
9.8261
10.4863
12.8083
13.9860
11.8064
11.4564
14.2305
15.6498
14.0853
12.6715
15.2704
15.9446
14.4927
12.9364
14.3921
16.0925
14.7526
13.0222
15.3170

9.1935
12.8541
14.3902
15.5248
15.6436
15.6366

% Release
Time
Tablet Wt
0
5
10
15
30
45
60

V2
0.009239
0.013471
0.015587
0.017467
0.017802
0.017971

V1

V2

V3

V4

V5

V6

0.00
63.29
83.13
90.84
96.35
98.42
98.17

0.00
55.43
80.68
93.24
104.33
106.30
107.28

0.00
41.82
65.51
78.71
93.90
96.62
98.35

0.00
54.30
69.91
76.38
84.48
86.24
86.81

0.00
61.14
85.39
94.87
101.80
95.95
102.11

0.00
61.29
85.69
95.93
103.50
104.29
104.24

Vml
900
895
890
885
880
875

SD

CFX01_OPA

7.89
8.58
8.56
7.55
7.11
7.13

0.00
56.21
78.39
88.33
97.39
97.97
99.50

Dissolution profile CFX01_OPA, temp 37oC, 55 rpm, 0.07N HCl

120.00

100.00

Dissolved (%)

80.00

60.00

CFX01_OPA_V1
CFX01_OPA_V2
CFX_01_OPA_V3

40.00

CFX01_OPA_V4
CFX01_OPA_V5
CFX01_OPA_V6

20.00

Zinnat 250mg

0.00
0

10

20

30

40

Time (minutes)

50

60

70

CFX01 AMB
Cefuroxime Axetil

20-Oct-09

Medium: 0.07 N HCl

CFX
Concentration
Time
5
10
15
30
45
60

V1
0.009629
0.014163
0.015935
0.017025
0.017135
0.017238

5
10
15
30
45
60

CFX
V3
V4
0.007127 0.011197
0.010230 0.014478
0.011630 0.015645
0.013061 0.016344
0.014223 0.016533
0.015850 0.016655

V5
0.008248
0.011164
0.012303
0.013759
0.014088
0.014358

V6
0.009513
0.012944
0.014572
0.016286
0.016634
0.016839

CxVml
8.6660
12.6759
14.1822
15.0671
15.0788
15.0833

(=amount of active released in the vessel)

6.2998
6.4139
10.0773
7.4233
8.4364
9.1559
12.9578
9.9918
9.3539
10.3507
13.9241
10.9497
10.3147
11.5590
14.4644
12.1767
10.6894
12.5162
14.5490
12.3974
10.8500
13.8688
14.5731
12.5633

8.5613
11.5849
12.9691
14.4131
14.6379
14.7341

5
10
15
30
45
60

CxVs
0.00000
0.04814
0.11896
0.19863
0.28376
0.36943

(=amount of active withdrawn)

0.00000
0.00000
0.00000
0.03500
0.03563
0.05599
0.08213
0.08678
0.12838
0.13468
0.14493
0.20660
0.19296
0.21024
0.28832
0.25369
0.28135
0.37099

0.00000
0.04124
0.09706
0.15858
0.22737
0.29781

0.00000
0.04756
0.11228
0.18514
0.26657
0.34974

5
10
15
30
45
60

Qn
8.6660
12.7240
14.3011
15.2658
15.3626
15.4527

(corrected amount of active released)

6.2998
6.4139
10.0773
7.4233
8.4714
9.1915
13.0138
10.0330
9.4360
10.4375
14.0524
11.0467
10.4494
11.7039
14.6710
12.3353
10.8823
12.7265
14.8374
12.6248
11.1037
14.1501
14.9441
12.8611

8.5613
11.6324
13.0814
14.5983
14.9045
15.0839

% Release
Time
V1
Tablet Wt
0
0
5
57.77
10
84.83
15
95.34
30
101.77
45
102.42
60
103.02

V2
0.007000
0.009426
0.010510
0.011655
0.012147
0.012400

V2

V3

V4

V5

V6

0
42.00
56.48
62.91
69.66
72.55
74.02

0
42.76
61.28
69.58
78.03
84.84
94.33

0
67.18
86.76
93.68
97.81
98.92
99.63

0
49.49
66.89
73.64
82.24
84.17
85.74

0
57.08
77.55
87.21
97.32
99.36
100.56

Vml
900
895
890
885
880
875

SD

CFX01_AMB

9.78
12.61
13.53
12.97
11.71
11.10

0.0
52.71
72.30
80.39
87.80
90.38
92.88

Dissolution profile CFX01_AMB, temp 37oC, 55rpm, 0.07 N HCl

120

100

Dissolved (% )

80

60

CFX01_AMB_V1
CFX01_AMB_V2
CFX_01_AMB_V3

40

CFX01_AMB_V4
CFX01_AMB_V5

20

CFX01_AMB_V6
Zinnat 250mg

0
0

10

20

30
Time (Minutes)

40

50

60

70