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Level II Pharmacology Outline Review Notes
Level II Pharmacology Outline Review Notes
II.
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VII.
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IV.
V.
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A. Chlordiazepoxide (Librium) class IV. Used also for treatment of alcohol withdrawl
syndrome DTs, anxiety and tension. For anxiety usual PO dose is 5-25mg t.i.d. or
q.i.d. For alcohol withdrawl PO/IM/IV 50-100mg max. 300mg/d
B. Flurazepam (Dalmane) {Prototype}
C. Temazepam (Restoril)
D. Triazolam ( Halicon)
E. Lorazepam (Ativan)
{Prototype} used for treatment of mild to moderate
anxiety. PB 85-95%, t 3.5- 21 hr.
F. Diazepam (Valium) used to manage anxiety, muscle spasms status post
epilepticus. PO/IM/IV 2-10mg b.i.d.- q.i.d. For Post epilepticus IV 5-10mg q 10-20
min. max. 30mg
Non benzodiazepines Used for short term insomonia (< 10 days duration)
a. Zolpidem (Ambien) .Duration is 6-8 hrs. with a short t1/2 of 2 to 2.5 hrs. M
a. Metabolized in the liver to 3 inactive metabolites and excreted in bile, urine, and
feces.
Chloral Hydrate- It is used to induce sleep and decrease nocturnal awakenings. Fewer
occurrences of hang-over, resp. depression, and tolerance. Effective in older clients. It can
be given to patients with mild hepatic dysfunction, but should be avoided if liver or renal
failure is severe.
Anesthetics - Two classifications
1. General Anesthetic depresses the CNS, alleviates pain, and causes loss of
consciousness. One of the first ones used was Nitrous Oxide (laughing gas)
1. Four Stages of Anesthesia1st stage is Analgesia (induction stage) (consciousness and goes to loss of
consciousness. Loss of sensation of smell and pain occur.
2. 2nd stage is Excitement Or Delirium produces loss of consciousness caused
by depression of the cerebral cortex. Confusion, excitement or delirium occurs.
3. 3rd stage Surgical Surgical procedure is performed during this stage.
4. 4th stage Medullary Paralysis Toxic stage of anesthesia Resp. are lost &
circulatory collapse occurs. Must be on Ventilator.
2. Inhalation Anesthetics- used during the 3rd stage, inhalation gases are used. Some
like Nitrous Oxide are absorbed quickly, have rapid action but also eliminated
quickly. Some examples in the 1950s and later are Halothane, Methoxyflurane,
Enflurane ,Isoflurane, Desflurane, and in 1995 Seroflurane.
Inhalation agents are usually combined with a barbiturate, a strong analgesic like
morphine, and a muscle relaxant like pancuronium.
Potential adverse effects are respiratory depression, hypotension, dysrhythmias,&
hepatic dysfunction.
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D. Propionic Acid New group of NSAIDs but are stronger than ASA but have less
GI irritation.
1. Examples Ibuprofen (Motrin Advil) {Prototype}, Fenoprofen Calcium
(Nalfon), Naproxen (Naprosyn), Ketoprofen (Orudis), Flurbiprofen (Ansaid) and
Oxaprozin ( Daypro).
E. Fenarnates and Oxicams are the last two classification of 1st generation of
NSAIDs.
F. Only one true COX2 inhibitor is Celecoxib (Celebrax){Prototype}. Remember
biggest Cautious use listed was Heart Failure and Bleeding tendencies.
G. Corticosteriods Have a long half life of > 24 hrs. When drugs are D/C the dose
should be tapered over a period of 5-10 days before it is just stopped.
I.Examples Prednsone, Prednisolone and Dexamethazone.
H. Disease Modifying Antirheumatic Drugs these therapies include such elements
as Gold {Prototype}, Immunosuppressive Agents, Immunodulators , &
Antimalaries.
I. Antigout Drug - Gout inflammatory condition that affects the joints, tendons, and
other tissues. Characterized by a buildup of urates (uric acid salts) uric acid
levels(hypouricemia) d/t kidneys being unable to excrete. Also uric acid my
buildup in the kidneys causing uric acid calculi. When patient are on anti-gout
medication make sure that fluid intake is .Patients should be instructed to avoid
alcohol. They should also take Tylenol for discomfort instead of aspirin d/t
aspirin would the acid levels even more.
1. Examples of anti-gout medications are Uric acid inhibitors like
Allopurinol (Zyloprin) {Prototype}.
2. Uricosurics increase the rate of uric acid excretion by inhibiting its
reabsorption. They are used for the chronic condition not an acute attack.
Potential side effects flushed skin, sore gums, and headache. Also might
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cause a metallic taste. Instruct patients to avoid alcohol and caffeine because
they can uric acid levels.
Examples - Probenecid (Benemid)- this drug may cause gastric irritation and
when this occurs should be taken with food.
Sulfinpyrazone ( Anturane)- is even more potent the Benemid and should
be taken with food or with and antacid to prevent gastric irritation.
II.
III.
IV.
V.
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II.
III. Cephalosporins In 1960s were used with clinical success however there chemical
molecules had to be altered and a semi synthetic cephalosporin was developed.
Active against gram-positive and gram- negative bacteria. They are effective by
inhibiting the bacterial enzyme necessary for cell wall synthesis. Lysis of the cell
occurs and thus the bacterial cell dies.
A. First generation Examples are Cefazolin Sodium ( Ancef, Kefzol )
B. 2nd generation Cefaclor ( Ceclor)
IV.
2nd, 3rd, and 4th Generation Cephalosporins. These drugs are bactericidal with
actions similar to penicillin. It is the 3rd & 4th generations that are effective in
treating sepsis and many strains of gram-negative bacilli.
A. Examples- Aztreonam, Imipenem- cilastain. There is a 10% chance that a
patient who is allergic to Penicillin will also be allergic to cephalosporins
d. Other Cephalosporins- Ceftazidine ,Cefepime, along with Aztreonam & ImiNIP Fall 2010
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A. Pharmacokinetics- Ketek is given orally and is well absorbed from GI tract and
is not affect by food intake. It is excreted in the feces and urine. It is 60-70% PB.
Half life is 10 hrs.
B. Pharmacodynamics Blocks protein synthesis in microorganisms.
1. Peak is 1 hr.
2. Side Effects visual disturbances, stomatitis glossitis, gastritis, N/V, abdominal
distention, flatulence, oral and vaginal candidiasis, constipation, and watery stools.
3. Adverse Reactions Ketek may also lead to an exacerbation of myasthesis
gravis.
4. Drug Interactions if taken concurrently with anti-lipidemics (simvastatin,
lovastatin, atorvastatin), class 1A or class antidysrhythmics. Ketek blood levels are
decreased when taken with rifamin, phenytoin, carbamazepine, phenbarbital,
producing a sub-therapeutic level.
V. Tetracyclines were the first broad-spectrum antibiotics effective against grampositive and negative bacteria, mycobacteria, rickettsiae, spirochetes, and chlamydiae.
Tetracyclines act by inhibiting bacterial protein synthesis and have a bacteriostatic
effect. They are not effective against Staphylococcus aureus(except for the newer
forms of tetracycline),Pseudomonas, or Proteus. Tetracycline in combination with
metronidazole and bismuth subsalicylate is useful in treating Helicobacter
pylori(bacterium in the stomach that can cause peptic ulcer).It can be given orally,
intramuscular, or intravenously. IM is very painful and is seldom used. Newer oral
forms are : Doxycycline {Prototype}, minocycline and methacycline these
preparations should not be taken with aluminum and magnesium antacids, milk
products containing calcium, or iron- containing drugs d/t substances binding with
tetracycline and prevent absorption.
Doxycycline & Minocycline- there absorption is improved with food ingestion.
A. Side Effects GI disturbances such as N/V, diarrhea. Photosensitivity may
occur especially when taking Demclocycline(Declomycin).Pregnant women should
not take tetracycline during the 1st trimester d/t possible teratogenic effects. Women
in their last trimester and children older than 8 yrs. should not take tetracycline d/t
irreversibly discoloration of the permanent teeth. Minocycline(Minocin)can
cause damage to the vestibular part of the inner ear which leads to difficulty
maintaining balance.
B. Adverse Reactions Nephrotoxicity results when higher doses of tetracycline
have been given. It can also disrupt microflora in the body and lead to
Superinfection.
C. Drug Interactions Antacids (Maalox and others) and iron-containing drugs can
prevent absorption of tetracycline from the GI tract. Milk and other drugs high in
calcium can do the same, so to avoid decrease absorption of tetracycline while those
drugs they should be taken 2 hrs,apart from the tetracycline.The desired effect of
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1. Side Effects These drugs exert adverse effects on rapidly growing normal
cells such as skin, hair blood cells. They also affect the GI tract, mucous
membranes, bone marrow and the reproductive systems.
II. Alkylating Drugs cause cross- linking of DNA strands, abnormal pairing, or
DNA strand breaks. Drugs in this category are effective against many types of
cancer including acute and chronic leukemias, lymphomas multiple myeloma, and
solid tumors of the breast, ovary, uterus, lung, bladder, and stomach.
A. Examples Mustard gas derivatives Cyclophosphamide (Cytoxan)- used to treat
Hodgkins disease. Vesicant can cause tissue necrosis if it infiltrates into the
tissue. Patients should be well hydrated while taking this drug. Drug
Interactions occur when taking aspirin, allopurinol, Phenobarbital, warfarin,
Thiazides and some psychiatric medications.
B. Ethylenimines Thiotepa (Thiopex),
Alkylsulfonates- Busulfan (Myleran)
Metal Salts- Cisplatin (Platinol)
C. Side Effects- N/V, hemorrhagic cystitis, alopecia, anemia, leucopenia,
thrombocytopenia, bone marrow suppression, 2nd malignancy and sterility.
III. Antimetabolites resemble natural metabolites which synthesize, recycle, &
breakdown organic compounds for use by the body. They are used to treat acute
leukemia, breast cancer, head& neck cancer, lung cancer, osteosacroma and nonHodgkins lymphoma This group is classified by the substances with which they
interfere;
A. Folic Acid( folate) antagonists- examples
Methotrexate (Rheumatrex, Trexall) numerous drugs interactions occur with
Methotrexate (MTX ). Leucovorin is needed to rescue normal cells from the
adverse effects of the drug. Protein bound drugs like aspirin, phenytoin
increase the toxicity of MTX. Clients who are taking penicillins,
cyclooxygenase 2 inhibitors and OTC herbs interact with MTX.
The side effects of antimetabolites include bone marrow suppression (anemia,
leucopenia, thrombocytopenia), stomatitis, N/V, alopecia and hepatic and renal
dysfunction.
B. Pyrimidine antagonist- (Fluorouracil, Adrucil) (5 FU, {Prototype} used for
the treatment of colorectal cancer. Also can treat breast, stomach, liver,
pancreas, and skin cancers. Given IV for solid tumors and topically for
superficial basal cell cancer. IV half life is 10-20 minutes. Small amount is
excreted in urine and 80% is excreted by the lungs as CO2.
C. Purine antagonist- (6-mercaptopurine Purinethol
D. Adenosine deaminase inhibitors- (Fludarabine Fludara)
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IV.
VI.
Antitumor Antibiotics - inhibit protein & RNA synthesis and bind DNA, causing
fragmentation. All of these drugs are CCNS except for Bleomycin which has its
major effect on G2. Adverse reactions to antitumor antibiotics include alopecia, N/V,
stomatitis, leucopenia, and thrombocytopenia.
A. Anthracyclines - Doxorubicin (Adriamycin) {Prototype}, Daunorubicin (
Cerubidine), Mitomycin ( Mutamycin), Bleomycin (Blenoxane)
B. Doxorubicin ( Adriamycin) {Prototype} lead to the development of many
analogs Epirubicin (Ellence), Idarubicin (Idamycin). They have severe
cardiotoxic side effects must be given with caution. Maxium lifetime dose
is 550mg/m2 d/t cardiotoxicity.
1. Pharmacokinetics Administered IV and metabolized in the liver to active
and inactive metabolites. The initial phase is 12 minutes, intermediate
phase is 3 to 5 hrs., and final phase is 30 hrs.
2. Pharmacodynamics Prescribed in combination with other anticancer
agents for the treatment of breast, ovarian, lung, bladder, lymphomas and
leukemias. Has maxium lifetime dose of 550 mg/m2. This dose may be
lowered for patients with pre-existing cardiac conditions or those
whom are using other cardiac toxic medications, are older patients, or
have received chest radiation. Prior to administration cardiac function
must be assessed. Pts may be given Dexrazoxane (Zinecard) to help
prevent cardiac toxicities from occurring. It is a cytoprotective agent.
Remember that Green Tea might enhance the antitumor effect.
Use cautiously with Grape Seed(inhibits effects of Doxorubicin)
Garlic (anti- clotting properties may effectiveness of chemotherapy.
3. Side Effects and Adverse Reactions can cause organ toxicity. Patients
receiving Bleomycin may develop pneumonitis which progresses to
pulmonary fibrosis. Assessment of CBC, RBC, WBC, and Platelet counts
should be done. Drugs may be with held if RBCs, WBCs or Platelet
counts below predetermined levels.
Mitotic Inhibitors Plant Alkaloids and other compounds derived from natural
products that are CCS and block cell division at the M phase of the cell cycle.
A. Vinca Alkaloids Vinblastine (Velban),Vincristine (Oncovin) {Prototype},
Vinorelbine ( Navelbine ) are obtained from periwinkle plant.
B. The Docetaxel- ( Taxotere), Paclitaxel (Taxol), were originally procured from
the needles and bark of the Yew tree which only grows in the Pacific northwest;
d/t the scarcity of the natural resources semi-synthetic form of Paclitaxel was
developed Docetaxel ( Taxotere) .
1. Adverse Reactions include : leucopenia, allergic reactions, N/V , diarrhea,
and phlebitis. The plant alkaloids damage peripheral nerve fibers and may
cause reversible and irreversible neurotoxicity (muscle strength, tingling,
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1. Estrogen- used as a palliative treatment for men with prostate cancer and
women with hormonal responsive breast tumors to slow the growth of the
tumor down.
Examples: Diethlstibestrol (DES), EthinylEstradiol (Estinyl), Chlorotrianase
(TACE), and conjugated estrogen Premarin.
2. Progestrins may be used to treat breast, endometrial and renal cancers.
There drugs hydroxyprogesterone acetate (Depro- Provera), Megestrol
Acetate ( Megace) , act by shrinking cancer tissures.
3. Side Effects and Adverse Reactions include fluid retention and
thromboitic disorders.
4. Androgens given to treat advanced breast cancer in pre-menopausal
women. Male hormone promotes regression of tumor if taken for prolong
period of time it leads to secondary sexual characteristics like growth of
body hair, lowering of voice, and muscle growth.
5. Anti Estrogens- such as Tamoxifen (Nolvadex) & Fulvestrant (Faslodex)
Are used to treat breast cancer tumors that are estrogen- receptor
positive(ER+). Tamoxifen has shown efficacy in preventing tumor
reoccurrence in both pre- & post menopausal women.
a .Side Effects hot flashes, irregular menses, fatigue, H/A, impotence, and
libdo.
Chapter 41 Cardiac Glycosides, Antianginals, and Antidysrythmics
I. Cardiac Glycosides They are a group of drugs that inhibit the sodium- potassium
pump, resulting in in intracellular Na Ca which causes cardiac muscle fibers
to contract more efficiently. Three effects on the heart muscle are :
1. Positive Inotropic action- ( on mycocardial contraction& stroke volume).
2. Negative Chronotropic action- ( the heart rate)
3. Negative Dromotrophic action- (conduction of the heart cell)
The in myocardial contractility increases cardiac, peripheral and kidney
function by CO, preload, improving blood flow to the periphery and
kidneys, edema, and increasing fluid excretion.
II. Glycosides Used for the Treatment - Atrial Fibrillation and Atrial Flutter with rapid
Ventricular response with rates 200-300 beats/min. REMEMBER DIGOXIN DOES
NOT CONVERT A- FIBRILLATION TO NORMAL SINUS RYTHYM
A. Drugs used for Treatment of Heart FailureFirst drugs of choice is Inotropic medication like Dopamine and Dobutamin,
Phosphodiaesterase inhibitors like ( Inamrinone, & Milrinone -Primacor),
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B.
Other drugs used to treat Heart Failure- Digoxin (Lanoxin) {Prototype}1. Pharmacokinetics - Absorption is 90-100% in the capsule form. The
protein bounding power for Digoxin is low(25%).
t = 30- 45hrs. (remember that because of the longer half life that the
drug accumulation should be monitored very carefully).
Excretion is 70% in the urine and 30 % by liver metabolism.
2. Pharmacodynamics used in treatment of heart failure. They myocardial
contraction and cardiac output and improves circulation through the Atrial
Ventricular node the heart rate .
Therapeutic Serum level 0.5 2.0 ng/ml
3. Digitalis Toxicity Signs & Symptoms Anorexia, diarrhea, N/V, H/A,
Bradycardia, PVCs, blurred vision, (white & green halos), confusion, and
Delirium. Digitalis toxicity can lead to first degree hear t block then to 2nd
degree A V block and finally to a third or complete heart block. The antidote
for Digitalis Toxicity is (Ovine, Digibind) this agent binds with digoxin to
form complex molecules that can be excreted in the urine.
4. Herb Interactions Ginseng may falsely digoxin levels.
St. Johnss wart- absorption of digoxin.
Psyllium (Metamucil) digoxin absorption
Hawthorn - may the effect of digoxin
Licorice- promotes K+ loss digoxin toxicity.
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III. Other Drugs used to Treat Heart Failure- Vasodilators, Angiotension Converting
Enzyme Inhibitors, Angiotension II Receptor Antagonist Blockers, Diuretics,
Aldactone, & some Beta Aderenergic Blockers.
I. Vasodilators- venous blood return which decreases cardiac filling, ventricular
stretching (pre-load) and O2 demand on the heart. Arteriolar dilators act in 3 ways
1. Reduce cardiac after load which cardiac output.
2. Dilate the arterioles of the kidneys which improves renal profusion and
fluid loss
3. prefusion to the skeletal muscle
II.ACE inhibitors - usually prescribed for Heart failure to dilate venules and arterioles
improving renal blood flow(profusion) and blood fluid volume also moderately
Aldesterone which can K+ levels.
III.Angiotension II Receptor Blockers- Valsartan(Doivan) and Cardesartan(Atacand)
have been approved for Heart Failure for those clients whom cant tolerate ACE
inhibitors.
IV.Diuretics First line of drugs for Heart Failure when you are trying to fluid volume
used with Digoxin or other agents.
1. Spirolactone (Aldactone) K+ sparing , used for moderate to severe Heart
Failure. It blocks the production of Aldesterone. (Normally with Heart Failure
the Aldesterone production goes up Na and Water retention K+ and
Magnesium loss ( both electrolytes are need for the hearts contracts.
Usually dose is 12.5mg 25 mg/ day.
E. Beta Blockers usually contraindicated for clients with Heart Failure. Reduces
contractility .
1. Carvedilol- (Coreg) and Metopropolol( Toprolol)- have been shown to
improve cardiac performance.
F. Nesiritide (Natrecor)- an atrial Natuiretic Peptide hormone that inhibits AntiDiuretic hormone by Na loss (causes vasodilation, natriuresis, And diuresis.
G. Bi- Dilators combination of Hydralizine (which B/P) and Isosorbide dinatrate (
a dilator to relieve heart pain) in 2005 FDA approved it for the treatment of Heart
Failure especially in African Americans(who are 2 times more likely to have Heart
Failure than are Caucasians.
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Preganancy - C
Protein B. 95% , t = 30-50 hrs., Angina and Hypertension
1. Diltiazem ( Cardizem) - PO 30-60 mg Q.I.D. SR 60mg every 12 hrs.
Used for treatment of Angina Pectoris, its hypotensive effect is not as severe as with
procardia. Kidney function should be monitored, Pregnancy = C Protein B. = 7085%
t = 3.5- 9 hrs.
2. Nifedipine ( Procardia) - PO 10-30 mg every 6-8 hrs. max. dose = 180 mg/day. It is
used for to treat angina pectoris and hypertension. Suppresses contraction of cardiac
and vascular smooth muscle. Increases heart rate and cardiac output. Decreases
blood pressure. Pregnancy = C Protein B. > 99% t = 7-12 hrs.
3. Three of the Calcium Channel Blockers are used for the long term treatment of
Angina Verapamil( Calan), Nifedipine (Procardia), and Diltiazem (Cardizem).
Procardia is the most potent.
4. Side Effects H/A, hypotension ( more common with procardia) and less common
with Diltiazem.
D. Antidysrhythmia - A dysrhythmia is any deviation from a normal rate or pattern of a
heartbeat.
1. Dysrhythmia- disturbance of a heart rhythm.
2. Arrhythmia- absence of a heart rhythm
3. Aterial Dysrhythmia- prevents ventricular filling and.
4. Arrhythmia- absence of a heart rhythm
5. Aterial Dysrhythmia- prevents ventricular filling and cardiac output by 1/3
6. Ventricular Dysrhythmia- are life threatening because of ineffective filling of the
ventricle resulting in or absence of cardiac output.
7. Cardiac Dysrhythmias commonly occur after a M.I.(myocardial infarct) or
hypoxia or hypercapnia (level of CO 2 in the blood) , thyroid disease, C.A.D.,
Cardiac Surgery, Excessive catecholamines, or electrolyte imbalances.
8. Action Potential- Remember when Na+ and Ca+ enter the mycocardial cells muscle
contraction and depolarization occurs.
E. Anti-dysrhythmia drugs- there are four class of anti-arrhythmic drug which effect the
different phases of the action potential.
F. Class I: Sodium Chanel Blockers:
1A Slow condition which prolongs Repolarization (Atrial and Ventricular such as
PAT- Paroxysmal Atrial Tachycardia and SVT Supra Ventricular
Tachycardia)
1B Slow conduction that shortens Repolarization(Acute Ventricular Dysrhythmias)
1C Prolong condition with little effect on Repolarization (Life threatening
Ventricular dysrhythmias).
G. Class II: Beta Blockers: Reduce Ca+ entry, conduction velocity ,automaticity and
recovery time (refractory period) Used to treat (Atrial flutter & Fibrillation,
tachydysrhythmias and Ventricular and Supraventricular dysryhthmias).
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b.
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IV. Diuretics- Two main purposes A). Blood Pressure; & B). Edema
(peripheral/pulmonary). Diuretics work by inhibiting Na+ and H2O re-absorption
from the kidneys in the tubules thus promoting their loss through excretion in the
form of urine.
Renal Tubule Components- Proximal tubules, Loop of Henle descending and
ascending loops, and the collecting tubule. Every 1.5 hrs the total volume of the
bodys extracellular fluid goes through the kidneys glomeruli. Our glomeruli filter
electrolytes, drugs, glucose, and the waste products of protein metabolism. Large
particles such as protein & blood cells are not filtered from the blood & they remain
in the circulation. Na+ and H2O are the largest filtrate substances. Normally 99% of
Na+ is reabsorbed (50-55% is reabsorbed in the proximal tubules, 33-40% in the
Loop of Henle, 5-10% in the distal tubules and <3% in the collecting tubules.).
Diuretics that act on the tubules closest to the glomeruli have the > effect in causing
Natriuresis (Na+ loss in the urine). An example is Mannitol an osmotic Diuretic.
A. Five Categories of Diuretics:
1. * Thiazide and Thiazide like
2. * Loop or high ceiling diuretics
3. Osmotic
4. Carbonic anhydrase inhibitor
5. * Potassium sparing
(* Most frequently prescribed for HTN, edema associated with Heart failure)
6. Combination Diuretics- (Both K+ sparing and K+ wasting) used for the
treatment of HTN
Thiazide- Diuretics used primarily in patients with normal renal functions. If creatinine
clearance is < 3oml/min the effectiveness of thiazide is greatly decreased. Thiazide drugs cause
not only loss of Na+, K+, and magnesium they also cause calcium re-absorption, which may
lead to Hypercalcemia, another consideration that it cause glucose intolerance or possible
Hyperglycemia so it should be used with caution in patients with diabetes mellitus.1st drugs
used are in the Short Acting Chlorothaizide then Hydrochlorathiazide- HydroDIURIL,
HCTZ, Esidex, Oretic, Urozide{Prototype}- PO dose for HTN 12.5-50 mg/d
Edema PO dose: 25- 200mg in divided doses; maintenance dose 25100mg/day
Drug -Lab/Food Interactions: Drugs: digitalis toxicity with digitalis and
hypokalemia; K+ loss with steroids; antidiabetic effect; thiazide effect
with cholestramine and colestipol.
Lab: serum calcium, glucose, uric acid, serum potassium, sodium &
magnesium.
A. Pharmacokinetics- Readily absorbed from the GI tract
1. 65% Protein bound
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PO
PO
c.
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6.
I. Hypertension is defined as an increase in systolic B/P > 140 and the diastolic > 90 mmHg.
Essential HTN: affecting 90 % of persons with HTN exact origin of essential HTN is unknown.
A. Contributing Factors- Family Hx of HTN
Hyperlipidemia
African American backgroundDiabetes
Obesity
Aging
Stress
Excessive smoking and alcohol
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II. Secondary HTN- it is the other 10% of HTN cases are related to Renal & Endocrine disorders
Kindeys regulate the Reni- Angiotension I to Angiotension II-(causes release of Aldosterone
from the Adrenal glands). Baro-receptors in the Aorta and Carotid Sinus and the vasomotor in
center of the medulla assist in regulating B/P.
Catecholamines Norepinepherine released from sympathetic nerve terminals and Epinepherine
released from the Adrenal Medulla B/P through vasoconstriction activity on the blood vessels.
Anti- Diuretic Hormone (produced by hypothalamus by stored and ANP (atrial naturetic peptide
and Brain Naturetic Peptide) released by the posterior pituitary gland.
III. Non- Pharmacologic Control for HTN : If systolic is > 140 anti hypertension drugs are
generally necessary.
A. Stress reduction techniques
B. Exercise
C. Salt restriction
D. Alcohol ingestion
E. Weight reduction
IV. Most Clients may need two or more Anti - hypertensive drugs to achieve a goal Blood
pressure reading:
1. Six Categories of drugs to treat HTN:
1. Diuretics- ** see chapter 41
2. Sympatholytics-(Beta Adrenergic Blockers)
3. Direct- acting Arteriolar Vasodilators4. Angiotension Convert Enzyme inhibitors5. Angiotension II receptor Blockers
6. Calcium Channel Blockers
2. Beta Adrenergic Blocker : Beta ( 1 & 2) Adrenergic Blockers reduce cardiac output by
diminishing the sympathetic nervous system response to basal sympathetic tone. They
reduce heart rate, contractility, and Renin release. African Americans with HTN do NOT
respond as well to Beta blockers for HTN control so they are given beta blockers combined
with diuretics.
1. Metroprolol (Lopressor, Toprol SR)- Beta1 {Prototype}PO Adult dose for HTN 50-100mg/d in 1-2 divided doses Maintenance dose is 450mg/day
in divided doses.
Elderly- PO 25mg/day Maintenance dose of 25-300mg/day
Myocardial Infarction-
PO:
100mg B.I.D.
Drug- Lab/Food Interactions: Drug- bradycardia with digitalis: Hypotensive effect with
other anti-hypertensive, alcohol, anesthetics.
a. Pharmacokinetics :
1. Absorption: PO 95%
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IV Onset: Immediate
IV Peak : 20 min
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usually are given once/day. They do cause NA+ & water retention therefore a diuretic is
also given concomitantly to fluid accumulation.
More potent medications like Phenoxybenzamine and Tolazoline are used to treat HTN
Crisis & vere HTN resulting from catecholamine secreting tumors of the adrenal medulla
like (phenochromocytomas).
A. Prazosin HCL (Minipres) Alpha Adrenergic Blocker PO Adult dose 1mg B.I.D. or
T.I.D. With a maintenance dose of 3-15mg/day. Drug- lab/ Food Interactions:
Hypotension effect with other anti-hypertensives, nitrates and alcohol.
a.
Pharmacokinetics : Absorption in G.I. 60%, 5% in circulation
1. Distribution: Protein Bond 95%
2. Metabolism: 3 Hours
3.
Excretion: in bile & Feces 10% in urine.
4. Mode of Action: Dilation of peripheral blood vessels via blocking Alpha
Adrenergic receptors.
2. Pharmacodynamics: P.O. Onset o.5 2 hrs. Peak: 2-4 hrs. Duration: 10 hrs.
a. Adverse Reactions: Orthostatic Hypotension, palpitations, Tachycardia,
pancreatitis
b.
Side Effects: Drowsiness, H/A, N/V, diarrhea, impotence, vertigo, urinary
frequency, tinnitus.
c. Drug Interactions: when Alpha Adrenergics Blockers are taken with Antiinflammatory drugs and nitrates Fluid Retention peripheral edema
Nitrates - Lower B/P as do Alpha-Adrenergic which leads to syncope/fainting.
II. Adrenergic Neuron Blockers are potent antihypertensive drugs that block Norepinepherine
Release from the Sympathetic nerve endings, causing a decrease in B/P, & decrease in
Cardiac output & in peripheral vascular resistance.
A. Reserpine, Guanethidine, Guanadrel (are 3 very potent drugs) that are used to treat severe
HTN. Adrenergic Neuron Blockers are the LAST drugs considered for treatment of HTN
because of the orthostatic hypotension.
Reserpine can cause nightmares and suicidal tendencies.
III. Alpha1, Beta1, Adrenergic Blockers : Labetalol( Normodyne) & Carteolol(Cartrol) are
examples of Alpha/Beta blockers. When the Alpha1 receptor sites are blocked it causes
Vasodilation. , which decreases the resistance of the blood flow. The blocking of effect on
the Alpha receptor site is stronger than that on the Beta receptor therefore B/P is lowered
and pulse rate is moderately decreased.
A. Common side Effects: Orthostatic Hypotension, GIdistrubances, nervousness, dry
mouth, fatigue.
*** Large doses of Labetalol may cause Atrial Ventricular Heart Block. (Property of
Beta blockers that slows Atrial Ventricular conduction which in turn slows heart rate).
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IV. Direct Acting Arteriolar Vasodilators: This group of drugs act by relaxing the smooth
muscle of mainly the arterioles. Vasodilatation leads to blood flow to the Brain and
kidneys, with a decrease in B/P Na and water are retained leading to edema. This is why a
diuretic would be given with these drugs. Examples would be Hydralazine and Minoxidil
both can be used to treat mild to moderate HTN. Also because of the vasodilatation that
these drugs cause Reflex Tachycardia and Renin is released. Beta Blockers are frequently
prescribed with D.A.A. V. to decrease the Heart rate (counter act the Reflex Tachycardia).
A. Nitroprusside & Diazoxide : These are 2 very potent vasodilators used for acute
HTN emergency. Nitroprusside acts on both arterial & venous blood vessels, whereas
Diazoxide acts on only arteries. Common side effects: Hydralazine side effects are
tachycardia, palpitations, edema, nasal congestion, H/A, dizziness, bleeding, and
Lupus like symptoms.
Minoxidil & Diazoxide : Refex Tachycardia, palpitation, restlessness, agitation,
nausea, and confusion.
Diazoxide: hyperglycemia due to its action of inhibiting release of insulin from the
Pancreatic Beta cells.
V. Angiotension Converting Enzyme Inhibitors: They inhibit the formation of Angiotension II
and blocks the release of Aldesterone. When aldesterone is blocked Na and water are not
retained but are excerted. K + is retained. ACE inhibitors cause little change in Cardiac
Output or HR but do peripheral vascular resistance. These drugs can be used in patients
with renin levels. They are primarily used to treat HTN , some are effective in treatment of
Heart Failure. There are 10 drugs in this category:
1. First one discovered in 1970s is Captopril (Capoten)
7. Moexipril(Univasc)
2. Benzepril (Lotension)
8. Perindopril (Aceon)
3. Enalapril (Vasotec)
9. Fosinopril (Monopril)
4. Ramipril(Altace)
10. Quinapril (Accupril)
5. Trandolapril(Mavik)
6. Lisinopril(Prinavil Zestril)
These drugs can be used as the first line Anti Hypertensive agents but the use of Thiazide
diuretics are also recommended.
****** African Americans and Older Adults DO NOT RESPOND TO ACE inhibitors until
diuretics are added. SHOULD NOT PRESCRIPED/ADMINISTERED DURING
PREGNANCY (D/T the effect they have of reducing Placental blood flow).
A. Side Effects: Constant irritating cough; Nausea/Vomiting, diarrhea, H/A, dizziness,
fatigue, insomnia, Hyperkalemia, and tachycardia.
B. Contraindications: Should not be administered while pregnant will cause fetal harm
d/t decrease placental blood flow. Should not be taken with K+ sparing diuretics or salt
substitutes (those that use K instead of Na).
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VI. Angiotension II Receptor Blockers (ARBs): They are similar to the ACE drugs except
ARBs block Angiotension II from Angiotension receptors found in many tissues. ARBs
cause vasodilatation and peripheral resistance. They do not cause the constant irritating
cough. ARBs should not be taken during pregnancy either.
A. Examples: Losartan (Cozaar), Valsartan (Diovan) Irbesartan (Atacand), Olmesaran
Medoxomil (Benecar)- these agents block the vasoconstrictor effects of Angiotension II
at the receptor sites. ARBs can be used as a first line Treatment for HTN.
B. Pharmacokinestics: Cozaar is used primarily to manage HTN and to form active
metabolites.
1. Distribution: They are Highly Protein Bond
2. Metabolism: t - 1.2- 2 hours & metabolite half life is 6- 9 hrs.
3. Excretion: In the Urine and Feces
C. Pharmacodynamics: Losartan (Cozaar) is a potent vasodilator which blocks the binding of
Angiotension II to the Angiotension receptors found in many tissues. PATIENTS WITH
MILD HEPATIC INSUFFICENCY CAN TAKE THESE DRUGS. The Peak time is 6
hrs., Duration is 24 hrs. THEY ARE LESS EFFECTIVE IN AFRICAN AMERICAN and
may cause Angioedema
VII. Direct Renin Inhibitors: Aliskiren ( Tekturna) 1st FDA approved Renin inhibitor.
Aliskiren binds with Renin causing a in Angiotension, Angiotension II and Aldesterone
levels. Effective for the treatment of mild to moderate HTN. Can be used alone or with
another antihypertensive agent. Has an added effect in B/P when combined with Thiazide
diuretics or ARBs.
A. Prototype: Losartan ( Cozaar) Angiotension II receptor Blockers . Pregnancy C ( First
Trimester), D (2nd or 3rd Trimester can use Hyzaar). PO: For HTN- 25- 50 mg/day in single
or divided doses. Maxium dose is 100mg/ day.
Contraindicated: During Pregnancy and while Breastfeeding
Caution: Renal & Hepatic Impairment.
B. Pharmacokinestic:
1. Absorption: Rapidly absorbed in blood in 25-30 minutes.
2. Distribution: Protein bond 90-95%
3. Metabolism: t 1.2- 2 hrs. metabolites in 6-9hrs.
4. Excretion: 35% in the urine.
5. Side Effects: Dizziness, diarrhea, insomnia, & occ. Cough
6. Drug & Lab Interactions: Phenobarbital effect of Cozaar & its metabolites
May increase ALT, AST, ALP ,Bilirubin , Creatinine , Hbg. and Hct.
7. Adverse: Upper Respiratory Infections.
C. Pharmacodynamic: Onset: < 1 hr.
Peak : 6 hrs.
Duration: 24 hrs.
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D. Calicum Channel Blockers: These are a group of drugs that are slow channels found only in
myocardium & vascular smooth muscle. Free Ca+ muscle contractility, peripheral
resistance, & B/P. Ca+ channel blockers also called Calcium anti-agonist promote
vasodilation. Large central arteries are not as sensitive to Ca+ as the coronary, Cerebral and
peripheral arteries are. They are highly protein bond but have a short half- life. 3 groups of
Ca+ blockers. Calcium Channel Blockers lower B/P better in African Americans than
drugs in other categories.
1. Verapamil (Calan): is used for treatment of chronic HTN, angina pectoris & cardiac
dysrhythmias. Verapamil and Diltiazem act on the arterioles & the heart. Nifedopine is
used to prevent ischemic brain injury due to vasospasm that often accompanies
subarachnoid hemorrhage. Also used as treatment of choice in Variant angina (Prentz
Metal ) also thought to be caused by vasospasm of the coronary arteries.
2. Nifedipine (Procardia): Decreases B/P in older adults & in those with low serum Renin
values. In the immediate released capsules (10-20mg) it has been associated with
increased incident of sudden Cardiac Death especially when prescribed for outpatient at
high doses d/t the fact that Ca+ channel blockers cause reflex tachycardia. This tachycardia
is more prevalent with Procardia.
3. Prototype: Amlodipine (Norvasc) : It is used to treat mild to mod. HTN, and Angina
Pectoris.
Mode of action: Decreases peripheral vascular resistance (vasodilation), promoting in
B/P. PO 5- 10mg/day or for Elderly 2.5- 5mg/day.
Lotrel is a combination of Amlodipine with Benzepril.
Contra-Indications: Severe hypotension.
Cautious Use: Liver Disease, Heart Failure, Aortic Stenosis, pregnancy & lactation.
Drug- Lab Interactions: Drugs bradycardia with Adenosine
Labs: May Amlodipine
with Grapefruit juice.
1. Pharmacokinetics:
a. Absorption: > 90% is absorbed; gradually absorbed from the G.I. tract.
b. Distribution: Highly Protein Bond > 95%
c. Metabolism: t 30- 50 hrs. Elderly: t : 50- 100 hrs.
d. Excretion: in urine & feces as inactive metabolites.
2. Pharmacodynamics: Onset is gradual
only prescribed once a day.
4. Side Effects : Peripheral edema may occur because of its vasodilator effect, flushing,
dizziness and nausea.
5. Adverse: Reflex Tachycardia
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Emboli. LMWHs produce more stable responses at recommended doses, therefore frequent
monitoring of PTT is not required. LMWH inactivates factor Xa , but it is less able to
inactivate thrombin like Heparin is able to.
1. 4 Types of LMWH are: All can be given subcutaneously and do not require
monitoring of aPTT. Treatment is injection in the abdomen for 7-14 days. It is
usually started in the hospital 24 hrs. post-operatively. The half life of LMWH are
2 to 4 times longer than that of heparin. Instruct clients not to take aspirin or other
anti-platelet drugs while on LMWH. Bleeding with these drugs is less likely to
occur than with Heparin. If bleeding dose occur Protamine Sulfate is the antidote.(dose would be 1mg of Protamine S. for every 1mg of LMWH given.)
Contra-Indications: Pt. whom have had a stroke, peptic ulcers, or other blood
anomolies
a. Enoxaparin Sodium: (Lovenox)
b. Dalteparin Sodium: (Fragmin)
c. Danaparoid : ( Orgaran) - **It is considered LMWH but actually does not
have Heparin in its structure.
d. Tinzaparin Sodium: (Innohelp)
2. Direct Thrombin Inhibitors: Anticoagulants II There are 4 new parental anti-coagulants
that directly inhibit thrombin from converting fibrinogen to fibrin. Three are given
Intravenously and are very costly!
a. Argotroban ( Acova)
b. Bivalirudin (Angiomax) binds with inhibitors free flowing thrombin
c. Lepirudin (Refludan)
d. The 4th Drug is given Subcutaneously Desirudin (Iprivask)
C. Oral Anti-Coagulants- Examples would be Warfrin/Coumadin before it was used on humans it
was used on rodenticides to kill rats by causing them to hemorrhage. Oral anti-coagulants inhibit
hepatic synthesis of Vitamin K thus affecting clotting factors II, VIII, IX, and X. Warfrin is used
mainly to prevent thromboembolic conditions such as:
1. Thrombophlebitis
2. Pulmonary Embolism
3. Embolisms formation caused by Aterial Fibrillation which can lead to CVA
Prolong clotting time and monitoring of Prothrombin Time . INR = International Normalized
Ratio is used to account for the varibilities in reported levels from different labatories. Normal
INR is 1.3 to 2 however patients on Warfrin therapeutic range is 2-3 INR and for patients with
Mechanical Heart Valves INR is maintained at 2.5-3.5 and could go as high as 4 on the INR.
Coumadin has a long t and a very long duration. Drug accumulation can occur and lead to
external and internal bleeding. Teach patients to watch for signs of bleeding(petechiae,
ecchymosis, tarry stools, & hematemsis.
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E. Thrombolytic: Remember that normally it takes about 1-2 weeks for a blood
clot to disintegrate by natural fibrinolytic mechanisms. Our goal with
thrombolytic therapy is for this to occur much quicker thus preventing ischemia
& then tissue necrosis. These drugs work by promoting the mechanism of
converting plasminogen to plasmin, which destroys the fibrin in blood clot. The
thrombosis will disintegrate within 4 hours after the administration of a
thrombolytic drug. These drugs should be administered within 3 hours of a
thrombolytic stroke. They are also used in treatment of Pulmonary Emboli, &
Deep Vein thrombosis.
1. Five Types of Thrombolytics:
a. Steptokinase- enzyme
b. Urokinase- enzyme
c. Alteplase- alos know as a tissue plasminogen activator(tPA) Prototype)
d. Reteplase (Retavase)
e. Tenecteplase(TNKase)
*** all five of these drugs induce Fibrinolysis (fibrin breakdown)
** Anticoagulants and Anti-platelets increase the risk of hemorrhage
F. Alteplase: promotes the conversion of plasminogen to plasmin. Thrombolytic
agent. It Initiates fibrinolysis. Pregnancy Category :C
Trade name: tPA, Activase Adult Dose: IV Bolus 15mg, then 50mg infused
over 30 minutes, then 35mg infused over 60min. Maximum; 100 mg
Drug- Lab Food Interactions:
Drug: Increase bleeding when taken with oral anticoagulants, NSAIDS,
cefotetan, plicamycin
Lab; Decreases in plasminogen, fibrinogen, hematocrit, and hemogloblin
1. Pharmacokinetics:
a. Absorption: IV
b. Distribution: Protein Bind Unknown
c. Metabolism: t1/2- 5min
d. Excretion: Urine
2. Pharmacodynamics: PO Onset: immediate Peak: 5-10 min. Duration: 3hrs
3. Side Effects: Bleeding
4. Adverse Reactions: Life-threatening: Intracerebral hemorrhage, stroke,
atrial or ventricular dysrhythmias.
5. The Antithrombolytic drug Aminocaproic Acid(Amicar) is used to stop
bleeding by inhibiting plasminogen activation, which inhibits
thrombolysis.
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D. Ezetimibe (Zetia)- is a cholesterol absorption inhibitor that acts on the cells in the small
intestine to inhibit cholesterol absorption. It lowers levels of cholesterol and lipids from the
foods that are ingested. It lowers LDL, triglycerides, and ApoB levels. It also causes small
increase to the HDL. It MUST be combined with statins for optimum effect.
E. Statins- first introduced in 1987, inhibits the enzyme HMG CoA reuctase in cholesterol
synthesis in the liver. These drugs decrease the concentration of cholesterol, decreases the
LDL, and slightly increased HDL. May see a decrease in LDL in as early as 2 weeks. All
statins should be monitoring Liver enzymes and yearly eye examinations because of risk of
cataract formation and rhabdomyolysis.
1. Atorvastitin Calcium (Lipitor) Prototype
2. Fluvastain (Lescol)
3. Lovastatin (Mevacor)- 1st statin to be used . Side effects: GI disturbances, H/A, muscle
cramps, and tiredness .
4. Pravastatin Sodium ( Pravachol)
5. Simvastatin (Zocor)
6. RosuvastatinCalcium (Crestor)
F. Prototype Atrovastatin( Lipitor)- Decreases LDL by 25% with lower doses and 55% with
higher doses. It inhibits HMG-CoAreductase, the enzyme necessary for hepatic production of
cholesterol. Adult PO : 10mg/day may increase up to 80mg/day.
Drug Lab-Food Interactions:
Drug: Decrease effect with antiacids, propanolol. May increase digoxin level, oral contraceptives.
Increases effects with macrolide antiobiotics, and antifungals.
1. Pharmacokinetics;
a. Absorption: rapid
b. Distribution: Protein bond 98%
c. Metabolism: t1/2 14 hours: metabolites 20-30 hrs.
d. Excretion: to primarily in bile; some in urine
2. Pharmacodynamics: PO onset: 2 week for decreasing cholesterol
Peak: 1-2 h. 2-4 weeks to be effective
Duration: 24 hrs.
3. Side effects: Rare H/A, rash/pruitus, constipation/diarrhea, sinusitis, pharyngitis
4. Adverse Reactions: Rhabdomyolysis, myalgia, photosensitivity, cataracts
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Chapter 50 Endocrine
The endocrine System consists of ductless glands that secrete hormones in the blood stream.
Endocrine glands include: Pituitary (Hypophysis), Thyroid, Parathyroid, Adrenal , gonads, and
the Pancreas.
I.
II.
Hormones are chemicals synthesized from amino acids & cholesterol that act on body
tissue, organs & affect cellular activity.
GlandsA. Pituitary Gland- Located at the base of the brain. Divided into 2 lobes Anterior and
Posterior.
1. Anterior Lobe: (Adenohypophysis) Often called the Master Gland D/T its function of
secretions of hormones that stimulate the release of other hormones from target glands like
the thyroid. Parathyroid, adrenals, and gonads. It secretes a total of 6 hormones
a. Thyroid Stimulating Hormone (TSH) also called Thyrotropic Hormone - is
secreted in response to the Hypothalmus releasing Thyroid Releasing Hormone. When
this hormone is over secreted (hypersecretion) can cause Hyperthyroidism.
b. Adrenocorticotropic Hormone ( ACTH)- Hormone secreted to stimulate Adrenal
Cortex to release Glucocorticoid (cortisol), Mineralcorticoid hormone( Aldesterone).
More ACTH is secreted in the AM then in the PM
c. Gondtropins- Follicle stimulating hormone (FSH), & Luteinizing Hormone (LH) these
hormones control the release of hormones from the Thyroid and Adrenal, and
ovaries. Regulate hormone secretion from the ovaries & testes.
d. Growth Hormone (GH)or the Somatotrophic Hormone acts on body tissues,
particularly the bones & skeletal muscles. Regulated by the amount of Growth
Hormone Releasing Hormone & Growth Hormone Inhibiting Hormone (Somatostatin)
that is released from the Hypothalamus. Sympathomimetics drugs, Serotinin,
glucocorticoids can inhibit the secretion of Growth Hormone.
e. Prolactin (PL)- stimulates milk formation in the glandular breast tissue after childbirth
f. Melanocyte Stimulating Hormone (MSH)
Remember the amount of each hormone is regulated by negative feedback system to
the Anterior Pituitary Gland.
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Thyroid Gland- It also has 2 lobes and is located on either side of the anterior Trachea. It
secretes two hormones:
A. Thyroxine (T4)
B. Triiodothyronine( T3)
These hormones affect nearly every tissue & organ by controlling their metabolic rate.
Stimulation by the Thyroid hormone results in cardiac output, O2 consumption,
carbohydrate use, protein synthesis, & the breakdown of fats (Lipolysis). These hormones
also affect body heat regulation and womens menstrual cycles.\
IV. Parathyroid Gland: There are 4 parathyroid glands 2 pairs that lie on the dorsal surface of
the thyroid gland. It secretes 2 hormones
A. Parathyroid Hormone/PTH - this hormone regulates serum Ca+ levels. When there is a
in serum Ca+ (Hypocalcemia)the PTH is release from the parathyroid gland. PTH will
serum Ca+ levels by: 1) Mobilizing Ca+ from the bone. Remember PTH P for PTH pulls
Ca+ from the bone and puts it back into the blood stream; 2).Promotes Ca+ absorption from
the intestines; 3) Promotes Ca+ re-absorption from the renal tubules.
B. Calicitonin- Hormone that primarily is produced by Thyroid (and to a lesser extent the
Parathyroid & Thymus Glands). Its purpose is to inhibits Ca+ re-absorption by the bone &
renal excretion of Ca+ . Think Calcitonin Keeps Calcium in the bone, which is the
opposite effect of P.T.H.
V. Adrenal Glands: Located at the top of each Kidney. There are two separate sections:
A. Medulla or Center secretes catechlomanines Epinephrine and Norepinephrine.
B. Cortex- or known as the outer portion of the gland. Secretes 2 major hormones:
1. Glucocorticoids- Principal hormone is Cortisol
2. Mineralcorticoid- Aldersterone which acts in the kidney telling the kidney to
reabsorb Na+ and then water back in the systemic circulation. Some other
hormones to a smaller extent would be Androgen, Estrogen, and Progestin.
VI. Pancreas: Located to the left and behind the stomach is both an Exocrine and Endocrine
gland.
A. Exocrine property would be the secretion of digestive enzymes into the duodenum of
the small intestines.
B. Endocrine- hormones are secreted by cluster of cells called Islets of Langerhans
There are 2 types of cells the Alpha islet cells produce glucagon(which breaks glycogen
down into glucose in the liver). The Beta islet cells secrete Insulin (Regulates glucose
metabolism).
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VII. Growth Hormones: There are 2 which are secreted from the Hypothalamic Hormones:
A. Growth Hormone- releasing Hormone and Growth Hormone Inhibiting Hormone
(Somatostatin). Growth Hormone doesnt have a specific target gland but it does affect body
tissues and bones. Synthetic Growth Hormone Drugs cannot be given orally due to them
being inactivated by gastric enzymes. They are given subcutaneously or intramuscularly.
G.H. replacement therapy is very expensive. G.H. acts on newly forming bone and it must
be administered before the epiphyses are fused. Prolonged G. H. therapy can antagonize
Insulin secretion and eventually cause Diabetes Mellitus.
A. G. H. Deficiencies Drug Therapy: Drugs used to treat growth failure in children are :
1. Somatrem (Protropin)- Has identical amino acid plus an additional amino acid.
2. Somatropin (Humatrope) has identical amino acid sequences as Human G Hormone
(contraindicated in children with Prader Willi Syndrome and those children who are
severely obese or who have Respiratory impairment.
B. Growth Hormone Excess- Gigantism- excessive growth during childhood or
Acromegaly (excessive growth after puberty) can occur with Hypersecretion of G.H.
and is associated with Pituitary tumors. If the treatment with radiation is ineffective
the Prolactin- Release Inhibitor: Bromocriptine can inhibit the release of G. H.
C. Octreotide(Sandostatin) : is a potent synthetic Somatostatin used to suppress G.H.
release. It can be used alone or with Surgery and or Radiation. This drug is expensive.
G.I. side effects are common. This drug can also be used for severe diarrhea resulting
from carcinoid tumors.
VIII. Thyroid Stimulating Hormone: Adenohypophysis secretes T.S.H. in response to ThyroidReleasing Hormone from the Hypothalamus. TSH stimulates the thyroid to secrete:
Thyroxine (T4) & Triiodothyronine(T3).
A.
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XIII.
(Beta- Adrenergic Blocker) is used to control cardiac symptoms like the tachycardia and
palpitations.
A. Drugs- the purpose is to reduce excessive secretion of thyroid hormones T4 & T3 by
inhibiting their secretions.
1. Thiourea Derivatives (Thioamides) - are the drugs of choice. These drugs interfere
with the synthesis of thyroid hormones. They DO NOT destroy the thyroid tissue.
2. Propylthiouracil (PTU) and Methimazole(Tapazole)- are effective thiamide
antithyroid drugs. Useful for treatment for Thyrotoxic Crisis. PTU does inhibit peripheral
conversions of T4 & T3. Methimazole also doesnt inhibit peripheral conversion T4 & T3 but
is 10 times more potent and has a longer half life then PTU. Prolong use of thioamides may
cause a goiter to form. Stron Iodine solutions Lugols solution has been used to suppress
thyroid function. Sodium Iodine administered IV is useful for the management of thyrotoxic
crisis.
Drug Interaction Digoxin and Lithium can the action of thyroid drugs.
Dilantin serum T3 levels.
Parathyroid Gland- Parathyroid Hormone is secreted from this gland and is important in
serum Ca+ levels. The other hormone that is important in Ca+ levels is Calcitonin this
hormone serum Ca+ levels. The treatment for Hypoparathyroidism is the administration of
Parathyroid Hormone. The treatment of Hyperparathyroidism is with a synthetic form of
Calcitonin.
A. Calcitriol (Rocaltrol) is a Vitamin D analogue that promotes Ca+ absorption from the
GI tract & secretion of Ca+ from the bone into the blood stream. Mode of action enhancement of Calcium deposits in the bone.
Pregnancy Category: C
Dosage: PO 0.25 mcg/day
Contraindication: Hypersensitivity, hypercalcemia, hyperphosphatemia,
Hypervitaminosis D, malabsorption syndrome.
Caution: Cardiovascular diseases, renal calculi
1.Pharmacokinestics:
a. Absorption: PO well absorbed
b. Distribution: PB UK, crosses the placenta
c. Metabolism: t : 3-8 hrs.
d. Excretion: mostly in the feces
2. Pharmacodynamics: PO Onset: 2-6hrs. Peak: 10-12 hrs. Duration: 3-5 days
Side Effects- Anorexia, nausea, vomiting, diarrhea, cramps, drowsiness, H/A,
dizziness, lethargy, and photophobia.
Adverse Effects- Hypercalciuria, hyperphosphatemia, and hematuria
Drug; Food; Labs- Increase cardiac dysrhythmias with Digoxin and Verapamil.
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Insulin Is released from the Pancreatic Beta cells when there is an increase in serum glucose
level. Normal serum glucose levels are from 70-11-mg/dl. When serum levels go above 180mg/dl
then glucosuria (glucose in the urine) can occur. glucose in the blood acts as an osmotic
diuretic polyuria, when blood serum glucose levels are > 200mg/dl Diabetes Mellitus occurs.
Normally our bodies produce 0.2 to 0.5 units/kg/day of Insulin. Example pt weighs 154lbs which
is approx. 70 kg he would produce 14-35 units of Insulin/day.
Commercially prepared InsulinParental Insulin is obtained from either Pork or Beef . Pork Insulin is closely related to the Human
Insulin, it has only one different amino acid than Humans. Therefore Pork Insulin is a weaker
allergen then Beef. Beef Insulin has 4 different amino acids.
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Since 1983 Humulin Insulin was introduced. It has a very low incidence of causing an allergic
reaction and an Insulin resistance. Subcutaneous Human (humulin) insulin is absorbed much
faster and has a shorter duration than the animal insulins. This type of insulin is usually prescribed
for newly diagnosed clients that are insulin dependent diabetics or in a pregnant clients whom
develop hyperglycemia and those women who are diabetics and who become pregnant.
The usual dose concentration of Insulin is 100 Units/ml and is packaged in a 10 ml vial. Syringes
are also calibrated to match 100Units/ml to be used for the 100U/ml Insulin type. Before using a
vial of Insulin the nurse and or client must be taught not to shake the vial but to roll the vial
between their palms to mix contents.
Remember that Insulin is a protein and can NOT be given orally because GI secretions destroy
the insulin structure! Please also remember that REGULAR Insulin is the only type of insulin that
can be administered INTRAVENOUSLY! Clients should be taught a site rotation pattern to
help avoid Lipodystrophy (tissue atrophy or hypertrophy) which can interfere with insulin
absorption.
Insulin Absorption- > when given in the Deltoid & Abdominal areas. ( the use of heat and
massage will absorption). Of course illness and stress increase the need for insulin.
Types of Insulins- Go Back and Review your Onset Peak and Durations
Rapid Acting- clear Include Lispro Humalog, Novolog. Onset: 5-15min Peak 30-60 min D: 3-4h
Short Acting- Regular Humulin R. Onset:30-60min. Peak:2-3h D: 4-8 h
Intermediate Acting- cloudy. Humulin N. Onset:1-2h Peak:4-12h D: 18-24h
It may contain protamine (protein that prolongs action of or zinc that slow the onset of action and
prolongs the duration of action.
Long Acting- Glargine Lantus. Onset:1h Peak: None D: 24h
Combination-Humulin 70/30, Novolin 70/30, Humulin 50/50.
Review
Insulin Resistance- antibodies develop overtime in clients taking animals insulins which slows
down the onset and extends the duration of the insulin.
Insulin Pump
Somogyi Effect
Pre Dawn Syndrome
A. Oral Anti Diabetic Medications Used mostly for Type II diabetics because these clients
do produce some amounts of Insulin. First group of oral diabetics were Sulfonylureas.
These drugs stimulate beta cells to secrete more insulin. In the first generation of this
group :
Short Acting Tolbetamide Orinase
Intermediate Acting- Acetohexamide (Dymelor), Tolazamide(Tolinase)
Long Acting- Chlorpropamide (Diabinese)
2nd generation of Sulfonylureas- the tissue response to insulin& glucose production
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from the liver. They have greater hypoglycemic potency, longer duration and cause fewer
side effects. They should not be used in clients with liver or kidney dysfunction is present.
Glimepiride (Amaryl)
Glipizide (Glucotrol, Glucotrol XL) {Prototype} side effects Nausea/vomiting, diarrhea
and abdominal pain. Hypoglycemia is a major side effect.
Adverse: Hematological disorders aplastic anemia, leucopenia, thrombocytopenia,
seizures, coma
DosePharmacokinetics
Pharmacodynamics
Biguanides (Metformin, Glucophage) acts by hepatic production of glucose from the
stored glycogen, and absorption of glucose in the small intestine & it insulin receptor
sensitivity. It does not cause Hypoglycemia or Hyperglycemia. It is not recommended for
clients with Renal impairment. Hold for 48 hrs. before and after the client has IV contrast
d/t lactic acid build up or possible development of acute renal failure.
Other Anti- Diabetic Agents- Exenatide (Byetta) from amylin .Improves Betta Cell
responsivenessimproves glucose control in clients with Diabetes Type II. Action is to
enhance insulin secretion ; beta cell responsiveness , suppress glucagon secretion, slows
gastric emptying & food intake. It is not a substitute for Insulin & should be given to
patient whom have Type I Diabetes, Diabetic Ketoacidosis, some renal dysfunction, or
severe GI disease. Available in injectable pens.
Promlintide Acetate(Symlin) used to improve post prandial glucose control in diabetic clients
who are using Insulin but are
Pharmacology Review
Page 51
Pharmacology Review
Page 52