CELLULAR BIOLOGY OF

METABOLIC BONE DISEASES

Created by darti I
wibisono

Estrogen
deficiency

Vit D/calcium
parathyroi
d

Drug/steroid

Physic, chemical ,
thermal,ect
stre
ss

s
t
r

Regular
remodeling
Osteoid
formation,e
ct
Irregular
remodeling
Fibrous
dysplasia.ec
t

BONE CALCIFICATION
Ca lcium phosphate precipitation in
osteoid ?

OSTEOBLAST

ALKALINE
PHOSPHATASE

MINERALS

BONE AND CALCIUM

HOMEOSTASIS
parathyroid

RESTORATI
ON

Parathormon(PT
H)

Low Blood
Ca
BONE direct
action
induces
osteolysis
and
osteoclasis

BONE TURNOVER

Bone resorption

Bone formation

DISORDERS OF REMODELING

OSTEOPORESIS

NORMAL BONE

FORMATIO
N

RESORPTI
ON

OSTEOPORESIS

FORMATIO
N
RESORPTI
ON

osteopenia

osteoporesis

osteomalacia

RADIOLOGY

Increased porosity of
bones
(Loss of mineral and non
mineral components of
the bone)
Vit. D deficiency

OSTEOPORESIS

darti

A SYSTEMIC DISEASES
Characterised by :
1.Low bone mass
2.Micro architectural deterioration of
bone
3.An increase in bone fragility and
susceptibility to fracture

A patient is said to have osteoporesis if bone mineral

density > 2,5
Collapse
vertebral body
POROTIC BONE :
Wide honey comb
spaces

PEAK BONE MASS

darti

mal
e

female
THRESHOL
D FOR
FRACTURE

MENOPAUSE

PEAK BONE
MASS

LOW PEAK BONE MASS

STEROID,ALCO
HOL,ECT

LOW BONE MASS

1. Genetik predisposition
2. Nutrition
3. Excercise
fracture

OSTEOMALACI
A

RICKETS
VIT D
deficiency

FAILURE
CALCIFICATIO
N

Disturbance at
growing ends of
long bone

Failure
normal
remodelling

adult

Growing child

DEVELOPMENTAL
ABNORMALITIES
GENERELISED
ABNORMALITIES

1 .cartilage cells
2.The defect is in the osteoblast
fail to
synthesise collagen
properly.
*Type I collagen genes
chromosome 7
and 17
3.Osteoclasts are absent or
defective

LOCAL
ABNORMALITIES

CLEFT PALATE
SPINA BIFIDA
SCOLIOSIS
ECT

ACHONDROPLASIA DWARFISM
Irregular
development
of
cartilage cells
OSTEOGENESIS IMPERFECTA :
*The defect is in the osTeoblast which fail to
synthesise collagen properly
*Abnormal
in
:Type1
collagen
genes,shromosome 7 and 17

OSTEOPETROSIS (MARBLE
BONE DISEASE OF ALBERSSCNBERG)
Osteoclasts are absent or
defective

BONE MICELLANEUS

1.HYPERPARATHYROIDISM CYSTIC SPACE

2.HYPERTROPHY (ACROMEGALY)
3.FIBROUS DYSPLASIA
4.PAGETS DISEASE OF BONE

1.
2.
3.

Fracture
Osteoarthritis
Bone Sarcoma

CYSTIC LESIONS IN BONE

BONE DISORDERS
TRU
E?

Cystic
aneurysm
/degeneration
Eosiniphilic granuloma
Giant Cell Tumor of the
bone
ect