Mohammad Farzy Aliuden

RN, MAN

CI: Virginia Margallo,

DRUG STUDY

Generic
Name

Brand
Name

Classific
ation

Mode of
Action

Indication

Contraindica
tion

Actua Usual
l
Dose
Dose

Adverse
Effects

Nursing
Responsibiliti
es

Clopidog
rel

Thromb
ix

Antithro
mbotic

Inhibits
platelet
aggregati
on by
irreversibl
y
inhibiting
the
binding of
ATP to
platelet
receptors.

Reduction
Hypersensitivi
PO
PO
of atherosclero ty Pathologic
75mg 75mg
tic events (MI,
bleeding
4 tabs 1 tab
stroke,
(peptic ulcer,
STAT
OD
vascular death
intracranial
) in patients at
hemorrhage)
risk for such
Lactation.
events
including
Use
recent MI,
Cautiously
acute coronary
in:
syndrome
Patients at risk
(unstable
for bleeding
Therapeu angina/non-Q(trauma,
tic
wave MI),
surgery, or
Effects:
stroke,
other patholog
Decreased
or peripheral
ic
occurrenc vascular diseas conditions)His
e
e.
tory of GI
of atheros
bleeding/ulcer
clerotic
disease
events in
Severe
patients
hepatic
at risk.
impairment

CNS:
Depression
, Dizziness,
Fatigue,
Headache.
EENT:
Epistaxis.
Resp:
Cough,
Dyspnea.
CV:
Chest Pain,
Edema,
Hypertensi
on.
GI:
GI
Bleeding, A
bdominal
Pain,
Diarrhea,
Dyspepsia,
Gastritis.
Derma:
Pruritus,
Purpura,

Assessment
Assess patient for
symptoms of
stroke, peripheral
vascular disease,
or MI periodically
during therapy.
Monitor patient for
signs of thrombotic
thrombocytic
purpura
(thrombocytopenia
, microangiopathic
hemolytic anemia,
neurologic
findings, renal
dysfunction,
fever).May rarely
occur, even after
short exposure(<2
wk). Requires
prompt treatment.
Implementation
Discontinue
clopidogrel 5-7
days before
planned surgical
procedures.
PO:

Rash.
Hemat:
Bleeding,
Neutropeni
a,
Thrombotic
Thrombocy
topenic
Purpura.
Metab:
Hyperchole
sterolemia.
MS:
Arthralgia,
Back Pain.
Misc:
Fever,
Hypersensi
tivity
Reactions.

Administer
once daily without
regard to food.
Patient/Family
Teaching
Instruct patient to
take medication
exactly as
directed. Take
missed doses as
soon as possible
unless almost time
for next dose; do
not double
doses. Advise
patient to notify
health care
professional
promptly if fever,
chills, sore throat,
or unusual
bleeding or
bruising
occurs. Advise
patient to notify
health care
professional of
medication
regimen prior to

treatment or
surgery.