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    DARPP-32 is a protein that regulates intracellular signaling cascades in response to neuronal activity in the basal ganglia of the forebrain, which controls information processing and behaviors related to motivation and reward. The document discusses how calcium and cAMP concentrations regulate phosphorylation sites on DARPP-32, ultimately controlling dopamine receptor expression in the brain and its role in pathological conditions like Parkinson's disease and drug addiction. The signature block provides information about the author, SoYoung Kwon, a STEAM internship student in 2017, and her mentor Annalisa Scimemi.

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    DARPP-32 is a protein that regulates intracellular signaling cascades in response to neuronal activity in the basal ganglia of the forebrain, which controls information processing and behaviors related to motivation and reward. The document discusses how calcium and cAMP concentrations regulate phosphorylation sites on DARPP-32, ultimately controlling dopamine receptor expression in the brain and its role in pathological conditions like Parkinson's disease and drug addiction. The signature block provides information about the author, SoYoung Kwon, a STEAM internship student in 2017, and her mentor Annalisa Scimemi.

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    35 views1 page

    Signature Poster

    Uploaded by

    api-298628829
    DARPP-32 is a protein that regulates intracellular signaling cascades in response to neuronal activity in the basal ganglia of the forebrain, which controls information processing and behaviors related to motivation and reward. The document discusses how calcium and cAMP concentrations regulate phosphorylation sites on DARPP-32, ultimately controlling dopamine receptor expression in the brain and its role in pathological conditions like Parkinson's disease and drug addiction. The signature block provides information about the author, SoYoung Kwon, a STEAM internship student in 2017, and her mentor Annalisa Scimemi.

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    Signature: STEAM Internship 15-16

    SoYoung Kwon
    Class of 2017

    How do cAMP and calcium concentrations regulate phosphorylation sites


    of DARPP-32, ultimately controlling dopamine receptor expression?

    The brain controls the efficiency of processing information in response to neuronal


    activity. The basal ganglia of mammals in their forebrain are responsible for many
    behavioral functions related to motivation and reward, including pathological
    conditions such as Parkinson disease, Huntington chorea, schizophrenic syndromes,
    and drug addictions.
    DARPP-32 is one of the proteins that regulate intracellular signaling cascades in
    response to neuronal activity.

    Blog
    syksteam.weebly.com

    Mentor
    Annalisa Scimemi
    Assistant Professor of Biological Sciences at
    University at Albany
    https://sites.google.com/site/scimemilab2013/

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