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  • Nefroblastoma (Tumor Wilms)

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    Annisa Firizqi Nahlia
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    Nefroblastoma, also known as Wilms tumor, is a type of cancer that arises from embryonic kidney tissue. It typically occurs in children under 15 years old, with a peak incidence between ages 2-3. Diagnosis involves a physical exam, lab tests, imaging like ultrasound or CT scan, and histopathological examination of a biopsy sample. Treatment depends on tumor stage and differentiation, and may involve chemotherapy with vincristine, actinomycin D, and doxorubicin, as well as surgery and radiation therapy. Prognosis is generally good if caught early and treated aggressively.

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    Nefroblastoma, also known as Wilms tumor, is a type of cancer that arises from embryonic kidney tissue. It typically occurs in children under 15 years old, with a peak incidence between ages 2-3. Diagnosis involves a physical exam, lab tests, imaging like ultrasound or CT scan, and histopathological examination of a biopsy sample. Treatment depends on tumor stage and differentiation, and may involve chemotherapy with vincristine, actinomycin D, and doxorubicin, as well as surgery and radiation therapy. Prognosis is generally good if caught early and treated aggressively.

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    38 views12 pages

    Nefroblastoma (Tumor Wilms)

    Uploaded by

    Annisa Firizqi Nahlia
    Nefroblastoma, also known as Wilms tumor, is a type of cancer that arises from embryonic kidney tissue. It typically occurs in children under 15 years old, with a peak incidence between ages 2-3. Diagnosis involves a physical exam, lab tests, imaging like ultrasound or CT scan, and histopathological examination of a biopsy sample. Treatment depends on tumor stage and differentiation, and may involve chemotherapy with vincristine, actinomycin D, and doxorubicin, as well as surgery and radiation therapy. Prognosis is generally good if caught early and treated aggressively.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 12

    Nefroblastoma (Tumor

    Wilms)
    Annisa F. Nahlia
    13-199

    Definisi
    Tumor embrional yg berasal dr
    jaringan embrionik ginjal yg timbul
    dlm parenkim ginjal dan merupakan
    sisa2 blastoma nefrogen
    (metanephros)
    Tumor di kelilingi oleh jaringan
    pseudokapsul dan menekan sisa
    parenkim ginjal normal

    Epidemiologi
    Sering terjadi pd anak2 dgn insiden
    7,8:1000000 ( < 15 thn)
    pertahunnya
    Puncaknya pd usia 2,5 3 tahun
    PR : LK = 1 :1,2
    Insiden lbh srng pd ras AfrikaAmerika dibandingkan dgn ras Asia
    Nefroblastoma bilateral insidennya 510%

    Etiologi
    Idiopatik
    Faktor genetik yg diturunkan scr
    autosomal dominan
    Delesi kromosom 11p13 Wilms
    Tumor 1 (WT1)
    Delesi kromosom 11p15 Wilms
    Tumor2 (WT2)
    Delesi kromosom 16q Wilms
    Tumor3 (WT3)

    Gejala Klinis

    Perut membuncit
    Hematuria
    Hipertensi
    Anemia & penurunan BB
    Demam, malaise, muntah, anoreksia
    Nyeri perut yg bersifat kolik
    Tanda2 infeksi saluran kencing

    Penyebaran & metastase


    Tumor mendesak jar ginjal yg normal
    & membentuk pseudokapsul
    tumor lama2 mendesak
    pseudokapsul diikuti o/ infiltrasi ke
    dlm jar ginjal itu sndr menyebar ke
    dlm jar perirenal bermetastasis :
    perkontinuitatum, hematogen,
    limfogen

    Diagnosis

    Anamnesis
    Px. Fisik
    px. Penungjang
    Px lab
    px. histopatologi
    EKG
    USG abdomen
    CT Scan Abdomen

    Penatalaksanaan
    1. Farmakologi
    a. Pasien tanpa metastasis
    -. Vincristin 0,05 mg/kgBB/hr IV
    -. Actinomisin 15 mg/kgBB/hr IV
    b. Pasien dgn metastasis ke paru, tulang
    -. Doxurubicin
    c. Stadium 1 & 2 diferensiasi baik
    - Vincristin 0,05 mg/kgBB/hr IV
    - Actinomisin 15 mg/kgBB/hr IV

    d. Stadium 3 diferensiasi baik


    - Vincristin 0,05 mg/kgBB/hr IV
    - Actinomisin 15 mg/kgBB/hr IV
    - Doxurubicin
    - Terapi radiasi
    e. Stadium 4 diferensiasi baik
    - Vincristin 0,05 mg/kgBB/hr IV
    - Actinomisin 15 mg/kgBB/hr IV
    - Doxurubicin
    - Terapi radiasi
    - Jk ada tumor hepar radioterapi

    f. Tumor diferensiasi buruk


    - Vincristin
    - Actinomisin D
    - Siklofosfamid
    - Radioterapi
    2. Non Farmakologi
    - pembebedahan

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