WILMS TUMOR

By Nuzul Alimi
Introduction
 Wilms tumor, also known as nephroblastoma, is
a cancer of the kidneys that typically occurs
in children, rarely in adults.
Introduction

Wilms tumor is the most common childhood renal tumor,accounting for

approximately 6 % off all pediatric malignancies

This tumor tends to occur between ages 1 and 3 years

The incidence of wilms tumor is 1 in 10000 children

HISTOLOGY
EMBRIONAL RENAL
NEOPLASMA

BLASTEMAL

STROMAL

EPITHELIAL
CELLS
Histology
Wilms tumors may be separated into 2 prognostic
groups based on pathologic characteristics:
 Favorable - Contains well developed components
mentioned above
 Anaplastic - Contains diffuse anaplasia (poorly

developed cells)
Sign and symptoms
Typical signs and symptoms of Wilms tumor include the following:
 a painless, palpable abdominal mass

 loss of appetite

 abdominal pain

 Constipation

 SOB

 fever

 nausea and vomiting

 blood in the urine (in about 20% of cases)

 high blood pressure in some cases (especially if synchronous or

metachronous bilateral kidney involvement)
Diagnosis
 Chest radiography  detect pulmonary metastatis
 Abdominal radiography linear calcification
 Ultrasound  characteristic of the
mass,intravascular involment
 Ct scan of abdomen
 Biopsy(not typically performed due to seeding of
malignant tissue into abdomen) type of tumour
tissue.
Abd x ray
Diagnosis
Staging
Treatment
The main types of treatment are:
 Surgery-nephrectomy

Remove the tumour.

 Chemotherapy

 radiation therapy

Prognosis :
The overall 5-year survival is estimated to be approximately
90%
In case of relapse of Wilms tumor, the 4-year survival rate for
children with a standard-risk has been estimated to be 80%